National Institutes of Health

Summary

Organization: National Institutes of Health
Country: USA

Top Publications

  1. pmc Finding the missing heritability of complex diseases
    Teri A Manolio
    National Human Genome Research Institute, Building 31, Room 4B09, 31 Center Drive, MSC 2152, Bethesda, Maryland 20892 2152, USA
    Nature 461:747-53. 2009
  2. pdf DAVID: Database for Annotation, Visualization, and Integrated Discovery
    Glynn Dennis
    Science Applications International Corporation Frederick, Clinical Services Program, Laboratory of Immunopathogenesis and Bioinformatics, National Cancer Institute at Frederick, MD 21702, USA
    Genome Biol 4:P3. 2003
  3. pmc Database resources of the National Center for Biotechnology Information
    Eric W Sayers
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA
    Nucleic Acids Res 38:D5-16. 2010
  4. pmc Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
    S F Altschul
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Nucleic Acids Res 25:3389-402. 1997
  5. pmc CDD: specific functional annotation with the Conserved Domain Database
    Aron Marchler-Bauer
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA
    Nucleic Acids Res 37:D205-10. 2009
  6. pmc BLAST+: architecture and applications
    Christiam Camacho
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA
    BMC Bioinformatics 10:421. 2009
  7. pmc CDD: a Conserved Domain Database for the functional annotation of proteins
    Aron Marchler-Bauer
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA
    Nucleic Acids Res 39:D225-9. 2011
  8. pmc NCBI Reference Sequences: current status, policy and new initiatives
    Kim D Pruitt
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Rm 4As 47B, 45 Center Drive, Bethesda, MD, USA
    Nucleic Acids Res 37:D32-6. 2009
  9. pmc NCBI GEO: archive for functional genomics data sets--10 years on
    Tanya Barrett
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 45 Center Drive, Bethesda, MD 20892, USA
    Nucleic Acids Res 39:D1005-10. 2011
  10. pmc CHARMM: the biomolecular simulation program
    B R Brooks
    Laboratory of Computational Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Comput Chem 30:1545-614. 2009

Detail Information

Publications124 found, 100 shown here

  1. pmc Finding the missing heritability of complex diseases
    Teri A Manolio
    National Human Genome Research Institute, Building 31, Room 4B09, 31 Center Drive, MSC 2152, Bethesda, Maryland 20892 2152, USA
    Nature 461:747-53. 2009
    ....
  2. pdf DAVID: Database for Annotation, Visualization, and Integrated Discovery
    Glynn Dennis
    Science Applications International Corporation Frederick, Clinical Services Program, Laboratory of Immunopathogenesis and Bioinformatics, National Cancer Institute at Frederick, MD 21702, USA
    Genome Biol 4:P3. 2003
    ..A more judicious approach is to provide query-based access to an integrated database that disseminates biologically rich information across large datasets and displays graphic summaries of functional information...
  3. pmc Database resources of the National Center for Biotechnology Information
    Eric W Sayers
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA
    Nucleic Acids Res 38:D5-16. 2010
    ..Augmenting many of the web applications are custom implementations of the BLAST program optimized to search specialized data sets. All these resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov...
  4. pmc Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
    S F Altschul
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Nucleic Acids Res 25:3389-402. 1997
    ..PSI-BLAST is used to uncover several new and interesting members of the BRCT superfamily...
  5. pmc CDD: specific functional annotation with the Conserved Domain Database
    Aron Marchler-Bauer
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA
    Nucleic Acids Res 37:D205-10. 2009
    ....
  6. pmc BLAST+: architecture and applications
    Christiam Camacho
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA
    BMC Bioinformatics 10:421. 2009
    ..There are also some shortcomings in the user-interface of the current command-line applications...
  7. pmc CDD: a Conserved Domain Database for the functional annotation of proteins
    Aron Marchler-Bauer
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA
    Nucleic Acids Res 39:D225-9. 2011
    ..CDD can be accessed via http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml...
  8. pmc NCBI Reference Sequences: current status, policy and new initiatives
    Kim D Pruitt
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Rm 4As 47B, 45 Center Drive, Bethesda, MD, USA
    Nucleic Acids Res 37:D32-6. 2009
    ..In addition, we introduce RefSeqGene, a new initiative to support reporting variation data on a stable genomic coordinate system...
  9. pmc NCBI GEO: archive for functional genomics data sets--10 years on
    Tanya Barrett
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 45 Center Drive, Bethesda, MD 20892, USA
    Nucleic Acids Res 39:D1005-10. 2011
    ..This paper describes recent database enhancements, including new search and data representation tools, as well as a brief review of how the community uses GEO data. GEO is freely accessible at http://www.ncbi.nlm.nih.gov/geo/...
  10. pmc CHARMM: the biomolecular simulation program
    B R Brooks
    Laboratory of Computational Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Comput Chem 30:1545-614. 2009
    ..This article provides an overview of the program as it exists today with an emphasis on developments since the publication of the original CHARMM article in 1983...
  11. ncbi Modulation of oscillatory neuronal synchronization by selective visual attention
    P Fries
    Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Building 49, Room 1B80, 9000 Rockville Pike, Bethesda, MD 20892 4415, USA
    Science 291:1560-3. 2001
    ..Because postsynaptic integration times are short, these localized changes in synchronization may serve to amplify behaviorally relevant signals in the cortex...
  12. pmc Database resources of the National Center for Biotechnology Information
    Eric W Sayers
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA
    Nucleic Acids Res 39:D38-51. 2011
    ..Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of these resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov...
