Christina M Wyatt

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. doi request reprint In vitro generation of renal tubular epithelial cells from fibroblasts: implications for precision and regenerative medicine in nephrology
    Christina M Wyatt
    Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 91:265-267. 2017
  2. doi request reprint Higher hemoglobin levels and quality of life in patients with advanced chronic kidney disease: no longer a moving target?
    Christina M Wyatt
    Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 89:971-3. 2016
  3. doi request reprint ISCHEMIA in chronic kidney disease: improving the representation of patients with chronic kidney disease in cardiovascular trials
    Christina M Wyatt
    Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 89:1178-9. 2016
  4. doi request reprint Intensive glycemic control and the risk of end-stage renal disease: an ADVANCE in the management of diabetes?
    Christina M Wyatt
    Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 90:8-10. 2016
  5. doi request reprint Of mice and women: do sex-dependent responses to ischemia-reperfusion injury in rodents have implications for delayed graft function in humans?
    Christina M Wyatt
    Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 90:10-3. 2016
  6. doi request reprint Clinical trials of intensive versus less intensive control of hypertension: HOPE or HYPE?
    Christina M Wyatt
    Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 90:460-2. 2016
  7. doi request reprint Timing is everything? Reconciling the results of recent trials in acute kidney injury
    Christina M Wyatt
    Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 90:718-21. 2016
  8. ncbi request reprint Renal disease in patients with HIV
    Christina M Wyatt
    Division of Nephrology, Box 1243, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Curr Infect Dis Rep 8:76-81. 2006
  9. doi request reprint HIF stabilization by prolyl hydroxylase inhibitors for the treatment of anemia in chronic kidney disease
    Christina M Wyatt
    Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 90:923-925. 2016
  10. doi request reprint Folic acid supplementation and chronic kidney disease progression
    Christina M Wyatt
    Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 90:1144-1145. 2016

Detail Information

Publications49

  1. doi request reprint In vitro generation of renal tubular epithelial cells from fibroblasts: implications for precision and regenerative medicine in nephrology
    Christina M Wyatt
    Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 91:265-267. 2017
    ....
  2. doi request reprint Higher hemoglobin levels and quality of life in patients with advanced chronic kidney disease: no longer a moving target?
    Christina M Wyatt
    Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 89:971-3. 2016
    ..Limitations of the available data suggest that individualized targets should nonetheless remain an option in future clinical practice guidelines...
  3. doi request reprint ISCHEMIA in chronic kidney disease: improving the representation of patients with chronic kidney disease in cardiovascular trials
    Christina M Wyatt
    Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 89:1178-9. 2016
    ..Two ongoing trials are assessing the risk:benefit of aggressive evaluation and intervention for ischemic heart disease in patients with advanced chronic kidney disease. ..
  4. doi request reprint Intensive glycemic control and the risk of end-stage renal disease: an ADVANCE in the management of diabetes?
    Christina M Wyatt
    Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 90:8-10. 2016
    ..In a more detailed analysis, intensive glycemic control appears to be of benefit only before the development of clinically evident kidney disease or in patients with documented early-stage chronic kidney disease. ..
  5. doi request reprint Of mice and women: do sex-dependent responses to ischemia-reperfusion injury in rodents have implications for delayed graft function in humans?
    Christina M Wyatt
    Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 90:10-3. 2016
    ..A recent publication suggests that this sex-dependent response to injury may have clinical implications for delayed graft function after kidney transplantation. ..
  6. doi request reprint Clinical trials of intensive versus less intensive control of hypertension: HOPE or HYPE?
    Christina M Wyatt
    Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 90:460-2. 2016
    ..The results of Systolic Blood Pressure Intervention Trial (SPRINT) and HOPE-3 highlight the importance of considering differences in study design and patient population when interpreting the results of clinical trials. ..
  7. doi request reprint Timing is everything? Reconciling the results of recent trials in acute kidney injury
    Christina M Wyatt
    Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 90:718-21. 2016
    ..Careful consideration of differences between the 2 studies is essential when applying the results to clinical practice in the intensive care unit. ..
  8. ncbi request reprint Renal disease in patients with HIV
    Christina M Wyatt
    Division of Nephrology, Box 1243, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Curr Infect Dis Rep 8:76-81. 2006
    ..Recently published guidelines highlight the increased awareness of kidney disease in the infectious disease community and provide guidelines for the detection and management of chronic kidney disease in patients with HIV...
