Sergei Yakushin

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi request reprint Spatial properties of central vestibular neurons
    Sergei B Yakushin
    Department of Neurology, Box 1135, Mount Sinai School of Medicine, 1 E 100th St, New York, NY 10029, USA
    J Neurophysiol 95:464-78. 2006
  2. pmc Tuning of gravity-dependent and gravity-independent vertical angular VOR gain changes by frequency of adaptation
    Sergei B Yakushin
    Dept of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Neurophysiol 107:3349-56. 2012
  3. pmc Complementary gain modifications of the cervico-ocular (COR) and angular vestibulo-ocular (aVOR) reflexes after canal plugging
    Sergei B Yakushin
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Brain Res 210:549-60. 2011
  4. pmc Spatial orientation of the angular vestibulo-ocular reflex (aVOR) after semicircular canal plugging and canal nerve section
    Sergei B Yakushin
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Brain Res 210:583-94. 2011
  5. ncbi request reprint Spatial properties of central vestibular neurons of monkeys after bilateral lateral canal nerve section
    Sergei B Yakushin
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Neurophysiol 94:3860-71. 2005
  6. ncbi request reprint The role of gravity in adaptation of the vertical angular vestibulo-ocular reflex
    Sergei B Yakushin
    Department of Neurology, Box 1135, Mount Sinai School of Medicine, 1 East 100th Street, New York, NY 10029, USA
    Ann N Y Acad Sci 1039:97-110. 2005
  7. ncbi request reprint Spatial distribution of gravity-dependent gain changes in the vestibuloocular reflex
    Sergei B Yakushin
    Dept of Neurology, Box 1135, Mount Sinai School of Medicine, 1 E 100th St, New York, NY 10029, USA
    J Neurophysiol 93:3693-8. 2005
  8. ncbi request reprint Dependence of adaptation of the human vertical angular vestibulo-ocular reflex on gravity
    Sergei B Yakushin
    Department of Neurology, Mount Sinai School of Medicine, 1 East 100th Street, Box 1135, New York, NY 10029, USA
    Exp Brain Res 152:137-42. 2003
  9. doi request reprint Dynamics of binocular fixation of targets during fore-aft motion
    Sergei B Yakushin
    Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA
    Prog Brain Res 171:303-11. 2008
  10. ncbi request reprint Gravity-specific adaptation of the angular vestibuloocular reflex: dependence on head orientation with regard to gravity
    Sergei B Yakushin
    Department of Neurology, Mount Sinai School of Medicine, New York City, New York 11210, USA
    J Neurophysiol 89:571-86. 2003

