Neil E Caporaso

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Current insight on trends, causes, and mechanisms of Hodgkin's lymphoma
    Neil E Caporaso
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer J 15:117-23. 2009
  2. pmc C-reactive protein and risk of lung cancer
    Anil K Chaturvedi
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Rockville, MD 20852, USA
    J Clin Oncol 28:2719-26. 2010
  3. pmc Genetic variation in innate immunity and inflammation pathways associated with lung cancer risk
    Meredith S Shiels
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA
    Cancer 118:5630-6. 2012
  4. pmc A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma
    Maria Teresa Landi
    Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Hum Genet 85:679-91. 2009
  5. pmc Alcohol consumption and lung cancer risk in the Environment and Genetics in Lung Cancer Etiology (EAGLE) study
    Vincenzo Bagnardi
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 7114, Bethesda, MD 20892 7236, USA
    Am J Epidemiol 171:36-44. 2010
  6. pmc Chronic obstructive pulmonary disease and altered risk of lung cancer in a population-based case-control study
    Jill Koshiol
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS ONE 4:e7380. 2009
  7. ncbi request reprint Risks of cancer among a cohort of 23,935 men and women with osteoporosis
    Katherine A McGlynn
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, EPS Suite 550, 6120 Executive Boulevard, Rockville, MD 20852 7234, USA
    Int J Cancer 122:1879-84. 2008
  8. pmc MicroRNA expression differentiates histology and predicts survival of lung cancer
    Maria Teresa Landi
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892 7236, USA
    Clin Cancer Res 16:430-41. 2010
  9. pmc Survival patterns among lymphoma patients with a family history of lymphoma
    Lesley A Anderson
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    J Clin Oncol 26:4958-65. 2008
  10. pmc Family history of cancer and nonmalignant lung diseases as risk factors for lung cancer
    Ying Gao
    Division of Cancer Epidemiology and Genetics, Genetic Epidemiology Branch, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7236, USA
    Int J Cancer 125:146-52. 2009

Detail Information

Publications95

  1. doi request reprint Current insight on trends, causes, and mechanisms of Hodgkin's lymphoma
    Neil E Caporaso
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer J 15:117-23. 2009
    ..These results emphasize an interaction between environmental and genetic risk factors in HL...
  2. pmc C-reactive protein and risk of lung cancer
    Anil K Chaturvedi
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Rockville, MD 20852, USA
    J Clin Oncol 28:2719-26. 2010
    ..We investigated the association of circulating high-sensitivity C-reactive protein (CRP, an inflammation biomarker) and CRP single nucleotide polymorphisms (SNPs) with prospective lung cancer risk...
  3. pmc Genetic variation in innate immunity and inflammation pathways associated with lung cancer risk
    Meredith S Shiels
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA
    Cancer 118:5630-6. 2012
    ....
  4. pmc A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma
    Maria Teresa Landi
    Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Hum Genet 85:679-91. 2009
    ..In conclusion, a lung cancer GWAS identified a distinct hereditary contribution to adenocarcinoma...
  5. pmc Alcohol consumption and lung cancer risk in the Environment and Genetics in Lung Cancer Etiology (EAGLE) study
    Vincenzo Bagnardi
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 7114, Bethesda, MD 20892 7236, USA
    Am J Epidemiol 171:36-44. 2010
    ..Although residual confounding by tobacco smoking cannot be ruled out, this finding may reflect interplay between alcohol and smoking, emphasizing the need for preventive measures...
  6. pmc Chronic obstructive pulmonary disease and altered risk of lung cancer in a population-based case-control study
    Jill Koshiol
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS ONE 4:e7380. 2009
    ..Chronic obstructive pulmonary disease (COPD) has been consistently associated with increased risk of lung cancer. However, previous studies have had limited ability to determine whether the association is due to smoking...
  7. ncbi request reprint Risks of cancer among a cohort of 23,935 men and women with osteoporosis
    Katherine A McGlynn
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, EPS Suite 550, 6120 Executive Boulevard, Rockville, MD 20852 7234, USA
    Int J Cancer 122:1879-84. 2008
    ..Conversely, factors associated with later onset osteoporosis may be related to a decreased risk of cancer...
