Bernardo Nadal-Ginard

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi [Cardiovascular regenerative medicine at the crossroads. Clinical trials of cellular therapy must now be based on reliable experimental data from animals with characteristics similar to human's]
    Bernardo Nadal-Ginard
    The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Rev Esp Cardiol 59:1175-89. 2006
  2. ncbi Myocyte death and renewal: modern concepts of cardiac cellular homeostasis
    Georgina M Ellison
    Cardiovascular Institute and Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nat Clin Pract Cardiovasc Med 4:S52-9. 2007
  3. pmc Acute beta-adrenergic overload produces myocyte damage through calcium leakage from the ryanodine receptor 2 but spares cardiac stem cells
    Georgina M Ellison
    Zena and Michael A Wiener Cardiovascular Institute and Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 282:11397-409. 2007
  4. ncbi Resident progenitors and bone marrow stem cells in myocardial renewal and repair
    Simon Mendez-Ferrer
    Cardiovascular Institute and Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nat Clin Pract Cardiovasc Med 3:S83-9. 2006
  5. ncbi Resident human cardiac stem cells: role in cardiac cellular homeostasis and potential for myocardial regeneration
    Daniele Torella
    Laboratory of Molecular and Cellular Cardiology, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, Italy
    Nat Clin Pract Cardiovasc Med 3:S8-13. 2006
  6. ncbi Cardiac stem and progenitor cell biology for regenerative medicine
    Daniele Torella
    Division of Cardiology, Magna Graecia University, Catanzaro, Italy
    Trends Cardiovasc Med 15:229-36. 2005
  7. ncbi Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion
    Jan Kajstura
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 96:127-37. 2005
  8. ncbi Adult cardiac stem cells are multipotent and support myocardial regeneration
    Antonio P Beltrami
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Cell 114:763-76. 2003
  9. ncbi Myocyte growth and cardiac repair
    Piero Anversa
    Cardiovascular Research Institute, Department of Medicine, Valhalla, New York 10595, USA
    J Mol Cell Cardiol 34:91-105. 2002
  10. ncbi Primitive cells and tissue regeneration
    Piero Anversa
    Circ Res 92:579-82. 2003

