Genomes and Genes
Affiliation: National Institutes of Health
- A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han ChinesePing An
Basic Research Laboratory, SAIC Frederick, Maryland, USA
J Infect Dis 203:943-7. 2011..We showed for the first time to our knowledge that it is a predictor for HBV clearance (odds ratio, 2.41; P < .001). However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma...
- Polymorphisms of CUL5 are associated with CD4+ T cell loss in HIV-1 infected individualsPing An
Laboratory of Genomic Diversity, SAIC Frederick, Incorporated, National Cancer Institute, Frederick, Maryland, United States of America
PLoS Genet 3:e19. 2007....
- APOBEC3B deletion and risk of HIV-1 acquisitionPing An
Laboratory of Genomic Diversity, SAIC Frederick, National Cancer Institute Frederick, Frederick, MD 21702, USA
J Infect Dis 200:1054-8. 2009..01; P=. 03), and viral set point (P= .04). These findings suggest that the loss of APOBEC3B may increase host susceptibility to HIV-1 acquisition and progression to AIDS and warrant further study...
- Role of exonic variation in chemokine receptor genes on AIDS: CCRL2 F167Y association with pneumocystis pneumoniaPing An
Basic Research Laboratory, SAIC Frederick, National Cancer Institute Frederick, Frederick, Maryland, USA
PLoS Genet 7:e1002328. 2011..28-6.31) among four major AIDS-defining conditions. Considering the newly defined role of CCRL2 in lung dendritic cell trafficking, this atypical chemokine receptor may affect PCP through immune regulation and inducing inflammation...
- Dominant effects of CCR2-CCR5 haplotypes in HIV-1 disease progressionCheryl A Winkler
Laboratory of Genomic Diversity, Division of Basic Research, SAIC Frederick, NCI, Frederick, MD, USA
J Acquir Immune Defic Syndr 37:1534-8. 2004....
- Genetic variation in the CCL18-CCL3-CCL4 chemokine gene cluster influences HIV Type 1 transmission and AIDS disease progressionWilliam S Modi
SAIC Frederick, Inc, Basic Research Program, Frederick, MD 21702 1201, USA
Am J Hum Genet 79:120-8. 2006..01-.02). These results reiterate the importance of chemokine gene variation in HIV-1/AIDS pathogenesis and emphasize that localized linkage disequilibrium makes the identification of causal mutations difficult...
- Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15George W Nelson
Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
Hum Mol Genet 19:1805-15. 2010..Rs5750250 combined with rs11912763 had receiver operator characteristic (ROC) C statistics of 0.80, 0.73 and 0.65 for HIVAN, FSGS and H-ESKD, respectively, allowing prediction of genetic risk by typing two SNPs...
- APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathyJeffrey B Kopp
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland, USA
J Am Soc Nephrol 22:2129-37. 2011..These data add to the evidence base required to determine whether genetic testing for APOL1 has a use in clinical practice...
- Genome-wide association study implicates PARD3B-based AIDS restrictionJennifer L Troyer
Laboratory of Genomic Diversity, SAIC Frederick, Inc, Frederick, MD 21702, USA
J Infect Dis 203:1491-502. 2011..Here we used clinically well-characterized subjects from 5 pretreatment HIV/AIDS cohorts for a genome-wide association study to identify gene associations with rate of AIDS progression...
- Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis PneumoniaPing An
Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
PLoS Genet 12:e1005921. 2016..An in vitro assay revealed that the A3F I231V variant may influence Vif mediated A3F degradation. Our results provide genetic epidemiological evidence that A3F modulates HIV-1/AIDS disease progression. ..
- Host genes associated with HIV/AIDS: advances in gene discoveryPing An
Laboratory of Genomic Diversity, SAIC Frederick, Inc, National Cancer Institute at Frederick, Frederick, MD 21702, USA
Trends Genet 26:119-31. 2010..Multidisciplinary approaches integrating genetic epidemiology to systems biology will be required to fully understand virus-host interactions to effectively combat HIV/AIDS...
- APOBEC3G genetic variants and their influence on the progression to AIDSPing An
Basic Research Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
J Virol 78:11070-6. 2004..These studies suggest that there may be a modifying role of variants of APOBEC3G on HIV-1 disease progression that warrants further investigation...
- Sequencing rare and common APOL1 coding variants to determine kidney disease riskSophie Limou
Molecular Genetic Epidemiology Section, Basic Research Laboratory, Basic Science Program, NCI, Leidos Biomedical Research, Frederick National Laboratory, Frederick, Maryland, USA
Kidney Int 88:754-63. 2015..Hence, in most potential clinical or screening applications, our study suggests that sequencing APOL1 exons is unlikely to bring additional information compared to genotyping only APOL1 G1 and G2 risk alleles...
- Patterns of ethnic diversity among the genes that influence AIDSCheryl Winkler
Basic Research Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
Hum Mol Genet 13:R9-19. 2004..These genes are undergoing present day natural selection in populations with high AIDS prevalence...