  8. pmc MicroRNA expression differentiates histology and predicts survival of lung cancer
    Maria Teresa Landi
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892 7236, USA
    Clin Cancer Res 16:430-41. 2010
    ..The molecular drivers that determine histology in lung cancer are largely unknown. We investigated whether microRNA (miR) expression profiles can differentiate histologic subtypes and predict survival for non-small cell lung cancer...
  9. pmc Survival patterns among lymphoma patients with a family history of lymphoma
    Lesley A Anderson
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    J Clin Oncol 26:4958-65. 2008
    ..Only a few small studies have assessed clinical characteristics and prognosis for familial patients, with inconsistent findings...
  10. pmc Family history of cancer and nonmalignant lung diseases as risk factors for lung cancer
    Ying Gao
    Division of Cancer Epidemiology and Genetics, Genetic Epidemiology Branch, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7236, USA
    Int J Cancer 125:146-52. 2009
    ..23-1.80) and decreased (OR = 0.73, 95% CI = 0.61-0.87) lung cancer risk, respectively. FH of lung cancer and nonmalignant lung diseases affected lung cancer risk independently, and did not appear to be modified by FH of smoking...
  11. ncbi request reprint Genetic variation in catechol-O-methyltransferase (COMT) and obesity in the prostate, lung, colorectal, and ovarian (PLCO) cancer screening trial
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 5104, MSC 7234, Rockville, MD 20852, USA
    Hum Genet 122:41-9. 2007
    ..Our results support a need for comprehensive evaluation of COMT variations and their functional relevance as COMT may be an important molecular target to evaluate for new treatments regarding obesity...
  12. pmc Obesity is associated with an increased risk of monoclonal gammopathy of undetermined significance among black and white women
    Ola Landgren
    Center for Cancer Research and Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 116:1056-9. 2010
    ..Our findings support the hypothesis that obesity is etiologically linked to myelomagenesis. The 2-fold excess of MGUS among blacks compared with whites of similar socioeconomic status supports a role for susceptibility genes in MGUS...
  13. pmc Circulating inflammation markers and prospective risk for lung cancer
    Meredith S Shiels
    Affiliations of authors Infections and Immunoepidemiology Branch MSS, AH, EAE, JK, AKC, Biostatistics Branch RMP, HAK, and Genetic Epidemiology Branch NEC, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD HPV Immunology Laboratory, SAIC Frederick Inc, Frederick, MD TJK, gs, LAP Department of Statistics, Dongguk University, Seoul, Korea J HP
    J Natl Cancer Inst 105:1871-80. 2013
    ..Despite growing recognition of an etiologic role for inflammation in lung carcinogenesis, few prospective epidemiologic studies have comprehensively investigated the association of circulating inflammation markers with lung cancer...
  14. pmc Are women who smoke at higher risk for lung cancer than men who smoke?
    Sara De Matteis
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Epidemiol 177:601-12. 2013
    ..g., tobacco type, inhalation depth, Fagerström-assessed nicotine dependence). These findings do not support a higher female susceptibility to tobacco-related lung cancer...
  15. pmc Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression
    Melissa Rotunno
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 4:e5652. 2009
    ..Our findings emphasize the necessity of post-GWAS fine mapping and SNP functional assessment to further elucidate cancer risk associations...
  16. pmc Dietary quercetin, quercetin-gene interaction, metabolic gene expression in lung tissue and lung cancer risk
    Tram Kim Lam
    Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 31:634-42. 2010
    ..Our findings suggest an interplay between quercetin intake, tobacco smoking, and lung cancer risk. Further research on this relationship is warranted...
  17. pmc Heme-related gene expression signatures of meat intakes in lung cancer tissues
    Tram Kim Lam
    Cancer Prevention Fellowship Program, Office of Preventive Oncology, Genetic Epidemiology Branch, National Cancer Institute, National Institutes of Health NIH, DHHS, Bethesda, Maryland Division of Cancer Epidemiology and Genetics, Genetic Epidemiology Branch, National Cancer Institute, National Institutes of Health NIH, DHHS, Bethesda, Maryland
    Mol Carcinog 53:548-56. 2014
    ..g., TPO, SGK2, and MTHFR) that may be indirectly related to heme-toxicity. The study's results provide preliminary evidence that heme-iron toxicity might be one underlying mechanism linking fresh red meat intake and lung cancer...
