Francisco Borrego

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint The first molecular basis of the "missing self" hypothesis
    Francisco Borrego
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rm 205, Twinbrook II, 12440 Parklawn Drive, Rockville, MD 20852, USA
    J Immunol 177:5759-60. 2006
  2. ncbi request reprint NK cell CD94/NKG2A inhibitory receptors are internalized and recycle independently of inhibitory signaling processes
    Francisco Borrego
    Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 169:6102-11. 2002
  3. ncbi request reprint The inhibitory leukocyte-associated Ig-like receptor-1 (LAIR-1) is expressed at high levels by human naive T cells and inhibits TCR mediated activation
    Kerima Maasho
    Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Mol Immunol 42:1521-30. 2005
  4. ncbi request reprint The cell biology of the human natural killer cell CD94/NKG2A inhibitory receptor
    Francisco Borrego
    Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Mol Immunol 42:485-8. 2005
  5. pmc Membrane-type 6 matrix metalloproteinase regulates the activation-induced downmodulation of CD16 in human primary NK cells
    Giovanna Peruzzi
    Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 191:1883-94. 2013
  6. ncbi request reprint Human NKG2F is expressed and can associate with DAP12
    Dae Ki Kim
    Receptor Cell Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II, 12441 Parklawn Dr, Rockville, MD 20852, USA
    Mol Immunol 41:53-62. 2004
  7. pmc Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin
    Sriram Narayanan
    Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS ONE 5:e10636. 2010
  8. ncbi request reprint IL-21 down-regulates NKG2D/DAP10 expression on human NK and CD8+ T cells
    Steven J Burgess
    Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 176:1490-7. 2006
  9. ncbi request reprint Regulation of human DAP10 gene expression in NK and T cells by Ap-1 transcription factors
    Alina I Marusina
    Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 1742, USA
    J Immunol 180:409-17. 2008
  10. doi request reprint Uncommon endocytic and trafficking pathway of the natural killer cell CD94/NKG2A inhibitory receptor
    Madhan Masilamani
    Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Traffic 9:1019-34. 2008

