Jose A Apud

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc COMT Val158Met polymorphism, cognitive stability and cognitive flexibility: an experimental examination
    Elise C Rosa
    Clinical Brain Disorders Branch, National Institute of Mental Heath National Institutes of Health, 10 Center Drive, MSC 1379, Bethesda, MD 20892, USA
    Behav Brain Funct 6:53. 2010
  2. doi request reprint The extraction, isolation and purification of an endogenous regulator for the 5-HT2 receptor
    Jose A Apud
    Clinical Brain Disorders Branch, GCAP, NIMH, NIH, Building 10, CRC 7 3342, 10 Center Dr, Bethesda, MD 20892, United States
    Pharmacol Res 64:312-3. 2011
  3. pmc Pharmacogenetic tools for the development of target-oriented cognitive-enhancing drugs
    Jose A Apud
    Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Health and Human Services, Bethesda, Maryland 20892, USA
    NeuroRx 3:106-16. 2006
  4. ncbi request reprint Treatment of cognitive deficits associated with schizophrenia: potential role of catechol-O-methyltransferase inhibitors
    Jose A Apud
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    CNS Drugs 21:535-57. 2007
  5. pmc Effect of tolcapone on brain activity during a variable attentional control task: a double-blind, placebo-controlled, counter-balanced trial in healthy volunteers
    Sophia C Magalona
    Clinical Brain Disorders Branch CBDB, National Institute of Mental Health NIMH, National Institutes of Health NIH, Bethesda, MD, USA
    CNS Drugs 27:663-73. 2013
  6. pmc Effective connectivity of AKT1-mediated dopaminergic working memory networks and pharmacogenetics of anti-dopaminergic treatment
    Hao Yang Tan
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892, USA
    Brain 135:1436-45. 2012
  7. pmc Modulatory effects of modafinil on neural circuits regulating emotion and cognition
    Roberta Rasetti
    Clinical Brain Disorders Branch Genes, Cognition, and Psychosis Program, NIMH, NIH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 35:2101-9. 2010
  8. pmc Neural correlates of probabilistic category learning in patients with schizophrenia
    Thomas W Weickert
    Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 29:1244-54. 2009
  9. ncbi request reprint Tolcapone improves cognition and cortical information processing in normal human subjects
    Jose A Apud
    Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20854, USA
    Neuropsychopharmacology 32:1011-20. 2007
  10. pmc Dopaminergic therapy removal differentially effects learning in schizophrenia and Parkinson's disease
    Thomas W Weickert
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Schizophr Res 149:162-6. 2013