  18. pmc A gene expression signature from peripheral whole blood for stage I lung adenocarcinoma
    Melissa Rotunno
    Division of Cancer Epidemiology and Genetics, NCI, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Cancer Prev Res (Phila) 4:1599-608. 2011
    ..81, 95% CI = 0.74-0.87). Our finding suggests the use of gene expression from PWB for the identification of early detection markers of lung cancer in the future...
  19. pmc DNA repair gene polymorphisms and tobacco smoking in the risk for colorectal adenomas
    Ying Gao
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7236, USA
    Carcinogenesis 32:882-7. 2011
    ....
  20. pmc SLC6A3 and body mass index in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
    Elizabeth M Azzato
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, Maryland, USA
    BMC Med Genet 10:9. 2009
    ....
  21. pmc Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer
    Sharon R Pine
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 4258, USA
    J Natl Cancer Inst 103:1112-22. 2011
    ..Previous studies that were based primarily on small numbers of patients suggested that certain circulating proinflammatory cytokines may be associated with lung cancer; however, large independent studies are lacking...
  22. doi request reprint Maternal EPHX1 polymorphisms and risk of phenytoin-induced congenital malformations
    Elizabeth M Azzato
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, Maryland 20852, USA
    Pharmacogenet Genomics 20:58-63. 2010
    ....
  23. pmc GSTM1 and GSTT1 copy numbers and mRNA expression in lung cancer
    Melissa Rotunno
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7248, USA
    Mol Carcinog 51:E142-50. 2012
    ..A protective effect of the same mutations may be operative in never-smokers and women, possibly because of reduced activity of other genotoxic chemicals...
  24. pmc No effect of meat, meat cooking preferences, meat mutagens or heme iron on lung cancer risk in the prostate, lung, colorectal and ovarian cancer screening trial
    Natasa Tasevska
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Int J Cancer 128:402-11. 2011
    ..In this population, we found no association between meat type, cooking method, doneness level or intake of specific meat mutagens or heme iron and lung cancer risk...
  25. pmc Time to smoke first morning cigarette and lung cancer in a case-control study
    Fangyi Gu
    Affiliations of authors Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD FG, SW, SK, OAP, CR G, NDF, SDM, MTL, NEC Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College London, London, UK SDM Epidemiology Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico and Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, Milan, Italy SDM, DC, PAB Center for Health Sciences, SRI International, Menlo Park, CA AWB
    J Natl Cancer Inst 106:dju118. 2014
    ..We evaluated whether time to first cigarette after waking (TTFC), a single-item measure of nicotine dependency, could improve stratification of lung cancer risk beyond standard smoking metrics (intensity, duration, and pack-years)...
  26. pmc Influence of quercetin-rich food intake on microRNA expression in lung cancer tissues
    Tram K Lam
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 21:2176-84. 2012
    ..A quercetin-rich diet might modulate microRNA (miR) expression; however, this mechanism has not been fully examined...
  27. pmc Mood disorders and risk of lung cancer in the EAGLE case-control study and in the U.S. Veterans Affairs inpatient cohort
    David E Capo-Ramos
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e42945. 2012
    ..Mood disorders may affect lung cancer risk. We evaluated this hypothesis in two large studies...
  28. pmc Helicobacter pylori seropositivity and risk of lung cancer
    Jill Koshiol
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS ONE 7:e32106. 2012
    ..pylori seropositivity. Despite earlier small studies suggesting that H. pylori may contribute to lung carcinogenesis, H. pylori seropositivity does not appear to be associated with lung cancer...
  29. pmc Evidence of serum immunoglobulin abnormalities up to 9.8 years before diagnosis of chronic lymphocytic leukemia: a prospective study
    Huei Ting Tsai
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD, USA
    Blood 114:4928-32. 2009
    ..These findings support a role for chronic immune stimulation in CLL genesis...
  30. pmc Intakes of red meat, processed meat, and meat mutagens increase lung cancer risk
    Tram Kim Lam
    Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute, NIH, Department of Health and Human Services, corrected Bethesda, Maryland 20892 7236, USA
    Cancer Res 69:932-9. 2009
    ..In summary, red meat, processed meat, and meat mutagens were independently associated with increased risk of lung cancer...
  31. pmc Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 113:5412-7. 2009
    ..In the present study, an asymptomatic MGUS stage consistently preceded MM. Novel molecular markers are needed to better predict progression to MM in patients with MGUS...
