Genomes and Genes
Affiliation: National Institutes of Health
- Identification of innate immunity genes and pathways using a comparative genomics approachScott Alper
Laboratory of Environmental Lung Disease, National Heart Lung and Blood Institute, National Institutes of Health, 111 TW Alexander Drive, Durham, NC 27709, USA
Proc Natl Acad Sci U S A 105:7016-21. 2008..These genes may prove critical to understanding host defense and represent potential therapeutic targets for infectious and immunological diseases...
- Specificity and complexity of the Caenorhabditis elegans innate immune responseScott Alper
Laboratory of Respiratory Biology, National Institutes of Environmental Health Sciences, National Institutes of Health, Durham, NC 27709, USA
Mol Cell Biol 27:5544-53. 2007..We also propose the existence of an "antimicrobial fingerprint," which will aid in assigning newly identified C. elegans innate immunity genes to known immune signaling pathways...
- Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicityYuxia Cui
Nicholas School of the Environment and Earth Sciences, Duke University, Durham, NC 27708, USA
Genome Biol 8:R122. 2007..Exposure to cadmium is associated with a variety of human diseases. At low concentrations, cadmium activates the transcription of stress-responsive genes, which can prevent or repair the adverse effects caused by this metal...
- Cell fusion in Caenorhabditis elegansScott Alper
Laboratory of Respiratory Biology, NIEHS, NIH, Department of Medicine, Duke University Medical Center, Durham, NC, USA
Methods Mol Biol 475:53-74. 2008..elegans cell fusion genes, including those that regulate the fusion cell fate decision and two genes that encode components of the cell fusion machinery...
- The zinc finger protein REF-2 functions with the Hox genes to inhibit cell fusion in the ventral epidermis of C. elegansScott Alper
Department of Biochemistry and Biophysics, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0448, USA
Development 129:3335-48. 2002..p cells to be generated and to remain unfused. REF-2 functions with the Hox proteins to prevent Pn.p cell fusion. ref-2 may also be a transcriptional target of the Hox proteins...