Rebecca J Brown

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Effects of beta-cell rest on beta-cell function: a review of clinical and preclinical data
    Rebecca J Brown
    Clinical Endocrinology Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Pediatr Diabetes 9:14-22. 2008
  2. pmc Metreleptin improves blood glucose in patients with insulin receptor mutations
    Rebecca J Brown
    MD, MHSC, Building 10 CRC, Room 6 5942, 10 Center Drive, Bethesda, Maryland 20892
    J Clin Endocrinol Metab 98:E1749-56. 2013
  3. pmc Non-nutritive sweeteners and their role in the gastrointestinal tract
    Rebecca J Brown
    National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892 1645, USA
    J Clin Endocrinol Metab 97:2597-605. 2012
  4. pmc Effects of diet soda on gut hormones in youths with diabetes
    Rebecca J Brown
    National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA
    Diabetes Care 35:959-64. 2012
  5. pmc Artificial sweeteners: a systematic review of metabolic effects in youth
    Rebecca J Brown
    National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Pediatr Obes 5:305-12. 2010
  6. pmc Ingestion of diet soda before a glucose load augments glucagon-like peptide-1 secretion
    Rebecca J Brown
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes Care 32:2184-6. 2009
  7. pmc Too much glucagon, too little insulin: time course of pancreatic islet dysfunction in new-onset type 1 diabetes
    Rebecca J Brown
    National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA
    Diabetes Care 31:1403-4. 2008
  8. pmc Bone mineral content in patients with congenital generalized lipodystrophy is unaffected by metreleptin replacement therapy
    John D Christensen
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases J D C, E C, P G, K I R, R J B, National Institute of Dental and Craniofacial Research M T C, R I G, Nuclear Medicine Department, Clinical Center J C R, National Institutes of Health, Bethesda, Maryland 20892 and Joslin Diabetes Center A O L, Brookline, Massachusetts 02215
    J Clin Endocrinol Metab 99:E1493-500. 2014
  9. pmc Uncoupling intensive insulin therapy from weight gain and hypoglycemia in type 1 diabetes
    Rebecca J Brown
    National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Diabetes Technol Ther 13:457-60. 2011
  10. doi request reprint Effects of Recombinant Human Leptin (Metreleptin) on Nocturnal Luteinizing Hormone Secretion in Lipodystrophy Patients
    Brent S Abel
    Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, Bethesda, MD, USA
    Neuroendocrinology 103:402-7. 2016