  32. pmc Inherited variation at chromosome 12p13.33, including RAD52, influences the risk of squamous cell lung carcinoma
    Jianxin Shi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Cancer Discov 2:131-9. 2012
    ..33 (RAD52, rs6489769) and replicated the association in 3 independent studies totaling 3,359 squamous cell lung carcinoma cases and 9,100 controls (OR = 1.20, P(combined) = 2.3 × 10(-8))...
  33. pmc Risk of plasma cell and lymphoproliferative disorders among 14621 first-degree relatives of 4458 patients with monoclonal gammopathy of undetermined significance in Sweden
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, and Center for Cancer Research, Medical Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Blood 114:791-5. 2009
    ..Among first-degree relatives of a nationwide MGUS cohort, we found elevated risks of MGUS, MM, LPL/WM, and CLL, supporting a role for germline susceptibility genes, shared environmental influences, or an interaction between both...
  34. pmc Lower risk of lung cancer after multiple pneumonia diagnoses
    Jill Koshiol
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, MSC 7248, Bethesda, MD 20892 7248, USA
    Cancer Epidemiol Biomarkers Prev 19:716-21. 2010
    ..Although pneumonia has been suggested as a risk factor for lung cancer, previous studies have not evaluated the influence of number of pneumonia diagnoses in relation to lung cancer risk...
  35. pmc Environment And Genetics in Lung cancer Etiology (EAGLE) study: an integrative population-based case-control study of lung cancer
    Maria Teresa Landi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA
    BMC Public Health 8:203. 2008
    ..A new framework of research is needed to address the challenges offered by this complex disease...
  36. pmc Predictors of sustained smoking cessation: a prospective analysis of chronic smokers from the alpha-tocopherol Beta-carotene cancer prevention study
    Erik M Augustson
    National Cancer Institute, DCCPS TCRB, EPN 4039B, 6130 Executive Blvd, MSC 7337, Bethesda, MD 20892 7337, USA
    Am J Public Health 98:549-55. 2008
    ..Using a nested case-control design, we explored the association between ability to sustain cessation over an extended period and demographic, smoking, medical, and behavioral variables...
  37. ncbi request reprint Risk of malignant disease among 1525 adult male US Veterans with Gaucher disease
    Ola Landgren
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Arch Intern Med 167:1189-94. 2007
    ..The aim of this study was to assess the pattern of Gaucher disease and subsequent malignancies among male veterans admitted to US Veterans Affairs hospitals...
  38. doi request reprint Circulating Inflammation Markers, Risk of Lung Cancer, and Utility for Risk Stratification
    Meredith S Shiels
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD MSS, HAK, AH, RMP, EAE, NEC, AKC HPV Immunology Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, MD MW, TJK, LAP
    J Natl Cancer Inst 107:. 2015
    ..We conducted two independent nested case-control studies to identify circulating inflammation markers reproducibly associated with lung cancer risk and to investigate the utility of replicated markers for lung cancer risk stratification...
  39. pmc Cigarette smoking behaviour and blood metabolomics
    Fangyi Gu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Int J Epidemiol 45:1421-1432. 2016
    ..However, previous studies are limited, generally small, and have largely targeted a priori metabolites...
  40. pmc Characterizing human lung tissue microbiota and its relationship to epidemiological and clinical features
    Guoqin Yu
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Genome Biol 17:163. 2016
    ..Here we characterized the taxonomic and derived functional profiles of lung microbiota in 165 non-malignant lung tissue samples from cancer patients...
  41. pmc Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Nat Commun 7:10933. 2016
    ..2 (rs1274963, CSRNP1, P=2.12 × 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility. ..
  42. pmc Targeting of low-dose CT screening according to the risk of lung-cancer death
    Stephanie A Kovalchik
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, and Information Management Services, Rockville, MD, USA
    N Engl J Med 369:245-54. 2013
    ..It is not known whether the benefits and potential harms of such screening vary according to lung-cancer risk...
  43. pmc Urinary concentrations of estrogens and estrogen metabolites and smoking in caucasian women
    Fangyi Gu
    National Cancer Institute, 6120 Executive Blvd, Room 7110, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 22:58-68. 2013
    ..However, comprehensive studies of smoking and estrogen metabolism by 2-, 4-, or 16-hydroxylation are sparse...