  13. pmc PID: the Pathway Interaction Database
    Carl F Schaefer
    National Cancer Institute, Center for Biomedical Informatics and Information Technology, Rockville MD, USA
    Nucleic Acids Res 37:D674-9. 2009
    ..The database is updated with new pathway content every month and supplemented by specially commissioned articles on the practical uses of other relevant online tools...
  14. ncbi Physical activity in the United States measured by accelerometer
    Richard P Troiano
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Med Sci Sports Exerc 40:181-8. 2008
    ..To describe physical activity levels of children (6-11 yr), adolescents (12-19 yr), and adults (20+ yr), using objective data obtained with accelerometers from a representative sample of the U.S. population...
  15. ncbi Prediction of coronary heart disease using risk factor categories
    P W Wilson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
    Circulation 97:1837-47. 1998
    ....
  16. pmc NCBI GEO: archive for high-throughput functional genomic data
    Tanya Barrett
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 45 Center Drive, Bethesda, MD 20892, USA
    Nucleic Acids Res 37:D885-90. 2009
    ..This article summarizes the GEO repository structure, content and operating procedures, as well as recently introduced data mining features. GEO is freely accessible at http://www.ncbi.nlm.nih.gov/geo/...
  17. ncbi Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
    Michelle L Block
    Neuropharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Nat Rev Neurosci 8:57-69. 2007
    ....
  18. pmc Analysis of gene expression data using BRB-ArrayTools
    Richard Simon
    Biometric Research Branch, National Cancer Institute, Bethesda, MD 20892 7434, USA
    Cancer Inform 3:11-7. 2007
    ....
  19. pmc Nitric oxide and peroxynitrite in health and disease
    Pal Pacher
    Section on Oxidative Stress Tissue Injury, Laboratory of Physiologic Studies, National Institutes of Health, National Institute of Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
    Physiol Rev 87:315-424. 2007
    ..Hence, novel pharmacological strategies aimed at removing peroxynitrite might represent powerful therapeutic tools in the future. Evidence supporting these novel roles of NO and peroxynitrite is presented in detail in this review...
  20. pmc Pathways towards and away from Alzheimer's disease
    Mark P Mattson
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Nature 430:631-9. 2004
    ..But rapid progress towards understanding the cellular and molecular alterations that are responsible for the neuron's demise may soon help in developing effective preventative and therapeutic strategies...
  21. ncbi Natural products as sources of new drugs over the last 25 years
    David J Newman
    Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute Frederick, P O Box B, Frederick, MD 21702, USA
    J Nat Prod 70:461-77. 2007
    ....
  22. pmc Differentiation of effector CD4 T cell populations (*)
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1892, USA
    Annu Rev Immunol 28:445-89. 2010
    ....
  23. ncbi Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    David E Kleiner
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Hepatology 41:1313-21. 2005
    ..NAS of > or =5 correlated with a diagnosis of NASH, and biopsies with scores of less than 3 were diagnosed as "not NASH."..
  24. pmc dbSNP: the NCBI database of genetic variation
    S T Sherry
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, 20894, USA
    Nucleic Acids Res 29:308-11. 2001
    ..The complete contents of dbSNP are available to the public at website: http://www.ncbi.nlm.nih.gov/SNP. The complete contents of dbSNP can also be downloaded in multiple formats via anonymous FTP at ftp://ncbi.nlm.nih.gov/snp/...
  25. pmc Community-associated meticillin-resistant Staphylococcus aureus
    Frank R Deleo
    Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Lancet 375:1557-68. 2010
    ..Here we review the most up-to-date knowledge and provide a perspective for the future prophylaxis or new treatments for CA-MRSA infections...
  26. ncbi Immunology of hepatitis B virus and hepatitis C virus infection
    Barbara Rehermann
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 9B16, 10 Center Drive, Bethesda, MD 20892, USA
    Nat Rev Immunol 5:215-29. 2005
    ..This review assesses recent advances in our understanding of viral hepatitis, contrasts mechanisms of virus-host interaction in acute hepatitis B and hepatitis C, and outlines areas for future studies...
  27. pmc Body-mass index and mortality among 1.46 million white adults
    Amy Berrington de Gonzalez
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    N Engl J Med 363:2211-9. 2010
    ....
  28. pmc Two types of dopamine neuron distinctly convey positive and negative motivational signals
    Masayuki Matsumoto
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    Nature 459:837-41. 2009
    ..A similar anatomical difference was observed for their responses to actual airpuffs. These findings suggest that different groups of dopamine neurons convey motivational signals in distinct manners...
  29. ncbi Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain
    Susan M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, Maryland 21224 6825, USA
    J Neurosci 23:3295-301. 2003
    ....
  30. ncbi Human papillomavirus and cervical cancer
    Mark Schiffman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Lancet 370:890-907. 2007
    ..If applied wisely, HPV-related technology can minimise the incidence of cervical cancer, and the morbidity and mortality it causes, even in low-resource settings...
  31. pmc Entrez Gene: gene-centered information at NCBI
    Donna Maglott
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20852, USA
    Nucleic Acids Res 39:D52-7. 2011
    ....
  32. ncbi alpha-Synuclein locus triplication causes Parkinson's disease
    A B Singleton
    Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA
    Science 302:841. 2003
  33. ncbi Oxidants, oxidative stress and the biology of ageing
    T Finkel
    Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute National Institutes of Health, Bethesda, Maryland 20892 1622, USA
    Nature 408:239-47. 2000
    ..Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span...
  34. pmc Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease
    E Sidransky
    Section on Molecular Neurogenetics, Medical Genetics Branch, NHGRI, National Institutes of Health, Bethesda, MD 20892 3708, USA
    N Engl J Med 361:1651-61. 2009
    ..We aimed to ascertain the frequency of GBA mutations in an ethnically diverse group of patients with Parkinson's disease...
