N E Robinson

Summary

Affiliation: Michigan State University
Country: USA

Publications

  1. pmc Genomic analysis establishes correlation between growth and laryngeal neuropathy in Thoroughbreds
    Adam R Boyko
    Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824, USA
    BMC Genomics 15:259. 2014
  2. doi request reprint Fluticasone propionate aerosol is more effective for prevention than treatment of recurrent airway obstruction
    N E Robinson
    Equine Pulmonary Laboratory, Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824, USA
    J Vet Intern Med 23:1247-53. 2009
  3. ncbi request reprint Effect of tracheal mucus and tracheal cytology on racing performance in Thoroughbred racehorses
    S J Holcombe
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824, USA
    Equine Vet J 38:300-4. 2006
  4. ncbi request reprint Stabling is associated with airway inflammation in young Arabian horses
    S J Holcombe
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824-1314, USA
    Equine Vet J 33:244-9. 2001
  5. ncbi request reprint Histological evaluation of the equine larynx after unilateral laser-assisted ventriculocordectomy
    P Robinson
    Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, Michigan 48824, USA
    Equine Vet J 39:222-5. 2007
  6. ncbi request reprint Regional distribution of collagen and haemosiderin in the lungs of horses with exercise-induced pulmonary haemorrhage
    F J Derksen
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824, USA
    Equine Vet J 41:586-91. 2009
  7. ncbi request reprint Efficacy of oral and intravenous dexamethasone in horses with recurrent airway obstruction
    C J Cornelisse
    Pulmonary Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824 1314, USA
    Equine Vet J 36:426-30. 2004
  8. ncbi request reprint Effects of unilateral laser-assisted ventriculocordectomy in horses with laryngeal hemiplegia
    P Robinson
    Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, Michigan 48824
    Equine Vet J 38:491-6. 2006
  9. ncbi request reprint Persistent mucin glycoprotein alterations in equine recurrent airway obstruction
    A M Jefcoat
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824, USA
    Am J Physiol Lung Cell Mol Physiol 281:L704-12. 2001
  10. ncbi request reprint Effect of laryngoplasty on respiratory noise reduction in horses with laryngeal hemiplegia
    J A Brown
    Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, Michigan 48824, USA
    Equine Vet J 36:420-5. 2004

