Willem J M Mulder

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi request reprint Magnetic resonance molecular imaging contrast agents and their application in atherosclerosis
    Willem J M Mulder
    Sinai Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, New York, NY 10029, USA
    Top Magn Reson Imaging 18:409-17. 2007
  2. pmc Nanoparticulate assemblies of amphiphiles and diagnostically active materials for multimodality imaging
    Willem J M Mulder
    Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    Acc Chem Res 42:904-14. 2009
  3. doi request reprint Molecular imaging of tumor angiogenesis using alphavbeta3-integrin targeted multimodal quantum dots
    Willem J M Mulder
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Angiogenesis 12:17-24. 2009
  4. doi request reprint Multimodality nanotracers for cardiovascular applications
    Willem J M Mulder
    Sinai Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Nat Clin Pract Cardiovasc Med 5:S103-11. 2008
  5. ncbi request reprint Magnetic and fluorescent nanoparticles for multimodality imaging
    Willem J M Mulder
    Mount Sinai School of Medicine, Imaging Science Laboratories, Department of Radiology, New York, NY 10029, USA
    Nanomedicine (Lond) 2:307-24. 2007
  6. pmc Quantum dots for multimodal molecular imaging of angiogenesis
    Willem J M Mulder
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York, NY 10029, USA
    Angiogenesis 13:131-4. 2010
  7. pmc RGD peptide functionalized and reconstituted high-density lipoprotein nanoparticles as a versatile and multimodal tumor targeting molecular imaging probe
    Wei Chen
    Translational and Molecular Imaging Institute, Department of Radiology and Medicine, Mt Sinai School of Medicine, New York, NY 10029, USA
    FASEB J 24:1689-99. 2010
  8. pmc Annexin A5-functionalized bimodal nanoparticles for MRI and fluorescence imaging of atherosclerotic plaques
    Geralda A F van Tilborg
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Bioconjug Chem 21:1794-803. 2010
  9. pmc Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes
    Karen C Briley-Saebo
    Imaging Science Laboratory, Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Circulation 117:3206-15. 2008
  10. pmc Improved magnetic resonance molecular imaging of tumor angiogenesis by avidin-induced clearance of nonbound bimodal liposomes
    Geralda A F van Tilborg
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Neoplasia 10:1459-69. 2008

Detail Information

Publications75

  1. ncbi request reprint Magnetic resonance molecular imaging contrast agents and their application in atherosclerosis
    Willem J M Mulder
    Sinai Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, New York, NY 10029, USA
    Top Magn Reson Imaging 18:409-17. 2007
    ..Subsequent to the discussion of the above topics, we will describe some examples of molecular imaging agents that successfully detect specific markers in atherosclerotic plaques that are of interest in several stages of this disease...
  2. pmc Nanoparticulate assemblies of amphiphiles and diagnostically active materials for multimodality imaging
    Willem J M Mulder
    Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    Acc Chem Res 42:904-14. 2009
    ....
  3. doi request reprint Molecular imaging of tumor angiogenesis using alphavbeta3-integrin targeted multimodal quantum dots
    Willem J M Mulder
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Angiogenesis 12:17-24. 2009
    ..Furthermore, the current technology might be developed for molecular imaging of other pathophysiological processes...
  4. doi request reprint Multimodality nanotracers for cardiovascular applications
    Willem J M Mulder
    Sinai Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Nat Clin Pract Cardiovasc Med 5:S103-11. 2008
    ..Lastly, several examples of cardiovascular applications are discussed, including combined imaging and therapy approaches...
  5. ncbi request reprint Magnetic and fluorescent nanoparticles for multimodality imaging
    Willem J M Mulder
    Mount Sinai School of Medicine, Imaging Science Laboratories, Department of Radiology, New York, NY 10029, USA
    Nanomedicine (Lond) 2:307-24. 2007
    ..This review gives a survey of the different types of fluorescent and magnetic nanoparticles that have been employed for both magnetic resonance and optical imaging studies...
  6. pmc Quantum dots for multimodal molecular imaging of angiogenesis
    Willem J M Mulder
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York, NY 10029, USA
    Angiogenesis 13:131-4. 2010
    ..In the current mini-review we summarize the synthesis procedure, the in vitro testing and, importantly, the in vivo application for multimodal molecular imaging of tumor angiogenesis...