  35. pmc Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates
    Brenda K Edwards
    Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland 20892 8315, USA
    Cancer 116:544-73. 2010
    ....
  36. pmc Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling
    P Schuck
    Molecular Interactions Resource, Bioengineering and Physical Science Program, ORS, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biophys J 78:1606-19. 2000
    ....
  37. pmc Search for a 'Tree of Life' in the thicket of the phylogenetic forest
    Pere Puigbò
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    J Biol 8:59. 2009
    ..However, the possibility remains that a statistical central trend still exists in the phylogenetic 'forest of life'...
  38. doi HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells
    James Arthos
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 9:301-9. 2008
    ..On CD4+ T cells, engagement of alpha4beta7 by gp120 resulted in rapid activation of LFA-1, the central integrin involved in the establishment of virological synapses, which facilitate efficient cell-to-cell spreading of HIV-1...
  39. pmc Membrane budding and scission by the ESCRT machinery: it's all in the neck
    James H Hurley
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0580, USA
    Nat Rev Mol Cell Biol 11:556-66. 2010
    ..Recent studies of ultrastructures induced by ESCRT-III overexpression in cells and the in vitro reconstitution of the budding and scission reactions have led to breakthroughs in understanding these remarkable membrane reactions...
  40. pmc A genome-wide association study of hypertension and blood pressure in African Americans
    Adebowale Adeyemo
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD, USA
    PLoS Genet 5:e1000564. 2009
    ....
  41. ncbi The BCL-2 protein family: opposing activities that mediate cell death
    Richard J Youle
    Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Mol Cell Biol 9:47-59. 2008
    ..Although these insights into interactions among BCL-2 family proteins reveal how these proteins are regulated, a unifying hypothesis for the mechanisms they use to activate caspases remains elusive...
  42. doi Transcription dynamics
    Gordon L Hager
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 35:741-53. 2009
    ..Its dynamic nature is not only a fundamental property of the transcription machinery, but it is emerging as an important modulator of physiological processes, particularly in differentiation and development...
  43. pmc Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium
    Santhi K Ganesh
    National Human Genome Research Institute, Division of Intramural Research, Bethesda, MD, USA
    Nat Genet 41:1191-8. 2009
    ..This study has identified new determinants of erythrocyte traits, offering insight into common variants underlying variation in erythrocyte measures...
  44. pmc Archiving next generation sequencing data
    Martin Shumway
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Nucleic Acids Res 38:D870-1. 2010
    ..ebi.ac.uk/ena from EBI and at http://www.ddbj.nig.ac.jp/sub/trace_sra-e.html from DDBJ. Users of these resources can obtain data sets deposited in any of the three SRA instances. Links and submission instructions are provided...
  45. pmc Non-Smad pathways in TGF-beta signaling
    Ying E Zhang
    Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Res 19:128-39. 2009
    ..This review focuses on recent advances in the understanding of the molecular and biochemical mechanisms of non-Smad pathways. In addition, functions of these non-Smad pathways are also discussed...
  46. doi T-cell quality in memory and protection: implications for vaccine design
    Robert A Seder
    Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 8:247-58. 2008
    ....
  47. pmc Size-distribution analysis of proteins by analytical ultracentrifugation: strategies and application to model systems
    Peter Schuck
    Division of Bioengineering and Physical Science, Office of Research Services, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Biophys J 82:1096-111. 2002
    ..Although c(s) is computationally the most complex, it has the potential for the highest resolution and sensitivity of the methods described...
  48. ncbi Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation
    Michael R Betts
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, MD 20892, USA
    J Immunol Methods 281:65-78. 2003
    ....
  49. ncbi Early life genetic, epigenetic and environmental factors shaping emotionality in rodents
    Andrew Holmes
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health, Bethesda, MD 20892 1256, Rockville, MD 20852, USA
    Neurosci Biobehav Rev 29:1335-46. 2005
    ....
  50. pmc Epidemiology and risk factors for kidney cancer
    Wong Ho Chow
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 7240, USA
    Nat Rev Urol 7:245-57. 2010
    ..Large consortium efforts employing genome-wide scanning technology are underway, which hold promise for novel discoveries in renal carcinogenesis...
  51. pmc Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells
    JOHN J O'SHEA
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1616, USA
    Science 327:1098-102. 2010
    ..Herein, we review recent advances that pertain to this topic and the mechanisms that contribute to helper CD4+ T cell commitment and plasticity. The therapeutic implications of these new findings are also considered...
  52. pmc Multiple roles of HDAC inhibition in neurodegenerative conditions
    De Maw Chuang
    Molecular Neurobiology Section, National Institute of Mental Health, National Institutes of Health, 10 Center Drive MSC 1363, Bethesda, MD 20892 1363, USA
    Trends Neurosci 32:591-601. 2009
    ..We discuss the targets and mechanisms underlying these effects of HDAC inhibition and comment on the potential for some HDAC inhibitors to prove clinically effective in the treatment of neurodegenerative disorders...
  53. pmc Outcomes for children and adolescents with cancer: challenges for the twenty-first century
    Malcolm A Smith
    Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD 20892, USA
    J Clin Oncol 28:2625-34. 2010
    ..This report provides an overview of current childhood cancer statistics to facilitate analysis of the impact of past research discoveries on outcome and provide essential information for prioritizing future research directions...
  54. pmc From complete genome sequence to 'complete' understanding?
    Michael Y Galperin
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Trends Biotechnol 28:398-406. 2010
    ..We also discuss problems in understanding the functions of the remaining 'conserved hypothetical' genes...
  55. pmc A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray
    Peter D Crompton
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
    Proc Natl Acad Sci U S A 107:6958-63. 2010
    ....