Collaborators

Detail Information

Publications25

  1. ncbi [Cardiovascular regenerative medicine at the crossroads. Clinical trials of cellular therapy must now be based on reliable experimental data from animals with characteristics similar to human's]
    Bernardo Nadal-Ginard
    The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Rev Esp Cardiol 59:1175-89. 2006
    ..Without it, we run the risk of holding back the field for decades, as happened with the first human heart transplants and with trials of gene therapy...
  2. ncbi Myocyte death and renewal: modern concepts of cardiac cellular homeostasis
    Georgina M Ellison
    Cardiovascular Institute and Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nat Clin Pract Cardiovasc Med 4:S52-9. 2007
    ..In this article, we review the developments in cardiac cell biology that might, in our opinion, have a broad impact on cardiovascular medicine...
  3. pmc Acute beta-adrenergic overload produces myocyte damage through calcium leakage from the ryanodine receptor 2 but spares cardiac stem cells
    Georgina M Ellison
    Zena and Michael A Wiener Cardiovascular Institute and Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 282:11397-409. 2007
    ..The latter could contribute to the ability of the myocardium to rapidly recover from acute hyperadrenergic damage...
  4. ncbi Resident progenitors and bone marrow stem cells in myocardial renewal and repair
    Simon Mendez-Ferrer
    Cardiovascular Institute and Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nat Clin Pract Cardiovasc Med 3:S83-9. 2006
    ..Here, we briefly review the use of bone-marrow-derived and cardiac-derived stem/progenitor cells in myocardial regeneration studies and discuss their significance for the future of the field of myocardial regeneration...
  5. ncbi Resident human cardiac stem cells: role in cardiac cellular homeostasis and potential for myocardial regeneration
    Daniele Torella
    Laboratory of Molecular and Cellular Cardiology, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, Italy
    Nat Clin Pract Cardiovasc Med 3:S8-13. 2006
    ....
  6. ncbi Cardiac stem and progenitor cell biology for regenerative medicine
    Daniele Torella
    Division of Cardiology, Magna Graecia University, Catanzaro, Italy
    Trends Cardiovasc Med 15:229-36. 2005
    ..This will enable us to design better protocols for the regeneration of functional contractile mass after myocardial injury...
  7. ncbi Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion
    Jan Kajstura
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 96:127-37. 2005
    ..In conclusion, BMCs adopt the cardiac cell lineages and have an important therapeutic impact on ischemic heart failure...
  8. ncbi Adult cardiac stem cells are multipotent and support myocardial regeneration
    Antonio P Beltrami
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Cell 114:763-76. 2003
    ..The existence of these cells opens new opportunities for myocardial repair...
  9. ncbi Myocyte growth and cardiac repair
    Piero Anversa
    Cardiovascular Research Institute, Department of Medicine, Valhalla, New York 10595, USA
    J Mol Cell Cardiol 34:91-105. 2002
    ..Methodologies are currently available to recognize and measure quantitatively the contribution of myocyte size, number and death to the adaptation of the overloaded heart and its progression to cardiac failure...
  10. ncbi Primitive cells and tissue regeneration
    Piero Anversa
    Circ Res 92:579-82. 2003
  11. ncbi Myocyte renewal and ventricular remodelling
    Piero Anversa
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Nature 415:240-3. 2002
    ....
  12. ncbi Growth-factor-mediated cardiac stem cell activation in myocardial regeneration
    Daniele Torella
    Magna Graecia University, Catanzaro, Italy
    Nat Clin Pract Cardiovasc Med 4:S46-51. 2007
    ..Here, we discuss the properties of endogenous myocardial stem cells that might be exploited to produce clinical myocardial regeneration without the need for cell transplantation...
  13. ncbi Myocardial cell therapy at the crossroads
    Bernardo Nadal-Ginard
    Nat Clin Pract Cardiovasc Med 4:1. 2007
  14. ncbi Bone marrow cells have a potent anti-ischemic effect against myocardial cell death in humans
    Chandrashekhar Kubal
    Department of Cardiovascular Sciences, Cardiac Surgery Unit, The Glenfield Hospital, University of Leicester, Leicester, United Kingdom
    J Thorac Cardiovasc Surg 132:1112-8. 2006
    ..We sought to elucidate whether bone marrow cells ameliorate the outcomes of myocardial ischemia by reduction of cell death and to investigate whether the benefit is mediated by activation of intracellular kinases...
  15. pmc bcl-2 overexpression promotes myocyte proliferation
    Federica Limana
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 99:6257-62. 2002
    ..Taken together, these observations reveal a previously uncharacterized replication-enhancing function of Bcl-2 in myocytes in vivo in the absence of stressful conditions...
  16. ncbi Chimera or not chimera?
    Bernardo Nadal-Ginard
    Circ Res 90:E72. 2002
  17. ncbi Cardiac chimerism: methods matter
    Piero Anversa
    Circulation 106:e129-31; author reply e129-31. 2002
  18. ncbi Cardiac stem cells and myocardial regeneration
    Bernardo Nadal-Ginard
    Department of Medicine, Cardiovascular Research Institute, Vosburgh Pavilion, New York Medical College, Valhalla, NY 10595, USA
    Novartis Found Symp 265:142-54; discussion 155-7, 204-11. 2005
    ..Thus, although in the adult heart most cardiac myocytes are permanently withdrawn from the cell cycle, the heart has an intrinsic regenerative potential and it is not a terminally differentiated organ...
  19. pmc Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation
    Annarosa Leri
    Department of Medicine, Cardiovascular Research Institute, New York Medical College, Valhalla, NY 10595, USA
    EMBO J 22:131-9. 2003
    ..Telomere shortening with age could also contribute to cardiac failure in humans, opening the possibility for new therapies...
  20. ncbi Myocyte growth in the failing heart
    Jan Kajstura
    New York Medical College, Valhalla, NY 10595, USA
    Surg Clin North Am 84:161-77. 2004
    ..The recognition that myocyte hypertrophy and regeneration, as well as myocyte necrosis and apoptosis, occur in cardiac diseases has contributed to enhancing our understanding of the plasticity of the human heart...
  21. ncbi Myocyte death, growth, and regeneration in cardiac hypertrophy and failure
    Bernardo Nadal-Ginard
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 92:139-50. 2003
    ..The possibility of reconstituting dead myocardium by stem-like cells is advanced and proposed as a major area of future research...
  22. ncbi Senescence and death of primitive cells and myocytes lead to premature cardiac aging and heart failure
    Cristina Chimenti
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Vosburgh Pavilion, Room 302, Valhalla, NY 10595, USA
    Circ Res 93:604-13. 2003
    ..In conclusion, telomere erosion, cellular senescence, and death characterize aged diseased hearts and the development of cardiac failure in humans...
  23. pmc Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy
    Konrad Urbanek
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 100:10440-5. 2003
    ..Their presence is consistent with the notion that myocyte hyperplasia significantly contributes to cardiac hypertrophy and accounts for the subpopulation of cycling myocytes...
  24. pmc A matter of life and death: cardiac myocyte apoptosis and regeneration
    Bernardo Nadal-Ginard
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    J Clin Invest 111:1457-9. 2003
  25. ncbi Chimerism of the transplanted heart
    Federico Quaini
    Department of Medicine, New York Medical College, Valhalla 10595, USA
    N Engl J Med 346:5-15. 2002
    ..The Y chromosome can be used to detect migrated undifferentiated cells expressing stem-cell antigens and to discriminate between primitive cells derived from the recipient and those derived from the donor...