  7. pmc RGD peptide functionalized and reconstituted high-density lipoprotein nanoparticles as a versatile and multimodal tumor targeting molecular imaging probe
    Wei Chen
    Translational and Molecular Imaging Institute, Department of Radiology and Medicine, Mt Sinai School of Medicine, New York, NY 10029, USA
    FASEB J 24:1689-99. 2010
    ..This study demonstrates the ability to reroute HDL from its natural targets to tumor blood vessels and its potential for multimodal imaging of tumor-associated processes...
  8. pmc Annexin A5-functionalized bimodal nanoparticles for MRI and fluorescence imaging of atherosclerotic plaques
    Geralda A F van Tilborg
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Bioconjug Chem 21:1794-803. 2010
    ....
  9. pmc Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes
    Karen C Briley-Saebo
    Imaging Science Laboratory, Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Circulation 117:3206-15. 2008
    ....
  10. pmc Improved magnetic resonance molecular imaging of tumor angiogenesis by avidin-induced clearance of nonbound bimodal liposomes
    Geralda A F van Tilborg
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Neoplasia 10:1459-69. 2008
    ....
  11. doi request reprint Incorporation of an apoE-derived lipopeptide in high-density lipoprotein MRI contrast agents for enhanced imaging of macrophages in atherosclerosis
    Wei Chen
    Translational and Molecular Imaging Institute, Imaging Science Laboratories, Departments of Radiology and Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Contrast Media Mol Imaging 3:233-42. 2008
    ..The results of the current study confirm the hypothesis that intraplaque macrophage uptake of rHDL may be enhanced by the incorporation of the P2fA2 peptide into the modified HDL particle...
  12. doi request reprint Synergistic targeting of alphavbeta3 integrin and galectin-1 with heteromultivalent paramagnetic liposomes for combined MR imaging and treatment of angiogenesis
    Ewelina Kluza
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Nano Lett 10:52-8. 2010
    ..We show in vitro, using optical techniques and MRI, that the dual-targeting approach produces synergistic targeting effects, causing a dramatically elevated uptake of nanoparticles as compared to single ligand targeting...
  13. ncbi request reprint Molecular imaging of macrophages in atherosclerotic plaques using bimodal PEG-micelles
    Willem J M Mulder
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Magn Reson Med 58:1164-70. 2007
    ..In conclusion, this study demonstrates that macrophages in apoE-KO mice can be effectively and specifically detected by molecular MRI and optical methods upon administration of a pegylated micellar CA...
  14. pmc Comparison of synthetic high density lipoprotein (HDL) contrast agents for MR imaging of atherosclerosis
    David P Cormode
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Bioconjug Chem 20:937-43. 2009
    ..The half-lives of 37pA-Gd and 18A-Gd are 2.6 and 2.1 h, respectively. Despite the more favorable lipid interactions of 37pA, both agents gave similar, excellent contrast for the detection of atherosclerotic macrophages using MRI...
  15. pmc Collagen-specific peptide conjugated HDL nanoparticles as MRI contrast agent to evaluate compositional changes in atherosclerotic plaque regression
    Wei Chen
    Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA
    JACC Cardiovasc Imaging 6:373-84. 2013
    ..This study sought to develop magnetic resonance contrast agents based on high-density lipoprotein (HDL) nanoparticles to noninvasively visualize intraplaque macrophages and collagen content in mouse atherosclerotic plaques...
  16. pmc Tumor angiogenesis phenotyping by nanoparticle-facilitated magnetic resonance and near-infrared fluorescence molecular imaging
    Peter A Jarzyna
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neoplasia 14:964-73. 2012
    ..NIRF imaging revealed significant differences in accumulation kinetics between the models. In conclusion, this technology can serve as an in vivo biomarker for antiangiogenesis treatment and angiogenesis phenotyping...
  17. ncbi request reprint MR molecular imaging and fluorescence microscopy for identification of activated tumor endothelium using a bimodal lipidic nanoparticle
    Willem J M Mulder
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, MB Eindhoven, The Netherlands
    FASEB J 19:2008-10. 2005
    ....