  56. pmc Performance of common genetic variants in breast-cancer risk models
    Sholom Wacholder
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 5050, MSC 7244, Bethesda, MD 20892, USA
    N Engl J Med 362:986-93. 2010
    ..Genomewide association studies have identified multiple genetic variants associated with breast cancer. The extent to which these variants add to existing risk-assessment models is unknown...
  57. pmc NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins
    Kim D Pruitt
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Rm 6An 12J, 45 Center Drive, Bethesda, MD 20892 6510, USA
    Nucleic Acids Res 35:D61-5. 2007
    ..The format of all RefSeq records is validated, and an increasing number of tests are being applied to evaluate the quality of sequence and annotation, especially in the context of complete genomic sequence...
  58. pmc The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1
    Claudia Cicala
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:20877-82. 2009
    ..The specific affinity of gp120 for alpha(4)beta(7) provides a mechanism for HIV-1 to target activated cells that are critical for efficient virus propagation and dissemination following sexual transmission...
  59. doi Genetic and antigenic features of the transmitted virus
    Brandon F Keele
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Curr Opin HIV AIDS 4:352-7. 2009
    ..The findings suggest that a better understanding of the restricted viral diversity that follows mucosal transmission could lead to novel strategies for vaccine, microbicide or other therapeutic interventions...
  60. ncbi Prospects for a dengue virus vaccine
    Stephen S Whitehead
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Microbiol 5:518-28. 2007
    ..In this Review we discuss the unique immunological concerns in dengue virus vaccine development and the current prospects for the development of an acceptable vaccine, a goal that is likely to be reached in the near future...
  61. ncbi Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review
    Aimee R Kreimer
    International Agency for Research on Cancer, Lyon, France
    Cancer Epidemiol Biomarkers Prev 14:467-75. 2005
    ..Small sample size and publication bias complicate the assessment of the prevalence of HPV in head and neck sites beyond the oropharynx...
  62. pmc Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression
    Wayne C Drevets
    Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health NIH NIMH DIRP, 15K North Dr, Room 210, Bethesda, MD 20892, USA
    Brain Struct Funct 213:93-118. 2008
    ..This paper discusses these systems together with the neurochemical systems that impinge on them and form the basis for most pharmacological therapies...
  63. doi Lecture notes: 2010 and beyond, the decade of high-performance computing for the next-generation sequence analysis
    Mary Qu Yang
    Department of Health and Human Services, Oak Ridge, DOE, United States National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20852, USA
    Int J Comput Biol Drug Des 2:204-6. 2009
    ..We focus mainly on the development of high-performance genetic algorithms based on multi-core technology as an example and open to fast-moving competing platforms to be emerged...
  64. pmc Developments in clinical cell therapy
    David Stroncek
    National Institutes of Health, Bethesda, Maryland, USA
    Cytotherapy 12:425-8. 2010
    ..NHLBI) and Production Assistance for Cellular Therapies (PACT), held on 23-24 April 2009 at the National Institutes of Health (NIH, USA)...
  65. ncbi Osmiophilic bodies and the odd organelles of alveolates
    Karen Hayton
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8132, USA
    Mol Microbiol 67:236-40. 2008
    ..These findings suggest that targeting PFG377 may be a strategy to block parasite transmission...
  66. pmc The 1918 influenza pandemic: lessons for 2009 and the future
    David M Morens
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Crit Care Med 38:e10-20. 2010
    ..Thus, we must remain vigilant and use the knowledge we have gained from 1918 and other influenza pandemics to direct targeted research and pandemic influenza preparedness planning, emphasizing prevention, containment, and treatment...
  67. ncbi Anti-mesothelin immunotoxin SS1P in combination with gemcitabine results in increased activity against mesothelin-expressing tumor xenografts
    Raffit Hassan
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, and the Clinical Center, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 13:7166-71. 2007
    ..To determine the antitumor activity of the anti-mesothelin immunotoxin SS1P in combination with gemcitabine against mesothelin-expressing tumor xenografts...
  68. pmc Gating of nicotinic ACh receptors: latest insights into ligand binding and function
    Jerrel L Yakel
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, Department of Health and Human Services, PO Box 12233, Research Triangle Park, NC 27709, USA
    J Physiol 588:597-602. 2010
    ....
  69. pmc HIV-1 induced activation of CD4+ T cells creates new targets for HIV-1 infection in human lymphoid tissue ex vivo
    Angelique Biancotto
    Laboratory of Molecular and Cellular Biophysics, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Blood 111:699-704. 2008
    ..In vivo, such self-perpetuating cycle could contribute to HIV-1 disease...
  70. pmc Response to iron deprivation in Saccharomyces cerevisiae
    Caroline C Philpott
    Liver Diseases Branch, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 9B 16, 10 Center Drive, MSC 1800, Bethesda, MD 20892 1800, USA
    Eukaryot Cell 7:20-7. 2008
  71. pmc Trunk and hip muscle activation patterns are different during walking in young children with and without cerebral palsy
    Laura A Prosser
    Rehabilitation Medicine Department, National Institutes of Health Clinical Center, Bldg 10 CRC, 1 1469 10 Center Dr, Bethesda, MD 20892, USA
    Phys Ther 90:986-97. 2010
    ..Poor control of postural muscles is a primary impairment in people with cerebral palsy (CP)...
  72. pmc Gallstones and the risk of biliary tract cancer: a population-based study in China
    A W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852 7234, USA
    Br J Cancer 97:1577-82. 2007
    ..9 vs 2.8 grams; P=0.001). We estimate that in Shanghai 80% (95% CI 75-84%), 59% (56-61%), and 41% (29-59%) of gallbladder, bile duct, and ampulla of Vater cancers, respectively, could be attributed to gallstones...
