Scott S Auerbach

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc A comparative 90-day toxicity study of allyl acetate, allyl alcohol and acrolein
    Scott S Auerbach
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States
    Toxicology 253:79-88. 2008
  2. doi request reprint Toxicity and carcinogenicity studies of methylene blue trihydrate in F344N rats and B6C3F1 mice
    Scott S Auerbach
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States
    Food Chem Toxicol 48:169-77. 2010
  3. pmc RNA-Seq profiling reveals novel hepatic gene expression pattern in aflatoxin B1 treated rats
    B Alex Merrick
    Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 8:e61768. 2013
  4. doi request reprint RNA-Seq-based toxicogenomic assessment of fresh frozen and formalin-fixed tissues yields similar mechanistic insights
    Scott S Auerbach
    Biomolecular Screening Branch, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA
    J Appl Toxicol 35:766-80. 2015
  5. pmc Testing an aflatoxin B1 gene signature in rat archival tissues
    B Alex Merrick
    Biomolecular Screening Branch, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States
    Chem Res Toxicol 25:1132-44. 2012
  6. doi request reprint Predicting the hepatocarcinogenic potential of alkenylbenzene flavoring agents using toxicogenomics and machine learning
    Scott S Auerbach
    National Toxicology Program, National Institute of Environmental Health Sciences, NIH, RTP, NC 27709, USA
    Toxicol Appl Pharmacol 243:300-14. 2010
  7. pmc Global gene profiling of spontaneous hepatocellular carcinoma in B6C3F1 mice: similarities in the molecular landscape with human liver cancer
    Mark J Hoenerhoff
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Science, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 39:678-99. 2011
  8. doi request reprint Comparative phenotypic assessment of cardiac pathology, physiology, and gene expression in C3H/HeJ, C57BL/6J, and B6C3F1/J mice
    Scott S Auerbach
    National Toxicology Program, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 38:923-42. 2010

Collaborators

Detail Information

Publications8

  1. pmc A comparative 90-day toxicity study of allyl acetate, allyl alcohol and acrolein
    Scott S Auerbach
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States
    Toxicology 253:79-88. 2008
    ..Increased systemic exposure to acrolein is likely responsible for the differences in hepatic toxicological profile observed with these chemicals...
  2. doi request reprint Toxicity and carcinogenicity studies of methylene blue trihydrate in F344N rats and B6C3F1 mice
    Scott S Auerbach
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States
    Food Chem Toxicol 48:169-77. 2010
    ..There were no significant increases in neoplastic transformation observed in the mice; however, positive trends were noted for adenoma or carcinoma (combined) of the small intestine and malignant lymphoma...
  3. pmc RNA-Seq profiling reveals novel hepatic gene expression pattern in aflatoxin B1 treated rats
    B Alex Merrick
    Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 8:e61768. 2013
    ..We find the rat transcriptome contains many previously unidentified, AFB1-responsive exons and transcripts supporting RNA-Seq's capabilities to provide new insights into AFB1-mediated gene expression leading to hepatocellular carcinoma...
  4. doi request reprint RNA-Seq-based toxicogenomic assessment of fresh frozen and formalin-fixed tissues yields similar mechanistic insights
    Scott S Auerbach
    Biomolecular Screening Branch, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA
    J Appl Toxicol 35:766-80. 2015
    ..These results indicate that phenotypically anchored archival specimens represent a potentially informative resource for signature-based biomarker discovery and mechanistic characterization of toxicity...
  5. pmc Testing an aflatoxin B1 gene signature in rat archival tissues
    B Alex Merrick
    Biomolecular Screening Branch, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States
    Chem Res Toxicol 25:1132-44. 2012
    ..We conclude that an evaluation of gene signatures in archival tissues can be an important toxicological tool for evaluating critical molecular events associated with chemical exposures...
  6. doi request reprint Predicting the hepatocarcinogenic potential of alkenylbenzene flavoring agents using toxicogenomics and machine learning
    Scott S Auerbach
    National Toxicology Program, National Institute of Environmental Health Sciences, NIH, RTP, NC 27709, USA
    Toxicol Appl Pharmacol 243:300-14. 2010
    ..Furthermore, we find that exposure duration is a critical variable in the success or failure of such an approach, particularly when evaluating chemicals with unknown carcinogenic potency...
  7. pmc Global gene profiling of spontaneous hepatocellular carcinoma in B6C3F1 mice: similarities in the molecular landscape with human liver cancer
    Mark J Hoenerhoff
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Science, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 39:678-99. 2011
    ....
  8. doi request reprint Comparative phenotypic assessment of cardiac pathology, physiology, and gene expression in C3H/HeJ, C57BL/6J, and B6C3F1/J mice
    Scott S Auerbach
    National Toxicology Program, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 38:923-42. 2010
    ..Our studies indicate that genetically determined baseline differences in cardiac phenotype have the potential to influence the results of cardiotoxicity studies...