Patrick J Shaw

Summary

Affiliation: Michigan State University
Country: USA

Publications

  1. ncbi request reprint The role of the hemostatic system in murine liver injury induced by coexposure to lipopolysaccharide and trovafloxacin, a drug with idiosyncratic liability
    Patrick J Shaw
    Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, East Lansing, MI 48824, USA
    Toxicol Appl Pharmacol 236:293-300. 2009
  2. pmc Tumor necrosis factor alpha is a proximal mediator of synergistic hepatotoxicity from trovafloxacin/lipopolysaccharide coexposure
    Patrick J Shaw
    Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA
    J Pharmacol Exp Ther 328:62-8. 2009
  3. pmc Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity
    Patrick J Shaw
    Department of Pharmacology and Toxicology, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 111:288-301. 2009
  4. pmc Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury
    Patrick J Shaw
    Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 107:270-80. 2009
  5. pmc Trovafloxacin enhances the inflammatory response to a Gram-negative or a Gram-positive bacterial stimulus, resulting in neutrophil-dependent liver injury in mice
    Patrick J Shaw
    Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA
    J Pharmacol Exp Ther 330:72-8. 2009
  6. ncbi request reprint Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha
    Patrick J Shaw
    Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 100:259-66. 2007
  7. ncbi request reprint Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine
    James P Luyendyk
    Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, 48824, USA
    J Pharmacol Exp Ther 314:1023-31. 2005

Collaborators

Detail Information

Publications7

  1. ncbi request reprint The role of the hemostatic system in murine liver injury induced by coexposure to lipopolysaccharide and trovafloxacin, a drug with idiosyncratic liability
    Patrick J Shaw
    Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, East Lansing, MI 48824, USA
    Toxicol Appl Pharmacol 236:293-300. 2009
    ..Both thrombin activation and PAI-1 play critical roles in the progression of TVX/LPS-induced liver injury, but through different modes of action...
  2. pmc Tumor necrosis factor alpha is a proximal mediator of synergistic hepatotoxicity from trovafloxacin/lipopolysaccharide coexposure
    Patrick J Shaw
    Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA
    J Pharmacol Exp Ther 328:62-8. 2009
    ..In summary, TNFalpha acts through p55 and p75 receptors to precipitate an innocuous inflammatory cascade. TVX enhances this cascade, converting it into one that results in hepatocellular injury...
  3. pmc Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity
    Patrick J Shaw
    Department of Pharmacology and Toxicology, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 111:288-301. 2009
    ..In summary, TVX reduced the clearance of TNF independent of either receptor shedding or kidney dysfunction. Additionally, TVX interacted with TNF to enhance inflammation and sensitize hepatocytes to TNF-induced cell death...
  4. pmc Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury
    Patrick J Shaw
    Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 107:270-80. 2009
    ..In conclusion, the altered expression of genes involved in IFN signaling in TVX/LPS-treated mice led to the finding that IL-18 and IFN-gamma play a critical role in TVX/LPS-induced liver injury...
  5. pmc Trovafloxacin enhances the inflammatory response to a Gram-negative or a Gram-positive bacterial stimulus, resulting in neutrophil-dependent liver injury in mice
    Patrick J Shaw
    Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA
    J Pharmacol Exp Ther 330:72-8. 2009
    ....
  6. ncbi request reprint Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha
    Patrick J Shaw
    Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 100:259-66. 2007
    ..The results suggest that the model in mice is able to distinguish between drugs with and without the propensity to cause idiosyncratic liver injury and that the hepatotoxicity is dependent on TNFalpha...
  7. ncbi request reprint Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine
    James P Luyendyk
    Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, 48824, USA
    J Pharmacol Exp Ther 314:1023-31. 2005
    ..The results suggest that PMNs are involved in the hepatocellular injury caused by LPS/RAN-cotreatment and that hemostasis increases sensitivity to PMN-induced hepatocellular injury by causing liver hypoxia...