Dara L Dickstein
Affiliation: Mount Sinai School of Medicine
- Altered synaptic structure in the hippocampus in a mouse model of Alzheimer's disease with soluble amyloid-β oligomers and no plaque pathologyKatherine A Price
Fishberg Department of Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L, Levy Place, Box 1639, New York, NY 10029, USA
Mol Neurodegener 9:41. 2014..We performed quantitative analyses of neuronal pathology, including dendrite morphology, spine density, and synapse ultrastructure in individual hippocampal CA1 neurons...
- Dendritic spine changes associated with normal agingD L Dickstein
Fishberg Department of Neuroscience, Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, USA Computational Neurobiology and Imaging Center, Mount Sinai School of Medicine, New York, NY 10029, USA Electronic address
Neuroscience 251:21-32. 2013....
- Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathologySteve Pedrini
Farber Institute for the Neurosciences, Jefferson Medical College, Philadelphia PA USA
Mol Neurodegener 4:40. 2009..The current study examines how dietary composition modulates cerebral amyloidosis and neuronal integrity in the TgCRND8 mouse model of AD...
- Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communicationOzlem Bozdagi
Seaver Autism Center for Research and Treatment, Mount Sinai School of Medicine, New York, NY 10029, USA
Mol Autism 1:15. 2010....
- Role of vascular risk factors and vascular dysfunction in Alzheimer's diseaseDara L Dickstein
Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, NY, USA
Mt Sinai J Med 77:82-102. 2010..Here we discuss vascular factors with respect to Alzheimer's disease and dementia and review the factors that give rise to vascular dysfunction and contribute to Alzheimer's disease...
- Changes in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tauDara L Dickstein
Department of Neuroscience, Mount Sinai School of Medicine, Box 1065, One Gustave L Levy Place, New York, NY, 10029, USA
Brain Struct Funct 214:161-79. 2010..Such alterations in dendrites and spines may result in the deterioration of neuronal function observed in AD, and provide a morphologic substrate for the relationship between synaptic integrity and cognitive decline...
- Changes in the structural complexity of the aged brainDara L Dickstein
Department of Neuroscience, Mount Sinai School of Medicine, New York 10029, USA
Aging Cell 6:275-84. 2007..Together these multiple alterations in the brain may constitute the substrate for age-related loss of cognitive function...
- Age-related vascular pathology in transgenic mice expressing presenilin 1-associated familial Alzheimer's disease mutationsMiguel A Gama Sosa
Research and Development, James J Peters Department of Veterans Affairs Medical Center, Bronx, New York, USA
Am J Pathol 176:353-68. 2010..These studies thus have implications for the role of neuronal to vascular signaling in the pathogenesis of the vascular pathology associated with AD...
- Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer's disease-type neuropathology and cognitive deteriorationLap Ho
Department of Psychiatry, Mount Sinai School of Medicine, NY, USA
J Alzheimers Dis 16:59-72. 2009..Results from these studies suggest the possibility of developing a "combination" of dietary polyphenolic compounds for AD prevention and/or therapy by modulating multiple Abeta-related mechanisms...
- Early fear memory defects are associated with altered synaptic plasticity and molecular architecture in the TgCRND8 Alzheimer's disease mouse modelJohn W Steele
Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY, 10065, USA Fishberg Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA
J Comp Neurol 522:2319-35. 2014..These changes, taken together with toxic insults from amyloid-β protein, may underlie the observed neuronal loss...
- Blast overpressure induces shear-related injuries in the brain of rats exposed to a mild traumatic brain injuryMiguel A Gama Sosa
Department of Veterans Affairs Medical Center, General Medical Research Service, Bronx, New York, USA
Acta Neuropathol Commun 1:51. 2013..However, how blast waves affect the brain is poorly understood. To understand their effects, we analyzed the brains of rats exposed to single or multiple (three) 74.5 kPa blast exposures, conditions that mimic a mild TBI...
- Morphologic evidence for spatially clustered spines in apical dendrites of monkey neocortical pyramidal cellsAniruddha Yadav
Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
J Comp Neurol 520:2888-902. 2012..We also found that mushroom-shaped and stubby spines are predominant in clusters on dendritic segments that display prolific clustering, independently supporting a causal link between spine morphology and synaptic clustering...
