S Wilk

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi request reprint Properties of the proteasome activator subunit PA28 alpha and its des-tyrosyl analog
    S Wilk
    Department of Pharmacology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York, 10029, USA
    Arch Biochem Biophys 359:283-90. 1998
  2. ncbi request reprint Modulators of the activation of the proteasome by PA28 (11S reg)
    S Wilk
    Department of Pharmacology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Biol Rep 26:39-44. 1999
  3. ncbi request reprint Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase
    S Wilk
    Department of Pharmacology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 273:15961-70. 1998
  4. ncbi request reprint Modulation of the PA28alpha-20S proteasome interaction by a peptidyl alcohol
    S Wilk
    Department of Pharmacology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York, 10029, USA
    Arch Biochem Biophys 362:283-90. 1999
  5. ncbi request reprint Properties of the beta subunit of the proteasome activator PA28 (11S REG)
    S Wilk
    Department of Pharmacology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Arch Biochem Biophys 384:174-80. 2000
  6. ncbi request reprint Dissociation and reassociation of the bovine pituitary multicatalytic proteinase complex
    M E Figueiredo-Pereira
    Department of Pharmacology, Mount Sinai School of Medicine, City University of New York, New York 10029
    J Biol Chem 269:621-6. 1994
  7. ncbi request reprint Changes in proteasome expression and activity during differentiation of neuronal precursor NTera 2 clone D1 cells
    C Wojcik
    Department of Pharmacology, Mount Sinai School of Medicine, New York, NY, USA
    Neurochem Int 34:131-6. 1999
  8. ncbi request reprint Proteasome activator (PA28) subunits, alpha, beta and gamma (Ki antigen) in NT2 neuronal precursor cells and HeLa S3 cells
    C Wojcik
    Department of Pharmacology, Mount Sinai School of Medicine, New York, NY, USA
    Eur J Cell Biol 77:151-60. 1998
  9. ncbi request reprint Purification of the eukaryotic 20S proteasome
    S Wilk
    Mount Sinai School of Medicine, New York, New York, USA
    Curr Protoc Protein Sci . 2001
  10. ncbi request reprint Rat kidney glutamyl aminopeptidase (aminopeptidase A): molecular identity and cellular localization
    L Song
    Department of Pharmacology, Mount Sinai School of Medicine, City University of New York, New York 10029
    Am J Physiol 267:F546-57. 1994

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Properties of the proteasome activator subunit PA28 alpha and its des-tyrosyl analog
    S Wilk
    Department of Pharmacology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York, 10029, USA
    Arch Biochem Biophys 359:283-90. 1998
    ..It is concluded that the lack of activity of des-tyrosyl-PA28alpha is due to conformational changes resulting in dissociation and that the oligomeric form of PA28alpha is required for activation...
  2. ncbi request reprint Modulators of the activation of the proteasome by PA28 (11S reg)
    S Wilk
    Department of Pharmacology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Biol Rep 26:39-44. 1999
    ..PA28- proteasome modulators by modifying the profile of peptides produced by the activated proteasome, may either enhance or suppress the immune response...
  3. ncbi request reprint Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase
    S Wilk
    Department of Pharmacology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 273:15961-70. 1998
    ..Aspartyl aminopeptidase is found at relatively high levels in all mammalian tissues examined and is likely to play an important role in intracellular protein and peptide metabolism...
  4. ncbi request reprint Modulation of the PA28alpha-20S proteasome interaction by a peptidyl alcohol
    S Wilk
    Department of Pharmacology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York, 10029, USA
    Arch Biochem Biophys 362:283-90. 1999
    ..Proteasome modulators represent a novel class of molecules with a potential for altering the processing of antigens by the PA28-proteasome complex for presentation by the MHC class I system...
  5. ncbi request reprint Properties of the beta subunit of the proteasome activator PA28 (11S REG)
    S Wilk
    Department of Pharmacology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Arch Biochem Biophys 384:174-80. 2000
    ..These studies show that oligomerization of PA28beta is required for proteasome activation and that PA28beta monomers are potent proteasome inhibitors...
  6. ncbi request reprint Dissociation and reassociation of the bovine pituitary multicatalytic proteinase complex
    M E Figueiredo-Pereira
    Department of Pharmacology, Mount Sinai School of Medicine, City University of New York, New York 10029
    J Biol Chem 269:621-6. 1994
    ..Evidence for catalytically active subcomplexes was not obtained indicating that structural integrity may be necessary for expression of all defined activities...
  7. ncbi request reprint Changes in proteasome expression and activity during differentiation of neuronal precursor NTera 2 clone D1 cells
    C Wojcik
    Department of Pharmacology, Mount Sinai School of Medicine, New York, NY, USA
    Neurochem Int 34:131-6. 1999
    ..Changes in proteasome activity and composition may contribute to the processes leading to differentiation of human neurons in vitro and to the properties of fully differentiated neurons...
  8. ncbi request reprint Proteasome activator (PA28) subunits, alpha, beta and gamma (Ki antigen) in NT2 neuronal precursor cells and HeLa S3 cells
    C Wojcik
    Department of Pharmacology, Mount Sinai School of Medicine, New York, NY, USA
    Eur J Cell Biol 77:151-60. 1998
    ..PA28gamma complexed with the proteasome may serve a function other than or in addition to activation and may also have a proteasome-independent function...
  9. ncbi request reprint Purification of the eukaryotic 20S proteasome
    S Wilk
    Mount Sinai School of Medicine, New York, New York, USA
    Curr Protoc Protein Sci . 2001
    ..A support protocol details an enzyme assay used in evaluating proteasomal activity. The 20S proteasome is the catalytic core of the major extralysosomal proteolytic system of the cell...
  10. ncbi request reprint Rat kidney glutamyl aminopeptidase (aminopeptidase A): molecular identity and cellular localization
    L Song
    Department of Pharmacology, Mount Sinai School of Medicine, City University of New York, New York 10029
    Am J Physiol 267:F546-57. 1994
    ....
  11. ncbi request reprint Comparison of the effect of calpain inhibitors on two extralysosomal proteinases: the multicatalytic proteinase complex and m-calpain
    M E Figueiredo-Pereira
    Department of Pharmacology, Mount Sinai School of Medicine, CUNY, New York 10029
    J Neurochem 62:1989-94. 1994
    ..Calpeptin may be a better choice for such studies, although its effect on other cysteine or serine proteinases remains to be determined...
  12. ncbi request reprint A new inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (20S proteasome) induces accumulation of ubiquitin-protein conjugates in a neuronal cell
    M E Figueiredo-Pereira
    Department of Pharmacology, Mount Sinai School of Medicine, CUNY, New York 10029
    J Neurochem 63:1578-81. 1994
    ..Furthermore, the inhibitor may help develop a model for the study of neurodegeneration where accumulation of ubiquitin-protein conjugates is commonly detected in abnormal brain inclusions...
  13. ncbi request reprint Pyroglutamyl peptidase II inhibition specifically increases recovery of TRH released from rat brain slices
    J L Charli
    Departamento de Bioquimica, Universidad Nacional Autonoma de Mexico, Cuernavaca Mor
    Neuropeptides 14:191-6. 1989
    ..These data further support the involvement of pyroglutamyl peptidase II in the extracellular inactivation of brain TRH...