Rod Balhorn

Summary

Affiliation: Nash and Associates
Country: USA

Publications

  1. pmc Hexa-arginine enhanced uptake and residualization of selective high affinity ligands by Raji lymphoma cells
    Rod Balhorn
    University of California, Department of Applied Science, Hertz Hall, Livermore, CA 94551, USA
    Mol Cancer 8:25. 2009
  2. ncbi request reprint Selective high-affinity ligand antibody mimics for cancer diagnosis and therapy: initial application to lymphoma/leukemia
    Rod Balhorn
    Chemistry, Materials and Life Sciences and Computations, Lawrence Livermore National Laboratory, Livermore, California, 94550, USA
    Clin Cancer Res 13:5621s-5628s. 2007
  3. ncbi request reprint Recombinant expression of the beta-subunit of HLA-DR10 for the selection of novel lymphoma targeting molecules
    Huguette Albrecht
    Cancer Center, University of California, Davis Medical Center, Sacramento, CA 95816, USA
    Cancer Biother Radiopharm 22:531-42. 2007
  4. pmc Nanomolecular HLA-DR10 antibody mimics: A potent system for molecular targeted therapy and imaging
    Gerald L DeNardo
    University of California, Davis Medical Center, Sacramento, USA
    Cancer Biother Radiopharm 23:783-96. 2008
  5. ncbi request reprint Identification of a thermo-regulated glutamine-binding protein from Yersinia pestis
    Monique Cosman
    Lawrence Livermore National Laboratory, Livermore, CA 94551, USA
    Protein Pept Lett 15:887-94. 2008
  6. doi request reprint Raman spectroscopy of DNA packaging in individual human sperm cells distinguishes normal from abnormal cells
    Thomas Huser
    NSF Center for Biophotonics Science and Technology, University of California, Davis, Sacramento, CA 95817, USA
    J Biophotonics 2:322-32. 2009
  7. ncbi request reprint Dynamics of protamine 1 binding to single DNA molecules
    Laurence Brewer
    Electronic Engineering Technologies Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    J Biol Chem 278:42403-8. 2003
  8. ncbi request reprint Electrospray mass spectrometry of NeuAc oligomers associated with the C fragment of the tetanus toxin
    Maria C Prieto Conway
    Chemistry and Materials Science Directorate, Lawrence Livermore National Laboratory, Livermore, California 94550, USA
    J Am Soc Mass Spectrom 17:967-76. 2006
  9. pmc Systemic radiotherapy can cure lymphoma: a paradigm for other malignancies?
    Gerald L DeNardo
    Department of Internal Medicine, University of California, Davis, Sacramento, CA 95816, USA
    Cancer Biother Radiopharm 23:383-97. 2008
  10. ncbi request reprint Synthesis and radiolabeling of selective high-affinity ligands designed to target non-Hodgkin's lymphoma and leukemia
    Saphon Hok
    Chemistry, Materials and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
    Bioconjug Chem 18:912-21. 2007

