Faiyaz Ahmad

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice
    Young Hun Choi
    Pulmonary Critical Care Medicine Branch, NIH, Bethesda, MD 20892, USA
    J Clin Invest 116:3240-51. 2006
  2. pmc Regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2
    Faiyaz Ahmad
    From the Cardiovascular Pulmonary Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 290:6763-76. 2015
  3. doi request reprint Cyclic nucleotide phosphodiesterase 3 signaling complexes
    F Ahmad
    Cardiovascular Pulmonary Branch, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA
    Horm Metab Res 44:776-85. 2012
  4. ncbi request reprint Cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorporation in FDCP2 cells
    F Ahmad
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 164:4678-88. 2000
  5. pmc Differential regulation of adipocyte PDE3B in distinct membrane compartments by insulin and the beta3-adrenergic receptor agonist CL316243: effects of caveolin-1 knockdown on formation/maintenance of macromolecular signalling complexes
    Faiyaz Ahmad
    Translational Medicine Branch, NHLBI, NIH, Bethesda, MD 20892, USA
    Biochem J 424:399-410. 2009
  6. pmc Insulin-induced formation of macromolecular complexes involved in activation of cyclic nucleotide phosphodiesterase 3B (PDE3B) and its interaction with PKB
    Faiyaz Ahmad
    Pulmonary Critical Care Medicine Branch, NHLBI National Heart, Lung and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bldg 10, Room 5N307, Bethesda, MD 20892, USA
    Biochem J 404:257-68. 2007
  7. pmc A role for phosphodiesterase 3B in acquisition of brown fat characteristics by white adipose tissue in male mice
    Emilia Guirguis
    Pulmonary Cardiovascular Branch, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 154:3152-67. 2013
  8. pmc White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function
    Youn Wook Chung
    Cardiovascular and Pulmonary Branch CPB, National Heart, Lung, and Blood Institute NHLBI, National Institutes of Health NIH, Bethesda, Maryland, 20892, USA
    Sci Rep 7:40445. 2017
  9. pmc Female infertility in PDE3A(-/-) mice: polo-like kinase 1 (Plk1) may be a target of protein kinase A (PKA) and involved in meiotic arrest of oocytes from PDE3A(-/-) mice
    Weixing Shen
    Translational Medicine Branch TMB, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Cell Cycle 9:4720-34. 2010
  10. ncbi request reprint Effects of heterologous expression of human cyclic nucleotide phosphodiesterase 3A (hPDE3A) on redox regulation in yeast
    Dong Keun Rhee
    Laboratory of Biochemical Physiology, Cardiovascular and Pulmonary Branch, NHLBI NIH, Room 5N 307, Building 10, Bethesda, MD 20892 1434, USA
    Biochem J 473:4205-4225. 2016

