Affiliation: Mount Sinai School of Medicine
- Reconstruction of regulatory networks through temporal enrichment profiling and its application to H1N1 influenza viral infectionElena Zaslavsky
Center for Translational Systems Biology and Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
BMC Bioinformatics 14:S1. 2013..Identifying the underlying transcriptional network driving these changes, and how this program is altered by virally-encoded immune antagonists, is a fundamental challenge in systems immunology...
- Antiviral response dictated by choreographed cascade of transcription factorsElena Zaslavsky
Center for Translational Systems Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
J Immunol 184:2908-17. 2010..More generally, our results show how a genetic program can be temporally controlled through a single regulatory network to achieve the large-scale genetic reprogramming characteristic of cell-state transitions...
- Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1 Influenza VirusesBoris M Hartmann
Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Center for Translational Systems Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
J Virol 89:10190-205. 2015..Comparison of the global responses to the seasonal and pandemic strains showed that a dramatic divergence occurred after 4 h, with only the seasonal strains inducing widespread mRNA loss...
- Computational approaches to understanding dendritic cell responses to influenza virus infectionElena Zaslavsky
Department of Neurology and Center for Translational Systems Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
Immunol Res 54:160-8. 2012..Our tools, models, and data can be accessed at http://tsb.mssm.edu/primeportal/ ...
- CellCODE: a robust latent variable approach to differential expression analysis for heterogeneous cell populationsMaria Chikina
Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15217, USA and Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Bioinformatics 31:1584-91. 2015..However, there is no method that comprehensively addresses mixture analysis in the context of differential expression without relying on additional proportion information, which can be inaccurate and is frequently unavailable...
- β-catenin regulates GnRH-induced FSHβ gene expressionQian Wang
Department of Neurology, Center for Translational Systems Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
Mol Endocrinol 27:224-37. 2013..Furthermore, knockdown of Brms1L significantly attenuated GnRH-induced FSHβ expression. Thus, our findings indicate that the expression of Brms1L depends on β-catenin activity and contributes to FSHβ induction by GnRH...