  73. pmc Tocilizumab in systemic lupus erythematosus: data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study
    Gabor G Illei
    National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, USA
    Arthritis Rheum 62:542-52. 2010
    ..To assess the safety of interleukin-6 receptor inhibition and to collect preliminary data on the clinical and immunologic efficacy of tocilizumab in patients with systemic lupus erythematosus (SLE)...
  74. pmc Phase I/II, open-label trial of safety and immunogenicity of meningococcal (groups A, C, Y, and W-135) polysaccharide diphtheria toxoid conjugate vaccine in human immunodeficiency virus-infected adolescents
    George K Siberry
    Pediatric, Adolescent, and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892 7510, USA
    Pediatr Infect Dis J 29:391-6. 2010
    ..Quadrivalent meningococcal polysaccharide conjugate vaccine (MCV4) is routinely recommended for healthy youth in the United States, but there are no data about its use in HIV-infected people...
  75. pmc Reversibility of object recognition but not spatial memory impairment following binge-like alcohol exposure in rats
    Andrea Cippitelli
    Laboratory of Clinical and Translational Studies LCTS, National Institute of Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH Bethesda, MD 20892, USA
    Neurobiol Learn Mem 94:538-46. 2010
    ....
  76. pmc Refinements in the cryopreservation of mouse ovaries
    Jorge Sztein
    Veterinary Research and Resources Section, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Am Assoc Lab Anim Sci 49:420-2. 2010
    ..This advantage is especially important in situations where the only males available in the line are infertile, aged, or problematic breeders...
  77. pmc Correlation of echocardiographic findings with cerebral infarction in elderly adults: the AGES-Reykjavik study
    Dorothea McAreavey
    NIH Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Stroke 41:2223-8. 2010
    ..In this cross-sectional analysis of elderly subjects, we investigated the relationship of a comprehensive set of echocardiographic measures with cerebral infarction detected by MRI...
  78. pmc Linear analysis near a steady-state of biochemical networks: control analysis, correlation metrics and circuit theory
    William J Heuett
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Syst Biol 2:44. 2008
    ..Here, we present a comprehensive theory of linear analysis for nonequilibrium steady-state (NESS) biochemical reaction networks that unites these disparate approaches in a common mathematical framework and thermodynamic basis...
  79. doi Radiation doses and cancer risks in the Marshall Islands associated with exposure to radioactive fallout from Bikini and Enewetak nuclear weapons tests: summary
    Steven L Simon
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Health Phys 99:105-23. 2010
    ..The 170 excess cancers are in comparison to about 10,600 cancers that would spontaneously arise, unrelated to radioactive fallout, among the same cohort of Marshallese people...
  80. pmc Release of genotype 1 hepatitis E virus from cultured hepatoma and polarized intestinal cells depends on open reading frame 3 protein and requires an intact PXXP motif
    Suzanne U Emerson
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, MSC 8009, Bethesda, MD 20892, USA
    J Virol 84:9059-69. 2010
    ..ORF3 protein and lipids were intimately associated with virus particles produced in either cell line; ORF2 epitopes were masked in these particles and could not be immunoprecipitated with anti-ORF2...
  81. pmc Validity of the reduced-sample insulin modified frequently-sampled intravenous glucose tolerance test using the nonlinear regression approach
    Anne E Sumner
    Clinical Endocrinology Branch, NIDDK, NIH, Bethesda, MD 20892 1612, USA
    Metabolism 58:220-5. 2009
    ..The agreement and maintenance of rank order of S(I) between protocols support the use of the nonlinear regression approach to the minimal model and the Reduced-Sample-IM-FSIGT in clinical studies...
  82. doi Vaccines to prevent infections by oncoviruses
    John T Schiller
    Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Annu Rev Microbiol 64:23-41. 2010
    ..Efforts to develop KSHV vaccines have been more limited...
  83. pmc Hematopoietic stem cell transplantation for leukemia
    Alan S Wayne
    Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room 1 3750, 9000 Rockville Pike, MSC 1104, Bethesda, MD 20892 1104, USA
    Pediatr Clin North Am 57:1-25. 2010
    ..The characteristics of these high-risk subgroups and the role of HSCT in childhood leukemias are discussed...
  84. pmc Pharmacologic modulation of niche accessibility via tyrosine kinase inhibition enhances marrow and thymic engraftment after hematopoietic stem cell transplantation
    Natasha M Fewkes
    Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 115:4120-9. 2010
    ..We conclude that transient, pharmacologic inhibition of KIT enhances accessibility of marrow and thymic niches, and provides a novel, noncytotoxic approach to accomplish engraftment after stem cell transplantation...
  85. ncbi Disentangling causal paths between obesity and in vitro fertilization outcomes: an intractable problem?
    Penelope P Howards
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Fertil Steril 89:1604-5. 2008
    ..Disentangling causal paths between obesity and in vitro fertilization outcomes may be an intractable problem, but other research questions of clinical importance can be addressed through appropriate study designs and analytic methods...
  86. ncbi Testing logistic regression coefficients with clustered data and few positive outcomes
    Sally Hunsberger
    Biometric Research Branch, National Cancer Institute, Bethesda, MD 20892, U S A
    Stat Med 27:1305-24. 2008
    ..The proposed method is also useful when testing goodness-of-fit of logistic regression models using deciles-of-risk tables...