  9. doi request reprint HIF stabilization by prolyl hydroxylase inhibitors for the treatment of anemia in chronic kidney disease
    Christina M Wyatt
    Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 90:923-925. 2016
    ..More experience is needed to establish long-term efficacy, tolerability, and safety, and to determine whether their use is associated with lower iron requirements...
  10. doi request reprint Folic acid supplementation and chronic kidney disease progression
    Christina M Wyatt
    Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 90:1144-1145. 2016
    ..Differences in the study population and study intervention may explain these discordant results...
  11. doi request reprint A rose by any other name: is stage 3a chronic kidney disease really a disease?
    Christina M Wyatt
    Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 91:6-8. 2017
    ..Despite limited generalizability, the results support the current, more nuanced classification of chronic kidney disease for use in clinical practice and in future epidemiologic research...
  12. doi request reprint Proton pump inhibitors and chronic kidney disease: is it time to sound the alarm?
    Christina M Wyatt
    Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 89:732-3. 2016
    ..Although the study does not prove causality, the robustness of the findings in two cohorts suggests a need for further study and reevaluation of the safety of these agents for widespread, non-prescription use. ..
  13. doi request reprint We still go for the jugular: implications of the 3SITES central venous catheter study for nephrology
    Christina M Wyatt
    Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 89:522-4. 2016
    ....
  14. doi request reprint Fibroblast growth factor receptor 4: the missing link between chronic kidney disease and FGF23-induced left ventricular hypertrophy?
    Christina M Wyatt
    Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 89:7-9. 2016
    ....
  15. doi request reprint Will a new tenofovir prodrug for the treatment of HIV reduce the risk of nephrotoxicity?
    Christina M Wyatt
    Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 89:5-6. 2016
    ..Phase 3 trials of a new prodrug, tenofovir alafenamide, suggest a lower potential for kidney injury. ..
  16. pmc Hepatitis B and C co-infection are independent predictors of progressive kidney disease in HIV-positive, antiretroviral-treated adults
    Amanda Mocroft
    Research Department of Infection and Population Health, University College London Medical School, London, United Kingdom
    PLoS ONE 7:e40245. 2012
    ..Future studies should validate the relationship between HCV viremia and CKD...
  17. pmc Estimating kidney function in HIV-infected adults in Kenya: comparison to a direct measure of glomerular filtration rate by iohexol clearance
    Christina M Wyatt
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 8:e69601. 2013
    ..Equations to estimate glomerular filtration rate (GFR) from serum creatinine were derived in Western populations and may be less accurate in this population...
  18. ncbi request reprint The burden of acute renal failure in nonrenal solid organ transplantation
    Christina M Wyatt
    Division of Nephrology, Mount Sinai Medical Center, New York, NY 10029 6574, USA
    Transplantation 78:1351-5. 2004
    ..This study examines the incidence of acute renal failure and its associated mortality and morbidity in a modern multicenter cohort...
  19. doi request reprint Recent progress in HIV-associated nephropathy
    Christina M Wyatt
    Department of Medicine, Division of Nephrology, Mount Sinai School Medicine, New York, New York 10029, USA
    Annu Rev Med 63:147-59. 2012
    ..This article reviews recent progress in the pathogenesis and treatment of HIVAN and describes the changing epidemiology of HIV-related kidney disease...
  20. pmc Pre-existing albuminuria predicts AIDS and non-AIDS mortality in women initiating antiretroviral therapy
    Christina M Wyatt
    Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, New York, NY, USA
    Antivir Ther 16:591-6. 2011
    ..We previously reported an increased risk of all-cause and AIDS mortality among HIV-infected women with albuminuria (proteinuria or microalbuminuria) enrolled in the Women's Interagency HIV Study (WIHS) prior to the introduction of HAART...
  21. pmc Microalbuminuria is associated with all-cause and AIDS mortality in women with HIV infection
    Christina M Wyatt
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Acquir Immune Defic Syndr 55:73-7. 2010
    ..We investigated whether microalbuminuria is associated with mortality in HIV-infected women not receiving antiretroviral therapy...
  22. ncbi request reprint Antiretroviral therapy and the kidney: balancing benefit and risk in patients with HIV infection
    Christina M Wyatt
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Expert Opin Drug Saf 5:275-87. 2006
    ....