Collaborators

Detail Information

Publications45

  1. pmc Genomic analysis establishes correlation between growth and laryngeal neuropathy in Thoroughbreds
    Adam R Boyko
    Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824, USA
    BMC Genomics 15:259. 2014
    ..To better understand RLN pathogenesis and its genetic basis, we performed a genome-wide association (GWAS) of 282 RLN-affected and 268 control Thoroughbreds...
  2. doi request reprint Fluticasone propionate aerosol is more effective for prevention than treatment of recurrent airway obstruction
    N E Robinson
    Equine Pulmonary Laboratory, Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824, USA
    J Vet Intern Med 23:1247-53. 2009
    ..Efficacy of inhaled fluticasone propionate (FP) for management of recurrent airway obstruction (RAO) has only been evaluated after several weeks' treatment...
  3. ncbi request reprint Effect of tracheal mucus and tracheal cytology on racing performance in Thoroughbred racehorses
    S J Holcombe
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824, USA
    Equine Vet J 38:300-4. 2006
    ..Accumulations of mucus within the trachea are often found during endoscopic examinations of the airways of poorly performing racehorses, but the clinical importance of this finding is unknown...
  4. ncbi request reprint Stabling is associated with airway inflammation in young Arabian horses
    S J Holcombe
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824-1314, USA
    Equine Vet J 33:244-9. 2001
    ..We conclude that stabling is associated with inflammation of both the upper and lower airway of young horses...
  5. ncbi request reprint Histological evaluation of the equine larynx after unilateral laser-assisted ventriculocordectomy
    P Robinson
    Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, Michigan 48824, USA
    Equine Vet J 39:222-5. 2007
    ..However, removal of the vocal fold and ventricle takes considerable laser energy and could cause collateral tissue damage, including injury to the adjacent laryngeal cartilages...
  6. ncbi request reprint Regional distribution of collagen and haemosiderin in the lungs of horses with exercise-induced pulmonary haemorrhage
    F J Derksen
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824, USA
    Equine Vet J 41:586-91. 2009
    ..The current study quantified site-specific changes in vein walls, collagen and haemosiderin accumulation, and pleural vascular profiles in the lungs of horses suffering EIPH...
  7. ncbi request reprint Efficacy of oral and intravenous dexamethasone in horses with recurrent airway obstruction
    C J Cornelisse
    Pulmonary Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824 1314, USA
    Equine Vet J 36:426-30. 2004
    ....
  8. ncbi request reprint Effects of unilateral laser-assisted ventriculocordectomy in horses with laryngeal hemiplegia
    P Robinson
    Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, Michigan 48824
    Equine Vet J 38:491-6. 2006
    ..These techniques require general anaesthesia and are invasive. A minimally invasive transnasal surgical technique for treatment of RLN that may be employed in the standing, sedated horse would be advantageous...
  9. ncbi request reprint Persistent mucin glycoprotein alterations in equine recurrent airway obstruction
    A M Jefcoat
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824, USA
    Am J Physiol Lung Cell Mol Physiol 281:L704-12. 2001
    ..These results indicated that persistent changes in the quantity and/or quality of mucus glycoproteins occurred in the RAO-affected horses...
  10. ncbi request reprint Effect of laryngoplasty on respiratory noise reduction in horses with laryngeal hemiplegia
    J A Brown
    Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, Michigan 48824, USA
    Equine Vet J 36:420-5. 2004
    ..However, there are no quantitative data in the literature describing the effect of laryngoplasty on upper airway noise or its relationship to upper airway mechanics in horses with laryngeal hemiplegia...
  11. ncbi request reprint The effects of a single acupuncture treatment in horses with severe recurrent airway obstruction
    D V Wilson
    Pulmonary Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48823, USA
    Equine Vet J 36:489-94. 2004
    ..Acupuncture may be recommended for horses with 'heaves' because it is being increasingly applied to treat human asthma. Therefore, its efficacy was investigated in horses with this asthma-like disease...
  12. ncbi request reprint Airway inflammation in Michigan pleasure horses: prevalence and risk factors
    N E Robinson
    Department of Large Animal Clinical Sciences, Michigan State University, East Lansing 48824 1314, USA
    Equine Vet J 38:293-9. 2006
    ..Although subclinical airway inflammation is thought to be common in horses, there is little information on its prevalence and none on risk factors...
  13. ncbi request reprint Spectrum analysis of respiratory sounds in exercising horses with experimentally induced laryngeal hemiplegia or dorsal displacement of the soft palate
    F J Derksen
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824, USA
    Am J Vet Res 62:659-64. 2001
    ..If other conditions causing airway obstruction are also associated with unique sound patterns, spectrum analysis of respiratory sounds may prove to be useful in the diagnosis of airway abnormalities in horses...
  14. ncbi request reprint Beta-adrenergic receptor activity in ponies with recurrent obstructive pulmonary disease
    J S Scott
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824 1314
    Am J Vet Res 52:1416-22. 1991
    ....
  15. doi request reprint Local airborne particulate concentration is associated with visible tracheal mucus in Thoroughbred racehorses
    M L Millerick-May
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA
    Equine Vet J 45:85-90. 2013