Collaborators

Detail Information

Publications20

  1. pmc Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice
    Young Hun Choi
    Pulmonary Critical Care Medicine Branch, NIH, Bethesda, MD 20892, USA
    J Clin Invest 116:3240-51. 2006
    ..Altered expression and/or regulation of PDE3B may contribute to metabolic dysregulation, including systemic insulin resistance...
  2. pmc Regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2
    Faiyaz Ahmad
    From the Cardiovascular Pulmonary Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 290:6763-76. 2015
    ....
  3. doi request reprint Cyclic nucleotide phosphodiesterase 3 signaling complexes
    F Ahmad
    Cardiovascular Pulmonary Branch, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA
    Horm Metab Res 44:776-85. 2012
    ....
  4. ncbi request reprint Cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorporation in FDCP2 cells
    F Ahmad
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 164:4678-88. 2000
    ..These results suggest that PDE3B, not PDE4, is a target of PKB and that activated PDE3B may regulate cAMP pools that modulate effects of PKB on thymidine incorporation and BAD phosphorylation in FDCP2 cells...
  5. pmc Differential regulation of adipocyte PDE3B in distinct membrane compartments by insulin and the beta3-adrenergic receptor agonist CL316243: effects of caveolin-1 knockdown on formation/maintenance of macromolecular signalling complexes
    Faiyaz Ahmad
    Translational Medicine Branch, NHLBI, NIH, Bethesda, MD 20892, USA
    Biochem J 424:399-410. 2009
    ..These results suggest that cav-1 acts as a molecular chaperone or scaffolding molecule in cholesterol-rich lipid rafts that may be necessary for the proper stabilization and activation of PDE3B in response to CL and insulin...
  6. pmc Insulin-induced formation of macromolecular complexes involved in activation of cyclic nucleotide phosphodiesterase 3B (PDE3B) and its interaction with PKB
    Faiyaz Ahmad
    Pulmonary Critical Care Medicine Branch, NHLBI National Heart, Lung and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bldg 10, Room 5N307, Bethesda, MD 20892, USA
    Biochem J 404:257-68. 2007
    ..Recruitment of PDE3B in macromolecular complexes may be critical for regulation of specific cAMP pools and signalling pathways by insulin, e.g. lipolysis...
  7. pmc A role for phosphodiesterase 3B in acquisition of brown fat characteristics by white adipose tissue in male mice
    Emilia Guirguis
    Pulmonary Cardiovascular Branch, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 154:3152-67. 2013
    ....
  8. pmc White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function
    Youn Wook Chung
    Cardiovascular and Pulmonary Branch CPB, National Heart, Lung, and Blood Institute NHLBI, National Institutes of Health NIH, Bethesda, Maryland, 20892, USA
    Sci Rep 7:40445. 2017
    ....
  9. pmc Female infertility in PDE3A(-/-) mice: polo-like kinase 1 (Plk1) may be a target of protein kinase A (PKA) and involved in meiotic arrest of oocytes from PDE3A(-/-) mice
    Weixing Shen
    Translational Medicine Branch TMB, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Cell Cycle 9:4720-34. 2010
    ..PKAc phosphorylated rPlk1 and Hela cell Plk1 and inhibited Plk1 activity in vitro. Our results suggest that PKA-induced inhibition of Plk1 may be critical in oocyte meiotic arrest and female infertility in PDE3A(-/-) mice...
  10. ncbi request reprint Effects of heterologous expression of human cyclic nucleotide phosphodiesterase 3A (hPDE3A) on redox regulation in yeast
    Dong Keun Rhee
    Laboratory of Biochemical Physiology, Cardiovascular and Pulmonary Branch, NHLBI NIH, Room 5N 307, Building 10, Bethesda, MD 20892 1434, USA
    Biochem J 473:4205-4225. 2016
    ..These results suggest that, during oxidative stress, TOR-Sch9 signaling might regulate PKA activity, and that post-translational modifications of hPDE3A are critical in its regulation of cellular recovery from oxidative stress...
  11. pmc Effects of the human immunodeficiency virus-protease inhibitor, ritonavir, on basal and catecholamine-stimulated lipolysis
    Diane C Adler-Wailes
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 90:3251-61. 2005
    ..We conclude that ritonavir decreases PDE3B and perilipin protein expression and affects both basal and catecholamine-stimulated lipolysis in 3T3-L1 adipocytes primarily through actions at sites downstream of PKA...
  12. pmc Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity
    Ermanno Puxeddu
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:6158-63. 2009
    ..Thus, PDE3A in these BIG1 and BIG2 AKAP complexes may contribute to the regulation of ARF function via limitation of cAMP effects with spatial and temporal specificity...
  13. pmc Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue
    Faiyaz Ahmad
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Sci Rep 6:28056. 2016
    ..Collectively, these data establish a role for PDE3B in modulating inflammatory response, which may contribute to a reduced inflammatory state in adipose tissue. ..
  14. ncbi request reprint Adenovirus-mediated overexpression of murine cyclic nucleotide phosphodiesterase 3B
    Faiyaz Ahmad
    Pulmonary Critical Care Medicine Branch, NHLBI, NIH, Bethesda, USA
    Methods Mol Biol 307:93-107. 2005
    ..Thus, adenovirus-mediated gene transfer is effective for studying expression and regulation of recombinant PDE3 in insulin-responsive cells as well as insulin-secreting cells...
  15. pmc Clinical and molecular genetics of the phosphodiesterases (PDEs)
    Monalisa F Azevedo
    Section on Endocrinology Genetics M F A, F R F, E B, A H, I L, R B d A, C A S, Program on Developmental Endocrinology Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, National Institutes of Health NIH, Bethesda, Maryland 20892 Section of Endocrinology M F A, University Hospital of Brasilia, Faculty of Medicine, University of Brasilia, Brasilia 70840 901, Brazil Group for Advanced Molecular Investigation F R F, R B d A, Graduate Program in Health Science, Medical School, Pontificia Universidade Catolica do Parana, Curitiba 80215 901, Brazil Cardiovascular Pulmonary Branch F A, V M, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892 and Pediatric Endocrinology Inter Institute Training Program C A S, NICHD, NIH, Bethesda, Maryland 20892
    Endocr Rev 35:195-233. 2014
    ....
  16. pmc Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases
    Sung Jun Park
    Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 148:421-33. 2012
    ..Therefore, administration of PDE4 inhibitors may also protect against and ameliorate the symptoms of metabolic diseases associated with aging...
  17. ncbi request reprint Multisite phosphorylation of adipocyte and hepatocyte phosphodiesterase 3B
    Rebecka Lindh
    Department of Experimental Medical Sciences, Division for Diabetes, Metabolism and Endocrinology, Lund University, Lund, Sweden
    Biochim Biophys Acta 1773:584-92. 2007
    ..Several of the sites were phosphorylated by insulin as well as cAMP-increasing hormones indicating integration of the two signalling pathways upstream of PDE3B, maybe at the level of protein kinase B...
  18. ncbi request reprint Plasma membrane cyclic nucleotide phosphodiesterase 3B (PDE3B) is associated with caveolae in primary adipocytes
    Rebecka Nilsson
    Department of Experimental Medical Science, Lund University, BMC C11, 221 84 Lund, Sweden
    Cell Signal 18:1713-21. 2006
    ..Thus, PDE3B, a key enzyme in insulin signalling, appears to be associated with caveolae in adipocytes and this localization seems to be functionally important...
  19. ncbi request reprint Tumor necrosis factor-alpha stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracellular cAMP
    Hui H Zhang
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Diabetes 51:2929-35. 2002
    ..Cotreatment with PD98059 restored PDE3B expression. These studies suggest that in human adipocytes, TNF-alpha stimulates lipolysis through activation of MEK-ERK and subsequent increase in intracellular cAMP...
  20. ncbi request reprint Isoforms of cyclic nucleotide phosphodiesterase PDE3 and their contribution to cAMP hydrolytic activity in subcellular fractions of human myocardium
    Ryan Hambleton
    Cardiology Section, Veterans Affairs Salt Lake City Health Care System, Salt Lake City, Utah 84148, USA
    J Biol Chem 280:39168-74. 2005
    ..cGMP may amplify cAMP-mediated signaling in intracellular compartments of human myocardium by PDE3-dependent and PDE3-independent mechanisms...