L M Refolo
Affiliation: Nathan Kline Institute
- Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse modelL M Refolo
Nathan S Kline Institute for Dementia Research, Orangeburg, New York, USA
Neurobiol Dis 7:321-31. 2000..These data demonstrate that high dietary cholesterol increases Abeta accumulation and accelerates the AD-related pathology observed in this animal model. Thus, we propose that diet can be used to modulate the risk of developing AD...
- A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's diseaseL M Refolo
Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
Neurobiol Dis 8:890-9. 2001..This study demonstrates that hypocholesterolemia is associated with reduced Abeta accumulation suggesting that lowering cholesterol by pharmacological means may be an effective approach for reducing the risk of developing AD...
- Modulation of A(beta) peptides by estrogen in mouse modelsH Zheng
Huffington Center on Aging, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
J Neurochem 80:191-6. 2002..These results provide evidence that post-menopausal estrogen depletion may be linked to an increased risk of AD through A(beta) modulation...
- Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathologyM A Pappolla
University of South Alabama, Mobile, USA
Neurology 61:199-205. 2003..Epidemiologic and experimental data suggest that cholesterol may play a role in the pathogenesis of AD. Modulation of cholesterolemia in transgenic animal models of AD strongly alters amyloid pathology...
- A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43)C B Eckman
Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
Hum Mol Genet 6:2087-9. 1997....
- New directions in neuroprotection: basic mechanisms, molecular targets and treatment strategiesL M Refolo
J Alzheimers Dis 6:S1-2. 2004