Affiliation: Mount Sinai School of Medicine
- HPK1 as a novel target for cancer immunotherapySansana Sawasdikosol
Department of Oncological Sciences, Tisch Cancer Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, Icahn 15 75B, New York, NY 10029, USA
Immunol Res 54:262-5. 2012..Given that HPK1 is not expressed in any major organs, it is less likely that an inhibitor of HPK1 kinase activity would cause any serious side effects...
- Hematopoietic progenitor kinase 1 is a critical component of prostaglandin E2-mediated suppression of the anti-tumor immune responseSaba Alzabin
NYU Cancer Institute, Department of Medicine, New York University School of Medicine, New York, 10016, USA
Cancer Immunol Immunother 59:419-29. 2010..We conclude that PGE(2) utilizes HPK1 to suppress T cell-mediated anti-tumor responses...
- Prostaglandin E2 activates HPK1 kinase activity via a PKA-dependent pathwaySansana Sawasdikosol
New York University School of Medicine, New York University Cancer Institute, New York, New York 10016 6402, USA
J Biol Chem 282:34693-9. 2007..We speculate that this unique signaling pathway enables PGE(2) signals to engage a proven negative regulator of TCR signal transduction pathway and uses it to inhibit T cell activation...
- Detecting tyrosine-phosphorylated proteins by Western blot analysisSansana Sawasdikosol
Mount Sinai School of Medicine, New York, New York, USA
Curr Protoc Immunol . 2010..This unit will describe in detail the steps needed to perform the standard anti-phosphotyrosine western blot analysis...
- Hematopoietic progenitor kinase 1 is a negative regulator of dendritic cell activationSaba Alzabin
Department of Pathology, New York University Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
J Immunol 182:6187-94. 2009..c. Lewis Lung Carcinoma more efficiently than their WT counterpart. Our data reveal a novel role for HPK1 as a negative regulator of DC functions, identifying its potential as a molecular target for DC-based immunotherapy against cancers...