Kin Chan

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc The choice of nucleotide inserted opposite abasic sites formed within chromosomal DNA reveals the polymerase activities participating in translesion DNA synthesis
    Kin Chan
    Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA Electronic address
    DNA Repair (Amst) 12:878-89. 2013
  2. pmc Base damage within single-strand DNA underlies in vivo hypermutability induced by a ubiquitous environmental agent
    Kin Chan
    Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
    PLoS Genet 8:e1003149. 2012
  3. pmc An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers
    Kin Chan
    Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA
    Nat Genet 47:1067-72. 2015
  4. pmc Clusters of Multiple Mutations: Incidence and Molecular Mechanisms
    Kin Chan
    Mechanisms of Genome Dynamics Group, National Institute of Environmental Health Sciences, Department of Health and Human Services, National Institutes of Health, Durham, North Carolina 27709 email
    Annu Rev Genet 49:243-67. 2015

Collaborators

Detail Information

Publications4

  1. pmc The choice of nucleotide inserted opposite abasic sites formed within chromosomal DNA reveals the polymerase activities participating in translesion DNA synthesis
    Kin Chan
    Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA Electronic address
    DNA Repair (Amst) 12:878-89. 2013
    ..Our results underscore the utility of this system for studying TLS bypass of many types of lesions within genomic DNA. ..
  2. pmc Base damage within single-strand DNA underlies in vivo hypermutability induced by a ubiquitous environmental agent
    Kin Chan
    Chromosome Stability Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
    PLoS Genet 8:e1003149. 2012
    ..Our results suggest that sulfite-induced lesions in DNA can be particularly deleterious, since cells might not possess the means to repair or bypass such lesions accurately...
  3. pmc An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers
    Kin Chan
    Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA
    Nat Genet 47:1067-72. 2015
    ..We propose that APOBEC3A-mediated mutagenesis is much more frequent because APOBEC3A itself is highly proficient at generating DNA breaks, whose repair can trigger the formation of single-strand hypermutation substrates. ..
  4. pmc Clusters of Multiple Mutations: Incidence and Molecular Mechanisms
    Kin Chan
    Mechanisms of Genome Dynamics Group, National Institute of Environmental Health Sciences, Department of Health and Human Services, National Institutes of Health, Durham, North Carolina 27709 email
    Annu Rev Genet 49:243-67. 2015
    ..Future research on clustered mutagenesis may shed light onto important mechanistic details of genome maintenance, with potentially profound implications for human health. ..