Collaborators

Detail Information

Publications29

  1. pmc Effects of beta-cell rest on beta-cell function: a review of clinical and preclinical data
    Rebecca J Brown
    Clinical Endocrinology Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Pediatr Diabetes 9:14-22. 2008
  2. pmc Metreleptin improves blood glucose in patients with insulin receptor mutations
    Rebecca J Brown
    MD, MHSC, Building 10 CRC, Room 6 5942, 10 Center Drive, Bethesda, Maryland 20892
    J Clin Endocrinol Metab 98:E1749-56. 2013
    ..Hyperglycemia in RMS is very difficult to treat, and patients are at risk for early morbidity and mortality from complications of diabetes...
  3. pmc Non-nutritive sweeteners and their role in the gastrointestinal tract
    Rebecca J Brown
    National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892 1645, USA
    J Clin Endocrinol Metab 97:2597-605. 2012
    ..Because consumption of non-nutritive sweeteners is common in the United States, understanding the physiological effects of these substances is of interest and importance...
  4. pmc Effects of diet soda on gut hormones in youths with diabetes
    Rebecca J Brown
    National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA
    Diabetes Care 35:959-64. 2012
    ..In this study, we examined the effect of diet soda on gut hormones in youths with diabetes...
  5. pmc Artificial sweeteners: a systematic review of metabolic effects in youth
    Rebecca J Brown
    National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Pediatr Obes 5:305-12. 2010
    ....
  6. pmc Ingestion of diet soda before a glucose load augments glucagon-like peptide-1 secretion
    Rebecca J Brown
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes Care 32:2184-6. 2009
    ..The goal of this study was to determine the effect of artificial sweeteners on glucose, insulin, and glucagon-like peptide (GLP)-1 in humans...
  7. pmc Too much glucagon, too little insulin: time course of pancreatic islet dysfunction in new-onset type 1 diabetes
    Rebecca J Brown
    National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA
    Diabetes Care 31:1403-4. 2008
    ..To determine the time course of changes in glucagon and insulin secretion in children with recently diagnosed type 1 diabetes...
  8. pmc Bone mineral content in patients with congenital generalized lipodystrophy is unaffected by metreleptin replacement therapy
    John D Christensen
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases J D C, E C, P G, K I R, R J B, National Institute of Dental and Craniofacial Research M T C, R I G, Nuclear Medicine Department, Clinical Center J C R, National Institutes of Health, Bethesda, Maryland 20892 and Joslin Diabetes Center A O L, Brookline, Massachusetts 02215
    J Clin Endocrinol Metab 99:E1493-500. 2014
    ..PATIENTS with congenital generalized lipodystrophy (CGL) have low leptin due to deficient adipose mass and serve as models of leptin deficiency and replacement...
  9. pmc Uncoupling intensive insulin therapy from weight gain and hypoglycemia in type 1 diabetes
    Rebecca J Brown
    National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Diabetes Technol Ther 13:457-60. 2011
    ..In this pilot study, we determined the effect of optimized insulin therapy on weight gain and frequency of hypoglycemia in patients with long-standing type 1 diabetes mellitus...
  10. doi request reprint Effects of Recombinant Human Leptin (Metreleptin) on Nocturnal Luteinizing Hormone Secretion in Lipodystrophy Patients
    Brent S Abel
    Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, Bethesda, MD, USA
    Neuroendocrinology 103:402-7. 2016
    ..Leptin replacement in patients with leptin gene mutations improves hypogonadotropic hypogonadism. The effects of leptin replacement on luteinizing hormone (LH) secretion in patients with lipodystrophy are unknown...
  11. pmc Effect of ingested interferon-alpha on beta-cell function in children with new-onset type 1 diabetes
    Kristina I Rother
    National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA
    Diabetes Care 32:1250-5. 2009
    ..To evaluate the safety and efficacy of ingested human recombinant interferon-alpha (hrIFN-alpha) for preservation of beta-cell function in young patients with recent-onset type 1 diabetes...
  12. ncbi request reprint Type B Insulin Resistance Masquerading As Ovarian Hyperthecosis
    Rebecca J Brown
    1 National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    J Clin Endocrinol Metab . 2016
    ..Hyperinsulinemia can lead to pathologic ovarian growth and androgen production...
  13. pmc Effect of Leptin Replacement on PCSK9 in ob/ob Mice and Female Lipodystrophic Patients
    Amy E Levenson
    Division of Endocrinology A E L, M E H, J M, S B B, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115 Diabetes, Endocrinology, and Obesity Branch R J B, R M, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 and Department of Cardiology S D d F, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115
    Endocrinology 157:1421-9. 2016
    ..On the other hand, in lipodystrophic females, leptin treatment reduced plasma PCSK9 in parallel with LDL cholesterol. ..
  14. pmc Metreleptin for injection to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy
    Cristina Adelia Meehan
    a Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Expert Rev Clin Pharmacol 9:59-68. 2016
    ..Finally, we speculate on future uses and development of metreleptin. ..
  15. pmc Challenging recruitment of youth with type 2 diabetes into clinical trials
    Tammy T Nguyen
    Section on Pediatric Diabetes and Metabolism, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland
    J Adolesc Health 54:247-54. 2014
    ..We explored whether similar strategies might be applicable to pediatric patients with type 2 diabetes...
  16. pmc Syndromic insulin resistance: models for the therapeutic basis of the metabolic syndrome and other targets of insulin resistance
    Phillip Gorden
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocr Pract 18:763-71. 2012
    ..To investigate the link between insulin resistance and the metabolic syndrome how to develop treatment approaches...
  17. pmc Hormonal responses to non-nutritive sweeteners in water and diet soda
    Allison C Sylvetsky
    Section on Pediatric Diabetes and Metabolism DEOB, NIDDK, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 8C432A, Bethesda, MD 20892 USA Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA Sumner M Redstone Global Center for Prevention and Wellness, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA
    Nutr Metab (Lond) 13:71. 2016
    ..g. obesity and diabetes) in epidemiologic studies. We aimed to test acute metabolic effects of NNS in isolation (water or seltzer) and in diet sodas...
  18. pmc Lymphoma in acquired generalized lipodystrophy
