Affiliation: Methodist Healthcare
- " 'Tis a gift to be simple..."Richard G Wunderink
Chest 124:777-8. 2003
- Pneumonia complicating the acute respiratory distress syndromeRichard G Wunderink
Methodist LeBonheur Healthcare, Memphis, Tennessee, USA
Semin Respir Crit Care Med 23:443-8. 2002..Somewhat surprisingly, the mortality of ARDS patients with VAP is not significantly greater than that of ARDS patients without VAP, although subsequent duration of mechanical ventilation is consistently prolonged in patients with VAP...
- Science review: Genetic variability in the systemic inflammatory responseGrant W Waterer
Department of Medicine, University of Western Australia, Australia
Crit Care 7:308-14. 2003..However, large, phenotypically detailed studies are required to address all of the other potential polymorphisms in inflammatory molecule genes and their interactions...
- Linezolid vs vancomycin: analysis of two double-blind studies of patients with methicillin-resistant Staphylococcus aureus nosocomial pneumoniaRichard G Wunderink
Methodist Healthcare Memphis and the University of Tennessee, Memphis, TN 38104 3499, USA
Chest 124:1789-97. 2003..To assess the effect of baseline variables, including treatment, on outcome in patients with nosocomial pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA)...
- Genetics of sepsis and pneumoniaRichard G Wunderink
Research Department, Methodist LeBonheur Healthcare, Memphis, Tennessee, USA
Curr Opin Crit Care 9:384-9. 2003..Recent association studies in pneumonia and sepsis will be reviewed...
- Filgrastim in patients with pneumonia and severe sepsis or septic shockR Wunderink
University of Tennessee, College of Medicine, Memphis, TN, USA
Chest 119:523-9. 2001....
- Continuation of a randomized, double-blind, multicenter study of linezolid versus vancomycin in the treatment of patients with nosocomial pneumoniaRichard G Wunderink
Methodist Healthcare Memphis and the University of Tennessee, Memphis, Tennessee 38104 3499, USA
Clin Ther 25:980-92. 2003....
- Tumor necrosis factor gene polymorphisms and the variable presentation and outcome of community-acquired pneumoniaRichard G Wunderink
Methodist Le Bonheur Healthcare Foundation, University of Tennessee, Memphis, TN, USA
Chest 121:87S. 2002
- Association between surfactant protein B + 1580 polymorphism and the risk of respiratory failure in adults with community-acquired pneumoniaMichael W Quasney
Division of Critical Care, Department of Pediatrics, University of Tennessee, Memphis, Children s Foundation Research Center of Memphis, Le Bonheur Children s Medical Center, 50 N Dunlap, Memphis, TN 38103, USA
Crit Care Med 32:1115-9. 2004..The objective was to determine whether the SP-B + 1580 CC genotype is associated with an increased risk of respiratory failure and ARDS in adults with community-acquired pneumonia...
- Association of tumor necrosis factor gene polymorphisms and prolonged mechanical ventilation after coronary artery bypass surgerySachin Yende
Methodist Healthcare University Hospital, Memphis, TN, USA
Crit Care Med 31:133-40. 2003....
- Impact of cytokine gene polymorphisms on outcomes of coronary artery bypass graft surgerySachin Yende
Methodist Healthcare and University of Tennessee, Memphis, TN 38104, USA
Chest 121:86S. 2002
- Intracellular adhesion molecule Gly241Arg polymorphism has no impact on ARDS or septic shock in community-acquired pneumoniaMichael W Quasney
Department of Pediatrics, Crippled Children s Foundation Research Center, University of Tennessee, Memphis, 38103, USA
Chest 121:85S-86S. 2002
- Pharmaceutical industry research and cost savings in community-acquired pneumoniaLori A Kessler
Physicians Research Network, Methodist Le Bonheur Healthcare Foundation, Memphis, Tenn 38104, USA
Am J Manag Care 8:798-800. 2002..To provide financial justification for continuing pharmaceutical research in an environment that has met with increasing resistance from insurance carriers to paying for the care of patients enrolled in research studies...
- Use and limitations of clinical and radiologic diagnosis of pneumoniaMatthew Mabie
Research Department, Methodist University Hospital, Memphis, TN, USA
Semin Respir Infect 18:72-9. 2003..An accurate assessment of the normal, expected response of pneumonia to antibiotic therapy is therefore crucial. A discussion of the clinical response to treatment concludes the article...