  87. pmc Structural insights into the function of P2X4: an ATP-gated cation channel of neuroendocrine cells
    Stanko S Stojilkovic
    Section on Cellular Signaling, Program in Developmental Neuroscience, NICHD, National Institutes of Health, Bldg 49, Room 6A 36, 49 Convent Drive, Bethesda, MD 20892 4510, USA
    Cell Mol Neurobiol 30:1251-8. 2010
    ..In this brief article, we summarize this study and re-interpret it using a model based on crystallization of the zebrafish P2X4.1 receptor...
  88. ncbi Targeted immunotherapy for staphylococcal infections : focus on anti-MSCRAMM antibodies
    Michael Otto
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Hamilton, Montana 59840, USA
    BioDrugs 22:27-36. 2008
    ..In addition, polysaccharide and other nonprotein antigens may represent suitable vaccine targets on the staphylococcal cell surface...
  89. pmc The effect of a low-glycemic diet vs a standard diet on blood glucose levels and macronutrient intake in children with type 1 diabetes
    Alisha J Rovner
    Division of Epidemiology, Statistics and Prevention Research, NICHD, NIH, DHHS, Bethesda, MD 20892 7510, USA
    J Am Diet Assoc 109:303-7. 2009
    ..7+/-12.2 g vs 76.8+/-32.4 g, P<0.005); however, there were no differences in energy, carbohydrate, or protein intake. In this pilot study, a low-GI diet was associated with improved diet quality and a reduction in hyperglycemia...
  90. pmc A novel missense mutation (G43S) in the switch I region of Rab27A causing Griscelli syndrome
    Wendy Westbroek
    Section on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Mol Genet Metab 94:248-54. 2008
    ..Co-immunoprecipitation studies showed that Rab27A(G43S) fails to interact with its effector Melanophilin, indicating that the switch I region functions in the recruitment of Rab effector proteins...
  91. pmc Computational modeling of cancer cachexia
    Kevin D Hall
    Laboratory of Biological Modeling, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 5621, USA
    Curr Opin Clin Nutr Metab Care 11:214-21. 2008
    ..Thus, models of cancer-associated weight loss are an important tool for helping to understand this debilitating condition...
  92. pmc Respiratory cancer and inhaled inorganic arsenic in copper smelters workers: a linear relationship with cumulative exposure that increases with concentration
    Jay H Lubin
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Environ Health Perspect 116:1661-5. 2008
    ....
  93. pmc Preventing NAD(+) depletion protects neurons against excitotoxicity: bioenergetic effects of mild mitochondrial uncoupling and caloric restriction
    Dong Liu
    Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, USA
    Ann N Y Acad Sci 1147:275-82. 2008
    ..Our findings suggest that mild mitochondrial uncoupling and caloric restriction exert hormetic effects by stimulating bioenergetics in neurons thereby increasing tolerance of neurons to metabolic stress...
  94. pmc Iodine-125 radioprobing of intramolecular quadruplex conformation of human telomeric DNA in the presence of cationic porphyrin TMPyP4
    Timur I Gaynutdinov
    Department of Nuclear Medicine, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    Int J Radiat Biol 84:984-90. 2008
    ..We applied (125)I -radioprobing to assess the conformation of the human telomeric DNA fragment in a complex with the quadruplex-specific drug - cationic porphyrin TMPyP4...
  95. pmc Deletion of nonstructural proteins NS1 and NS2 from pneumonia virus of mice attenuates viral replication and reduces pulmonary cytokine expression and disease
    Ursula J Buchholz
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Virol 83:1969-80. 2009
    ..In contrast, in the absence of NS2, there was an early, transient innate response involving moderate levels of IFN, IL-6, and CXCL10 that restricted virus replication and prevented disease...
  96. doi Importance of patient-centered care in enhancing patient well-being: a cancer survivor's perspective
    Neeraj K Arora
    Outcomes Research Branch, Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, 6130 Executive Blvd, Bethesda, MD 20892 7344, USA
    Qual Life Res 18:1-4. 2009
    ..The important role played by patient-centered care in reducing patient suffering and enhancing well-being is underscored in this commentary...
  97. pmc Transporter-mediated GABA responses in horizontal and bipolar cells of zebrafish retina
    Ralph Nelson
    Basic Neurosciences Program, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Rockville, Maryland 20892 9406, USA
    Vis Neurosci 25:155-65. 2008
    ..The ATPase activity generates AHP. In addition to a GABA clearance function, these large-amplitude transporter responses may provide an outer plexiform layer GABA sensor mechanism...
  98. pmc A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction
    Adam J Kimple
    NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 3370, USA
    Comb Chem High Throughput Screen 11:396-409. 2008
    ..84 and 0.66 for the green- and red-label assays, respectively...
  99. pmc White matter in learning, cognition and psychiatric disorders
    R Douglas Fields
    Nervous System Development and Plasticity Section, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Neurosci 31:361-70. 2008
    ..Cell-culture studies have identified molecular mechanisms regulating myelination by electrical activity, and myelin also limits the critical period for learning through inhibitory proteins that suppress axon sprouting and synaptogenesis...
  100. pmc Breathing variability at rest is positively associated with 24-h blood pressure level
    David E Anderson
    Clinical Research Branch, National Institute on Aging, Intramural Research Program, NIH, Bethesda, MD, USA
    Am J Hypertens 21:1324-9. 2008
    ..The present study hypothesized that the variability of breathing and end-tidal CO(2) (PetCO(2)) in seated women at rest is positively associated with their 24-h blood pressure level...
  101. pmc To pool or not to pool, from whether to when: applications of pooling to biospecimens subject to a limit of detection
    Enrique F Schisterman
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA
    Paediatr Perinat Epidemiol 22:486-96. 2008
    ..e. DT). Several Monte Carlo simulations and an example based on actual biomarker data illustrate the results of the article...

