John F Andersen

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Biochemical and functional characterization of recombinant Rhodnius prolixus platelet aggregation inhibitor 1 as a novel lipocalin with high affinity for adenosine diphosphate and other adenine nucleotides
    Ivo M B Francischetti
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Room 4 126, MSC 0425, National Institutes of Health, Bethesda, Maryland 20892 0425, USA
    Biochemistry 41:3810-8. 2002
  2. ncbi request reprint A secreted salivary inositol polyphosphate 5-phosphatase from a blood-feeding insect: allosteric activation by soluble phosphoinositides and phosphatidylserine
    John F Andersen
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochemistry 45:5450-7. 2006
  3. pmc An insight into the sialome of the oriental rat flea, Xenopsylla cheopis (Rots)
    John F Andersen
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Genomics 8:102. 2007
  4. pmc The role of salivary lipocalins in blood feeding by Rhodnius prolixus
    John F Andersen
    Laboratory of Malaria and Vector Research, National Institutes of Health, NIAID, Rockville, Maryland 20852, USA
    Arch Insect Biochem Physiol 58:97-105. 2005
  5. pmc Recognition of anionic phospholipid membranes by an antihemostatic protein from a blood-feeding insect
    John F Andersen
    Laboratory of Malaria and Vector Research, National Institutes of Health, NIAID, Rockville, Maryland 20852, USA
    Biochemistry 43:6987-94. 2004
  6. pmc Structure and mechanism in salivary proteins from blood-feeding arthropods
    John F Andersen
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 2E 32B Twinbrook 3 Bldg, 12735 Twinbrook Parkway, Rockville, MD 20852, USA
    Toxicon 56:1120-9. 2010
  7. pmc An insight into the sialotranscriptome of the cat flea, Ctenocephalides felis
    Jose M C Ribeiro
    Vector Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Rockville, Maryland, USA
    PLoS ONE 7:e44612. 2012
  8. pmc The function and three-dimensional structure of a thromboxane A2/cysteinyl leukotriene-binding protein from the saliva of a mosquito vector of the malaria parasite
    Patricia H Alvarenga
    Laboratory of Malaria and Vector Research, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rockville, Maryland, United States of America
    PLoS Biol 8:e1000547. 2010
  9. pmc Multifunctionality and mechanism of ligand binding in a mosquito antiinflammatory protein
    Eric Calvo
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 106:3728-33. 2009
  10. pmc Comparative sialomics between hard and soft ticks: implications for the evolution of blood-feeding behavior
    Ben J Mans
    Laboratory for Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Insect Biochem Mol Biol 38:42-58. 2008

Detail Information

Publications58

  1. ncbi request reprint Biochemical and functional characterization of recombinant Rhodnius prolixus platelet aggregation inhibitor 1 as a novel lipocalin with high affinity for adenosine diphosphate and other adenine nucleotides
    Ivo M B Francischetti
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Room 4 126, MSC 0425, National Institutes of Health, Bethesda, Maryland 20892 0425, USA
    Biochemistry 41:3810-8. 2002
    ..We conclude that RPAI-1 exerts an antiplatelet effect due to scavenging of low concentrations of ADP in vitro and in vivo. RPAI-1 is the first lipocalin described so far with unique specificity for adenine nucleotides...
  2. ncbi request reprint A secreted salivary inositol polyphosphate 5-phosphatase from a blood-feeding insect: allosteric activation by soluble phosphoinositides and phosphatidylserine
    John F Andersen
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochemistry 45:5450-7. 2006
    ..If allosteric activation of type II IPPs by PI(4)P and PS is a widespread feature of the group, it may represent a novel regulatory mechanism for these important enzymes...
  3. pmc An insight into the sialome of the oriental rat flea, Xenopsylla cheopis (Rots)
    John F Andersen
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Genomics 8:102. 2007
    ..Fleas represent a relatively recent group of insects that evolved hematophagy independently of other insect orders...
  4. pmc The role of salivary lipocalins in blood feeding by Rhodnius prolixus
    John F Andersen
    Laboratory of Malaria and Vector Research, National Institutes of Health, NIAID, Rockville, Maryland 20852, USA
    Arch Insect Biochem Physiol 58:97-105. 2005
    ..In the course of these investigations, anticoagulant, antiplatelet, antiinflammatory, and vasodilatory molecules have been described...
