Genomes and Genes
- Steatosis in chronic hepatitis C: relative contributions of obesity, diabetes mellitus, and alcoholAlexander Monto
Department of Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, CA 94121, USA
Hepatology 36:729-36. 2002..Significant alcohol or NASH injury was found in only 6% of biopsy specimens. In conclusion, steatosis in HCV infection is associated with risk factors for NASH, particularly obesity, rather than alcohol consumption...
- Risks of a range of alcohol intake on hepatitis C-related fibrosisAlexander Monto
Department of Gastroenterology, University of California at San Francisco, 4150 Clement Street 111B, San Francisco, CA 94121, USA
Hepatology 39:826-34. 2004..Age, serum ALT, and inflammation are independently associated with fibrosis in multivariate analysis, highlighting the fact that variables other than alcohol intake predominate in the production of hepatic fibrosis...
- Hepatic steatosis in HIV/hepatitis C coinfection: prevalence and significance compared with hepatitis C monoinfectionAlexander Monto
Gastroenterology Section, Veterans Affairs Medical Center, University of California, 4150 Clement Street 111B, San Francisco, CA 94121, USA
Hepatology 42:310-6. 2005..In conclusion, steatosis is less common in HIV/HCV coinfected patients than similar HCV monoinfected patients, and predictors of steatosis differ between the two groups...
- Monocyte activation in HIV/HCV coinfection correlates with cognitive impairmentHans Rempel
Department of Laboratory Medicine, Veterans Affairs Medical Center, San Francisco, California, USA
PLoS ONE 8:e55776. 2013..HIV-suppressed coinfected subjects with controlled HIV viral load experiencing immune activation could benefit significantly from successful anti-HCV therapy and may be considered as preferential candidates...
- Contributions to hepatic fibrosis in HIV-HCV coinfected and HCV monoinfected patientsAlexander Monto
Gastroenterology Section, Veterans Affairs Medical Center, San Francisco, California 94121, USA
Am J Gastroenterol 101:1509-15. 2006..The aim of this study was to further explore the severity of liver disease and its predictors in a cohort of hepatitis C virus (HCV) infected patients, some of whom were coinfected with the human immunodeficiency virus (HIV)...
- Nonresponse to interferon-α based treatment for chronic hepatitis C infection is associated with increased hazard of cirrhosisMyrna L Cozen
Department of Medicine, Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California, USA
PLoS ONE 8:e61568. 2013..The long-term consequences of unsuccessful interferon-α based hepatitis C treatment on liver disease progression and survival have not been fully explored...
- Retreatment of hepatitis C with consensus interferon and ribavirin after nonresponse or relapse to pegylated interferon and ribavirin: a national VA clinical practice studyHelen S Yee
Gastroenterology Section, Department of Veterans Affairs Medical Center VAMC, 4150 Clement Street 111B, San Francisco, CA 94121, USA
Dig Dis Sci 56:2439-48. 2011..As such, CIFN/RBV use and efficacy in clinical practice were evaluated within the Department of Veterans Affairs (VA), the largest national, integrated system for HCV care...
- Lessons from HIV therapy applied to viral hepatitis therapy: summary of a workshopAlexander Monto
Department of Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
Am J Gastroenterol 105:989-1004; quiz 988, 1005. 2010..This article summarizes that conference...
- Expanded use of aggressive therapies improves survival in early and intermediate hepatocellular carcinomaEdith Y Ho
Division of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA
HPB (Oxford) 16:758-67. 2014..Despite the increasing annual incidence of hepatocellular carcinoma (HCC) in the USA, now estimated at 2.7 cases per 100 000 population, only a small proportion of patients receive treatment and 5-year survival rates range from 9% to 17%...
- Non-Markov multistate modeling using time-varying covariates, with application to progression of liver fibrosis due to hepatitis C following liver transplantPeter Bacchetti
University of California, San Francisco, CA, USA
Int J Biostat 6:Article 7. 2010....