- Presenilin transgenic mice as models of Alzheimer's diseaseGregory A Elder
Neurology Service 3E16, James J Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA
Brain Struct Funct 214:127-43. 2010..The relevance of PS transgenic mice as models of AD is discussed...
- The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's diseaseHannah Brautigam
Fishberg Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Mol Neurodegener 7:58. 2012..We investigated whether two APP mouse models characterized by different folding states of amyloid showed different neuronal densities using an accurate method of cell counting...
- Carvedilol as a potential novel agent for the treatment of Alzheimer's diseaseJun Wang
Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
Neurobiol Aging 32:2321.e1-12. 2011..Our novel observation that carvedilol interferes with the neuropathologic, biochemical, and electrophysiological mechanisms underlying cognitive deterioration in AD supports the potential development of carvedilol as a treatment for AD...
- Novel cerebrovascular pathology in mice fed a high cholesterol dietSonia Franciosi
Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Mol Neurodegener 4:42. 2009..Cholesterol is less known for affecting the microvasculature and has not been previously reported to induce microvascular pathology in the central nervous system (CNS)...
- Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1-/- phenotype and forms complexes with wildtype PS1 and nicastrinHannah Brautigam
Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029
Sci Rep 5:17042. 2015..These data support that catalytically inactive PS1(∆exon8) is generated physiologically and participates in protein-protein interactions. ..
- Automatic Dendritic Spine Quantification from Confocal Data with Neurolucida 360Dara L Dickstein
Fishberg Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York
Curr Protoc Neurosci 77:1.27.1-1.27.21. 2016..These protocols will be a valuable reference for scientists working towards quantifying and characterizing spines. © 2016 by John Wiley & Sons, Inc...
- Automated three-dimensional detection and shape classification of dendritic spines from fluorescence microscopy imagesAlfredo Rodriguez
Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America
PLoS ONE 3:e1997. 2008..The technique opens new horizons on the objective evaluation of spine changes with synaptic plasticity, normal development and aging, and with neurodegenerative disorders that impair cognitive function...
- Major Histocompatibility Complex class I proteins are critical for maintaining neuronal structural complexity in the aging brainMaciej J Lazarczyk
Fishberg Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Sci Rep 6:26199. 2016....
- Pepsin pretreatment allows collagen IV immunostaining of blood vessels in adult mouse brainSonia Franciosi
Department of Psychiatry, Box 1230, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
J Neurosci Methods 163:76-82. 2007..This method should be widely applicable for labeling the brain vasculature of the mouse in aldehyde fixed tissue from both normal and pathological states...
- Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's diseaseJun Wang
Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Pl, New York, NY 10029, USA
FASEB J 20:2313-20. 2006....
- Selective vulnerability of the cerebral vasculature to blast injury in a rat model of mild traumatic brain injuryMiguel A Gama Sosa
General Medical Research Service, James J, Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, New York, USA
Acta Neuropathol Commun 2:67. 2014..Rats were sacrificed 24 hours or between 6 and 10 months after exposure. Blast-induced cerebral vascular pathology was examined by a combination of light microscopy, immunohistochemistry, and electron microscopy...
- Abeta peptide immunization restores blood-brain barrier integrity in Alzheimer diseaseDara L Dickstein
Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
FASEB J 20:426-33. 2006..The data therefore provide an intellectual framework for understanding how the immune system can clear amyloid deposits from AD brains and suggest new strategies for limiting disease progression in amyloidopathies...
- Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease modelMaki Ujiie
Biotechnology Laboratory, University of British Columbia, Vancouver V6T 1Z3, Canada
Microcirculation 10:463-70. 2003....
- p97 as a biomarker for Alzheimer diseaseMaki Ujiie
Biotechnology Laboratory and the Biomedical Research Centre Department of Medical Genetics, 2222 Health Sciences Mall, University of British Columbia, Vancouver, BC, V6T 1Z3
Front Biosci 7:e42-7. 2002..The relationship between elevated levels of serum p97 and AD, together with the possible future clinical application of p97 are considered in this report...