Collaborators

Detail Information

Publications34

  1. ncbi request reprint The first molecular basis of the "missing self" hypothesis
    Francisco Borrego
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rm 205, Twinbrook II, 12440 Parklawn Drive, Rockville, MD 20852, USA
    J Immunol 177:5759-60. 2006
  2. ncbi request reprint NK cell CD94/NKG2A inhibitory receptors are internalized and recycle independently of inhibitory signaling processes
    Francisco Borrego
    Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 169:6102-11. 2002
    ..Thus, the mechanisms that control cell surface homeostasis of CD94/NKG2A are independent of functional signaling...
  3. ncbi request reprint The inhibitory leukocyte-associated Ig-like receptor-1 (LAIR-1) is expressed at high levels by human naive T cells and inhibits TCR mediated activation
    Kerima Maasho
    Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Mol Immunol 42:1521-30. 2005
    ....
  4. ncbi request reprint The cell biology of the human natural killer cell CD94/NKG2A inhibitory receptor
    Francisco Borrego
    Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Mol Immunol 42:485-8. 2005
    ..The constant renewal of CD94/NKG2A receptors at the cell surface and their free mobility within the plasma membrane likely facilitates and insures inhibitory capacity...
  5. pmc Membrane-type 6 matrix metalloproteinase regulates the activation-induced downmodulation of CD16 in human primary NK cells
    Giovanna Peruzzi
    Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 191:1883-94. 2013
    ....
  6. ncbi request reprint Human NKG2F is expressed and can associate with DAP12
    Dae Ki Kim
    Receptor Cell Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II, 12441 Parklawn Dr, Rockville, MD 20852, USA
    Mol Immunol 41:53-62. 2004
    ....
  7. pmc Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin
    Sriram Narayanan
    Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS ONE 5:e10636. 2010
    ..We conclude that CD300a(+) human Th1 cells tend to be polyfunctional and after stimulation up-regulate Eomes...
  8. ncbi request reprint IL-21 down-regulates NKG2D/DAP10 expression on human NK and CD8+ T cells
    Steven J Burgess
    Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 176:1490-7. 2006
    ..These data indicate that IL-21 is able to channel NK and CD8+ T cell function by altering the expression pattern of activation/costimulatory receptors...
  9. ncbi request reprint Regulation of human DAP10 gene expression in NK and T cells by Ap-1 transcription factors
    Alina I Marusina
    Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 1742, USA
    J Immunol 180:409-17. 2008
    ....
  10. doi request reprint Uncommon endocytic and trafficking pathway of the natural killer cell CD94/NKG2A inhibitory receptor
    Madhan Masilamani
    Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Traffic 9:1019-34. 2008
    ..These results indicate that CD94/NKG2A utilizes a previously undescribed endocytic mechanism coupled with an abbreviated trafficking pattern, perhaps to insure surface expression...
  11. ncbi request reprint Role that each NKG2A immunoreceptor tyrosine-based inhibitory motif plays in mediating the human CD94/NKG2A inhibitory signal
    Juraj Kabat
    National Institute of Allergy and Infectious Diseases, Rockville, MD 20852, USA
    J Immunol 169:1948-58. 2002
    ..This probably reflects the opposite orientation of the ITIMs in type II vs type I proteins...
  12. ncbi request reprint NKG2D is a costimulatory receptor for human naive CD8+ T cells
    Kerima Maasho
    Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 1742, USA
    J Immunol 174:4480-4. 2005
    ..These results indicate that NKG2D can regulate the priming of human naive CD8+ T cells, which may provide an alternative mechanism for potentiating and channeling the immune response...
  13. ncbi request reprint GATA-3 is an important transcription factor for regulating human NKG2A gene expression
    Alina I Marusina
    Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 174:2152-9. 2005
    ..Taken together, our data indicate that GATA-3 is an important transcription factor for regulating NKG2A gene expression...
  14. pmc Exclusion of lipid rafts and decreased mobility of CD94/NKG2A receptors at the inhibitory NK cell synapse
    Tolib B Sanni
    Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Mol Biol Cell 15:3210-23. 2004
    ..These results suggest that immobilization of the CD94/NKG2A receptors at ligation sites not only promote sustenance of the inhibitory signal, but by lipid rafts exclusion prevent formation of activation signaling complexes...
  15. pmc A single residue, arginine 65, is critical for the functional interaction of leukocyte-associated inhibitory receptor-1 with collagens
    Xiaobin Tang
    Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 182:5446-52. 2009
    ..Likewise, LAIR-1 R65K protein has decreased avidity for cells expressing transmembrane collagen XVII. Thus, a single residue, Arg65, is critical for the interaction of LAIR-1 with collagens...
  16. ncbi request reprint CD94/NKG2A inhibits NK cell activation by disrupting the actin network at the immunological synapse
    Madhan Masilamani
    Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 177:3590-6. 2006
    ..The net effect is to maintain an inhibitory state in the proximity of the iNKIS, while allowing the formation of activation synapse at distal points within the same NK cell...
  17. pmc Endosomal trafficking of the ligated FcvarepsilonRI receptor
    Gul nar V Fattakhova
    Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, United States
    Mol Immunol 46:793-802. 2009
    ....
  18. pmc CD300a is expressed on human B cells, modulates BCR-mediated signaling, and its expression is down-regulated in HIV infection
    Rodolfo Silva
    Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA
    Blood 117:5870-80. 2011
    ..Altogether, these data demonstrate a novel mechanism for suppressing the activity of B cells and suggest a potential role for CD300a in the B-cell dysfunction observed in HIV-induced immunodeficiency...
  19. doi request reprint The NKG2D receptor: immunobiology and clinical implications
    Steven J Burgess
    Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA
    Immunol Res 40:18-34. 2008