Research Grants

  1. VESTIBULAR AFFERENT ACTIVITY AFTER CANAL PLUGGING
    Sergei Yakushin; Fiscal Year: 2002

Detail Information

Publications31

  1. ncbi request reprint Spatial properties of central vestibular neurons
    Sergei B Yakushin
    Department of Neurology, Box 1135, Mount Sinai School of Medicine, 1 E 100th St, New York, NY 10029, USA
    J Neurophysiol 95:464-78. 2006
    ..This convergence could provide the basis for gravity-dependent eye velocity orientation induced through velocity storage...
  2. pmc Tuning of gravity-dependent and gravity-independent vertical angular VOR gain changes by frequency of adaptation
    Sergei B Yakushin
    Dept of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Neurophysiol 107:3349-56. 2012
    ..The gravity-independent component of the aVOR had a substantial tuning curve only at an adaptation frequency of 0.25 Hz...
  3. pmc Complementary gain modifications of the cervico-ocular (COR) and angular vestibulo-ocular (aVOR) reflexes after canal plugging
    Sergei B Yakushin
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Brain Res 210:549-60. 2011
    ..Thus, while there are individual variations in the time of adaptation of the gain and phase parameters, the essential functional organization of the adaption to vestibular lesions is uniform across these species...
  4. pmc Spatial orientation of the angular vestibulo-ocular reflex (aVOR) after semicircular canal plugging and canal nerve section
    Sergei B Yakushin
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Brain Res 210:583-94. 2011
    ..We conclude that there is no spatial adaptation of the aVOR even after complete loss of specific semicircular canal input...
  5. ncbi request reprint Spatial properties of central vestibular neurons of monkeys after bilateral lateral canal nerve section
    Sergei B Yakushin
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Neurophysiol 94:3860-71. 2005
    ..There were substantial neck and/or otolith-related inputs activating the vertical canal-related neurons in the nerve-sectioned animals, which could have contributed to oculomotor compensation after nerve section...
  6. ncbi request reprint The role of gravity in adaptation of the vertical angular vestibulo-ocular reflex
    Sergei B Yakushin
    Department of Neurology, Box 1135, Mount Sinai School of Medicine, 1 East 100th Street, New York, NY 10029, USA
    Ann N Y Acad Sci 1039:97-110. 2005
    ..These results are similar to those in humans, indicating that the gravity-dependent adaptation of the aVOR is likely to be a common phenomenon across species...
  7. ncbi request reprint Spatial distribution of gravity-dependent gain changes in the vestibuloocular reflex
    Sergei B Yakushin
    Dept of Neurology, Box 1135, Mount Sinai School of Medicine, 1 E 100th St, New York, NY 10029, USA
    J Neurophysiol 93:3693-8. 2005
    ..It is likely that this gravitational dependence optimizes the stability of retinal images during movement in three-dimensional space...
  8. ncbi request reprint Dependence of adaptation of the human vertical angular vestibulo-ocular reflex on gravity
    Sergei B Yakushin
    Department of Neurology, Mount Sinai School of Medicine, 1 East 100th Street, Box 1135, New York, NY 10029, USA
    Exp Brain Res 152:137-42. 2003
    ..We conclude that there is a component of the vertical aVOR gain change in humans that is dependent on the head orientation in which the gain was adapted, and that this dependence can persist for substantial periods...
  9. doi request reprint Dynamics of binocular fixation of targets during fore-aft motion
    Sergei B Yakushin
    Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA
    Prog Brain Res 171:303-11. 2008
    ..Thus, although pursuit alone does not contribute to visual following at higher frequencies, the interaction of binocular pursuit and the lVOR supported accurate binocular fixation for frequencies up to 3 Hz...
  10. ncbi request reprint Gravity-specific adaptation of the angular vestibuloocular reflex: dependence on head orientation with regard to gravity
    Sergei B Yakushin
    Department of Neurology, Mount Sinai School of Medicine, New York City, New York 11210, USA
    J Neurophysiol 89:571-86. 2003
    ..These data demonstrate that head orientation to gravity plays an important role in both orienting and tuning the gain of the vertical aVOR...
  11. doi request reprint Modification of the cervico-ocular reflex by canal plugging
    Sergei B Yakushin
    Departments of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Ann N Y Acad Sci 1164:60-7. 2009
    ..5 Hz and shifted toward 270 degrees as frequencies were increased to 4 Hz. This study demonstrates that adaptation of COR gain is tuned to a frequency range at which the aVOR is compromised by the canal plugging...
  12. pmc Dependence of the roll angular vestibuloocular reflex (aVOR) on gravity
    Sergei B Yakushin
    Dept of Neurology, Box 1135, Mount Sinai School of Medicine, 1 E 100th St, New York, NY 10029 6574, USA
    J Neurophysiol 102:2616-26. 2009
    ..These behavioral differences support the idea that there is a fundamental difference in the central organization of canal-otolith convergence of the roll and yaw/pitch aVORs...
  13. ncbi request reprint Compensatory and orienting eye movements induced by off-vertical axis rotation (OVAR) in monkeys
    Keisuke Kushiro
    Department of Neurology, Mount Sinai School of Medicine, New York City 10029, Brooklyn, New York 11210, USA
    J Neurophysiol 88:2445-62. 2002
    ..These data support the postulates that OVAR generates compensatory eye velocity through activation of velocity storage and that oscillatory components arise predominantly through lVOR orientation mechanisms...
  14. ncbi request reprint Adaptive changes in the angular VOR: duration of gain changes and lack of effect of nodulo-uvulectomy
    Sergei B Yakushin
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Ann N Y Acad Sci 1004:78-93. 2003
    ..Vertical gravity-dependent gain changes were not significantly different before and after surgery, indicating that the nodulus and uvula do not have a critical role in producing them...
  15. ncbi request reprint Semicircular canal plugging shifts the frequency of spatial-temporal convergence (STC) in central vestibular neurons
    Sergei B Yakushin
    Mount Sinai School of Medicine, Neurology Dept, Box 1135, 5E 98 Street, New York, NY 10029, USA
