Lisheng Cai

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Synthesis and evaluation of two 18F-labeled 6-iodo-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridine derivatives as prospective radioligands for beta-amyloid in Alzheimer's disease
    Lisheng Cai
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA
    J Med Chem 47:2208-18. 2004
  2. ncbi request reprint Synthesis and evaluation of N-methyl and S-methyl 11C-labeled 6-methylthio-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridines as radioligands for imaging beta-amyloid plaques in Alzheimer's disease
    Lisheng Cai
    Molecular Imaging Branch and Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Med Chem 51:148-58. 2008
  3. ncbi request reprint Synthesis and structure-affinity relationships of new 4-(6-iodo-H-imidazo[1,2-a]pyridin-2-yl)-N-dimethylbenzeneamine derivatives as ligands for human beta-amyloid plaques
    Lisheng Cai
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Med Chem 50:4746-58. 2007
  4. ncbi request reprint Radioligand development for PET imaging of beta-amyloid (Abeta)--current status
    Lisheng Cai
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Med Chem 14:19-52. 2007
  5. ncbi request reprint Brain and whole-body imaging in nonhuman primates with [11C]MeS-IMPY, a candidate radioligand for beta-amyloid plaques
    Nicholas Seneca
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 2035, USA
    Nucl Med Biol 34:681-9. 2007
  6. pmc N'-3-(Trifluoromethyl)phenyl Derivatives of N-Aryl-N'-methylguanidines as Prospective PET Radioligands for the Open Channel of the N-Methyl-d-aspartate (NMDA) Receptor: Synthesis and Structure-Affinity Relationships
    Gregory R Naumiec
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3 C346A, 10 Center Drive, Bethesda, Maryland 20892 1003, United States
    J Med Chem 58:9722-30. 2015
  7. ncbi request reprint Imaging and in vivo quantitation of beta-amyloid: an exemplary biomarker for Alzheimer's disease?
    Lisa Nichols
    Molecular Imaging Branch, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    Biol Psychiatry 59:940-7. 2006
  8. pmc Rapid Room-Temperature 11C-Methylation of Arylamines with [11C]Methyl Iodide Promoted by Solid Inorganic Bases in DMF
    Lisheng Cai
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Building 10, Room B3 C346A, Bethesda MD 20892, USA
    European J Org Chem 2012:1303-1310. 2012
  9. doi request reprint Candidate PET Radioligand Development for Neurofibrillary Tangles: Two Distinct Radioligand Binding Sites Identified in Postmortem Alzheimer's Disease Brain
    Lisheng Cai
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, United States
    ACS Chem Neurosci 7:897-911. 2016
  10. pmc Exploration of the labeling of [11C]tubastatin A at the hydroxamic acid site with [11C]carbon monoxide
    Shuiyu Lu
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    J Labelled Comp Radiopharm 59:9-13. 2016