  44. pmc Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway
    H Dean Hosgood
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 29:1938-43. 2008
    ..These results should be viewed as exploratory until they are replicated in a larger study...
  45. pmc Assessment of human papillomavirus in lung tumor tissue
    Jill Koshiol
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7248, USA
    J Natl Cancer Inst 103:501-7. 2011
    ..Lung cancer kills more than 1 million people worldwide each year. Whereas several human papillomavirus (HPV)-associated cancers have been identified, the role of HPV in lung carcinogenesis remains controversial...
  46. pmc Lung cancer risk following detection of pulmonary scarring by chest radiography in the prostate, lung, colorectal, and ovarian cancer screening trial
    Ying Ying Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 7076, Rockville, MD 20892, USA
    Arch Intern Med 168:2326-32; discussion 2332. 2008
    ..However, the nature of the relationship between pulmonary scarring and lung cancer remains uncertain. Our objective was to test whether localized pulmonary scarring is associated with increased lung cancer risk...
  47. ncbi request reprint Cigarette smoking and lung cancer: modeling total exposure and intensity
    Jay H Lubin
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 15:517-23. 2006
    ..e., smoking at a lower intensity for longer duration is more deleterious than smoking at a higher intensity for shorter duration)...
  48. pmc Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data
    Jianxin Shi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS Genet 12:e1006493. 2016
    ....
  49. pmc Genetic polymorphisms in the 9p21 region associated with risk of multiple cancers
    Wen Qing Li
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA, Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI, USA
    Carcinogenesis 35:2698-705. 2014
    ..In conclusion, we identified several genetic variants in the 9p21 region associated with the risk of multiple cancers, suggesting that this region may contribute to a shared susceptibility across different cancer types. ..
  50. pmc Lung cancer prognosis before and after recurrence in a population-based setting
    Dario Consonni
    Epidemiology Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy DC, PAB, ACP Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA MP Genetic Epidemiology Branch MP, MRo, AG, LG, NEC, MAT, MTL and Biostatistics Branch MHG, Jl, SW, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, Milan, Italy MRu, PAB, ACP
    J Natl Cancer Inst 107:djv059. 2015
    ..Population-based estimates of absolute risk of lung cancer recurrence, and of mortality rates after recurrence, can inform clinical management...
  51. pmc Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Bethesda, Maryland, USA
    Nat Genet 45:868-76. 2013
    ..3 (ODF1, P=5.40×10(-8)) and 5p15.33 (TERT, P=1.92×10(-7)). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism...
  52. pmc Increased risk for non-Hodgkin lymphoma in individuals with celiac disease and a potential familial association
    Ying Gao
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7236, USA
    Gastroenterology 136:91-8. 2009
    ..However, there are only limited data on risk in the current era of serologic testing and human leukocytes antigen typing to screen for CD. There is also no information on the role of family history of CD in relation to lymphoma risk...
  53. pmc Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7236, USA
    Blood 109:2198-201. 2007
    ..001). None of 9 other respiratory-tract infections was significantly associated with CLL risk. Pneumonia might be a potential CLL trigger or it could represent premalignant immune disruption preceding CLL...
  54. doi request reprint Monoclonal B cell lymphocytosis: clinical and population perspectives
    Neil E Caporaso
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cytometry B Clin Cytom 78:S115-9. 2010
    ..Further studies of MBL are needed to identify the molecular features and how they evolve during progression...
  55. doi request reprint Chlamydia pneumoniae infection and risk for lung cancer
    Anil K Chaturvedi
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 19:1498-505. 2010
    ....
  56. pmc Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome
    Mitchell J Machiela
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Nat Commun 7:11843. 2016
    ....
  57. pmc Impact of changing US cigarette smoking patterns on incident cancer: risks of 20 smoking-related cancers among the women and men of the NIH-AARP cohort
    Neal D Freedman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Int J Epidemiol 45:846-56. 2016
    ..However, more recent birth cohorts of women and men have similar smoking histories and have now reached the high-risk age for cancer. The impact of these changes on cancer incidence has not been systematically examined...
  58. pmc Differential Serum Cytokine Levels and Risk of Lung Cancer Between African and European Americans
    Sharon R Pine
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, New Jersey
    Cancer Epidemiol Biomarkers Prev 25:488-97. 2016
    ..We hypothesized that variations in serum cytokine levels exist between African Americans and European Americans, and increased circulating cytokine levels contribute to lung cancer differently in the two races...