  5. pmc Recognition of anionic phospholipid membranes by an antihemostatic protein from a blood-feeding insect
    John F Andersen
    Laboratory of Malaria and Vector Research, National Institutes of Health, NIAID, Rockville, Maryland 20852, USA
    Biochemistry 43:6987-94. 2004
    ..Molecular modeling of NP7 revealed a putative, positively charged membrane interaction surface comprised mainly of a helix lying outside of the lipocalin beta-barrel structure...
  6. pmc Structure and mechanism in salivary proteins from blood-feeding arthropods
    John F Andersen
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 2E 32B Twinbrook 3 Bldg, 12735 Twinbrook Parkway, Rockville, MD 20852, USA
    Toxicon 56:1120-9. 2010
    ..Structural studies performed on a number of these proteins have revealed biologically novel and sophisticated mechanisms used to perform their functions. Here, the results of these structural and mechanistic studies are reviewed...
  7. pmc An insight into the sialotranscriptome of the cat flea, Ctenocephalides felis
    Jose M C Ribeiro
    Vector Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Rockville, Maryland, USA
    PLoS ONE 7:e44612. 2012
    ..We present the analysis of the sialome of cat flea Ctenocephaides felis...
  8. pmc The function and three-dimensional structure of a thromboxane A2/cysteinyl leukotriene-binding protein from the saliva of a mosquito vector of the malaria parasite
    Patricia H Alvarenga
    Laboratory of Malaria and Vector Research, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rockville, Maryland, United States of America
    PLoS Biol 8:e1000547. 2010
    ..This article presents, to our knowledge, the first structural characterization of a protein from mosquito saliva that inhibits collagen mediated platelet activation...
  9. pmc Multifunctionality and mechanism of ligand binding in a mosquito antiinflammatory protein
    Eric Calvo
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 106:3728-33. 2009
    ....
  10. pmc Comparative sialomics between hard and soft ticks: implications for the evolution of blood-feeding behavior
    Ben J Mans
    Laboratory for Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Insect Biochem Mol Biol 38:42-58. 2008
    ..In conclusion, the ancestral tick may have possessed a simple (few members for each family), but diverse (many different protein families) salivary gland protein domain repertoire...
  11. ncbi request reprint Function and evolution of a mosquito salivary protein family
    Eric Calvo
    Section of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases NIH, 12735 Twinbrook Parkway, Rockville, MD 20852, USA
    J Biol Chem 281:1935-42. 2006
    ..This adaptation has been solved independently in ticks, bugs, and mosquitoes by co-option of either member of the lipocalin or, as shown here, by the odorant-binding protein families...
  12. ncbi request reprint Structural determinants of factor IX(a) binding in nitrophorin 2, a lipocalin inhibitor of the intrinsic coagulation pathway
    Nanda P Gudderra
    Laboratory of Malaria and Vector Research NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:25022-8. 2005
    ..Combination of four E-F loop mutations (K92A, A93K, V94A, E97A) in a single mutant reduced the inhibitory potency and binding to levels similar to those seen with NP3 without affecting heme or histamine binding...
  13. pmc Insight into the Sialome of the Bed Bug, Cimex lectularius
    Ivo M B Francischetti
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Rockville, Maryland 20852, USA
    J Proteome Res 9:3820-31. 2010
    ..This manuscript is a guide for the supplemental database files http://exon.niaid.nih.gov/transcriptome/C_lectularius/S1/Cimex-S1.zip and http://exon.niaid.nih.gov/transcriptome/C_lectularius/S2/Cimex-S2.xls...
  14. pmc Novel family of insect salivary inhibitors blocks contact pathway activation by binding to polyphosphate, heparin, and dextran sulfate
    Patricia H Alvarenga
    From the Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health, Rockville, MD P H A, X X, F O, A C C, I M B F, J G V, J M C R, J F A Laboratório de Bioquímica de Resposta ao Estresse, Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil P H A Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular INCT EM, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil P H A Instituto de Biofísica Carlos Chagas Filho, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil C R N, J S and Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil M A J, L J
    Arterioscler Thromb Vasc Biol 33:2759-70. 2013
    ..We are searching for salivary proteins from blood-feeding insects that counteract the effect of procoagulant and proinflammatory factors in the host, including elements of the contact pathway...