Collaborators

Detail Information

Publications19

  1. pmc Hexa-arginine enhanced uptake and residualization of selective high affinity ligands by Raji lymphoma cells
    Rod Balhorn
    University of California, Department of Applied Science, Hertz Hall, Livermore, CA 94551, USA
    Mol Cancer 8:25. 2009
    ....
  2. ncbi request reprint Selective high-affinity ligand antibody mimics for cancer diagnosis and therapy: initial application to lymphoma/leukemia
    Rod Balhorn
    Chemistry, Materials and Life Sciences and Computations, Lawrence Livermore National Laboratory, Livermore, California, 94550, USA
    Clin Cancer Res 13:5621s-5628s. 2007
    ....
  3. ncbi request reprint Recombinant expression of the beta-subunit of HLA-DR10 for the selection of novel lymphoma targeting molecules
    Huguette Albrecht
    Cancer Center, University of California, Davis Medical Center, Sacramento, CA 95816, USA
    Cancer Biother Radiopharm 22:531-42. 2007
    ..Therefore, this recombinant protein can be used as a surrogate for native heterodimeric HLA DR10 for the in vitro selection of SHALs and related targeting molecules...
  4. pmc Nanomolecular HLA-DR10 antibody mimics: A potent system for molecular targeted therapy and imaging
    Gerald L DeNardo
    University of California, Davis Medical Center, Sacramento, USA
    Cancer Biother Radiopharm 23:783-96. 2008
    ..Further, these SHALs can be used to transport and residualize cytotoxic agents near critical sites inside these malignant cells...
  5. ncbi request reprint Identification of a thermo-regulated glutamine-binding protein from Yersinia pestis
    Monique Cosman
    Lawrence Livermore National Laboratory, Livermore, CA 94551, USA
    Protein Pept Lett 15:887-94. 2008
    ..The identification and characterization of an unknown protein function using the strategy presented here has applicability to a variety of research areas, including functional genomics and proteomics efforts...
  6. doi request reprint Raman spectroscopy of DNA packaging in individual human sperm cells distinguishes normal from abnormal cells
    Thomas Huser
    NSF Center for Biophotonics Science and Technology, University of California, Davis, Sacramento, CA 95817, USA
    J Biophotonics 2:322-32. 2009
    ..These findings indicate that single cell Raman spectroscopy should be a valuable tool in assessing the quality of sperm cells for in-vitro fertilization...
  7. ncbi request reprint Dynamics of protamine 1 binding to single DNA molecules
    Laurence Brewer
    Electronic Engineering Technologies Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    J Biol Chem 278:42403-8. 2003
    ..The use of Arg, rather than Lys residues, and the inclusion of Tyr or Phe residues in the hinge regions between anchoring domains provide additional stability to the complex...
  8. ncbi request reprint Electrospray mass spectrometry of NeuAc oligomers associated with the C fragment of the tetanus toxin
    Maria C Prieto Conway
    Chemistry and Materials Science Directorate, Lawrence Livermore National Laboratory, Livermore, California 94550, USA
    J Am Soc Mass Spectrom 17:967-76. 2006
    ....
  9. pmc Systemic radiotherapy can cure lymphoma: a paradigm for other malignancies?
    Gerald L DeNardo
    Department of Internal Medicine, University of California, Davis, Sacramento, CA 95816, USA
    Cancer Biother Radiopharm 23:383-97. 2008
    ..Smaller radionuclide carriers, such as those used for pretargeted strategies, provide dose intensification. The potential of pretargeted RIT to improve patient outcomes is striking...
  10. ncbi request reprint Synthesis and radiolabeling of selective high-affinity ligands designed to target non-Hodgkin's lymphoma and leukemia
    Saphon Hok
    Chemistry, Materials and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
    Bioconjug Chem 18:912-21. 2007
    ..Radiolabeling reactions of DOTA-SHALs, with exactly one DOTA entity per targeting SHAL molecule, yielded products with greater than 90% radiochemical purity and specific activities ranging from 97 to 150 muCi/mug...
  11. ncbi request reprint Mass spectrometry and non-covalent protein-ligand complexes: confirmation of binding sites and changes in tertiary structure
    Sharon J Shields
    Chemistry and Materials Science, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
    J Am Soc Mass Spectrom 14:460-70. 2003
    ..These five peptides flank regions of decreased ion abundance, suggesting that doxorubicin not only binds to the surface, but also induces a conformational change in TetC...
  12. ncbi request reprint Computational approaches for identification of conserved/unique binding pockets in the A chain of ricin
    Carol L Ecale Zhou
    Lawrence Livermore National Laboratory 7000 E Avenue, Livermore, CA 94550, USA
    Bioinformatics 21:3089-96. 2005
    ..To reduce the time and cost of laboratory screening efforts for diagnostic reagents, we developed new methods for evaluating and selecting protein surface regions for ligand targeting...
  13. ncbi request reprint Application of NMR methods to identify detection reagents for use in development of robust nanosensors
    Monique Cosman
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA, USA
    Methods Mol Biol 300:141-63. 2005
    ..Using this assay, one can identify the optimal pairs of ligands to be linked together for creating detection reagents, as well as estimate the relative binding constants for ligands competing for the same site...
  14. pmc Mechanism of DNA compaction by yeast mitochondrial protein Abf2p
    Raymond W Friddle
    Biosecurity and Nanoscience Laboratory, Chemistry and Materials Science Directorate, Lawrence Livermore National Laboratory, Livermore, California, USA
    Biophys J 86:1632-9. 2004
    ..These studies indicate that Abf2p compacts DNA through a simple mechanism that involves bending of the DNA backbone. We discuss the implications of such a mechanism for mitochondrial DNA maintenance and organization...
  15. pmc The protamine family of sperm nuclear proteins
    Rod Balhorn
    Biosciences and Biotechnology Division, Chemistry, Materials and Life Sciences, Lawrence Livermore National Laboratory, East Avenue, Livermore, CA 94550, USA
    Genome Biol 8:227. 2007
    ..Both P1 and P2 have been shown to be required for normal sperm function in primates and many rodents...
  16. pmc Crystal structure of Clostridium botulinum neurotoxin protease in a product-bound state: Evidence for noncanonical zinc protease activity
    Brent Segelke
    University of California, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94551, USA
    Proc Natl Acad Sci U S A 101:6888-93. 2004
    ..The proposed BoNT/A substrate-binding mode and catalytic mechanism are markedly different from those previously proposed for the BoNT serotype B...
  17. ncbi request reprint Identification of novel small molecules that bind to two different sites on the surface of tetanus toxin C fragment
    Monique Cosman
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, California 94551 0808, USA
    Chem Res Toxicol 15:1218-28. 2002
    ....
  18. ncbi request reprint Monitoring dynamic protein expression in living E. coli. Bacterial cells by laser tweezers Raman spectroscopy
    James W Chan
    Applied Physics and Biophysics Division, Physics and Advanced Technologies Directorate, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
    Cytometry A 71:468-74. 2007
    ..Here, we demonstrate its use to monitor changes in a population of E. coli cells that occur during overexpression of a protein, the extracellular domain of myelin oligodendrocyte glycoprotein [MOG(1-120)]...
  19. doi request reprint Self-assembly of heptameric nanoparticles derived from tag-functionalized phi29 connectors
    Dominik J Green
    Department of Molecular and Cellular Biology, University of California, Davis, California 95616, USA
    ACS Nano 4:7651-9. 2010
    ..By modifying the surface-exposed C-terminal ends with application-appropriate moieties, the consistent structure and compact nature of these nanoparticles may prove beneficial in nanotechnological and nanomedical approaches...