Research Grants74

  1. A Prospective Cohort Study of Migraines, Platelet Activation, and Preeclampsia
    Michelle Williams; Fiscal Year: 2009
    ....
  2. A Prospective Cohort Study of Migraines, Platelet Activation, and Preeclampsia
    Michelle A Williams; Fiscal Year: 2010
    ....
  3. MECHANISM AND CONSEQUENCES OF HLA-B 27 MISFOLDING
    Robert Colbert; Fiscal Year: 2004
    ..They will provide insights into the mechanisms responsible for these differences, how they may relate to the pathogenesis of SpAs, and how they may be corrected. ..
  4. HLA-B27 Misfolding an the UPR in Spondyloarthritis
    Robert Colbert; Fiscal Year: 2006
    ..This work has the potential to drive translational studies in humans, and lead to the development of novel therapies targeting this pathological response. ..
  5. MicroRNA uridylation by Zcchc11 regulates pulmonary inflammation
    MATTHEW ROBERT JONES; Fiscal Year: 2010
    ..These results of these studies may help in the rational design of pharmacologic therapeutics that target novel mechanisms involved in regulating the immune response during infection. ..
  6. HLA-B27 Misfolding in Spondyloarthropathy Pathogenesis
    Robert Colbert; Fiscal Year: 2005
    ....
  7. HLA-B27 Misfolding an the UPR in Spondyloarthritis
    Robert Colbert; Fiscal Year: 2007
    ..This work has the potential to drive translational studies in humans, and lead to the development of novel therapies targeting this pathological response. ..
  8. Treatment of recently acquired hepatitis C virus infection
    GREGORY JOHN DORE; Fiscal Year: 2010
    ..Determining the most effective treatment strategies to enhance outcomes in this population is now required to address this important public health burden. ..
  9. Role of Regulatory T cells in Leishmania major infection
    Yasmine Belkaid; Fiscal Year: 2004
    ..major; and (2) Determine the mechanisms underlying Treg-mediated modulation of immune responses to L. major both in vitro and in vivo. ..
  10. MECHANISM AND CONSEQUENCES OF HLA-B 27 MISFOLDING
    Robert Colbert; Fiscal Year: 2000
    ..They will provide insights into the mechanisms responsible for these differences, how they may relate to the pathogenesis of SpAs, and how they may be corrected. ..
  11. HLA-B27 Misfolding in Spondyloarthropathy Pathogenesis
    Robert Colbert; Fiscal Year: 2001
    ....
  12. Computerized Dosing of Teen Nicotine Gum Use
    William Riley; Fiscal Year: 2002
    ..Various program use variables also will be assessed to guide Phase II modifications...
  13. Omega-3 polyunsaturated fatty acid supplementation and allergic diseases in child
    Isabelle Romieu; Fiscal Year: 2010
    ....
  14. Mother-Daughter Communication about Breast Cancer Risk
    Cynthia Grossman; Fiscal Year: 2004
    ..The role of daughters' age (adolescent versus young adult) will also be examined as a further potential moderator of the association between mother and daughter beliefs, knowledge and behaviors. ..
  15. Computerized SGR for Smoking Reduction
    William Riley; Fiscal Year: 2002
    ..Additionally, measures of smoking typography will be obtained to measure directly the degree of compensatory smoking resulting from reduced smoking. PROPOSED COMMERCIAL APPLICATION: Not Available ..
  16. COMPUTERIZED SCHEDULING OF NICOTINE NASAL SPRAY
    William Riley; Fiscal Year: 2003
    ..proposed commercial application: not available ..
  17. College Smoking Cessation via Wireless Devices
    William Riley; Fiscal Year: 2002
    ..abstract_text> ..
  18. Triggers of Abruptio Placentae - A Case Crossover Study of an Ischemic Placental
    MICHELLE A contact WILLIAMS; Fiscal Year: 2010
    ....
  19. Wireless SMS Delivery of Smoking Cessation Interventions
    William Riley; Fiscal Year: 2004
    ..S., nearly all with text messaging capabilities, this program has the potential to impact a large number of current smokers and provide a low cost, easily disseminated behavioral smoking cessation intervention. ..
  20. A Cohort Study of Preterm Delivery in Relation to Partner Abuse, Mood and Anxiety
    Michelle A Williams; Fiscal Year: 2010
    ..S. Congress'passing of the Prematurity Research Expansion and Education for Mothers who Deliver Infants Early (PREEMIE) Act (P.L. 109-450)234. ..
  21. Omega-3 polyunsaturated fatty acid supplementation and allergic diseases in child
    Isabelle Romieu; Fiscal Year: 2009
    ....
  22. Impact of Mortality Concerns on Cancer Risk Behavior
    Jamie Arndt; Fiscal Year: 2010
    ....
  23. SIV, IDO, and the Host Response in neuroAIDS
    Larisa Poluektova; Fiscal Year: 2010
    ....
  24. Impact of Mortality Concerns on Cancer Risk Behavior
    Jamie Arndt; Fiscal Year: 2009
    ....
  25. CRCNS: Role of sensory feedback in locomotor recovery after spinal cord injury
    Michel A Lemay; Fiscal Year: 2010
    ..We also expect the models developed in the project to be used in classes taught by Drs. Lemay and Prilutsky on the neural control and biomechanics of locomotion at their respective institutions. ..
  26. From Adhesion to Bone Resorption: The role of Dynamin in Osteoclasts
    ROLAND E BARON; Fiscal Year: 2010
    ..This project proposes to explore a novel concept, based on strong (and partially published) preliminary data, which we believe will help further understand the mechanisms that regulate bone resorption. ..
  27. Pragmatic Skills of Young Males and Females with Fragile X Syndrome
    GARY EVERETT MARTIN; Fiscal Year: 2010
    ....