Detail Information

Publications13

  1. pmc Synthesis and evaluation of two 18F-labeled 6-iodo-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridine derivatives as prospective radioligands for beta-amyloid in Alzheimer's disease
    Lisheng Cai
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA
    J Med Chem 47:2208-18. 2004
    ....
  2. ncbi request reprint Synthesis and evaluation of N-methyl and S-methyl 11C-labeled 6-methylthio-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridines as radioligands for imaging beta-amyloid plaques in Alzheimer's disease
    Lisheng Cai
    Molecular Imaging Branch and Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Med Chem 51:148-58. 2008
    ..The ex vivo brain radiometabolites observed in rats have a peripheral origin. Overall, [ (11)C] 7 merits further evaluation in human subjects...
  3. ncbi request reprint Synthesis and structure-affinity relationships of new 4-(6-iodo-H-imidazo[1,2-a]pyridin-2-yl)-N-dimethylbenzeneamine derivatives as ligands for human beta-amyloid plaques
    Lisheng Cai
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Med Chem 50:4746-58. 2007
    ..The structure-activity relationships revealed in this study extends insight into the topography of the binding site for IMPY-like ligands in human Abeta plaques...
  4. ncbi request reprint Radioligand development for PET imaging of beta-amyloid (Abeta)--current status
    Lisheng Cai
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Med Chem 14:19-52. 2007
    ..Also a few radioligands applicable to imaging Abeta plaques in living human brain with positron emission tomography (PET) have emerged, including [(11)C]PIB, [(11)C]SB-13 and [(18)F]FDDNP...
  5. ncbi request reprint Brain and whole-body imaging in nonhuman primates with [11C]MeS-IMPY, a candidate radioligand for beta-amyloid plaques
    Nicholas Seneca
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 2035, USA
    Nucl Med Biol 34:681-9. 2007
    ..Calculated dosimetry results are comparable with those for other (11)C-labeled brain imaging radioligands...
  6. pmc N'-3-(Trifluoromethyl)phenyl Derivatives of N-Aryl-N'-methylguanidines as Prospective PET Radioligands for the Open Channel of the N-Methyl-d-aspartate (NMDA) Receptor: Synthesis and Structure-Affinity Relationships
    Gregory R Naumiec
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3 C346A, 10 Center Drive, Bethesda, Maryland 20892 1003, United States
    J Med Chem 58:9722-30. 2015
    ....
  7. ncbi request reprint Imaging and in vivo quantitation of beta-amyloid: an exemplary biomarker for Alzheimer's disease?
    Lisa Nichols
    Molecular Imaging Branch, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    Biol Psychiatry 59:940-7. 2006
    ..This review explores the utility of amyloid as a biomarker and the use of positron emission tomography and magnetic resonance imaging in the diagnosis and treatment of AD...
  8. pmc Rapid Room-Temperature 11C-Methylation of Arylamines with [11C]Methyl Iodide Promoted by Solid Inorganic Bases in DMF
    Lisheng Cai
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Building 10, Room B3 C346A, Bethesda MD 20892, USA
    European J Org Chem 2012:1303-1310. 2012
    ..An ultrasound device proved useful to provide remote and constant agitation of the radioactive heterogeneous reaction mixtures, but imparted no 'ultrasound-specific' chemical effect...
  9. doi request reprint Candidate PET Radioligand Development for Neurofibrillary Tangles: Two Distinct Radioligand Binding Sites Identified in Postmortem Alzheimer's Disease Brain
    Lisheng Cai
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, United States
    ACS Chem Neurosci 7:897-911. 2016
    ..Some compounds with high affinity and selectivity for the THK-523 binding site emerged from this set, including one with amenability to labeling with fluorine-18, namely, ligand 10b. ..
  10. pmc Exploration of the labeling of [11C]tubastatin A at the hydroxamic acid site with [11C]carbon monoxide
    Shuiyu Lu
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    J Labelled Comp Radiopharm 59:9-13. 2016
    ..However, success in labeling the hydroxamic acid group of [(11)C]tubastatin A was not transferable to the labeling of three other model hydroxamic acids...
  11. pmc New N-aryl-N'-(3-(substituted)phenyl)-N'-methylguanidines as leads to potential PET radioligands for imaging the open NMDA receptor
    Gregory R Naumiec
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3 C346A, 10 Center Drive, Bethesda, MD 20892, United States
    Bioorg Med Chem Lett 25:225-8. 2015
    ..7nM), 3'-trifluoromethyl (20; Ki 18.3nM) and 3'-methylthio (2; Ki 39.8nM) derivatives of N-1-naphthyl-N'-(phenyl)-N'-methylguanidine were identified as especially attractive leads for PET radioligand development. ..
  12. ncbi request reprint Lipophilic analogs of thioflavin S as novel amyloid-imaging agents
    Chunying Wu
    College of Pharmacy, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Curr Alzheimer Res 3:259-66. 2006
    ..Potential applications of these amyloid binding agents include facilitating drug screening in animal models and use as in vivo markers of early and definitive diagnosis of AD...
  13. ncbi request reprint PET imaging of brain with the beta-amyloid probe, [11C]6-OH-BTA-1, in a transgenic mouse model of Alzheimer's disease
    Hiroshi Toyama
    Department of Radiology, Fujita Health University, 1 98, Dengakugakubo, Kutsukake, Toyoake, 470 1192, Aichi, Japan
    Eur J Nucl Med Mol Imaging 32:593-600. 2005
    ..The purpose of this study was to evaluate the capacity of [11C]6-OH-BTA-1 and positron emission tomography (PET) to quantify beta-amyloid (Abeta) plaques in the Tg2576 mouse model of Alzheimer's disease (AD)...