    ..Accumulations of tracheal mucus assessed by endoscopic examination are associated with poor performance in racehorses. The air quality in horses' stalls may contribute to this visible tracheal mucus...
  16. ncbi request reprint Expression of toll-like receptor 2 mRNA in bronchial epithelial cells is not induced in RAO-affected horses
    A Berndt
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824, USA
    Equine Vet J 41:76-81. 2009
    ..This pathway is negatively regulated by the zinc finger protein A20. This study was performed to enhance understanding of innate immune mechanisms in RAO...
  17. ncbi request reprint Effect of ventriculectomy versus ventriculocordectomy on upper airway noise in draught horses with recurrent laryngeal neuropathy
    P Cramp
    Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, Michigan 48824 1314, USA
    Equine Vet J 41:729-34. 2009
    ..Little is known about the efficacy of bilateral ventriculectomy (VE) or bilateral ventriculocordectomy (VCE) in draught horses...
  18. ncbi request reprint Inhibitory nerve distribution and mediation of NANC relaxation by nitric oxide in horse airways
    M Yu
    Department of Large Animal Clinical Sciences, Michigan State University, East Lansing 48824
    J Appl Physiol (1985) 76:339-44. 1994
    ..These results indicate that: 1) adrenergic innervation is limited to cranial trachealis, 2) iNANC nerves supply the trachea and central bronchi, and 3) NO mediates iNANC function...
  19. ncbi request reprint Pulmonary response to airway instillation of autologous blood in horses
    F J Derksen
    Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, Michigan 48824, USA
    Equine Vet J 39:334-9. 2007
    ..Associated pulmonary lesions include alveolar and airway wall fibrosis, which may enhance the severity of EIPH. Further work is required to understand the pulmonary response to blood in the equine airways...
  20. ncbi request reprint Airway mucus in recurrent airway obstruction--short-term response to environmental challenge
    V Gerber
    Pulmonary Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824 1314, USA
    J Vet Intern Med 18:92-7. 2004
    ..Healthy controls show considerable variability in mucus accumulation but, despite an influx of neutrophils into the airways, no increase of mucus accumulation after exposure to hay dust...
  21. ncbi request reprint Endoscopic scoring of mucus quantity and quality: observer and horse variance and relationship to inflammation, mucus viscoelasticity and volume
    V Gerber
    Pulmonary Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, E Lansing, USA
    Equine Vet J 36:576-82. 2004
    ..Endoscopic scoring of airway mucus quantity and quality has not been critically assessed...
  22. ncbi request reprint Prednisone per os is likely to have limited efficacy in horses
    D L Peroni
    Department of Large Animal Clinical Sciences, Michigan State University, East Lansing 48824, USA
    Equine Vet J 34:283-7. 2002
    ..In contrast, prednisolone tablets have excellent bioavailability and should be useful as a therapeutic agent in horses...
  23. ncbi request reprint Effect of magnitude and direction of force on laryngeal abduction: implications for the nerve-muscle pedicle graft technique
    P Cramp
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824 1314, USA
    Equine Vet J 41:328-33. 2009
    ..The nerve-muscle pedicle graft technique is a treatment for recurrent laryngeal neuropathy (RLN), but the optimal placement of the pedicles within the cricoarytenoideus dorsalis (CAD) muscle is unknown...
  24. ncbi request reprint Airway inflammation and mucus in two age groups of asymptomatic well-performing sport horses
    V Gerber
    Pulmonary Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, USA
    Equine Vet J 35:491-5. 2003
    ..Horses housed in conventional stable environments are exposed to high dust loads. Long-term exposure to inhaled dust may lead to subclinical airway disease...
  25. doi request reprint Regional pulmonary veno-occlusion: a newly identified lesion of equine exercise-induced pulmonary hemorrhage
    K J Williams
    Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Vet Pathol 45:316-26. 2008
    ....
  26. doi request reprint Owner assessment in judging the efficacy of airway disease treatment
    V Gerber
    Department of Large Animal Clinical Sciences, Michigan State University, USA
    Equine Vet J 43:153-8. 2011
    ..These trials are technically challenging and may not adequately reflect the spectrum of disease and owner complaints encountered in clinical practice...
  27. ncbi request reprint Thermographic study of in vivo modulation of vascular responses to phenylephrine and endothelin-1 by dexamethasone in the horse
    C J Cornelisse
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48823 1314, USA
    Equine Vet J 38:119-26. 2006
    ..In vitro, glucocorticoids potentiate vasoconstriction of equine digital vessels to catecholamines and this has been implicated as a mechanism of glucocorticoid-induced laminitis. This observation has never been confirmed in vivo...
  28. ncbi request reprint Efficacy of three corticosteroids for the treatment of heaves
    N E Robinson
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48823, USA
    Equine Vet J 34:17-22. 2002
    ..These results demonstrate that dexamethasone rapidly relieved airway obstruction in heaves-affected horses. Oral prednisone had inconsistent effects but may be beneficial in some horses after more than a week of treatment...
  29. ncbi request reprint Equine multinodular pulmonary fibrosis: a newly recognized herpesvirus-associated fibrotic lung disease
    K J Williams
    College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Vet Pathol 44:849-62. 2007
    ..Further, we propose that this newly described disease develops in association with infection by the equine gamma-herpesvirus, EHV-5...
  30. doi request reprint The effect of intravenous lidocaine infusion on bronchoalveolar lavage cytology in equine recurrent airway obstruction
    M E Wilson