- Clinical relevance of angiotensin-converting enzyme gene polymorphisms to predict risk of mechanical ventilation after coronary artery bypass graft surgerySachin Yende
Physician Research Network SY, Methodist Healthcare Memphis, Memphis, TN, USA
Crit Care Med 32:922-7. 2004..Therefore, we examined interactions between these polymorphisms...
- Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit studyDaniel H Kett
Department of Medicine, Division of Pulmonary and Critical Care, The University of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, FL, USA
Crit Care Med 39:665-70. 2011..To provide a global, up-to-date picture of the prevalence, treatment, and outcomes of Candida bloodstream infections in intensive care unit patients and compare Candida with bacterial bloodstream infection...
- Potential impact of vancomycin pulmonary distribution on treatment outcomes in patients with methicillin-resistant Staphylococcus aureus pneumoniaMarc H Scheetz
Department of Pharmacy, Northwestern Memorial Hospital, Chicago, Illinois 60611, USA
Pharmacotherapy 26:539-50. 2006..The possibility of increased serum vancomycin concentrations as a method to optimize current treatment outcomes is also explored...
- A CAP on antibiotic durationRichard G Wunderink
Am J Respir Crit Care Med 174:3-5. 2006
- Methicillin-Resistant S. aureus Ventilator-Associated Pneumonia: Strategies to Prevent and TreatAnna P Lam
Division of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Semin Respir Crit Care Med 27:92-103. 2006..Treatment with linezolid, which penetrates well into the lung, is associated with higher cure and survival rates. Further data are needed to evaluate the efficacy of new antibiotics in MRSA VAP...
- Delayed administration of antibiotics and atypical presentation in community-acquired pneumoniaGrant W Waterer
University of Western Australia, School of Medicine and Pharmacology, 4th Floor MRF Building, Royal Perth Hospital, GPO Box X2213, Perth, WA, Australia 6847
Chest 130:11-5. 2006..We investigated the factors that predict a prolonged TFAD and their association with mortality...
- [Assessment of patients with poor resolution of HAP]Richard G Wunderink
Division of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine Chicago, Illinois, USA
Enferm Infecc Microbiol Clin 23:52-7. 2005..Biochemical markers may be more accurate than clinical but still don't discriminate between causes. The appropriate diagnostic strategy and treatment algorithms have not been fully addressed and more research is clearly needed...
- Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsisSachin Yende
The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Am J Respir Crit Care Med 177:1242-7. 2008..Survivors of hospitalization for community-acquired pneumonia (CAP) are at increased risk of cardiovascular events, repeat infections, and death in the following months but the cause is unknown...
- Healthcare-associated bacteremia: Stirring the mudRichard G Wunderink
Crit Care Med 34:2685-6. 2006
- 4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumoniaSachin Yende
CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Am J Respir Crit Care Med 176:1129-37. 2007..Whether variation within the PAI-1 gene is associated with increased susceptibility to infection is unknown...
- Derivation of a triage algorithm for chest radiography of community-acquired pneumonia patients in the emergency departmentDemetrios N Kyriacou
Department of Emergency Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Acad Emerg Med 15:40-4. 2008..Community-acquired pneumonia (CAP) accounts for 1.5 million emergency department (ED) patient visits in the United States each year...
- Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adultsLionel A Mandell
McMaster University Medical School, Hamilton, Ontario, Canada
Clin Infect Dis 44:S27-72. 2007
- Dollars and sense in the intensive care unit: the costs of ventilator-associated pneumoniaAndrew F Shorr
Crit Care Med 31:1582-3. 2003
- Genetics of community-acquired pneumoniaRichard G Wunderink
Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Semin Respir Crit Care Med 26:553-62. 2005..The real value of these genetic studies in CAP and other severe infections will be when the management of an individual patient can be optimized by therapy based on the individual's genotype for molecules important in outcome...
- Clinical cure and survival in Gram-positive ventilator-associated pneumonia: retrospective analysis of two double-blind studies comparing linezolid with vancomycinMarin H Kollef
Pulmonary and Critical Care Division, Department of Internal Medicine, School of Medicine, Washington University, 660 South Euclid Avenue, St Louis, MO 63110, USA
Intensive Care Med 30:388-94. 2004..To assess the effect of baseline variables, including treatment, on clinical cure and survival rates in patients with Gram-positive, ventilator-associated pneumonia (VAP)...
