Vira V Artym
Affiliation: National Institutes of Health
- Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling networkVira V Artym
Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research Proteomics Core Facility, National Heart, Lung, and Blood Institute Biomolecular Engineering and Physical Sciences Shared Resource Program, National Institute of Biomolecular Imaging and Bioengineering Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research National Institutes of Health, Bethesda, MD 20892 Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical School and Department of Biostatistics, Bioinformatics, and Biomathematics Georgetown University, Washington, DC 20057
J Cell Biol 208:331-50. 2015..This novel phosphosignaling mechanism regulates cell surface invadopodia via kindlin2 for local proteolytic remodeling of the ECM. ..
- Dynamic membrane remodeling at invadopodia differentiates invadopodia from podosomesVira V Artym
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical School, Washington, DC 20057, USA
Eur J Cell Biol 90:172-80. 2011....
- Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and functionVira V Artym
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical School, Washington, District of Columbia 20057 1469, USA
Cancer Res 66:3034-43. 2006..Based on these results, we propose a stepwise model of invadopodia formation and function...
- The matrix reorganized: extracellular matrix remodeling and integrin signalingMelinda Larsen
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, MSC 4370, Bethesda, MD 20892 4370, USA
Curr Opin Cell Biol 18:463-71. 2006..These recent advances in the field provide new insights and raise new questions about the mechanisms of ECM synthesis and proteolytic degradation, as well as the roles of integrins and tension in ECM remodeling...
- ECM degradation assays for analyzing local cell invasionVira V Artym
LCDB NIDCR, National Institutes of Health, Bethesda, MD 20892, USA
Methods Mol Biol 522:211-9. 2009..In this chapter, we provide a detailed protocol for preparation of thin fluorescent gelatin matrices and for evaluation of the results from this degradation assay...
- Imaging cells in three-dimensional collagen matrixVira V Artym
Laboratory of Cell and Developmental Biology, NIDCR, NIH, Bethesda, Maryland, USA
Curr Protoc Cell Biol . 2010..Additionally, the authors provide protocols for a "cell sandwiching" technique to prepare cell cultures in 3-D collagen matrices required for high-resolution confocal imaging...
- 3-D extracellular matrix from sectioned human tissuesCatherine B Campbell
Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland
Curr Protoc Cell Biol 62:Unit 19.16.1-20. 2014..This unit also provides protocols for quality control of acellular matrix preparations, and for immunostaining of cells for specific cellular proteins as well as of extracellular matrices for their components...