  59. pmc Time to First Morning Cigarette and Risk of Chronic Obstructive Pulmonary Disease: Smokers in the PLCO Cancer Screening Trial
    Kristin A Guertin
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health NIH, Department of Health and Human Services, Bethesda, MD, United States of America
    PLoS ONE 10:e0125973. 2015
    ..The association between TTFC and chronic obstructive pulmonary disease (COPD), the third leading cause of death in the United States, has not yet been reported...
  60. pmc Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types
    Joshua N Sampson
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD JNS, OP, SIB, QL, CCA, LTA, JDF, MTL, LM, SAS, PRT, KAM, PR, DA, DB, BAB, AB, LBR, WHC, CCC, JSC, JFFJr, NDF, LEBF, MGC, AMG, RNH, NH, WH, PDI, BTJ, CK, Suwon
    J Natl Cancer Inst 107:djv279. 2015
    ..We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites...
  61. pmc MEGSA: A Powerful and Flexible Framework for Analyzing Mutual Exclusivity of Tumor Mutations
    Xing Hua
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Am J Hum Genet 98:442-55. 2016
    ..7 × 10(-4)). For breast cancer, we identified a significant MEGS consisting of TP53 and four infrequently mutated genes (ARID1A, AKT1, MED23, and TBL1XR1), providing support for their role as cancer drivers...
  62. pmc Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
    Zhaoming Wang
    Division of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC Frederick, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD, USA
    Hum Mol Genet 23:6616-33. 2014
    ..33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci. ..
  63. pmc Large-scale pathway-based analysis of bladder cancer genome-wide association data from five studies of European background
    Idan Menashe
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e29396. 2012
    ..Identification of the aromatic amine metabolism pathway provides support for the ability of this approach to identify pathways with established relevance to bladder carcinogenesis...
  64. pmc Circulating markers of interstitial lung disease and subsequent risk of lung cancer
    Meredith S Shiels
    Infections and Immunoepidemiology Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 20:2262-72. 2011
    ..Circulating levels of surfactant protein-D (SP-D) and Krebs von Lungren-6 (KL-6) are elevated in interstitial lung disease patients and may be useful markers of processes contributing to lung cancer...
  65. pmc Common occurrence of monoclonal B-cell lymphocytosis among members of high-risk CLL families
    Lynn R Goldin
    Genetic Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892 7236, USA
    Br J Haematol 151:152-8. 2010
    ..Our findings show that MBL occurs at a very high rate in high risk CLL families. Both the age and gender distribution of MBL are parallel to CLL, implying a shared inherited risk...
  66. ncbi request reprint Prevalence of monoclonal gammopathy of undetermined significance among men in Ghana
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Bldg EPS Room 7110, Bethesda, MD 20892 7236, USA
    Mayo Clin Proc 82:1468-73. 2007
    ....
  67. pmc Familial chronic lymphocytic leukemia
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892 7236, USA
    Curr Opin Hematol 17:350-5. 2010
    ..However, predisposing germline mutations have not been identified. We will discuss the spectrum of conditions associated with CLL in families and the advances in identifying the underlying susceptibility genes...
  68. pmc Dietary factors and risk of chronic lymphocytic leukemia and small lymphocytic lymphoma: a pooled analysis of two prospective studies
    Huei Ting Tsai
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 19:2680-4. 2010
    ..Very few studies have investigated diet in relation to these leukemias, and no consistent associations are known...
  69. ncbi request reprint Why have we failed to find the low penetrance genetic constituents of common cancers?
    Neil E Caporaso
    Genetic Epidemiology Branch, National Cancer Institute, Rockville, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 11:1544-9. 2002
  70. pmc Metabolites of tobacco smoking and colorectal cancer risk
    Amanda J Cross
    Nutritional Epidemiology Branch, Biostatistics Branch, Genetic Epidemiology Branch and Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20850, USA
    Carcinogenesis 35:1516-22. 2014
    ..16, 95% CI: 0.57-2.37). Biomarkers capturing smoking behavior and metabolic variation exhibit stronger associations with colorectal cancer than self-report, providing additional evidence for a role for tobacco in this malignancy...