    ..The impact that NKG2D has in disease pathologies is also assessed...
  20. pmc Cutting edge: mouse CD300f (CMRF-35-like molecule-1) recognizes outer membrane-exposed phosphatidylserine and can promote phagocytosis
    Seung Chul Choi
    Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 187:3483-7. 2011
    ..The result of this recognition may vary with the overall qualitative and quantitative receptor content, as well as signaling capacity of the expressing effector cell, but enhanced phagocytosis is one measurable outcome...
  21. ncbi request reprint The CD94/NKG2 family of receptors: from molecules and cells to clinical relevance
    Francisco Borrego
    Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Immunol Res 35:263-78. 2006
    ....
  22. pmc Mouse IgM Fc receptor, FCMR, promotes B cell development and modulates antigen-driven immune responses
    Seung Chul Choi
    Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 190:987-96. 2013
    ..Our studies demonstrate that FCMR is required for B cell differentiation and homeostasis, the prevention of autoreactive B cells, and responsiveness to antigenic challenge...
  23. ncbi request reprint Structure and function of major histocompatibility complex (MHC) class I specific receptors expressed on human natural killer (NK) cells
    Francisco Borrego
    Receptor Cell Biology Section, Laboratory of Allergic Diseases, NIAID, NIH, Twinbrook II, Room 205, 12441 Parklawn Dr, Rockville, MD 20852, USA
    Mol Immunol 38:637-60. 2002
    ..In this review we will discuss the molecular structure, specificity, cellular expression patterns, and function of these HLA class I receptors, as well as the chromosomal location and genetic organization...
  24. ncbi request reprint Human CD94 gene expression: dual promoters differing in responsiveness to IL-2 or IL-15
    Louis D Lieto
    Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 171:5277-86. 2003
    ..These elements are highly conserved between mice and humans, which suggests that both species regulate CD94 gene expression via mechanisms that predate their evolutionary divergence...
  25. pmc Toso, a functional IgM receptor, is regulated by IL-2 in T and NK cells
    Yousuke Murakami
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA
    J Immunol 189:587-97. 2012
    ..In summary, our data indicate that Toso is a functional IgM receptor that is capable of activating signaling molecules, is regulated by IL-2, and is not inherently an antiapoptotic molecule...
  26. pmc Endocytosis as a mechanism of regulating natural killer cell function: unique endocytic and trafficking pathway for CD94/NKG2A
    Giovanna Peruzzi
    Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Twinbrook II, Room 205, MS 8180 12441 Parklawn Drive, Rockville, MD 20852, USA
    Immunol Res 43:210-22. 2009
    ..In this review, we focus on the ITIM-containing inhibitory receptor CD94/NKG2A showing that it is endocytosed by a previously undescribed macropinocytic-like process that may be related to the maintenance of its surface expression...
  27. pmc Complex regulation of human NKG2D-DAP10 cell surface expression: opposing roles of the γc cytokines and TGF-β1
    Yuk Pheel Park
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA
    Blood 118:3019-27. 2011
    ..This leads to the down-regulation of DAP10 expression and, as a consequence, NKG2D protein as well. Finally, we show that other γ(c) cytokines act similarly to IL-2 in up-regulating DAP10 expression and NKG2D-DAP10 surface expression...
  28. pmc The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signaling
    Yelina Alvarez
    Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Mol Immunol 45:253-8. 2008
    ..Therefore, at least for human neutrophils, the inhibitory signals mediated by the CD300a receptor may be selective in their action...
  29. ncbi request reprint The high-affinity immunoglobulin-E receptor (FcepsilonRI) is endocytosed by an AP-2/clathrin-independent, dynamin-dependent mechanism
    Gul nar Fattakhova
    Receptor Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Traffic 7:673-85. 2006
    ..We conclude that internalization of cross-linked FcRI does not require the AP-2/clathrin complex but is dynamin-dependent and may be lipid raft mediated...
  30. ncbi request reprint Efficient gene transfer into the human natural killer cell line, NKL, using the Amaxa nucleofection system
    Kerima Maasho
    Receptor Cell Biology Section, Laboratory of Allergic Diseases, NIAID, NIH, 12441 Parklawn Drive, Room 205, Rockville, MD 20852, USA
    J Immunol Methods 284:133-40. 2004
    ..The method used in this report proves to be far superior to existing methods for delivering DNA into this well studied NK cell line and, consequently, provides new experimental opportunities...
  31. pmc Leukocyte-associated Ig-like receptor-1-deficient mice have an altered immune cell phenotype
    Xiaobin Tang
    Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 188:548-58. 2012
    ..Taken together, these observations indicate that LAIR-1 plays a role in regulating immune cells and suggest that any adverse effects of its absence may be balanced in vivo by other inhibitory receptors...
  32. pmc Endocytosis and intracellular trafficking of human natural killer cell receptors
    Madhan Masilamani
    The Jaffe Food Allergy Institute, Department of Pediatrics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Traffic 10:1735-44. 2009
    ..In this review, we summarize the current knowledge of receptor endocytosis and trafficking, and integrate this with our current understanding of NK cell receptor trafficking...
  33. ncbi request reprint The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition
    Lucy C Sullivan
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    Immunity 27:900-11. 2007
    ....
  34. ncbi request reprint Inhibition of CD28-mediated natural cytotoxicity by KIR2DL2 does not require p56(lck) in the NK cell line YT-Indy
    Raquel Tarazona
    Faculty of Medicine, Department of Immunology, Reina Sofia Hospital, University of Cordoba, Avda Menendez Pidal s n, 14004, Cordoba, Spain
    Mol Immunol 38:495-503. 2002
    ..As YT-Indy-cl43 did not express detectable levels of p56(lck), these results indicate that this kinase is not required for transmitting the negative signals generated by KIR2DL2 ligation...