Xiajun Li

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. doi request reprint Genomic imprinting is a parental effect established in mammalian germ cells
    Xiajun Li
    Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, USA
    Curr Top Dev Biol 102:35-59. 2013
  2. pmc A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints
    Xiajun Li
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 15:547-57. 2008
  3. doi request reprint Extending the maternal-zygotic effect with genomic imprinting
    Xiajun Li
    Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Hum Reprod 16:695-703. 2010
  4. pmc Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development
    Yulia Shamis
    Department of Developmental and Regenerative Biology, Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029
    Proc Natl Acad Sci U S A 112:E2020-9. 2015
  5. pmc Zinc finger protein ZFP57 requires its co-factor to recruit DNA methyltransferases and maintains DNA methylation imprint in embryonic stem cells via its transcriptional repression domain
    Xiaopan Zuo
    Black Family Stem Cell Institute, Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 287:2107-18. 2012
  6. pmc Derivation of hybrid ES cell lines from two different strains of mice
    Ho Tak Lau
    Black Family Stem Cell Institute, Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA
    Stem Cell Res 16:252-5. 2016
  7. pmc Differential regulation of genomic imprinting by TET proteins in embryonic stem cells
    Lizhi Liu
    Black Family Stem Cell Institute, Department of Developmental and Regenerative Biology, Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA Black Family Stem Cell Institute, Department of Oncological Sciences, Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA
    Stem Cell Res 15:435-43. 2015
  8. pmc Genomic imprinting defect in Zfp57 mutant iPS cell lines
    Carol M McDonald
    Black Family Stem Cell Institute, Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA
    Stem Cell Res 16:259-63. 2016
  9. pmc Zfp57 mutant ES cell lines directly derived from blastocysts
    Ho Tak Lau
    Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA
    Stem Cell Res 16:282-6. 2016
  10. pmc Genomic imprinting is variably lost during reprogramming of mouse iPS cells
    Sachiko Takikawa
    Black Family Stem Cell Institute, Department of Developmental and Regenerative Biology, Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA
    Stem Cell Res 11:861-73. 2013

Collaborators

Detail Information

Publications12

  1. doi request reprint Genomic imprinting is a parental effect established in mammalian germ cells
    Xiajun Li
    Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, USA
    Curr Top Dev Biol 102:35-59. 2013
    ..In germ cells, around midgestation, the DNA methylation imprint is erased and undergoes another round of the DNA methylation imprint cycle that includes erasure, resetting, restoration, and maintenance of differential DNA methylation...
  2. pmc A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints
    Xiajun Li
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 15:547-57. 2008
    ..The effects on genomic imprinting are consistent with the maternal-zygotic lethality of Zfp57 mutants...
  3. doi request reprint Extending the maternal-zygotic effect with genomic imprinting
    Xiajun Li
    Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Hum Reprod 16:695-703. 2010
    ....
  4. pmc Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development
    Yulia Shamis
    Department of Developmental and Regenerative Biology, Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029
    Proc Natl Acad Sci U S A 112:E2020-9. 2015
    ..This serves as an example of a maternal effect that can influence mammalian organ development. It also links genomic imprinting to NOTCH signaling and particular developmental functions. ..
  5. pmc Zinc finger protein ZFP57 requires its co-factor to recruit DNA methyltransferases and maintains DNA methylation imprint in embryonic stem cells via its transcriptional repression domain
    Xiaopan Zuo
    Black Family Stem Cell Institute, Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 287:2107-18. 2012
    ..These results suggest that ZFP57 may recruit DNA methyltransferases to its target regions to maintain DNA methylation imprint, and this interaction is likely facilitated by KAP1/TRIM28/TIF1β...
  6. pmc Derivation of hybrid ES cell lines from two different strains of mice
    Ho Tak Lau
    Black Family Stem Cell Institute, Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA
    Stem Cell Res 16:252-5. 2016
    ..These hybrid ES clones will be useful for future studies to examine the allelic expression of the imprinted genes in ES cells and their differentiated progeny...
  7. pmc Differential regulation of genomic imprinting by TET proteins in embryonic stem cells
    Lizhi Liu
    Black Family Stem Cell Institute, Department of Developmental and Regenerative Biology, Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA Black Family Stem Cell Institute, Department of Oncological Sciences, Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA
    Stem Cell Res 15:435-43. 2015
    ..Therefore, TET proteins seem to be differentially involved in maintaining DNA methylation imprint at a subset of imprinted regions in ES cells and EBs. ..
  8. pmc Genomic imprinting defect in Zfp57 mutant iPS cell lines
    Carol M McDonald
    Black Family Stem Cell Institute, Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA
    Stem Cell Res 16:259-63. 2016
    ..Intriguingly, DNA methylation imprint was lost at the Peg1 and Peg3 but retained at the Snrpn and Dlk1-Dio3 imprinted regions in the iPS clones without zygotic Zfp57. This finding will be pursued in future studies...
  9. pmc Zfp57 mutant ES cell lines directly derived from blastocysts
    Ho Tak Lau
    Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA
    Stem Cell Res 16:282-6. 2016
    ..This result indicates that these blastocyst-derived Zfp57 mutant ES clones can be employed for functional analyses of Zfp57 in genomic imprinting. ..
  10. pmc Genomic imprinting is variably lost during reprogramming of mouse iPS cells
    Sachiko Takikawa
    Black Family Stem Cell Institute, Department of Developmental and Regenerative Biology, Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA
    Stem Cell Res 11:861-73. 2013
    ....
  11. pmc sel-7, a positive regulator of lin-12 activity, encodes a novel nuclear protein in Caenorhabditis elegans
    Jiabin Chen
    Department of Biochemistry and Molecular Biophysics, Molecular and Biophysical Studies, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Genetics 166:151-60. 2004
    ..8, that also interacts with SEL-8, a known component of the nuclear complex that forms upon LIN-12 activation. Our data suggest potential roles for SEL-7 in the assembly or function of this nuclear complex...
  12. pmc Identifying genes preferentially expressed in undifferentiated embryonic stem cells
    Xiajun Li
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    BMC Cell Biol 8:37. 2007
    ..The mechanism involved in the maintenance and differentiation of embryonic stem (ES) cells is incompletely understood...