- A long and winding roadRichard G Wunderink
Crit Care Med 32:1077-9. 2004
- Community-acquired pneumonia: pathophysiology and host factors with focus on possible new approaches to management of lower respiratory tract infectionsRichard G Wunderink
Northwestern University Feinberg School of Medicine, 676 North St Clair, Suite 14 044, Chicago, IL 60611, USA
Infect Dis Clin North Am 18:743-59, vii. 2004..This article reviews genetic variation in the molecules involved in the known patho-genic mechanisms of CAP, including cough, bacterial recognition, inflammation and the compensatory anti-inflammatory response,and organ dysfunction...
- Heat shock protein 70-2+1267 AA homozygotes have an increased risk of septic shock in adults with community-acquired pneumoniaGrant W Waterer
Department of Medicine, University of Western Australia
Crit Care Med 31:1367-72. 2003....
- High-dose, short-course levofloxacin for community-acquired pneumonia: a new treatment paradigmLala M Dunbar
Louisiana State University Medical Center, New Orleans, Louisiana, USA
Clin Infect Dis 37:752-60. 2003..2% and 92.4% in the 750-mg and 500-mg groups, respectively. These data demonstrate that 750 mg of levofloxacin per day for 5 days is at least as effective as 500 mg per day for 10 days for treatment of mild-to-severe CAP...
- Evaluation of ICU admission criteria and diagnostic methods for patients with severe community-acquired pneumonia: current practice surveyMarcos I Restrepo
Chest 133:828-9. 2008
- There is no "cap" on the importance of community-acquired pneumonia in the ICUAndrew F Shorr
Chest 133:590-2. 2008
- Health care-associated infection (HAI): a critical appraisal of the emerging threat-proceedings of the HAI SummitMarin H Kollef
Washington University School of Medicine, St Louis, Missouri 63110, USA
Clin Infect Dis 47:S55-99; quiz S100-1. 2008....
- Decreasing beta-lactam resistance in Pneumococci from the Memphis region: analysis of 2,152 isolates From 1996 to 2001Grant W Waterer
Department of Medicine, University of Western Australia, Crawley, Australia
Chest 124:519-25. 2003..In recent years, we have seen a significant shift in antibiotic use away from beta-lactams toward the newer quinolones and macrolides. We hypothesized that these changes would cause a shift in pneumococcal antibiotic resistance patterns...
- Nosocomial pneumonia, including ventilator-associated pneumoniaRichard G Wunderink
Pulmonary and Critical Care Division, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 North St Clair, Suite 14 044, Chicago, IL 60611, USA
Proc Am Thorac Soc 2:440-4. 2005..Adequate treatment of an initial infection is required for reversal of the temporary immunoparalysis, whereas specific immunomodulatory therapies can reverse the markers of immunoparalysis and may decrease the risk of infection...
- Severe pseudomonal infectionsGokhan M Mutlu
Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Curr Opin Crit Care 12:458-63. 2006..To review the most recent data on severe Pseudomonas aeruginosa infections. The focus will be on clinical studies with an emphasis on the critically ill...
- Genetic susceptibility to pneumoniaGrant W Waterer
School of Medicine and Pharmacology, University of Western Australia, Royal Perth Hospital, GP0 Box X2213, Perth, Western Australia
Clin Chest Med 26:29-38. 2005..IL-10 and IL-1 receptor antagonist polymorphisms have an important role in the anti-inflammatory response. Specific organ dysfunction, such as ARDS or DIC, may be related to polymorphisms in specific effector genes...
- Slow response times: is it the pneumonia or the physician?Richard G Wunderink
Crit Care Med 33:1429-30. 2005
- Medium-term survival after hospitalization with community-acquired pneumoniaGrant W Waterer
Department of Medicine, University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia
Am J Respir Crit Care Med 169:910-4. 2004....
- Genetic polymorphisms that predict outcome and need for treatment in cardiovascular diseaseSachin Yende
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Curr Opin Crit Care 12:420-5. 2006..The focus is on risk of complications or differences in management, rather than only susceptibility to cardiovascular disease itself...