  18. doi request reprint Kinetics of avidin-induced clearance of biotinylated bimodal liposomes for improved MR molecular imaging
    Geralda A F van Tilborg
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Netherlands
    Magn Reson Med 60:1444-56. 2008
    ..The ability to rapidly clear circulating contrast agents opens up exciting possibilities to study targeting kinetics, to increase the specificity of molecular MRI and to optimize nanoparticulate contrast agent formulations...
  19. ncbi request reprint Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe
    Willem J M Mulder
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands
    Nano Lett 6:1-6. 2006
    ..The bimodal character, the high relaxivity, and the specificity of this nanoparticulate probe make it an excellent contrast agent for molecular imaging purposes...
  20. pmc A versatile and tunable coating strategy allows control of nanocrystal delivery to cell types in the liver
    David P Cormode
    Translational and Molecular Imaging Institute, New York, USA
    Bioconjug Chem 22:353-61. 2011
    ....
  21. pmc Paramagnetic and fluorescent liposomes for target-specific imaging and therapy of tumor angiogenesis
    Gustav J Strijkers
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
    Angiogenesis 13:161-73. 2010
    ..Interestingly, liposomes can be designed to contain angiostatic therapeutics, allowing for image-supervised drug delivery and subsequent monitoring of therapeutic efficacy...
  22. pmc Iron oxide core oil-in-water emulsions as a multifunctional nanoparticle platform for tumor targeting and imaging
    Peter A Jarzyna
    Translational and Molecular Imaging Institute, Department of Radiology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York, NY 10029, USA
    Biomaterials 30:6947-54. 2009
    ..The accumulation of this novel nanocomposite in subcutaneous human tumors in nude mice was demonstrated with MRI and fluorescence imaging in vivo, and with Perl's staining of histological tumor sections ex vivo...
  23. pmc Atherosclerotic plaque composition: analysis with multicolor CT and targeted gold nanoparticles
    David P Cormode
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Radiology 256:774-82. 2010
    ....
  24. pmc The biological properties of iron oxide core high-density lipoprotein in experimental atherosclerosis
    Torjus Skajaa
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave, L Levy Place, Box 1234, New York, NY 10029, USA
    Biomaterials 32:206-13. 2011
    ..Moreover, we were able to qualitatively assess nanoparticle excretion, critical for translating nanotechnologies to the clinic...
  25. pmc Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform
    Anita Gianella
    Translational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    Chem Commun (Camb) 49:9392-4. 2013
    ..The concept was evaluated in vitro using biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles. ..
  26. pmc Multifunctional imaging nanoprobes
    Peter A Jarzyna
    Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, New York, NY, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 2:138-50. 2010
    ..Moreover, it will be demonstrated how multimodality imaging approaches improve our understanding of in vivo nanoparticle behavior and efficacy at different levels, ranging from the subcellular level to the whole body...
  27. pmc Multimodal clinical imaging to longitudinally assess a nanomedical anti-inflammatory treatment in experimental atherosclerosis
    Mark E Lobatto
    Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, United States
    Mol Pharm 7:2020-9. 2010
    ..Importantly, we demonstrate unprecedented rapid anti-inflammatory effects in atherosclerotic lesions after the nanomedical therapy...
  28. pmc In vivo characterization of a new abdominal aortic aneurysm mouse model with conventional and molecular magnetic resonance imaging
    Ahmed Klink
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, 1428 Madison Avenue, New York, NY 10029, USA
    J Am Coll Cardiol 58:2522-30. 2011
    ..The goal of this study was to use noninvasive conventional and molecular magnetic resonance imaging (MRI) to detect and characterize abdominal aortic aneurysms (AAAs) in vivo...
  29. pmc Multifunctional nanoemulsion platform for imaging guided therapy evaluated in experimental cancer
    Anita Gianella
    Translational and Molecular Imaging Institute, Department of Radiology, Mount Sinai School of Medicine, New York, New York 10029, United States
    ACS Nano 5:4422-33. 2011
    ..This study demonstrated that our nanoemulsions, when loaded with PAV, iron oxide nanocrystals, and Cy7, represent a flexible and unique theranostic nanoparticle platform that can be applied for imaging guided therapy of cancer...