Collaborators

Detail Information

Publications20

  1. pmc COMT Val158Met polymorphism, cognitive stability and cognitive flexibility: an experimental examination
    Elise C Rosa
    Clinical Brain Disorders Branch, National Institute of Mental Heath National Institutes of Health, 10 Center Drive, MSC 1379, Bethesda, MD 20892, USA
    Behav Brain Funct 6:53. 2010
    ..Thus, consistent with some earlier work, we predicted that Val carriers would display poorer performance when the maintenance component was taxed, while Met carriers would be less efficient when rapid updating was required...
  2. doi request reprint The extraction, isolation and purification of an endogenous regulator for the 5-HT2 receptor
    Jose A Apud
    Clinical Brain Disorders Branch, GCAP, NIMH, NIH, Building 10, CRC 7 3342, 10 Center Dr, Bethesda, MD 20892, United States
    Pharmacol Res 64:312-3. 2011
    ..Given the role of 5-HT2 receptors in the action of antidepressants, this finding may help understand some of the molecular mechanisms involved in antidepressant effect...
  3. pmc Pharmacogenetic tools for the development of target-oriented cognitive-enhancing drugs
    Jose A Apud
    Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Health and Human Services, Bethesda, Maryland 20892, USA
    NeuroRx 3:106-16. 2006
    ....
  4. ncbi request reprint Treatment of cognitive deficits associated with schizophrenia: potential role of catechol-O-methyltransferase inhibitors
    Jose A Apud
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    CNS Drugs 21:535-57. 2007
    ....
  5. pmc Effect of tolcapone on brain activity during a variable attentional control task: a double-blind, placebo-controlled, counter-balanced trial in healthy volunteers
    Sophia C Magalona
    Clinical Brain Disorders Branch CBDB, National Institute of Mental Health NIMH, National Institutes of Health NIH, Bethesda, MD, USA
    CNS Drugs 27:663-73. 2013
    ..The dorsal cingulate (dCC) and prefrontal (PFC) cortices play critical roles in attention. Evidence indicates that catechol-O-methyltransferase (COMT) modulates dopaminergic tone in the PFC and dCC...
  6. pmc Effective connectivity of AKT1-mediated dopaminergic working memory networks and pharmacogenetics of anti-dopaminergic treatment
    Hao Yang Tan
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892, USA
    Brain 135:1436-45. 2012
    ..Thus, we suggest that genetic modulation of DRD2-AKT1-related prefrontal-subcortical circuits could at least in part influence cognitive dysfunction in psychosis and its treatment...
  7. pmc Modulatory effects of modafinil on neural circuits regulating emotion and cognition
    Roberta Rasetti
    Clinical Brain Disorders Branch Genes, Cognition, and Psychosis Program, NIMH, NIH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 35:2101-9. 2010
    ....
  8. pmc Neural correlates of probabilistic category learning in patients with schizophrenia
    Thomas W Weickert
    Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 29:1244-54. 2009
    ....
  9. ncbi request reprint Tolcapone improves cognition and cortical information processing in normal human subjects
    Jose A Apud
    Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20854, USA
    Neuropsychopharmacology 32:1011-20. 2007
    ..Our results are consistent with data from animal studies and from computational models of the effects of selective enhancement of DA signaling in the prefrontal cortex...
  10. pmc Dopaminergic therapy removal differentially effects learning in schizophrenia and Parkinson's disease
    Thomas W Weickert
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Schizophr Res 149:162-6. 2013
    ....
  11. pmc Relative risk of probabilistic category learning deficits in patients with schizophrenia and their siblings
    Thomas W Weickert
    Genes, Cognition and Psychosis Program, Clinical, Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 67:948-55. 2010
    ..There are also discrepant findings regarding probabilistic category learning acquisition rate and performance in patients with schizophrenia...
  12. pmc Investigation of anatomical thalamo-cortical connectivity and FMRI activation in schizophrenia
    Stefano Marenco
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA
    Neuropsychopharmacology 37:499-507. 2012
    ..These results suggest that thalamocortical connectivity to the LPFC is altered in schizophrenia with functional consequences on working memory processing in LPFC...
  13. pmc Handedness, heritability, neurocognition and brain asymmetry in schizophrenia
    Amy Deep-Soboslay
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Brain 133:3113-22. 2010
    ..Our data neither provide strong support for 'atypical' handedness as a schizophrenia risk-associated heritable phenotype nor that it is associated with poorer neurocognition or anomalous cerebral asymmetries...
  14. doi request reprint Genetic variation in KCNH2 associated with expression in the brain of a unique hERG isoform modulates treatment response in patients with schizophrenia
    Jose A Apud
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, Intramural Research Program, NIMH, Bethesda, MD 20877, USA
    Am J Psychiatry 169:725-34. 2012
    ..1, that has unique physiological properties. The authors assessed whether genetic variation associated with KCNH2 3.1 expression influences the therapeutic effects of antipsychotic drugs...
  15. pmc Using latent class growth analysis to form trajectories of premorbid adjustment in schizophrenia
    Veronica T Cole
    Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Abnorm Psychol 121:388-95. 2012
    ..The potential implications of this subtyping strategy, including those pertaining to potential genetics studies, are discussed...
  16. pmc Cognitive fitness of cost-efficient brain functional networks
    Danielle S Bassett
    Genes Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:11747-52. 2009
    ..More generally, they echo the saying that "less is more": The information processing performance of a network can be enhanced by a sparse or low-cost configuration with disproportionately high efficiency...
  17. ncbi request reprint Catechol-O-methyltransferase val108/158met genotype predicts working memory response to antipsychotic medications
    Thomas W Weickert
    National Institutes of Health, National Institute of Mental Health, Clinical Brain Disorders Branch, Building 10, Room 4C 101, MSC 1379, Bethesda, MD 20892, USA
    Biol Psychiatry 56:677-82. 2004
    ..The present study tested the effects of several COMT polymorphisms on the cognitive response to antipsychotic medication in patients with schizophrenia...
  18. ncbi request reprint Neuroleptic withdrawal in treatment-resistant patients with schizophrenia: tardive dyskinesia is not associated with supersensitive psychosis
    Jose A Apud
    Neuropsychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892 1379, USA
    Schizophr Res 63:151-60. 2003
    ..It is possible that both group of patients may undergo supersensitive receptor changes, and that these changes may be more pronounced but potentially reversible in the group without TD...
  19. pmc Identification of candidate single-nucleotide polymorphisms in NRXN1 related to antipsychotic treatment response in patients with schizophrenia
    Aaron Jenkins
    1 Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institute of Health, National Institutes of Health, Bethesda, MD, USA 2 University of Kentucky College of Medicine, Lexington, KY, USA
    Neuropsychopharmacology 39:2170-8. 2014
    ..Furthermore, these findings potentially implicate NRXN1 in the therapeutic actions of antipsychotic drugs. ..
  20. pmc Estimating changing contexts in schizophrenia
    Claire M Kaplan
    1 Lieber Institute for Brain Development, Baltimore, Maryland, USA 2 Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, Maryland, USA
    Brain 139:2082-95. 2016
    ..These opposing cortical-subcortical effects relate in part to genetic risk for schizophrenia, with analogous imbalances in neural processing of less expected versus familiar information patterns. ..