  15. pmc Alboserpin, a factor Xa inhibitor from the mosquito vector of yellow fever, binds heparin and membrane phospholipids and exhibits antithrombotic activity
    Eric Calvo
    Section of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 286:27998-8010. 2011
    ..It conceivably uses heparin and phosphatidylcholine/phosphatidylethanolamine as anchors to increase protein localization and effective concentration at sites of injury, cell activation, or inflammation...
  16. ncbi request reprint Prostaglandin E2 is a major inhibitor of dendritic cell maturation and function in Ixodes scapularis saliva
    Anderson Sá-Nunes
    Section of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 179:1497-505. 2007
    ..The role of salivary PGE(2) in vector-host interaction and host immune modulation and inflammation in vivo is also discussed. This study is the first to identify molecularly a DC inhibitor from blood-sucking arthropods...
  17. pmc Salivary antigen-5/CAP family members are Cu2+-dependent antioxidant enzymes that scavenge O₂₋. and inhibit collagen-induced platelet aggregation and neutrophil oxidative burst
    Teresa C F Assumpção
    Vector Biology Section, Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 288:14341-61. 2013
    ..Antigen-5/CAP emerges as novel family of Cu(2+)-dependent antioxidant enzymes that inhibit neutrophil oxidative burst and negatively modulate platelet aggregation by a unique salivary mechanism...
  18. ncbi request reprint The crystal structure of D7r4, a salivary biogenic amine-binding protein from the malaria mosquito Anopheles gambiae
    Ben J Mans
    Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 282:36626-33. 2007
    ....
  19. pmc Cutting edge: Immunity against a "silent" salivary antigen of the Lyme vector Ixodes scapularis impairs its ability to feed
    Michalis Kotsyfakis
    Vector Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 181:5209-12. 2008
    ....
  20. ncbi request reprint Antiinflammatory and immunosuppressive activity of sialostatin L, a salivary cystatin from the tick Ixodes scapularis
    Michalis Kotsyfakis
    Vector Biology Section, Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 281:26298-307. 2006
    ....
  21. pmc The salivary gland transcriptome of the neotropical malaria vector Anopheles darlingi reveals accelerated evolution of genes relevant to hematophagy
    Eric Calvo
    Section of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA
    BMC Genomics 10:57. 2009
    ..Here we present and analyze data from a comprehensive salivary gland (SG) transcriptome of the neotropical malaria vector Anopheles darlingi (subgenus Nyssorhynchus)...
  22. pmc Structure and ligand-binding properties of the biogenic amine-binding protein from the saliva of a blood-feeding insect vector of Trypanosoma cruzi
    Xueqing Xu
    Laboratory of Malaria and Vector Research, NIH NIAID, Rockville, MD 20852, USA
    Acta Crystallogr D Biol Crystallogr 69:105-13. 2013
    ..The cavity contains significant additional volume, suggesting that this protein may have evolved from the related nitrophorin proteins, which bind a much larger heme ligand in the central cavity...
  23. pmc Triplatin, a platelet aggregation inhibitor from the salivary gland of the triatomine vector of Chagas disease, binds to TXA(2) but does not interact with glycoprotein PVI
    Dongying Ma
    Section of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Thromb Haemost 107:111-23. 2012
    ..It conceivably blocks platelet aggregation and vasoconstriction, thus contributing to successful blood feeding at the vector-host interface...
  24. ncbi request reprint Ixolaris, a novel recombinant tissue factor pathway inhibitor (TFPI) from the salivary gland of the tick, Ixodes scapularis: identification of factor X and factor Xa as scaffolds for the inhibition of factor VIIa/tissue factor complex
    Ivo M B Francischetti
    Section of Medical Entomology, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    Blood 99:3602-12. 2002
    ..Ixolaris may be a useful tool to study the structural features of FVIIa, FX, and FXa, and an alternative anticoagulant in cardiovascular diseases...
  25. pmc The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)
    Svenja Steinfelder
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 206:1681-90. 2009
    ..Based on this evidence, we hypothesize that S. mansoni omega-1 acts by limiting the interaction of DCs with CD4(+) T lymphocytes, thereby lowering the strength of the activation signal delivered...