- Management and treatment of patients with cirrhosis and portal hypertension: recommendations from the Department of Veterans Affairs Hepatitis C Resource Center Program and the National Hepatitis C ProgramGuadalupe Garcia-Tsao
Department of Veterans Affairs Medical Center, West Haven, Connecticut, USA
Am J Gastroenterol 104:1802-29. 2009..A rational management of cirrhosis will result in improvements in quality of life, treatment adherence, and, ultimately, in outcomes...
- Hepatocellular carcinoma after sustained virologic response in hepatitis C patients without cirrhosis on a pretreatment liver biopsyJustin L Sewell
Gastroenterology Section, University of California San Francisco, San Francisco, California 94143, USA
Eur J Gastroenterol Hepatol 21:225-9. 2009..As fibrosis may advance, and because SVR and lack of cirrhosis do not fully protect against HCC, future study should further evaluate the risk of HCC among hepatitis C patients after sustained virologic response...
- Liver disease in injection drug users with hepatitis C, with and without HIV coinfectionAlexander Monto
San Francisco Veterans Affairs Medical Center, CA, USA
J Addict Dis 27:49-59. 2008..Limiting liver disease progression in IDUs with hepatitis C may well be best accomplished through promoting their full utilization of health care...
- Contrast-enhanced CT quantification of the hepatic fractional extracellular space: correlation with diffuse liver disease severityMaurice H Zissen
1 Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Ave, Box 0628, M 372, San Francisco, CA 94143 0628
AJR Am J Roentgenol 201:1204-10. 2013..The purpose of this study was to determine whether contrast-enhanced CT quantification of the hepatic fractional extracellular space (ECS) correlates with the severity of diffuse liver disease...
- A prospective study to examine persistent HCV reinfection in injection drug users who have previously cleared the virusSue L Currie
Department of Medicine, University of California San Francisco, San Francisco, CA 94121, USA
Drug Alcohol Depend 93:148-54. 2008..Many HCV-infected persons with recent or ongoing injection drug use (IDU) do not receive HCV treatment due to the perceived risk of HCV reinfection. There are few prospective studies investigating HCV reinfection among IDUs...
- Differential cognitive impairment in HCV coinfected men with controlled HIV compared to HCV monoinfectionBing Sun
Department of Laboratory Medicine, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
J Acquir Immune Defic Syndr 62:190-6. 2013....
- Periprocedural complications by Child-Pugh class in patients undergoing transcatheter arterial embolization or chemoembolization to treat unresectable hepatocellular carcinoma at a VA medical centerJeffery S Russell
Department of Medicine, University of California, San Francisco, Medical Center, USA
Am J Surg 200:659-64. 2010..The aim of this study was to compare periprocedural complications in a population with hepatitis C virus-related hepatocellular carcinoma to evaluate for differences in complications by severity of liver disease...
- The human fetal immune response to hepatitis C virus exposure in uteroJennifer M Babik
Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA 94143 1234, USA
J Infect Dis 203:196-206. 2011..Although the rate of mother-to-child transmission of hepatitis C virus (HCV) is low, the effect of HCV exposure in utero on the fetal immune system is unknown...
- Role of retroviral restriction factors in the interferon-α-mediated suppression of HIV-1 in vivoSatish K Pillai
Department of Medicine, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 109:3035-40. 2012....
- Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis CHongjin Huang
Celera Diagnostics, Alameda, California, USA
Gastroenterology 130:1679-87. 2006..The aim of this study was to identify genetic polymorphisms that can predict the risk of advanced fibrosis in patients with CHC...
- Fibrosis progression in chronic hepatitis C patients with occult hepatitis B co-infectionChee Kin Hui
Department of Medicine, The University of Hong Kong, Hong Kong SAR, China
J Clin Virol 35:185-92. 2006..946). In conclusion, chronic HCV patients with occult HBV co-infection does not seem to progress more than patients without occult HBV infection. However, more large-scale studies are needed before a definite conclusion can be obtained...