C Brennan

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint The p75 neurotrophin receptor influences NT-3 responsiveness of sympathetic neurons in vivo
    C Brennan
    Neural Development Section, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, 36 Convent Dr, Bldg 36 Rm 2B08, Bethesda, Maryland 20892 4064, USA
    Nat Neurosci 2:699-705. 1999
  2. ncbi request reprint NT-3, like NGF, is required for survival of sympathetic neurons, but not their precursors
    N Francis
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio, 44106, USA
    Dev Biol 210:411-27. 1999

Collaborators

  • N Francis
  • L Reichardt
  • C Backus
  • S Landis
  • K Rivas-Plata
  • I Farinas

Detail Information

Publications2

  1. ncbi request reprint The p75 neurotrophin receptor influences NT-3 responsiveness of sympathetic neurons in vivo
    C Brennan
    Neural Development Section, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, 36 Convent Dr, Bldg 36 Rm 2B08, Bethesda, Maryland 20892 4064, USA
    Nat Neurosci 2:699-705. 1999
    ..When NT-3 levels are reduced (p75NTR-/- NGF+/- NT3 +/-), neuron number decreases compared to p75NTR-/- NGF+/- NT3+/+. Thus, without p75NTR, NT3 substitutes for NGF, suggesting that p75 alters the neurotrophin specificity of TrkA in vivo...
  2. ncbi request reprint NT-3, like NGF, is required for survival of sympathetic neurons, but not their precursors
    N Francis
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio, 44106, USA
    Dev Biol 210:411-27. 1999
    ..5 but does alter axon outgrowth and decrease salivary gland innervation. Taken together these results suggest that neurotrophin-3 is required for survival of some sympathetic neurons that also require nerve growth factor...