- The p75 neurotrophin receptor influences NT-3 responsiveness of sympathetic neurons in vivoC Brennan
Neural Development Section, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, 36 Convent Dr, Bldg 36 Rm 2B08, Bethesda, Maryland 20892 4064, USA
Nat Neurosci 2:699-705. 1999..When NT-3 levels are reduced (p75NTR-/- NGF+/- NT3 +/-), neuron number decreases compared to p75NTR-/- NGF+/- NT3+/+. Thus, without p75NTR, NT3 substitutes for NGF, suggesting that p75 alters the neurotrophin specificity of TrkA in vivo...
- NT-3, like NGF, is required for survival of sympathetic neurons, but not their precursorsN Francis
Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio, 44106, USA
Dev Biol 210:411-27. 1999..5 but does alter axon outgrowth and decrease salivary gland innervation. Taken together these results suggest that neurotrophin-3 is required for survival of some sympathetic neurons that also require nerve growth factor...