Ronald E Cannon

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain
    Ronald E Cannon
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 109:15930-5. 2012
  2. ncbi request reprint The Tg.AC mouse model passes test by failing to respond
    Ronald E Cannon
    Cancer Biology Group, National Center for Toxicogenomics, NIEHS, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 74:233-4. 2003
  3. pmc Mrp1 is essential for sphingolipid signaling to p-glycoprotein in mouse blood-brain and blood-spinal cord barriers
    Tara A Cartwright
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Cereb Blood Flow Metab 33:381-8. 2013
  4. pmc Nrf2 upregulates ATP binding cassette transporter expression and activity at the blood-brain and blood-spinal cord barriers
    Xueqian Wang
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709
    J Neurosci 34:8585-93. 2014
  5. ncbi request reprint Identification of Dss1 as a 12-O-tetradecanoylphorbol-13-acetate-responsive gene expressed in keratinocyte progenitor cells, with possible involvement in early skin tumorigenesis
    Sung Jen Wei
    National Center for Toxicogenomics and the Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 278:1758-68. 2003
  6. pmc Arsenic exposure in utero exacerbates skin cancer response in adulthood with contemporaneous distortion of tumor stem cell dynamics
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, North Carolina27709, USA
    Cancer Res 68:8278-85. 2008
  7. doi request reprint Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation
    Sung Jen Wei
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Mol Biol 383:693-712. 2008
  8. ncbi request reprint PPAR-α, a lipid-sensing transcription factor, regulates blood-brain barrier efflux transporter expression
    Vijay R More
    Signal Transduction Laboratory, National Institute of Environmental Health Sciences NIEHS, National Institute of Health, Research Triangle Park, NC, USA
    J Cereb Blood Flow Metab . 2016
  9. pmc Selective induction of P-glycoprotein at the CNS barriers during symptomatic stage of an ALS animal model
    Gary N Y Chan
    Signal Transduction Laboratory, National Institute of Environmental Health Sciences NIEHS, 111 T W Alexander Drive, Research Triangle Park, NC 27709, United States
    Neurosci Lett . 2016
  10. ncbi request reprint Signaling pathways that regulate basal ABC transporter activity at the blood- brain barrier
    David S Miller
    Laboratory of Toxicology and Pharmacology National Institute of Environmental Health, Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Curr Pharm Des 20:1463-71. 2014

Collaborators

  • C S Trempus
  • Sung Jen Wei
  • Jie Liu
  • Dori R Germolec
  • Carl D Bortner
  • Jerrold M Ward
  • M P Waalkes
  • David S Miller
  • Christopher R Campos
  • Gary N Y Chan
  • Vijay R More
  • Xueqian Wang
  • Tara A Cartwright
  • Michael C Humble
  • Raymond W Tennant
  • Karin Schreiber
  • Gary Ny Chan
  • Rebecca Evans
  • Emily Mesev
  • Rebecca A Evans
  • Keith D Oliver
  • David Banks
  • Jessica L Boni
  • John C Peart
  • Lindsay K Smith
  • Judson W Spalding
  • W Martin Kast
  • Lieping Chen
  • Thomas Krausz
  • Theodore Karrison
  • Stephen C Meredith
  • Gabriele Beck-Engeser
  • Dezheng Huo
  • Hans Schreiber
  • Heather Jensen

Detail Information

Publications12

  1. pmc Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain
    Ronald E Cannon
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 109:15930-5. 2012
    ....
  2. ncbi request reprint The Tg.AC mouse model passes test by failing to respond
    Ronald E Cannon
    Cancer Biology Group, National Center for Toxicogenomics, NIEHS, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 74:233-4. 2003
  3. pmc Mrp1 is essential for sphingolipid signaling to p-glycoprotein in mouse blood-brain and blood-spinal cord barriers
    Tara A Cartwright
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Cereb Blood Flow Metab 33:381-8. 2013
    ..These results identify Mrp1 as the transporter essential for S1P efflux from the endothelial cells and thus for inside-out S1P signaling to P-glycoprotein at the blood-brain and blood-spinal cord barriers...
  4. pmc Nrf2 upregulates ATP binding cassette transporter expression and activity at the blood-brain and blood-spinal cord barriers
    Xueqian Wang
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709
    J Neurosci 34:8585-93. 2014
    ..They imply that the barriers are tightened selectively (efflux transporter upregulation) by oxidative stress, providing increased neuroprotection, but also reduced penetration of many therapeutic drugs. ..
  5. ncbi request reprint Identification of Dss1 as a 12-O-tetradecanoylphorbol-13-acetate-responsive gene expressed in keratinocyte progenitor cells, with possible involvement in early skin tumorigenesis
    Sung Jen Wei
    National Center for Toxicogenomics and the Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 278:1758-68. 2003
    ..These results strongly suggest that Dss1 is a TPA-inducible gene that may play an important role in the early stages of skin carcinogenesis...
  6. pmc Arsenic exposure in utero exacerbates skin cancer response in adulthood with contemporaneous distortion of tumor stem cell dynamics
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, North Carolina27709, USA
    Cancer Res 68:8278-85. 2008
    ....
  7. doi request reprint Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation
    Sung Jen Wei
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Mol Biol 383:693-712. 2008
    ....
  8. ncbi request reprint PPAR-α, a lipid-sensing transcription factor, regulates blood-brain barrier efflux transporter expression
    Vijay R More
    Signal Transduction Laboratory, National Institute of Environmental Health Sciences NIEHS, National Institute of Health, Research Triangle Park, NC, USA
    J Cereb Blood Flow Metab . 2016
    ....
  9. pmc Selective induction of P-glycoprotein at the CNS barriers during symptomatic stage of an ALS animal model
    Gary N Y Chan
    Signal Transduction Laboratory, National Institute of Environmental Health Sciences NIEHS, 111 T W Alexander Drive, Research Triangle Park, NC 27709, United States
    Neurosci Lett . 2016
    ..Our observations imply that novel pharmacological approaches for treating ALS require selecting drugs that are not P-gp substrates in order to improve therapeutic efficacy in the CNS during ALS progression...
  10. ncbi request reprint Signaling pathways that regulate basal ABC transporter activity at the blood- brain barrier
    David S Miller
    Laboratory of Toxicology and Pharmacology National Institute of Environmental Health, Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Curr Pharm Des 20:1463-71. 2014
    ..Translation of these results to the clinic could provide improved pharmacotherapy for a number of CNS diseases, including, brain cancer, neuroAIDS and epilepsy...
  11. ncbi request reprint Biological, cellular, and molecular characteristics of an inducible transgenic skin tumor model: a review
    Michael C Humble
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA
    Oncogene 24:8217-28. 2005
    ..The further exploration and elucidation of the molecular controls of transgene expression will enhance the usefulness of this mouse and enable a better understanding of the Tg.AC's discriminate response to chemical carcinogens...
  12. ncbi request reprint Strong synergy between mutant ras and HPV16 E6/E7 in the development of primary tumors
    Karin Schreiber
    Department of Pathology, The University of Chicago, 5841 S Maryland Ave, MC 3008, Chicago, IL 60637, USA
    Oncogene 23:3972-9. 2004
    ..Thus, a remarkable synergy occurred between the v-Ha-ras and HPV16 E6/E7 oncogenes in the development of primary tumors in mice...