  23. ncbi request reprint Acute renal failure in hospitalized patients with HIV: risk factors and impact on in-hospital mortality
    Christina M Wyatt
    Division of Nephrology, Department of Medicine, Mount Sinai Medical Center, New York, NY 10029 6574, USA
    AIDS 20:561-5. 2006
    ..Kidney disease is an increasingly important complication of HIV...
  24. ncbi request reprint HIV-associated nephropathy in the era of antiretroviral therapy
    Christina M Wyatt
    Division of Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Med 120:488-92. 2007
    ....
  25. pmc The spectrum of kidney disease in patients with AIDS in the era of antiretroviral therapy
    Christina M Wyatt
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Kidney Int 75:428-34. 2009
    ....
  26. ncbi request reprint Therapy insight: how changes in renal function with increasing age affect cardiovascular drug prescribing
    Christina M Wyatt
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nat Clin Pract Cardiovasc Med 3:102-9. 2006
    ..This article reviews current approaches to the estimation of renal function, and unique considerations related to prescribing medication for elderly patients with concomitant renal and cardiovascular disease...
  27. ncbi request reprint HIV-1 and HIV-Associated Nephropathy 25 Years Later
    Christina M Wyatt
    Mount Sinai School of Medicine, Box 1243, One Gustave L Levy Place, New York, NY 10029
    Clin J Am Soc Nephrol 2:S20-4. 2007
    ..This article reviews the history of HIV and HIVAN, focusing on advances in the understanding of pathogenesis, epidemiology, and treatment...
  28. pmc HIV-associated nephropathy: clinical presentation, pathology, and epidemiology in the era of antiretroviral therapy
    Christina M Wyatt
    Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Semin Nephrol 28:513-22. 2008
    ....
  29. doi request reprint HIV-associated nephropathy
    Christina M Wyatt
    Department of Medicine, Mount Sinai School of Medicine, New York, N Y 10029, USA
    Contrib Nephrol 159:151-61. 2008
    ..Future therapies could also target different steps in the pathogenesis of HIVAN, including viral replication, epithelial cell entry and viral gene expression, and downstream cellular pathways...
  30. pmc The impact of hepatitis C virus coinfection on HIV-related kidney disease: a systematic review and meta-analysis
    Christina M Wyatt
    Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    AIDS 22:1799-807. 2008
    ..In the era of antiretroviral therapy, non-AIDS complications such as kidney disease are important contributors to morbidity and mortality...
  31. ncbi request reprint Chronic kidney disease in HIV infection: an urban epidemic
    Christina M Wyatt
    Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, New York, NY, USA
    AIDS 21:2101-3. 2007
    ..These data suggest that chronic kidney disease remains a common complication of HIV infection in the era of antiretroviral therapy...
  32. pmc In HIV/hepatitis C virus co-infected patients, higher 25-hydroxyvitamin D concentrations were not related to hepatitis C virus treatment responses but were associated with ritonavir use
    Andrea D Branch
    Divisions of Liver Diseases and Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Clin Nutr 98:423-9. 2013
    ..Data on the relation between 25(OH)D concentrations and HCV treatment response in HIV-infected patients are limited...
  33. doi request reprint Antiretroviral medications: adverse effects on the kidney
    Jennifer Jao
    Mount Sinai School of Medicine, New York, NY 10029, USA
    Adv Chronic Kidney Dis 17:72-82. 2010
    ....
  34. pmc Host APOL1 genotype is independently associated with proteinuria in HIV infection
    Michelle M Estrella
    Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Kidney Int 84:834-40. 2013
    ..Trials are needed to determine whether APOL1 genotyping identifies individuals who could benefit from earlier intervention to prevent overt renal disease...
  35. pmc Prevalence of kidney disease in HIV-infected and uninfected Rwandan women
    Christina M Wyatt
    Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 6:e18352. 2011
    ..We evaluated the prevalence of kidney disease among HIV-infected and uninfected Rwandan women...
  36. doi request reprint Acceptance of rapid HIV testing among medical inpatients in New York City
    Charu L Jain
    Mount Sinai School of Medicine, New York, New York 10013, USA
    AIDS Patient Care STDS 22:657-62. 2008
    ..In order to fully implement the new Centers for Disease Control and Prevention (CDC) recommendations for routine, voluntary testing, the optimal timing to offer HIV testing to acutely ill inpatients warrants further investigation...
