Neil Dalchau

Summary

Affiliation: Microsoft Research
Country: USA

Publications

  1. pmc Towards the rational design of synthetic cells with prescribed population dynamics
    Neil Dalchau
    Microsoft Research Cambridge, Roger Needham Building, 7 J J Thomson Avenue, Cambridge CB3 0FB, UK
    J R Soc Interface 9:2883-98. 2012
  2. doi request reprint Understanding biological timing using mechanistic and black-box models
    Neil Dalchau
    Microsoft Research, JJ Thomson Ave, Cambridge CB3 0FB, UK
    New Phytol 193:852-8. 2012
  3. pmc A peptide filtering relation quantifies MHC class I peptide optimization
    Neil Dalchau
    Biological Computation Group, Microsoft Research, Cambridge, United Kingdom
    PLoS Comput Biol 7:e1002144. 2011
  4. pmc The circadian oscillator gene GIGANTEA mediates a long-term response of the Arabidopsis thaliana circadian clock to sucrose
    Neil Dalchau
    Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, United Kingdom
    Proc Natl Acad Sci U S A 108:5104-9. 2011
  5. pmc Correct biological timing in Arabidopsis requires multiple light-signaling pathways
    Neil Dalchau
    Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, United Kingdom
    Proc Natl Acad Sci U S A 107:13171-6. 2010
  6. doi request reprint Systems analyses of circadian networks
    Katharine E Hubbard
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge, UK
    Mol Biosyst 5:1502-11. 2009
  7. ncbi request reprint The Arabidopsis circadian clock incorporates a cADPR-based feedback loop
    Antony N Dodd
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UK
    Science 318:1789-92. 2007
  8. pmc Orthogonal intercellular signaling for programmed spatial behavior
    Paul K Grant
    Department of Plant Sciences, University of Cambridge, Cambridge, UK Computational Science Laboratory, Microsoft Research, Cambridge, UK
    Mol Syst Biol 12:849. 2016
  9. pmc Characterization of Intrinsic Properties of Promoters
    Timothy J Rudge
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, United Kingdom
    ACS Synth Biol 5:89-98. 2016
  10. ncbi request reprint Modulation of environmental responses of plants by circadian clocks
    Carlos T Hotta
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge, CB2 3EA, UK
    Plant Cell Environ 30:333-49. 2007

Collaborators

Detail Information

Publications13

  1. pmc Towards the rational design of synthetic cells with prescribed population dynamics
    Neil Dalchau
    Microsoft Research Cambridge, Roger Needham Building, 7 J J Thomson Avenue, Cambridge CB3 0FB, UK
    J R Soc Interface 9:2883-98. 2012
    ..By identifying, integrating and automating key stages of the design process, we provide a computational framework for designing synthetic systems, which could be tested in future laboratory studies...
  2. doi request reprint Understanding biological timing using mechanistic and black-box models
    Neil Dalchau
    Microsoft Research, JJ Thomson Ave, Cambridge CB3 0FB, UK
    New Phytol 193:852-8. 2012
    ..In particular, formal analysis of large datasets with LTI systems can offer genome-scale inferences, which is of timely relevance as novel experimental techniques are generating increasingly large quantities of data...
  3. pmc A peptide filtering relation quantifies MHC class I peptide optimization
    Neil Dalchau
    Biological Computation Group, Microsoft Research, Cambridge, United Kingdom
    PLoS Comput Biol 7:e1002144. 2011
    ..We exemplify this by simulating optimization of the distribution of peptides derived from Human Immunodeficiency Virus Gag-Pol polyprotein...
  4. pmc The circadian oscillator gene GIGANTEA mediates a long-term response of the Arabidopsis thaliana circadian clock to sucrose
    Neil Dalchau
    Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, United Kingdom
    Proc Natl Acad Sci U S A 108:5104-9. 2011
    ..We demonstrate that GI acts as part of the sucrose-signaling network and propose this role permits metabolic input into circadian timing in Arabidopsis...
  5. pmc Correct biological timing in Arabidopsis requires multiple light-signaling pathways
    Neil Dalchau
    Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, United Kingdom
    Proc Natl Acad Sci U S A 107:13171-6. 2010
    ..Our findings uncover a fundamental design principle of circadian regulation, and identify the importance of rapid light-signaling pathways in temporal control...
  6. doi request reprint Systems analyses of circadian networks
    Katharine E Hubbard
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge, UK
    Mol Biosyst 5:1502-11. 2009
    ..We also highlight the need for systems analyses of the circadian regulation of proteins, metabolites and other physiological activities such as ion channel regulation...
  7. ncbi request reprint The Arabidopsis circadian clock incorporates a cADPR-based feedback loop
    Antony N Dodd
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UK
    Science 318:1789-92. 2007
    ..The effects of antagonists of cADPR signaling, manipulation of cADPR synthesis, and mathematical simulation of the interaction of cADPR with the circadian clock indicate that cADPR forms a feedback loop within the plant circadian clock...
  8. pmc Orthogonal intercellular signaling for programmed spatial behavior
    Paul K Grant
    Department of Plant Sciences, University of Cambridge, Cambridge, UK Computational Science Laboratory, Microsoft Research, Cambridge, UK
    Mol Syst Biol 12:849. 2016
    ..This work demonstrates the ability to systematically reduce crosstalk within intercellular signaling systems and to use these systems to engineer complex spatiotemporal patterning in cell populations. ..
  9. pmc Characterization of Intrinsic Properties of Promoters
    Timothy J Rudge
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, United Kingdom
    ACS Synth Biol 5:89-98. 2016
    ..This is a simple and reliable method to quantitatively describe promoter properties. ..
  10. ncbi request reprint Modulation of environmental responses of plants by circadian clocks
    Carlos T Hotta
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge, CB2 3EA, UK
    Plant Cell Environ 30:333-49. 2007
    ..Finally, we describe evidence that the circadian clock can increase plant fitness...
  11. doi request reprint Probabilistic Analysis of Localized DNA Hybridization Circuits
    Neil Dalchau
    Microsoft Research, Cambridge CB1 2FB, United Kingdom
    ACS Synth Biol 4:898-913. 2015
    ..Finally, we use our analysis to identify constraints in the rate parameters that enable localized circuits to retain their advantages in the presence of unintended interferences between strands. ..
  12. pmc Noise Reduction in Complex Biological Switches
    Luca Cardelli
    Microsoft Research, 21 Station Road, CB1 2FB, Cambridge, United Kingdom
    Sci Rep 6:20214. 2016
    ..Intrinsic noise tends to decrease with complexity, and extrinsic noise tends to have less impact. Our findings suggest a new role for increased complexity in biological networks, at parity of function. ..
  13. doi request reprint Disruption of two defensive signaling pathways by a viral RNA silencing suppressor
    Mathew G Lewsey
    Department of Plant Sciences, University of Cambridge, UK
    Mol Plant Microbe Interact 23:835-45. 2010
    ..Like many plant viruses, CMV is aphid transmitted. JA is important in plant defense against insects. This raises the possibility that disruption of JA-mediated gene expression by the 2b protein may influence CMV transmission by aphids...