    Rebecca J Brown
    a Diabetes, Endocrinology and Obesity Branch DEOB, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, National Institutes of Health NIH, Bethesda, MD, USA
    Leuk Lymphoma 57:45-50. 2016
    ..For most patients with AGL and severe metabolic complications, the proven benefits of metreleptin on metabolic disease will likely outweigh theoretical risks of metreleptin in lymphoma development or progression. ..
  19. pmc Partial and generalized lipodystrophy: comparison of baseline characteristics and response to metreleptin
    Talia Diker-Cohen
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892
    J Clin Endocrinol Metab 100:1802-10. 2015
    ..Lipodystrophies are extreme forms of metabolic syndrome. Metreleptin was approved in the United States for generalized lipodystrophy (GLD) but not partial lipodystrophy (PLD)...
  20. pmc Mild Caloric Restriction Decreases Insulin Requirements in Patients With Type 2 Diabetes and Severe Insulin Resistance
    Cristina Adelia Meehan
    From the Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive Kidney Diseases, National Institutes of Health, Bethesda, Maryland
    Medicine (Baltimore) 94:e1160. 2015
    ..Further studies are needed to determine if the intervention and results are sustainable outside of a hospital setting...
  21. doi request reprint Leptin Does Not Mediate Hypertension Associated With Human Obesity
    Rebecca J Brown
    Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 162:465-6. 2015
    ..This regulation, however, may not extend to humans, where a yet-to-be-identified factor is likely the underlying cause of hypertension. ..
  22. pmc Lipid regulation in lipodystrophy versus the obesity-associated metabolic syndrome: the dissociation of HDL-C and triglycerides
    Jalaja Joseph
    Diabetes, Endocrinology, and Obesity Branch J J, E K C, P G, R J B, National Institute of Diabetes and Digestive and Kidney Diseases, and National Heart Lung and Blood Institute R D S, National Institutes of Health, Bethesda, Maryland 20892
    J Clin Endocrinol Metab 99:E1676-80. 2014
    ..Patients with lipodystrophy have extreme insulin resistance with high triglycerides and low HDL-C. Leptin replacement in lipodystrophy leads to a marked decrease in triglycerides (∼60%)...
  23. pmc The liver diseases of lipodystrophy: the long-term effect of leptin treatment
    Elika Safar Zadeh
    Diabetes Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States
    J Hepatol 59:131-7. 2013
    ..Non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) are also features of this condition. We studied the spectrum of liver disease in lipodystrophy and the effects of leptin replacement...
  24. pmc Clinical trials in youth with type 2 diabetes
    Julie Anne L Gemmill
    Clinical Endocrinology Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Pediatr Diabetes 12:50-7. 2011
    ..We conclude that type 2 diabetes in youth is an important but difficult new field of clinical research, and we discuss the existing barriers to successful recruitment, conduct, and support of these clinical trials...
  25. pmc Resolution of type 2 diabetes following bariatric surgery: implications for adults and adolescents
    Radha Nandagopal
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Diabetes Technol Ther 12:671-7. 2010
    ..Finally, we discuss the available data on bariatric surgery in adolescent patients, including special considerations in this potentially vulnerable population...
  26. pmc Minocycline-induced drug hypersensitivity syndrome followed by multiple autoimmune sequelae
    Rebecca J Brown
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Rockville, Maryland, USA
    Arch Dermatol 145:63-6. 2009
    ..Long-term autoimmune sequelae of DHS have been reported, including hypothyroidism...
  27. pmc The Diagnosis and Management of Lipodystrophy Syndromes: A Multi-Society Practice Guideline
    Rebecca J Brown
    National Institute of Diabetes and Digestive and Kidney Diseases R J B, K I R, National Institutes of Health, Bethesda, Maryland 20892 Department of Medicine D A V, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain Department of Paediatrics and Adolescent Medicine P T C, The University of Hong Kong, Hong Kong Special Administrative Region, China Department of Paediatrics D D, University of Cambridge, Cambridge CB2 0QQ, United Kingdom Metabolic Research Laboratories Wellcome Trust D D, Medical Research Council MRC Institute of Metabolic Science, National Institute for Health Research Cambridge Comprehensive Biomedical Research Centre, MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, United Kingdom Division of Nutrition and Metabolic Diseases A G, Department of Internal Medicine and the Center for Human Nutrition, UT Southwestern Medical Center, Dallas, Texas 75390 Royal North Shore Hospital M J, Northern Clinical School, University of Sydney, St Leonards, NSW 2126, Australia Department of Paediatrics and Child Health L M, University of Nairobi, 00100 Nairobi, Kenya Brehm Center for Diabetes and Division of Metabolism, Endocrinology, and Diabetes E A O, Department of Internal Medicine, University of Michigan Medical School and Health Systems, Ann Arbor, Michigan 48109 Division of Pediatric Endocrinology N P, Department of Pediatrics, UT Southwestern Medical Center, Dallas, 9400 RA Assen
    J Clin Endocrinol Metab 101:4500-4511. 2016
    ..Due to their rarity, most clinicians are not familiar with their diagnosis and management. This practice guideline summarizes the diagnosis and management of lipodystrophy syndromes not associated with HIV or injectable drugs...
  28. pmc Effect of Leptin Administration on Circulating Apolipoprotein CIII levels in Patients With Lipodystrophy
    Andrea Kassai
    Diabetes, Endocrinology and Obesity Branch A K, R M, B S A, M R, M C S, P G, R J B, Clinical Core Laboratory M F W, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 Division of Endocrinology A E L, S B B, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115 and Division of Endocrinology, Diabetes, and Nutrition S I T, University of Maryland School of Medicine, Baltimore, Maryland 21201
    J Clin Endocrinol Metab 101:1790-7. 2016
    ..Patients with lipodystrophy had elevated apolipoprotein CIII (apoCIII) compared to healthy controls. ApoCIII did not change with leptin treatment despite significant reductions in serum triglyceride. ..
  29. pmc Cushing syndrome in the McCune-Albright syndrome
    Rebecca J Brown
    Clinical Endocrinology Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4320, USA
    J Clin Endocrinol Metab 95:1508-15. 2010
    ..Cushing syndrome (CS) is a rare but potentially fatal feature of McCune-Albright syndrome (MAS). Optimal management, prognostic features, and long-term follow-up of this disorder have not been described...