  71. pmc Precursors to lymphoproliferative malignancies
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, 6120 Executive Blvd, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 22:533-9. 2013
    ..A key focus for current work is to identify markers that predict progression to malignancy...
  72. pmc Genome-wide association study identifies two susceptibility loci for osteosarcoma
    Sharon A Savage
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, MD, USA
    Nat Genet 45:799-803. 2013
    ..2 (rs7591996 and rs10208273; P = 1.0 × 10⁻⁸ and 2.9 × 10⁻⁷, respectively). These two loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma...
  73. pmc Detectable clonal mosaicism and its relationship to aging and cancer
    Kevin B Jacobs
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
    Nat Genet 44:651-8. 2012
    ..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases...
  74. doi request reprint B-cell clones as early markers for chronic lymphocytic leukemia
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 360:659-67. 2009
    ..Hospital-based series indicate an excess risk of progression from MBL to chronic lymphocytic leukemia (CLL). In this prospective cohort study, we tested the hypothesis that CLL is always preceded by MBL...
  75. doi request reprint Tumor immunobiological differences in prostate cancer between African-American and European-American men
    Tiffany A Wallace
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4258, USA
    Cancer Res 68:927-36. 2008
    ..The profiles portray the existence of a distinct tumor microenvironment in these two patient groups...
  76. pmc A prospective study of meat, cooking methods, meat mutagens, heme iron, and lung cancer risks
    Natasa Tasevska
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7242, USA
    Am J Clin Nutr 89:1884-94. 2009
    ..Red and processed meat consumption may play a role in lung cancer pathogenesis because of these meats' fat and carcinogen content...
  77. pmc Patterns of autoimmunity and subsequent chronic lymphocytic leukemia in Nordic countries
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7236, USA
    Blood 108:292-6. 2006
    ....
  78. ncbi request reprint Aryl-hydrocarbon receptor-dependent pathway and toxic effects of TCDD in humans: a population-based study in Seveso, Italy
    Andrea Baccarelli
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7236, USA
    Toxicol Lett 149:287-93. 2004
    ..Markers within the AhR pathway were correlated with one another. Our findings suggest the presence of long-term effects in the subjects exposed to TCDD after the Seveso accident...
  79. ncbi request reprint ATM mutations and protein expression are not associated with familial B-CLL cases
    Naoko Ishibe
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, MSC 7236, Bethesda, MD 20892, USA
    Leuk Res 27:973-5. 2003
  80. ncbi request reprint A genome scan of 18 families with chronic lymphocytic leukaemia
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, 6120 Executive Boulevard, Room 7008, MSC 7236, Bethesda, MD 20892 7236, USA
    Br J Haematol 121:866-73. 2003
    ..Four of these six regions (6q, 13q, 12 and 17p) coincide with areas where cytogenetic abnormalities are frequently observed in CLL tumour cells and are, therefore, strong candidate regions for containing germ line changes...
  81. ncbi request reprint CYP1A1 and GSTM1 polymorphisms in relation to lung cancer risk in Chinese women
    Xiaohong R Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, Bethesda MD 20892, USA
    Cancer Lett 214:197-204. 2004
    ..In summary, our case-control study of lung cancer among women in northeast China revealed an elevated risk associated with the CYP1A1 I462V genotype, but no interaction with smoking or indoor air pollution was found...
  82. ncbi request reprint CYP1A1 Val462 and NQO1 Ser187 polymorphisms, cigarette use, and risk for colorectal adenoma
    Lifang Hou
    Department of Human and Health Services, Division of Cancer Epidemiology and Genetics, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Carcinogenesis 26:1122-8. 2005
    ..002). In summary, joint carriage of CYP1A1 Val(462) and NQO1 Ser(187) alleles, particularly in smokers, was related to colorectal adenoma risk, with a propensity for formation of multiple lesions...
  83. ncbi request reprint Mutations in the tyrosine kinase domain of the epidermal growth factor receptor in non-small cell lung cancer
    Sei Hoon Yang
    Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute NIH, 41 Library Drive, Bethesda, MD 20892, USA
    Clin Cancer Res 11:2106-10. 2005
    ..Screening subjects with EGFR mutations may identify patients whose tumors could respond to targeted therapy using tyrosine kinase inhibitors...