  30. pmc Gold nanocrystal labeling allows low-density lipoprotein imaging from the subcellular to macroscopic level
    Iris E Allijn
    Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States
    ACS Nano 7:9761-70. 2013
    ..Cellular localization was studied with transmission electron microscopy and fluorescence techniques. This LDL labeling procedure should permit the study of lipoprotein biointeractions in unprecedented detail. ..
  31. pmc High-density lipoprotein-based contrast agents for multimodal imaging of atherosclerosis
    Torjus Skajaa
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Arterioscler Thromb Vasc Biol 30:169-76. 2010
    ..By rerouting of HDL away from plaque macrophages, imaging of biological processes in diseases besides atherosclerosis may also be achieved...
  32. ncbi request reprint Liposome-enhanced MRI of neointimal lesions in the ApoE-KO mouse
    Willem J M Mulder
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Magn Reson Med 55:1170-4. 2006
    ..This study demonstrates that intimal thickening in ApoE-KO mice can be effectively detected by contrast-enhanced (CE)-MRI upon injection of paramagnetic liposomes...
  33. ncbi request reprint Annexin A5-conjugated quantum dots with a paramagnetic lipidic coating for the multimodal detection of apoptotic cells
    Geralda A F van Tilborg
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, 5600 MB Eindhoven, The Netherlands
    Bioconjug Chem 17:865-8. 2006
    ....
  34. pmc Well-defined, multifunctional nanostructures of a paramagnetic lipid and a lipopeptide for macrophage imaging
    Esad Vucic
    Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Am Chem Soc 131:406-7. 2009
    ....
  35. ncbi request reprint Early in vivo assessment of angiostatic therapy efficacy by molecular MRI
    Willem J M Mulder
    Biomedical NMR, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
    FASEB J 21:378-83. 2007
    ..In conclusion, this study provides evidence that molecular MRI can be used to noninvasively measure the efficacy of angiogenesis inhibitors during the course of therapy...
  36. pmc Pharmaceutical development and preclinical evaluation of a GMP-grade anti-inflammatory nanotherapy
    Mark E Lobatto
    Translational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, NY, NY, United States Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Nanomedicine 11:1133-40. 2015
    ..The present program led to institutional review board approval for two clinical trials with patients with atherosclerosis...
  37. pmc Synthesis of polymer-lipid nanoparticles for image-guided delivery of dual modality therapy
    Aneta J Mieszawska
    Translational and Molecular Imaging Institute and Imaging Science Laboratories and Zena and Michael and Michael A Wiener Cardiovascular Institute and Marie Josée and Henry R Kravis Center for Cardiovascular Health, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, New York 10029, United States
    Bioconjug Chem 24:1429-34. 2013
    ..In tumor bearing mice intravenously administered NPs were found to accumulate at the tumor site by fluorescence imaging. ..
  38. pmc Nanocrystal core high-density lipoproteins: a multimodality contrast agent platform
    David P Cormode
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York, New York 10029, USA
    Nano Lett 8:3715-23. 2008
    ..By including additional labels in the corona of the particles, they were made multifunctional. The characteristics of these nanoparticles, as well as their in vitro and in vivo behavior, revealed that they closely mimic native HDL...
  39. ncbi request reprint Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging
    Willem J M Mulder
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, 5600 MB Eindhoven, The Netherlands
    NMR Biomed 19:142-64. 2006
    ..The mechanisms of particle formation, conjugation strategies and applications in the field of contrast-enhanced, cellular and molecular MRI are discussed...
  40. pmc High-relaxivity gadolinium-modified high-density lipoproteins as magnetic resonance imaging contrast agents
    Karen C Briley-Saebo
    Molecular and Translational Imaging Institute, Mount Sinai School of Medicine, One Gustave Levy Place, P O Box 1234, New York, New York, USA
    J Phys Chem B 113:6283-9. 2009
    ..The high relaxivity of q = 2 HDL means it will be an efficacious contrast agent for future MR imaging studies...
