Affiliation: Mount Sinai School of Medicine
- Ankyrin binding mediates L1CAM interactions with static components of the cytoskeleton and inhibits retrograde movement of L1CAM on the cell surfaceOrlando D Gil
Dept of Pharmacology and Biological Chemistry, Box 1215, One Gustave L Levy Place, Mt Sinai School of Medicine, New York, NY 10029, USA
J Cell Biol 162:719-30. 2003..Moreover, inhibitors of L1CAM-ankyrin interactions promote L1CAM-mediated axon growth. Together, these results suggest that ankyrin binding plays a crucial role in the anti-coordinate regulation of L1CAM-mediated adhesion and migration...
- Teaching resources. Regulation of complexes by cytoskeletal elements: integrins serve as force transducers linking mechanical stimuli and biochemical signalsDan P Felsenfeld
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
Sci STKE 2005:tr27. 2005..The lecture focuses on the capacity of integrins to serve as mechanotransducers, with particular emphasis on signaling mechanisms downstream of integrins...
- Interactions between the L1 cell adhesion molecule and ezrin support traction-force generation and can be regulated by tyrosine phosphorylationTakeshi Sakurai
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
J Neurosci Res 86:2602-14. 2008..Collectively, these data suggest that L1-ezrin interactions mediated by the L1 juxtamembrane region are involved in traction-force generation and can be regulated by the phosphorylation of L1...
- REGULATION OF NEURONAL MOTILITYDAN FELSENFELD; Fiscal Year: 2005..Moreover, the information that we gain from studying adhesion receptors in neurons is likely to inform our understanding of cell migration in a variety of other systems, ranging from immune system function to tumor cell metastasis. ..