  84. pmc Association between a germline OCA2 polymorphism at chromosome 15q13.1 and estrogen receptor-negative breast cancer survival
    Elizabeth M Azzato
    J Natl Cancer Inst 102:650-62. 2010
    ....
  85. pmc A genome-wide association study of prognosis in breast cancer
    Elizabeth M Azzato
    Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom
    Cancer Epidemiol Biomarkers Prev 19:1140-3. 2010
    ..Traditional clinicopathologic features of breast cancer do not account for all the variation in survival. Germline genetic variation may provide additional prognostic information...
  86. ncbi request reprint Telomere length and heavy-chain mutation status in familial chronic lymphocytic leukemia
    Naoko Ishibe
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, MSC 7236, Rockville, MD 20892, USA
    Leuk Res 26:791-4. 2002
    ..Our results suggest that telomere length is associated with V(H) gene mutation status and provides further evidence that the biological basis of familial B-CLL is similar to that of sporadic patients...
  87. pmc Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival
    Maria Teresa Landi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, Maryland, USA
    PLoS ONE 3:e1651. 2008
    ..Tobacco smoking is responsible for over 90% of lung cancer cases, and yet the precise molecular alterations induced by smoking in lung that develop into cancer and impact survival have remained obscure...
  88. ncbi request reprint Acquired immune-related and inflammatory conditions and subsequent chronic lymphocytic leukaemia
    Ola Landgren
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA
    Br J Haematol 139:791-8. 2007
    ..14-fold (1.03-1.25) and 1.64-fold (1.14-2.37) elevated CLL risk. These association patterns suggest primary focus on infectious agents rather than autoantigens for future aetiologic CLL studies...
  89. ncbi request reprint New aspects in descriptive, etiologic, and molecular epidemiology of Hodgkin's lymphoma
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 6120 Executive Boulevard, Building EPS Room 7110, Bethesda, MD 20892 7236, USA
    Hematol Oncol Clin North Am 21:825-40. 2007
    ..These results emphasize an interaction between environmental and genetic risk factors in Hodgkin's lymphoma...
  90. ncbi request reprint DRD2 genetic variation in relation to smoking and obesity in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
    Lindsay M Morton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA
    Pharmacogenet Genomics 16:901-10. 2006
    ..To assess the specificity of genetic effects, we also investigated other reward-motivated characteristics (obesity, alcohol consumption)...
  91. ncbi request reprint Inflammatory cytokine gene polymorphisms, nonsteroidal anti-inflammatory drug use, and risk of adenoma polyp recurrence in the polyp prevention trial
    Leah B Sansbury
    Center for Cancer Research, National Cancer Institute, NIH, Department of Health and Human Services, Suite 702, 6116 Executive Boulevard, MSC 8235, Bethesda, MD 20892 8325, USA
    Cancer Epidemiol Biomarkers Prev 15:494-501. 2006
    ..Furthermore, common variants in cytokine genes may modify the anti-inflammatory effect of nonsteroidal anti-inflammatory drugs (NSAIDs) in the prevention of colorectal cancer...
  92. pmc Risk of monoclonal gammopathy of undetermined significance (MGUS) and subsequent multiple myeloma among African American and white veterans in the United States
    Ola Landgren
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, Bethesda, MD 20892 7236, USA
    Blood 107:904-6. 2006
    ..In the largest study to date, we suggest that the excess risk of MM in African Americans results from an increase in risk of MGUS rather than an increased risk of progression from MGUS to MM...
  93. pmc Integrative cancer epidemiology--the next generation
    Margaret R Spitz
    The Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Discov 2:1087-90. 2012
    ..We highlight the exciting opportunities to collaborate across large observational studies and to forge new interdisciplinary collaborative ventures...
  94. ncbi request reprint Family studies in chronic lymphocytic leukaemia and other lymphoproliferative tumours
    Lynn R Goldin
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Br J Haematol 139:774-9. 2007
    ..The ability to conduct large scale genomic studies will play an important role in detecting susceptibility genes for CLL over the next few years and thereby help to delineate aetiological pathways...
  95. pmc Prospective analysis of DNA damage and repair markers of lung cancer risk from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 32:69-73. 2011
    ..02), supporting the notion the assay may be a measure of cancer susceptibility. The Comet and HCR assays were unrelated to lung cancer risk...