  41. doi request reprint Cellular compartmentalization of internalized paramagnetic liposomes strongly influences both T1 and T2 relaxivity
    Maarten B Kok
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Magn Reson Med 61:1022-32. 2009
    ..This targeting strategy, however, strongly influenced both the longitudinal and transverse relaxivity of the internalized paramagnetic liposomes...
  42. pmc Nanoreporter PET predicts the efficacy of anti-cancer nanotherapy
    Carlos Pérez-Medina
    Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA
    Nat Commun 7:11838. 2016
    ..This non-invasive imaging tool may be developed into a robust inclusion criterion for patients amenable to nanotherapy. ..
  43. doi request reprint Contrast enhancement by differently sized paramagnetic MRI contrast agents in mice with two phenotypes of atherosclerotic plaque
    Glenda S van Bochove
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands
    Contrast Media Mol Imaging 6:35-45. 2011
    ..Low molecular weight compounds may be employed for target-specific imaging of highly abundant extravascular plaque-associated targets...
  44. doi request reprint An ApoA-I mimetic peptide high-density-lipoprotein-based MRI contrast agent for atherosclerotic plaque composition detection
    David P Cormode
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place Box 1234, New York, NY 10029, USA
    Small 4:1437-44. 2008
    ..Confirmation of the targeting of this nanoparticulate agent is achieved using confocal microscopy by tracking a fluorescent lipid incorporated into the nanoparticle...
  45. pmc Magnetic resonance molecular imaging of thrombosis in an arachidonic acid mouse model using an activated platelet targeted probe
    Ahmed Klink
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, Atran BM 24, Box 1234, One Gustave L Levy Place, New York, NY 10029, USA
    Arterioscler Thromb Vasc Biol 30:403-10. 2010
    ..We sought to determine whether the noninvasive in vivo visualization of activated platelets was effective when using a target-specific MRI contrast agent to identify thrombi, hallmarks of vulnerable or high-risk atherosclerotic plaques...
  46. pmc Modified natural nanoparticles as contrast agents for medical imaging
    David P Cormode
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Adv Drug Deliv Rev 62:329-38. 2010
    ..In this review, we discuss the various modified natural nanoparticles that have been exploited as contrast agents...
  47. pmc PET Imaging of Tumor-Associated Macrophages with 89Zr-Labeled High-Density Lipoprotein Nanoparticles
    Carlos Pérez-Medina
    Centro de Investigación en Red de Enfermedades Respiratorias, CibeRes, Madrid, Spain Centro Nacional de Investigaciones Cardiovasculares, CNIC, Madrid, Spain Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York
    J Nucl Med 56:1272-7. 2015
    ..Here, we describe the development of reconstituted high-density lipoprotein (rHDL)-facilitated TAM PET imaging in a breast cancer model...
  48. pmc Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging
    Aneta J Mieszawska
    Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
    Chem Commun (Camb) 48:5835-7. 2012
    ..The PLGA nanoparticles formed from modified PLGA polymers that were functionalized with either gold nanocrystals or quantum dots exhibited favorable features for computed tomography and optical imaging, respectively...
  49. pmc Imaging the efficacy of anti-inflammatory liposomes in a rabbit model of atherosclerosis by non-invasive imaging
    Mark E Lobatto
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, USA
    Methods Enzymol 508:211-28. 2012
    ....
  50. ncbi request reprint A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets
    Willem J M Mulder
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, 5600 MB, The Netherlands
    Bioconjug Chem 15:799-806. 2004
    ..This study suggests that this newly developed system may serve as a useful diagnostic tool to investigate pathological processes in vivo with MRI...
  51. doi request reprint Diagnostic and therapeutic strategies for small abdominal aortic aneurysms
    Ahmed Klink
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, 1428 Madison Avenue, New York, NY 10029, USA
    Nat Rev Cardiol 8:338-47. 2011
    ..We also describe the diagnostic potential of new imaging techniques and therapeutic potential of new treatments for the management of small AAA...
  52. ncbi request reprint Annexin A5-functionalized bimodal lipid-based contrast agents for the detection of apoptosis
    Geralda A F van Tilborg
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, 5600 MB Eindhoven, The Netherlands
    Bioconjug Chem 17:741-9. 2006
    ..The targeted nanoparticles presented in this study, which differ both in size and in magnetic properties, may have applications for the in vivo detection of apoptosis...
