Beatrice E Gee
Affiliation: Morehouse School of Medicine
- Elevated circulating angiogenic progenitors and white blood cells are associated with hypoxia-inducible angiogenic growth factors in children with sickle cell diseaseSolomon F Ofori-Acquah
Department of Pediatrics, Division of Hematology Oncology, Emory University School of Medicine, 2015 Uppergate Dr NE, Atlanta, GA 30322, USA
Anemia 2012:156598. 2012..Despite having a higher number of angiogenic progenitor cells, children with Hemoglobin SS had slower migration of cultured mononuclear cells...
- Biologic complexity in sickle cell disease: implications for developing targeted therapeuticsBeatrice E Gee
Department of Pediatrics, Cardiovascular Research Institute, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
ScientificWorldJournal 2013:694146. 2013..The relevance of individual pathways to important sickle cell outcomes needs to be demonstrated in vivo before investing in expensive and labor-intensive clinical trials...
- Plasma BDNF and PDGF-AA levels are associated with high TCD velocity and stroke in children with sickle cell anemiaHyacinth I Hyacinth
Genomics and Hemoglobinopathies Training Program, Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, USA
Cytokine 60:302-8. 2012..Stroke incidence and high TCD velocity were associated with elevated BDNF and PDGF-AA. These findings suggest a role for BDNF and PDGF-AA in the patho-physiological mechanism of cerebrovascular disease in SCA...
- Effect of Chronic Blood Transfusion on Biomarkers of Coagulation Activation and Thrombin Generation in Sickle Cell Patients at Risk for StrokeHyacinth I Hyacinth
Department of Pediatrics Hematology Oncology, Emory University School of Medicine, Atlanta, GA, United States of America Stroke Centre, Department of Neurology, Medical University of South Carolina, Charleston, SC, United States of America
PLoS ONE 10:e0134193. 2015..Reduction in levels of these biomarkers correlated with reduction in stroke risk (lower TCD velocity), indicating a possible role for hypercoagulation in SCD associated stroke...
- Frequent red cell transfusions reduced vascular endothelial activation and thrombogenicity in children with sickle cell anemia and high stroke riskHyacinth I Hyacinth
Stroke Center, Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia
Am J Hematol 89:47-51. 2014..Beyond improving hemoglobin levels, our results suggest that the protective effects of PRBC transfusion on reducing stroke in SCD may result from reduced thrombogenesis and vascular remodeling...
- Proinflammatory cytokines and the hypermetabolism of children with sickle cell diseaseJacqueline M Hibbert
Microbiology Biochemistry Immunology Pediatrics, Morehouse School of Medicine, 720 Westview Drive, S W, Atlanta, Georgia 30310 1495, USA
Exp Biol Med (Maywood) 230:68-74. 2005....
- Plasma interleukin-1beta concentration is associated with stroke in sickle cell diseaseKwaku Asare
Morehouse School of Medicine, Atlanta, GA 30310, USA
Cytokine 49:39-44. 2010..This result demonstrates a strong association of systemic inflammation with stroke development in HbSS via moderately increased plasma IL-1beta concentration, which is furthermore associated with a decreased likelihood of stroke in HbSS...
- Erythropoiesis and myocardial energy requirements contribute to the hypermetabolism of childhood sickle cell anemiaJacqueline M Hibbert
Department of Biochemistry, Morehouse School of Medicine, Atlanta, GA, USA
J Pediatr Gastroenterol Nutr 43:680-7. 2006..We hypothesized that an elevated hemoglobin synthesis rate (SynHb) and myocardial oxygen consumption (MVO2) contribute to the excess protein and energy metabolism reported in children with sickle cell anemia...
- Effect of hydroxyurea on growth in children with sickle cell anemia: results of the HUG-KIDS StudyWinfred C Wang
Hematology Division, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
J Pediatr 140:225-9. 2002..We report the growth characteristics of patients in the Phase I-II pediatric hydroxyurea trial (HUG-KIDS) before and during treatment at the maximum tolerated dose for one year...
- Vascular responses in transgenic sickle cell miceBeatrice Gee; Fiscal Year: 2007..Co-mentors, Drs. Freeman and Townes at Univ. of Alabama, Birmingham, are also experts in their fields. ..