  26. pmc The transcriptome of the salivary glands of the female western black-legged tick Ixodes pacificus (Acari: Ixodidae)
    Ivo M B Francischetti
    Section of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892 8132, USA
    Insect Biochem Mol Biol 35:1142-61. 2005
    ..Some of these proteins may be useful for studying vascular biology or the immune system, for vaccine development, or as immunoreagents to detect prior exposure to ticks. Electronic version of the manuscript can be found at...
  27. pmc Dipetalodipin, a novel multifunctional salivary lipocalin that inhibits platelet aggregation, vasoconstriction, and angiogenesis through unique binding specificity for TXA2, PGF2alpha, and 15(S)-HETE
    Teresa C F Assumpção
    Vector Biology Section, Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Bethesda, Maryland 20892 8132, USA
    J Biol Chem 285:39001-12. 2010
    ..Results suggest that DPTL blocks platelet aggregation, vasoconstriction, and angiogenesis through binding to distinct eicosanoids involved in inflammation...
  28. ncbi request reprint Inhibition of hemostasis by a high affinity biogenic amine-binding protein from the saliva of a blood-feeding insect
    John F Andersen
    Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:4611-7. 2003
    ..Molecular modeling of ABP suggests that ligand binding is mediated by interaction with the side chains of aromatic amino acids and charged residues that line the binding pocket...
  29. pmc Structure of protein having inhibitory disintegrin and leukotriene scavenging functions contained in single domain
    Xueqing Xu
    Laboratory of Malaria and Vector Research, NIAID, National Intitutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:10967-76. 2012
    ..Therefore, tablysin-15 functions as an inhibitor of integrin function and as an anti-inflammatory scavenger of eicosanoids...
  30. ncbi request reprint Selective cysteine protease inhibition contributes to blood-feeding success of the tick Ixodes scapularis
    Michalis Kotsyfakis
    Vector Biology Section, Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 282:29256-63. 2007
    ..scapularis cystatins attractive targets for development of anti-tick vaccines...
  31. ncbi request reprint Structural determinants of the anti-HIV activity of a CCR5 antagonist derived from Toxoplasma gondii
    Felix Yarovinsky
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 279:53635-42. 2004
    ..These findings shed light on the structural basis of the molecular mimicry of the chemokine function by a pathogen-derived protein and provide a basis for further modification of C-18 into an antiviral agent...
  32. pmc Characterization of anti-hemostatic factors in the argasid, Argas monolakensis: implications for the evolution of blood-feeding in the soft tick family
    Ben J Mans
    Laboratory for Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Insect Biochem Mol Biol 38:22-41. 2008
    ..This cross-reactivity could have facilitated the switching of soft ticks from avian to mammalian hosts and can explain in part the ability of Argas ticks, to feed on humans, thereby remaining a possible health risk...
  33. ncbi request reprint Strongyloides stercoralis recombinant NIE antigen shares epitope with recombinant Ves v 5 and Pol a 5 allergens of insects
    Varatharajalu Ravi
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Trop Med Hyg 72:549-53. 2005
    ....
  34. ncbi request reprint CCR5 N-terminal region plays a critical role in HIV-1 inhibition by Toxoplasma gondii-derived cyclophilin-18
    Hana Golding
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Biol Chem 280:29570-7. 2005
    ..The elucidation of the functional C-18-binding mechanism may help in the rational design of novel antiviral agents against HIV...
  35. pmc Insight into the sialome of the Black Fly, Simulium vittatum
    John F Andersen
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    J Proteome Res 8:1474-88. 2009
    ..niaid.nih.gov/transcriptome/S_vittatum/T1/SV-tb1.zip and http://exon.niaid.nih.gov/transcriptome/S_vittatum/T2/SV-tb2.zip ...
  36. pmc Structure, function, and evolution of biogenic amine-binding proteins in soft ticks
    Ben J Mans
    Laboratory for Malaria and Vector Research, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 283:18721-33. 2008
    ..The data generated were used to reconstruct the most probable evolutionary pathway for the evolution of biogenic amine-binding in tick lipocalins...