  37. pmc Short communication: Inadequate vitamin D exacerbates parathyroid hormone elevations in tenofovir users
    Kathryn E Childs
    Division of Infectious Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA
    AIDS Res Hum Retroviruses 26:855-9. 2010
    ..Because TDF is a potent and widely used antiretroviral drug, information about cofactors that may exacerbate its side effects is of significant clinical value...
  38. ncbi request reprint The kidney in HIV infection: beyond HIV-associated nephropathy
    Christina M Wyatt
    Mount Sinai School of Medicine, New York, NY, USA
    Top Antivir Med 20:106-10. 2012
    ..This article summarizes a presentation by Christina M. Wyatt, MD, at the IAS-USA continuing medical education program held in Chicago in May 2012, describing AKI and CKD using case illustrations...
  39. pmc Comorbid diabetes and the risk of progressive chronic kidney disease in HIV-infected adults: data from the Veterans Aging Cohort Study
    Raj K Medapalli
    Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Acquir Immune Defic Syndr 60:393-9. 2012
    ..Studies suggest that HIV and diabetes have an additive effect on chronic kidney disease (CKD) progression; however, this observation may be confounded by differences in traditional CKD risk factors...
  40. pmc Acute kidney injury in HIV-infected patients
    Sahir Kalim
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Semin Nephrol 28:556-62. 2008
    ....
  41. ncbi request reprint Kidney transplantation in HIV-infected patients
    Christina M Wyatt
    Division of Nephrology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Semin Dial 18:495-8. 2005
    ..This article reviews the literature on transplantation in HIV-infected patients, with a focus on kidney transplantation in the era of highly active antiretroviral therapy...
  42. doi request reprint Urine processing impacts uric acid level in HIV-infected adults: implications for diagnosing tenofovir-associated proximal tubulopathy
    Mathew T Hotta
    Mount Sinai School of Medicine, The Samuel F Bronfman Department of Medicine, Division of Nephrology, New York, NY 10029 USA
    AIDS 27:1827-9. 2013
    ..Delays in processing, even with refrigeration, may decrease the sensitivity of urine uric acid testing, with implications for the evaluation of proximal tubulopathy related to tenofovir...
  43. ncbi request reprint Knowledge of the Centers for Disease Control and Prevention's 2006 routine HIV testing recommendations among New York City internal medicine residents
    Charu L Jain
    Bureau of HIV AIDS Prevention and Control, New York City Department of Health and Mental Hygiene, 346 Broadway, Room 701, New York, NY 10013, USA
    AIDS Patient Care STDS 23:167-76. 2009
    ..Most identified institutional and policy barriers to routine testing. Efforts should be made to improve dissemination of guidelines and address institutional and policy barriers to allow more people to learn their HIV status...
  44. doi request reprint Big data in nephrology: promises and pitfalls
    Girish N Nadkarni
    Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA Electronic address
    Kidney Int 90:240-1. 2016
    ..Data from the electronic health records hold great promise for nephrology research. However, due to significant limitations, reporting guidelines have been formulated for analyses conducted using electronic health records data. ..
  45. ncbi request reprint Chronic organizing microangiopathy in a renal transplant recipient
    Christina M Wyatt
    Division of Nephrology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1104, New York, NY 10029, USA
    Nephrol Dial Transplant 20:1734-7. 2005
  46. ncbi request reprint HIV-associated nephropathy: a case study in race and genetics
    Christina M Wyatt
    Am J Kidney Dis 47:1084-5; author reply 1085. 2006
  47. ncbi request reprint Efavirenz: innocent bystander or direct nephrotoxin?
    Christina M Wyatt
    AIDS 21:1393. 2007
  48. ncbi request reprint Combining baseline clinical descriptors and real-time response to therapy: the incremental prognostic value of continuous ST-segment monitoring in acute myocardial infarction
    Arthur C P Maas
    Duke University Medical Center, Durham, NC, USA
    Am Heart J 147:698-704. 2004
    ....
  49. doi request reprint HIV and the kidney: a spotlight on racial disparities
    Christina M Wyatt
    J Infect Dis 197:1490-2. 2008