Genomes and Genes
Affiliation: National Institutes of Health
- A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han ChinesePing An
Basic Research Laboratory, SAIC Frederick, Maryland, USA
J Infect Dis 203:943-7. 2011..We showed for the first time to our knowledge that it is a predictor for HBV clearance (odds ratio, 2.41; P < .001). However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma...
- Polymorphisms of CUL5 are associated with CD4+ T cell loss in HIV-1 infected individualsPing An
Laboratory of Genomic Diversity, SAIC Frederick, Incorporated, National Cancer Institute, Frederick, Maryland, United States of America
PLoS Genet 3:e19. 2007....
- APOBEC3B deletion and risk of HIV-1 acquisitionPing An
Laboratory of Genomic Diversity, SAIC Frederick, National Cancer Institute Frederick, Frederick, MD 21702, USA
J Infect Dis 200:1054-8. 2009..01; P=. 03), and viral set point (P= .04). These findings suggest that the loss of APOBEC3B may increase host susceptibility to HIV-1 acquisition and progression to AIDS and warrant further study...
- Role of exonic variation in chemokine receptor genes on AIDS: CCRL2 F167Y association with pneumocystis pneumoniaPing An
Basic Research Laboratory, SAIC Frederick, National Cancer Institute Frederick, Frederick, Maryland, USA
PLoS Genet 7:e1002328. 2011..28-6.31) among four major AIDS-defining conditions. Considering the newly defined role of CCRL2 in lung dendritic cell trafficking, this atypical chemokine receptor may affect PCP through immune regulation and inducing inflammation...
- Dominant effects of CCR2-CCR5 haplotypes in HIV-1 disease progressionCheryl A Winkler
Laboratory of Genomic Diversity, Division of Basic Research, SAIC Frederick, NCI, Frederick, MD, USA
J Acquir Immune Defic Syndr 37:1534-8. 2004....
- Genetic variation in the CCL18-CCL3-CCL4 chemokine gene cluster influences HIV Type 1 transmission and AIDS disease progressionWilliam S Modi
SAIC Frederick, Inc, Basic Research Program, Frederick, MD 21702 1201, USA
Am J Hum Genet 79:120-8. 2006..01-.02). These results reiterate the importance of chemokine gene variation in HIV-1/AIDS pathogenesis and emphasize that localized linkage disequilibrium makes the identification of causal mutations difficult...
- APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathyJeffrey B Kopp
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland, USA
J Am Soc Nephrol 22:2129-37. 2011..These data add to the evidence base required to determine whether genetic testing for APOL1 has a use in clinical practice...
- Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15George W Nelson
Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
Hum Mol Genet 19:1805-15. 2010..Rs5750250 combined with rs11912763 had receiver operator characteristic (ROC) C statistics of 0.80, 0.73 and 0.65 for HIVAN, FSGS and H-ESKD, respectively, allowing prediction of genetic risk by typing two SNPs...
- Genome-wide association study implicates PARD3B-based AIDS restrictionJennifer L Troyer
Laboratory of Genomic Diversity, SAIC Frederick, Inc, Frederick, MD 21702, USA
J Infect Dis 203:1491-502. 2011..Here we used clinically well-characterized subjects from 5 pretreatment HIV/AIDS cohorts for a genome-wide association study to identify gene associations with rate of AIDS progression...
- Host genes associated with HIV/AIDS: advances in gene discoveryPing An
Laboratory of Genomic Diversity, SAIC Frederick, Inc, National Cancer Institute at Frederick, Frederick, MD 21702, USA
Trends Genet 26:119-31. 2010..Multidisciplinary approaches integrating genetic epidemiology to systems biology will be required to fully understand virus-host interactions to effectively combat HIV/AIDS...
- APOBEC3G genetic variants and their influence on the progression to AIDSPing An
Basic Research Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
J Virol 78:11070-6. 2004..These studies suggest that there may be a modifying role of variants of APOBEC3G on HIV-1 disease progression that warrants further investigation...
- Patterns of ethnic diversity among the genes that influence AIDSCheryl Winkler
Basic Research Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
Hum Mol Genet 13:R9-19. 2004..These genes are undergoing present day natural selection in populations with high AIDS prevalence...