  53. pmc Nanotechnology in medical imaging: probe design and applications
    David P Cormode
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York, NY 10029, USA
    Arterioscler Thromb Vasc Biol 29:992-1000. 2009
    ..In this review we discuss the different factors that are considered when designing a nanoparticle probe and highlight some of the most advanced examples...
  54. pmc Immune cell screening of a nanoparticle library improves atherosclerosis therapy
    Jun Tang
    Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029
    Proc Natl Acad Sci U S A 113:E6731-E6740. 2016
    ..Screening the immune cell specificity of nanoparticles can be used to develop tailored therapies for atherosclerosis and other inflammatory diseases...
  55. doi request reprint In Vivo PET Imaging of HDL in Multiple Atherosclerosis Models
    Carlos Pérez-Medina
    Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York
    JACC Cardiovasc Imaging 9:950-61. 2016
    ....
  56. doi request reprint Real-Time Monitoring of Nanoparticle Formation by FRET Imaging
    Brenda L Sanchez-Gaytan
    Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA
    Angew Chem Int Ed Engl . 2017
    ....
  57. pmc Three-dimensional dynamic contrast-enhanced MRI for the accurate, extensive quantification of microvascular permeability in atherosclerotic plaques
    Claudia Calcagno
    Department of Radiology, Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    NMR Biomed 28:1304-14. 2015
    ..We foresee that this approach may allow for the comprehensive and accurate evaluation of plaque permeability in patients, and may be a useful tool to assess the therapeutic response to approved and novel drugs for cardiovascular disease...
  58. pmc Multifunctional gold nanoparticles for diagnosis and therapy of disease
    Aneta J Mieszawska
    Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
    Mol Pharm 10:831-47. 2013
    ..This review covers basic principles and recent findings in gold nanoparticle applications for imaging, therapy and diagnostics, with a focus on reports of multifunctional AuNPs...
  59. pmc Perspectives and opportunities for nanomedicine in the management of atherosclerosis
    Mark E Lobatto
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York 10029, USA
    Nat Rev Drug Discov 10:835-52. 2011
    ..This Review elaborates on nanoparticle-targeting concepts in atherosclerotic disease, provides an overview of the use of nanomedicine in atherosclerosis, and discusses potential future applications and clinical benefits...
  60. pmc Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy
    Yiming Zhao
    Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA
    Nat Commun 7:11221. 2016
    ..Our results help elucidate nanomedicines' in vivo fate and provide guidelines for efficient drug delivery. ..
  61. pmc Imaging Macrophage and Hematopoietic Progenitor Proliferation in Atherosclerosis
    Yu Xiang Ye
    From the Center for Systems Biology, Department of Radiology Y X Y, G C, E J K, G R W, Y I, R W, F K S, M N and Division of Cardiology A T, Massachusetts General Hospital and Harvard Medical School, Boston Translational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY C C, J T, C P M, V M, S I, Z A F, W J M M Department of Clinical Physiology, Nuclear Medicine and PET and Cluster for Molecular Imaging T B, C B J, A K and Departments of Clinical Endocrinology PE and Surgery C U K, Rigshospitalet, National University Hospital and University of Copenhagen, Copenhagen, Denmark Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA P L, M F D C Department of Systems Biology, Harvard Medical School, Boston, MA R W Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Department of Internal Medicine
    Circ Res 117:835-45. 2015
    ..Local plaque macrophage proliferation and monocyte production in hematopoietic organs promote progression of atherosclerosis. Therefore, noninvasive imaging of proliferation could serve as a biomarker and monitor therapeutic intervention...
  62. pmc Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging
    Mark E Lobatto
    Translational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, New York 10029, United States
    ACS Nano 9:1837-47. 2015
    ..These key observations will enable the development of nanotherapeutic strategies for atherosclerosis. ..