  37. pmc Cyr61/CCN1 displays high-affinity binding to the somatomedin B(1-44) domain of vitronectin
    Ivo M B Francischetti
    Section of Vector Biology, Laboratory of Malaria and Vector Research, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 5:e9356. 2010
    ..While heparin sulphate proteoglycans reportedly mediate the interaction of Cyr61 with the matrix and cell surface, the role of other extracellular associated proteins has not been revealed...
  38. pmc Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells
    Venkateswara R Simhadri
    Laboratory of Molecular and Developmental Immunology, Division of Monoclonal Antibodies, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Blood 119:2799-809. 2012
    ..Collectively, our results indicate that PE and PS are ligands for CD300a, and that this interaction plays an important role in regulating the removal of dead cells...
  39. ncbi request reprint TLR11 activation of dendritic cells by a protozoan profilin-like protein
    Felix Yarovinsky
    Immunobiology Section, Laboratory of Parasitic Diseases National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Science 308:1626-9. 2005
    ..Moreover, TLR11 is required in vivo for parasite-induced IL-12 production and optimal resistance to infection, thereby establishing a role for the receptor in host recognition of protozoan pathogens...
  40. pmc Identification and Mechanistic Analysis of a Novel Tick-Derived Inhibitor of Thrombin
    Willy Jablonka
    Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS ONE 10:e0133991. 2015
    ..Injection of 2.5 mg/kg of hyalomin-1 increased arterial occlusion time in a mouse model of thrombosis, suggesting this peptide could be a candidate for clinical use as an antithrombotic. ..
  41. pmc Mitochondrial reactive oxygen species modulate mosquito susceptibility to Plasmodium infection
    Renata L S Goncalves
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS ONE 7:e41083. 2012
    ..Mitochondria perform multiple roles in cell biology, acting as the site of aerobic energy-transducing pathways and as an important source of reactive oxygen species (ROS) that modulate redox metabolism...
  42. doi request reprint Strongyloides stercoralis excretory/secretory protein strongylastacin specifically recognized by IgE antibodies in infected human sera
    Ravi Varatharajalu
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Microbiol Immunol 55:115-22. 2011
    ..stercoralis infected humans. Non-specific IgG antibodies to strongylastacin are present in both infected and normal humans. Further investigation is needed to understand the role of the host protective response against strongylastacin...
  43. pmc Structure and function of a "yellow" protein from saliva of the sand fly Lutzomyia longipalpis that confers protective immunity against Leishmania major infection
    Xueqing Xu
    Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 286:32383-93. 2011
    ..This may be the reason for differences in antigenicity between the two proteins...
  44. pmc Structure and Ligand-Binding Mechanism of a Cysteinyl Leukotriene-Binding Protein from a Blood-Feeding Disease Vector
    Willy Jablonka
    Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Rockville, Maryland 20852, United States
    ACS Chem Biol 11:1934-44. 2016
    ..LTC4 is cleaved in the complex, leaving free glutathione and a C20 fatty acid. Chromatographic analysis of bound ligands showed only intact LTC4, suggesting that cleavage could be radiation-mediated. ..
  45. pmc The structure of hookworm platelet inhibitor (HPI), a CAP superfamily member from Ancylostoma caninum
    Dongying Ma
    Laboratory of Malaria and Vector Research, NIH NIAID, 12735 Twinbrook Parkway, Rockville, MD 20852, USA
    Acta Crystallogr F Struct Biol Commun 71:643-9. 2015
    ..This result corroborates previous analyses of recombinant HPI and suggests that it might require post-translational modification or have a different biological function. ..
  46. doi request reprint A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in nonhuman primates
    Fabiano Oliveira
    Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Sci Transl Med 7:290ra90. 2015
    ..duboscqi bites recognized PdSP15, demonstrating its immunogenicity in humans. PdSP15 sequence and structure show no homology to mammalian proteins, further demonstrating its potential as a component of a vaccine for human leishmaniasis. ..
  47. pmc Evidence for a lectin specific for sulfated glycans in the salivary gland of the malaria vector, Anopheles gambiae
    Ivo M B Francischetti
    Section of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 9:e107295. 2014
    ..The role of salivary molecules (sialogenins) with lectin activity is discussed in the context of inflammation, and parasite-vector-host interactions. ..