  28. Role of Zfp521 in bone formation and anabolic responses
    ROLAND E BARON; Fiscal Year: 2010
    ..Functional characterization of this new regulator of bone formation may allow the discovery of novel pathways for anabolic drug discovery in osteoporosis and other low bone mass syndromes. ..
  29. CT Assessment of Lung Fissures: Anatomy and Correlated Function
    Jiantao Pu; Fiscal Year: 2010
    ....
  30. An Automated Multi-target Diagnostic System for Gastrointestinal Pathogens
    Margarita B Rogatcheva; Fiscal Year: 2010
    ..This novel tool will overcome diagnostic difficulties, improve the treatment and reduce the cost of diarrheal illness for individual patients, and improve public health by rapid detection of outbreaks. ..
  31. A Pan-Dengue Virus Immunotherapeutic for Prevention and Treatment
    LESLIE S JOHNSON; Fiscal Year: 2010
    ..Required studies will be performed under GLP conditions. This project aims to advance a collection of DV-neutralizing MAbs into a concise well-defined immunotherapeutic validated for initiation of clinical studies. ..
  32. Computerized Monitoring Tool for MR-Guided Cryoablation
    Kemal Tuncali; Fiscal Year: 2010
    ..Once proven, it can have a positive impact to public health since this cyber-tool can be adapted and used during all other type of image-guided ablations of tumors. ..
  33. Role of TGIF in Wnt-Induced Bone Formation
    Azeddine Atfi; Fiscal Year: 2010
    ....
  34. Mechanism of 4-1BBL-mediated sustained inflammation: target of anti-inflammation
    Young Jun Kang; Fiscal Year: 2010
    ..The information obtained from this study will help to develop new strategies to treat inflammatory diseases. ..
  35. Pragmatic Skills of Young Males and Females with Fragile X Syndrome
    Gary E Martin; Fiscal Year: 2010
    ....
  36. Targeting MDR hetero-resistant Gram-negatives: PK/PD for rational combinations
    Roger Nation; Fiscal Year: 2009
    ....
  37. Biochemical Markers of Traumatic Brain Injury
    STEVEN ROBICSEK; Fiscal Year: 2009
    ....
  38. Impact of Mortality Concerns on Cancer Risk Behavior
    Jamie Arndt; Fiscal Year: 2006
    ..abstract_text> ..
  39. Recycling of IFNgR2 modulates IFNg responsiveness
    Sergio Rosenzweig; Fiscal Year: 2004
    ..abstract_text> ..
  40. CALCIUM AND ENDOCYTOTIC MEMBRANE RETRIEVAL
    Steven Vogel; Fiscal Year: 2002
    ..Specifically we will determine how exocytotic activity influences membrane depolarization and the cellular distribution of P-type calcium channels. ..
  41. Impact of Mortality Concerns on Cancer Risk Behavior
    Jamie Arndt; Fiscal Year: 2002
    ..abstract_text> ..
  42. CALCIUM AND ENDOCYTOTIC MEMBRANE RETRIEVAL
    Steven Vogel; Fiscal Year: 2000
    ..Specifically we will determine how exocytotic activity influences membrane depolarization and the cellular distribution of P-type calcium channels. ..
  43. Use p105(sr) to study p50 homodimer in skin tumor/cancer
    Li Lin; Fiscal Year: 2005
    ..We will also test whether introducing p105(sr) into skin tumor cells facilitates apoptosis, and whether this approach significantly affects physiologic functions of normal keratinocytes. ..
  44. Daily Stress and Well-Being during Adulthood
    David Almeida; Fiscal Year: 2007
    ....
  45. An Open and Scalable Stochastic Simulation Library for Biology
    MARK STALZER; Fiscal Year: 2007
    ....
  46. Recycling of IFNgR2 modulates IFNgamma responsiveness
    Sergio Rosenzweig; Fiscal Year: 2007
    ..abstract_text> ..
  47. An Open and Scalable Stochastic Simulation Library for Biology
    MARK STALZER; Fiscal Year: 2009
    ....
  48. Pharmacodynamics of IV Citalopram Using Functional MRI
    KRISTIN BIGOS; Fiscal Year: 2006
    ..The purpose of this award is to provide the applicant with two years of support during her doctoral training, while she completes this research for her thesis. ..
  49. Racial Disparity in Quality of Clinical Care in End Stage Renal Disease
    Guofen Yan; Fiscal Year: 2010
    ..Understanding the sources of this disparity would help to minimize racial disparities and improve the care of patients with advanced chronic kidney disease. ..
  50. OXYTOCIN, VASOPRESSIN AND DEVELOPMENT OF SOCIAL BEHAVIOR
    James Winslow; Fiscal Year: 2002
    ....
  51. Reversal Learning in Pediatric Bipolar Disorder
    DANIEL DICKSTEIN; Fiscal Year: 2007
    ....
  52. OXYTOCIN, VASOPRESSIN AND DEVELOPMENT OF SOCIAL BEHAVIOR
    James Winslow; Fiscal Year: 1999
    ....
  53. Platelet-Derived FVIII Gene Therapy of Hemophilia A
    Qizhen Shi; Fiscal Year: 2010
    ..In this project, we will develop a gene therapy approach by targeting the synthesis of FVIII to blood platelets, that might cure hemophilia A patients as well as patients with inhibitors. ..
  54. Baseline Microdata for Analysis of U.S. Demographic Change
    EVAN W ROBERTS; Fiscal Year: 2010
    ..This basic infrastructure will stimulate health- related research on population growth and movement, fertility, mortality, and nuptiality, as well as the economic and social correlates of demographic behavior. ..