    Equine Pulmonary Laboratory, Large Animal Clinical Sciences, Michigan State University, East Lansing, MI, USA
    J Vet Intern Med 26:1427-32. 2012
    ..Neutrophilic bronchiolitis develops in recurrent airway obstruction (RAO), but it remains unknown if lidocaine infusion decreases neutrophil migration into the airways...
  31. doi request reprint Particle mapping in stables at an American Thoroughbred racetrack
    M L Millerick-May
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Equine Vet J 43:599-607. 2011
    ..The regional and seasonal distribution of particles of different sizes has never been investigated in American racing stables...
  32. doi request reprint Repeated blood instillation into the airway of the horse does not cause pulmonary fibrosis
    K J Williams
    Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, USA
    Equine Vet J 43:354-8. 2011
    ..Recent studies have attempted to identify the role of free blood within the airspaces, in the lung fibrosis that develops within the lungs of EIPH horses...
  33. doi request reprint Custom-designed airway surgery for the horse: a dream that may become reality
    N E Robinson
    Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824, USA
    Equine Vet J 40:195-7. 2008
  34. ncbi request reprint Electromyographic activity of the palatinus and palatopharyngeus muscles in exercising horses
    S J Holcombe
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48624, USA
    Equine Vet J 39:451-5. 2007
    ....
  35. ncbi request reprint Response to nasopharyngeal oxygen administration in horses with lung disease
    D V Wilson
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824 1314, USA
    Equine Vet J 38:219-23. 2006
    ..Guidelines for administration of oxygen to standing horses are unavailable because previous investigations of the efficacy of oxygen administration to increase arterial oxygenation in standing horses have produced equivocal results...
  36. ncbi request reprint Intratracheal clenbuterol in the horse: its pharmacological efficacy and analytical detection
    J D Harkins
    Maxwell H Gluck Equine Research Center and the Department of Veterinary Science, Michigan State University, East Lansing, USA
    J Vet Pharmacol Ther 23:251-60. 2000
    ..Furthermore, concomitant dose of furosemide does not interfere with detection or confirmation of clenbuterol...
  37. ncbi request reprint Airway physiology
    N E Robinson
    Department of Large Animal Clinical Sciences, Michigan State University College of Veterinary Medicine, East Lansing
    Vet Clin North Am Small Anim Pract 22:1043-64. 1992
    ..In the not-too-distant future, measurements of lung function will be used to prove the efficacy of new therapeutic agents for canine and feline airway disease and to guide the clinician in the use of these agents...
  38. doi request reprint Airborne particulates (PM10) and tracheal mucus: A case-control study at an American Thoroughbred racetrack
    M L Millerick-May
    Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, USA
    Equine Vet J 47:410-4. 2015
    ....
  39. ncbi request reprint Ventriculocordectomy reduces respiratory noise in horses with laryngeal hemiplegia
    J A Brown
    Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, Michigan 48824, USA
    Equine Vet J 35:570-4. 2003
    ..Therefore, the goal of surgery in these horses is to reduce respiratory noise but there are no quantitative studies evaluating the effect of any upper-airway surgery in LH-affected horses...
  40. ncbi request reprint Mucin genes in horse airways: MUC5AC, but not MUC2, may play a role in recurrent airway obstruction
    V Gerber
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824 1314, USA
    Equine Vet J 35:252-7. 2003
    ..Increased mucin gene expression may be an important cause of mucus accumulation observed in recurrent airway obstruction (RAO)-affected horses. To date, however, no mucin gene sequences are available for the horse...
  41. ncbi request reprint Genes and respiratory disease: a first step on a long journey
    S L Ewart
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 4882 1314, USA
    Equine Vet J 39:270-4. 2007
    ..The review summarises the future potential for such studies and places the report in this issue (p 236) by Jost et al. (2007) of the involvement of IL4RA as a candidate gene in RAO into this context...
  42. ncbi request reprint Excitatory prejunctional beta 2-adrenoceptor distribution within equine airway cholinergic nerves
    X Y Zhang
    Department of Large Animal Clinical Sciences, Michigan State University, East Lansing 48824 1314, USA
    Respir Physiol 106:81-90. 1996
    ....
  43. doi request reprint Ultrasound-guided biopsy of the cricoarytenoideus lateralis muscle: technique and safety in horses
    H D O'Neill
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, USA
    Equine Vet J 46:244-8. 2014
    ..Biopsy of the intrinsic laryngeal muscles may provide a method to identify the changes in fibre-type composition that occur in RLN before clinical signs become apparent...
  44. ncbi request reprint Equine thoracoscopy: normal anatomy and surgical technique
    J F Peroni
    Department of Large Animal Clinical Sciences, Michigan State University, East Lansing 48824 1314, USA
    Equine Vet J 33:231-7. 2001
    ..Surgery performed via the 8th intercostal space was hindered by the rigidity of the 8th and 9th ribs, and by the presence of a greater musculature, which did not allow easy cranial and caudal movements of the telescope...
  45. pmc Evidence for the absence of a functional role for muscarinic M2 inhibitory receptors in cat trachea in vivo: contrast with in vitro results
    C R Killingsworth
    Department of Large Animal Clinical Sciences, Michigan State University, East Lansing 48824 1314
    Br J Pharmacol 105:263-70. 1992
    ..This was despite repeated demonstration of muscarinic M2 receptor-mediated limitation of airway constriction of intrathoracic airways in vivo...