  63. doi request reprint Probing lipid coating dynamics of quantum dot core micelles via Förster resonance energy transfer
    Yiming Zhao
    Condensed Matter and Interfaces, Debye Institute, Utrecht University, Princetonplein 5, Utrecht, 3584 CC, The Netherlands Translational and Molecular Imaging Institute, Ichan School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY, 10029, USA
    Small 10:1163-70. 2014
    ..The findings presented here provide basic knowledge on these self-assembled structures and contribute to understanding their performance and to further design of nanomedicine. ..
  64. pmc A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation
    Raphael Duivenvoorden
    1 Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA 2 Department of Vascular Medicine, Academic Medical Center, Amsterdam 1105 AZ, The Netherlands 3
    Nat Commun 5:3065. 2014
    ..Statin-rHDL represents a novel potent atherosclerosis nanotherapy that directly affects plaque inflammation. ..
  65. ncbi request reprint Magnetic resonance imaging of vulnerable atherosclerotic plaques: current imaging strategies and molecular imaging probes
    Karen C Briley-Saebo
    Imaging Science Laboratories, Department of Radiology, Mount Sinai School of Medicine, New York, New York, USA
    J Magn Reson Imaging 26:460-79. 2007
    ..We also discuss molecular imaging strategies that are currently being used to design specific imaging probes targeted to biochemical and cellular markers of atherosclerotic plaque vulnerability...
  66. ncbi request reprint Protein-liposome conjugates using cysteine-lipids and native chemical ligation
    Sanne W A Reulen
    Laboratory of Macromolecular and Organic Chemistry, and Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, and SyMO Chem BV, P O Box 513, 5600 MB Eindhoven, The Netherlands
    Bioconjug Chem 18:590-6. 2007
    ..Our results show that NCL is an attractive addition to existing conjugation methods that allows direct, covalent, and highly specific coupling of recombinant proteins to liposomes and other lipid-based assemblies...
  67. ncbi request reprint MRI contrast agents: current status and future perspectives
    Gustav J Strijkers
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Anticancer Agents Med Chem 7:291-305. 2007
    ..To conclude some future perspectives are discussed...
  68. pmc Nanoparticles as magnetic resonance imaging contrast agents for vascular and cardiac diseases
    Wei Chen
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 3:146-61. 2011
    ..Although clinical application of these nanoparticles is largely unexplored, the potential for enhancing disease diagnosis and treatment is considerable...
  69. pmc Inorganic nanocrystals as contrast agents in MRI: synthesis, coating and introduction of multifunctionality
    David P Cormode
    Radiology Department, University of Pennsylvania, 3400 Spruce Street, 1 Silverstein, Philadelphia, PA 19104, USA
    NMR Biomed 26:766-80. 2013
    ..Therefore, we expect to see reports of preclinical applications of ever more complex MRI-active nanoparticles and their wider exploitation, as well as in novel clinical settings...
  70. doi request reprint Science to practice: versatile method to track transplanted encapsulated islet cells with multiple imaging modalities
    David P Cormode
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234 New York, NY 10029, USA
    Radiology 258:1-2. 2011
    ..Importantly, it was shown that the therapeutic effect of the islets was sustained for more than 50 days when implanted into mice...
  71. pmc A modular labeling strategy for in vivo PET and near-infrared fluorescence imaging of nanoparticle tumor targeting
    Carlos Pérez-Medina
    Centro de Investigación en Red de Enfermedades Respiratorias, Madrid, Spain Centro Nacional de Investigaciones Cardiovasculares, CNIC, Madrid, Spain Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York
    J Nucl Med 55:1706-11. 2014
    ..Capitalizing on recent achievements in this area, we sought to develop an (89)Zr-based labeling strategy for liposomal nanoparticles that accumulate in tumors via passive targeting mechanisms...
  72. pmc Imaging and nanomedicine in inflammatory atherosclerosis
    Willem J M Mulder
    Translational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA Department of Vascular Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Sci Transl Med 6:239sr1. 2014
    ..This review describes how the integration of engineering, nanotechnology, and cardiovascular immunology may yield precision diagnostics and efficient therapeutics for atherosclerosis and its ischemic complications...
  73. pmc Nanomedicine captures cardiovascular disease
    Willem J M Mulder
    Arterioscler Thromb Vasc Biol 28:801-2. 2008