    J Gravit Physiol 14:P71-2. 2007
  16. ncbi request reprint Gravity-dependent and gravity-independent gain changes during vertical vestibulo-ocular reflex (VOR) adaptation
    Yongqing Xiang
    Department of Computer and Information Science, Brooklyn College of the City University of New York, Brooklyn, New York 11210, USA
    J Gravit Physiol 11:P9-12. 2004
    ..We conclude that the alteration in gain of the aVOR always occurs in the context of gravity...
  17. pmc Head stabilization by vestibulocollic reflexes during quadrupedal locomotion in monkey
    Yongqing Xiang
    Department of Computer and Information Science, Brooklyn College, CUNY, Brooklyn, NY, USA
    J Neurophysiol 100:763-80. 2008
    ..We conclude that the behavioral state associated with active body motion is necessary to maintain head stability in pitch and roll over the full range of stride/step frequencies encountered during walking...
  18. pmc Adaptation of orientation of central otolith-only neurons
    Julia N Eron
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Ann N Y Acad Sci 1164:367-71. 2009
    ..In contrast, canal-convergent VO and VPS neurons optimize their response vector orientation to gravity when the head is oriented for prolonged periods...
  19. pmc Adaptation of orientation vectors of otolith-related central vestibular neurons to gravity
    Julia N Eron
    Department of Neurology, Mount Sinai School of Medicine, New York City, NY 10029 6574, USA
    J Neurophysiol 100:1686-90. 2008
    ..Such reorientation of central polarization vectors could provide the basis for changes in perception and eye movements related to prolonged head tilts relative to gravity or in microgravity...
  20. ncbi request reprint The nodulus and uvula: source of cerebellar control of spatial orientation of the angular vestibulo-ocular reflex
    Bernard Cohen
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Ann N Y Acad Sci 978:28-45. 2002
    ..These findings are further confirmation that these regions of the vestibulo-cerebellum control spatial orientation of the aVOR...
  21. doi request reprint Differential coding of head rotation by lateral-vertical canal convergent central vestibular neurons
    Julia N Eron
    Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA
    Prog Brain Res 171:313-8. 2008
    ..The otolith and canal inputs superposed when the animals were rotated about roll and pitch axes from an upright position. This insured that these neurons would respond over a broad frequency range from very low to high frequencies...
  22. doi request reprint Baclofen, motion sickness susceptibility and the neural basis for velocity storage
    Bernard Cohen
    Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA
    Prog Brain Res 171:543-53. 2008
    ....
  23. pmc Sinusoidal galvanic vestibular stimulation (sGVS) induces a vasovagal response in the rat
    Bernard Cohen
    Department of Neurology, Mount Sinai School of Medicine, Box 1135 1 East 100th Street, New York, NY 10029, USA
    Exp Brain Res 210:45-55. 2011
    ..These responses have a striking resemblance to human vasovagal responses. Thus, sGVS-activated rats can potentially serve as a useful experimental model of the vasovagal response in humans...
  24. doi request reprint Effect of canal plugging on quadrupedal locomotion in monkey
    Bernard Cohen
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Ann N Y Acad Sci 1164:89-96. 2009
    ..These findings indicate that the semicircular canals provide critical low frequency information to maximize the accuracy of stepping and stabilize the head during normal quadrupedal locomotion...
  25. ncbi request reprint Head fixed field coil system for measuring eye movements in freely moving monkeys
    Dmitri Ogorodnikov
    Department of Neurology, Mount Sinai School of Medicine, USA
    Conf Proc IEEE Eng Med Biol Soc 1:5567-70. 2006
    ..This system opens the possibility for studying eye movements in freely moving monkeys under a wide range of conditions...
  26. doi request reprint Effects of the linear vestibulo-ocular reflex on accommodative vergence eye movements
    Sergei B Yakushin
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Ann N Y Acad Sci 1164:499-504. 2009
    ..At higher frequencies, vergence could also be driven by the linear vestibulo-ocular reflex (lVOR). Thus, vision in one nonmoving eye and the lVOR combine to generate convergence over a wide range of frequencies and viewing distances...
  27. ncbi request reprint Dynamics of quadrupedal locomotion of monkeys: implications for central control
    Yongqing Xiang
    Department of Computer and Information Science, Brooklyn College, CUNY, Brooklyn, NY 11210, USA
    Exp Brain Res 177:551-72. 2007
    ....
  28. ncbi request reprint Modeling gravity-dependent plasticity of the angular vestibuloocular reflex with a physiologically based neural network
    Yongqing Xiang
    Department of Computer and Information Science, Brooklyn College of CUNY, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
    J Neurophysiol 96:3349-61. 2006
    ..The adaptation is tuned by how the weights from otolith input to the canal-otolith-convergent neurons are adapted for a given head orientation...
  29. ncbi request reprint Vestibular experiments in space
    Bernard Cohen
    Department of Neurology, Mount Sinai School of Medicine, New York, USA
    Adv Space Biol Med 10:105-64. 2005
  30. ncbi request reprint Spatial orientation of caloric nystagmus
    Yasuko Arai
    Department of Otolaryngology, Tokyo Women s Medical University, Daini Hospital, Tokyo, Japan
    Ann N Y Acad Sci 956:190-204. 2002
    ....
  31. ncbi request reprint Spatial orientation of caloric nystagmus in semicircular canal-plugged monkeys
    Yasuko Arai
    Department of Otolaryngology, Tokyo Women s Medical University Daini Hospital, Japan
    J Neurophysiol 88:914-28. 2002
    ..Although the response to convection currents dominates the normal response to caloric stimulation, velocity storage probably also contributes to the orientation of eye velocity...

Research Grants1

  1. VESTIBULAR AFFERENT ACTIVITY AFTER CANAL PLUGGING
    Sergei Yakushin; Fiscal Year: 2002
    ..This work should lead to a clearer understanding of how lesions, such as plugging and nerve section, affect the sensory processing of head movements and how the central vestibular system adapts to these types of lesions. ..