  48. pmc Examination of the ligand-binding and enzymatic properties of a bilin-binding protein from the poisonous caterpillar Lonomia obliqua
    Ana B G Veiga
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, Maryland, United States of America Center of Biotechnology, Universidade Federal do Rio Grande do Sul, Porto Alegre RS, Brazil
    PLoS ONE 9:e95424. 2014
    ..However, further reaction to form biliverdin was not observed, making it unlikely that biliverdin IXγ is formed by this pathway...
  49. pmc An Inhibitor of the Alternative Pathway of Complement in Saliva of New World Anopheline Mosquitoes
    Antonio F Mendes-Sousa
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 Department of Parasitology, University of Minas Gerais, Belo Horizonte, Minas Gerais 30123 970, Brazil and
    J Immunol 197:599-610. 2016
    ..The data indicate that albicin specifically recognizes the activated form of the complex, allowing more efficient inhibition by an inhibitor whose quantity is limited. ..
  50. pmc An insight into the sialome of the horse fly, Tabanus bromius
    Jose M C Ribeiro
    National Institute of Allergy and Infectious Diseases, Laboratory of Malaria and Vector Research, 12735 Twinbrook Parkway, Maryland 20852, USA Electronic address
    Insect Biochem Mol Biol 65:83-90. 2015
    ..These sequences provide for a platform from which further proteomic studies may be designed to identify salivary proteins from T. bromius that are of pharmacological interest or used as immunological markers of host exposure. ..
  51. ncbi request reprint Characterization of a recombinant immunodiagnostic antigen (NIE) from Strongyloides stercoralis L3-stage larvae
    Varatharajalu Ravi
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Room 126, Bethesda, MD 20892, USA
    Mol Biochem Parasitol 125:73-81. 2002
    ....
  52. pmc Induction of colitis by a CD4+ T cell clone specific for a bacterial epitope
    Marika C Kullberg
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:15830-5. 2003
    ....
  53. ncbi request reprint Role of binding site loops in controlling nitric oxide release: structure and kinetics of mutant forms of nitrophorin 4
    Estelle M Maes
    Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721, USA
    Biochemistry 43:6679-90. 2004
    ..Interestingly, the multiphasic kinetic behavior of rNPs was not affected by mutations, and its cause remains unclear...
  54. pmc Heme-assisted S-nitrosation of a proximal thiolate in a nitric oxide transport protein
    Andrzej Weichsel
    Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 102:594-9. 2005
    ....
  55. pmc An insight into the sialome of the blood-sucking bug Triatoma infestans, a vector of Chagas' disease
    Teresa C F Assumpção
    Laboratory of Host Parasite Interface, University of Brasilia, Brasília DF 70 910 900, Brazil
    Insect Biochem Mol Biol 38:213-32. 2008
    ..We present the analysis of a set of 1534 (SG) cDNA sequences, 645 of which coded for proteins of a putative secretory nature. Most salivary proteins described as lipocalins matched peptide sequences obtained from proteomic results...
  56. pmc Ixolaris binding to factor X reveals a precursor state of factor Xa heparin-binding exosite
    Robson Q Monteiro
    Instituto de Bioquimica Medica, Centro de Ciencias de Saude, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Protein Sci 17:146-53. 2008
    ..Ixolaris may be a useful tool to study the physiological role of the FX HBPE and to evaluate this domain as a target for anticoagulant drugs...
  57. ncbi request reprint An insight into the sialome of the adult female mosquito Aedes albopictus
    Bruno Arcà
    Department of Structural and Functional Biology, University Federico II, Naples, Italy
    Insect Biochem Mol Biol 37:107-27. 2007
    ..Supplemental spreadsheets with hyperlinks to all sequences used in this manuscript are hyperlinked throughout the text and can be found at http://www.ncbi.nlm.nih.gov/projects/omes/#salivarytranscriptomes...
  58. ncbi request reprint Bullous allergic hypersensitivity to bed bug bites mediated by IgE against salivary nitrophorin
    Martin Leverkus
    Department of Dermatology, University of Wurzburg, Wurzburg, Germany
    J Invest Dermatol 126:91-6. 2006
    ..lectularius nitrophorin, but not to 37 kDa C. lectularius apyrase. Our data demonstrate that bullous cimicosis may be the late-phase response of an allergic IgE-mediated hypersensitivity to C. lectularius nitrophorin...