Jayanthi J Wolf

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi request reprint Using QPCR to assign infectious potencies to adenovirus based vaccines and vectors for gene therapy: toward a universal method for the facile quantitation of virus and vector potency
    Fubao Wang
    Department of Bioprocess and Bioanalytical Research, Merck Research Laboratories, Merck and Co, Inc, West Point, PA 19486, USA
    Vaccine 23:4500-8. 2005
  2. ncbi request reprint Application of PCR technology in vaccine product development
    Jayanthi J Wolf
    Merck Research Laboratories, Biologics Safety Assessment, Merck and Co, Inc, PO Box 4, WP45 338, West Point, PA 19486, USA
    Expert Rev Vaccines 6:547-58. 2007
  3. doi request reprint Quantifying the titer and quality of adenovirus stocks
    Fubao Wang
    Vaccine and Biologics Research, Merck Research Laboratories, Merck and Co Inc, West Point, PA, USA
    Methods Mol Biol 434:25-36. 2008
  4. doi request reprint Lack of effects on fertility and developmental toxicity of a quadrivalent HPV vaccine in Sprague-Dawley rats
    L David Wise
    Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Birth Defects Res B Dev Reprod Toxicol 83:561-72. 2008
  5. ncbi request reprint Ensuring the quality, potency and safety of vaccines during preclinical development
    Jose A Lebron
    Senior Research Fellow, Merck Research Laboratories, Discovery and Biologics Safety Assessment, Merck Research Laboratories, Merck and Co, Inc, West Point, PA 19486, USA
    Expert Rev Vaccines 4:855-66. 2005
  6. doi request reprint Lack of effects on male fertility from a quadrivalent HPV vaccine in Sprague-Dawley rats
    L David Wise
    Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Birth Defects Res B Dev Reprod Toxicol 89:376-81. 2010
  7. doi request reprint Reliable quantification of mRNA in archived formalin-fixed tissue with or without paraffin embedding
    Zhibin Wang
    Department of Safety Assessment and Laboratory Animal Resources, Merck Research Laboratories, Merck and Co, Inc, 770 Sumneytown Pike, West Point, PA 19486, USA
    J Pharmacol Toxicol Methods 71:103-9. 2015
  8. doi request reprint Nonclinical safety assessment of vaccines and adjuvants
    Jayanthi J Wolf
    Merck Research Laboratories, Merck and Co, Inc, West Point, PA, USA
    Methods Mol Biol 626:29-40. 2010
  9. ncbi request reprint Production and formulation of adenovirus vectors
    Nedim E Altaras
    Fermentation and Cell Culture, Merck Research Laboratories, West Point, Pennsylvannia 19486 0004, USA
    Adv Biochem Eng Biotechnol 99:193-260. 2005
  10. doi request reprint A multi-species assay for siRNA-mediated mRNA knockdown analysis without the need for RNA purification
    Zhibin Wang
    Department of Safety Assessment, Merck Research Laboratories, Merck and Co, Inc, WP45 338, 770 Sumneytown Pike, West Point, PA 19486, USA
    J Pharmacol Toxicol Methods 63:174-9. 2011

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Using QPCR to assign infectious potencies to adenovirus based vaccines and vectors for gene therapy: toward a universal method for the facile quantitation of virus and vector potency
    Fubao Wang
    Department of Bioprocess and Bioanalytical Research, Merck Research Laboratories, Merck and Co, Inc, West Point, PA 19486, USA
    Vaccine 23:4500-8. 2005
    ..QPA assays owing to their simplicity and easy automation, rapidity, capacity and precision hold promise to become widely practiced methods for the quantitation of the potency of live virus vaccines and other recombinant virus vectors...
  2. ncbi request reprint Application of PCR technology in vaccine product development
    Jayanthi J Wolf
    Merck Research Laboratories, Biologics Safety Assessment, Merck and Co, Inc, PO Box 4, WP45 338, West Point, PA 19486, USA
    Expert Rev Vaccines 6:547-58. 2007
    ..The future outlook and the advantages and disadvantages of this technology are also discussed...
  3. doi request reprint Quantifying the titer and quality of adenovirus stocks
    Fubao Wang
    Vaccine and Biologics Research, Merck Research Laboratories, Merck and Co Inc, West Point, PA, USA
    Methods Mol Biol 434:25-36. 2008
    ....
  4. doi request reprint Lack of effects on fertility and developmental toxicity of a quadrivalent HPV vaccine in Sprague-Dawley rats
    L David Wise
    Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Birth Defects Res B Dev Reprod Toxicol 83:561-72. 2008
    ..These results demonstrate that this quadrivalent HPV vaccine had no detectable adverse effects in either the treated F0 female rats or the F1 generation...
  5. ncbi request reprint Ensuring the quality, potency and safety of vaccines during preclinical development
    Jose A Lebron
    Senior Research Fellow, Merck Research Laboratories, Discovery and Biologics Safety Assessment, Merck Research Laboratories, Merck and Co, Inc, West Point, PA 19486, USA
    Expert Rev Vaccines 4:855-66. 2005
    ..This review will highlight these regulatory expectations, and provide some clarity as to why they are in place...
  6. doi request reprint Lack of effects on male fertility from a quadrivalent HPV vaccine in Sprague-Dawley rats
    L David Wise
    Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Birth Defects Res B Dev Reprod Toxicol 89:376-81. 2010
    ..In addition, anti-HPV antibodies were measured during the study...
  7. doi request reprint Reliable quantification of mRNA in archived formalin-fixed tissue with or without paraffin embedding
    Zhibin Wang
    Department of Safety Assessment and Laboratory Animal Resources, Merck Research Laboratories, Merck and Co, Inc, 770 Sumneytown Pike, West Point, PA 19486, USA
    J Pharmacol Toxicol Methods 71:103-9. 2015
    ....
  8. doi request reprint Nonclinical safety assessment of vaccines and adjuvants
    Jayanthi J Wolf
    Merck Research Laboratories, Merck and Co, Inc, West Point, PA, USA
    Methods Mol Biol 626:29-40. 2010
    ..This review summarizes the requirements for the nonclinical testing of vaccines and adjuvants needed in support of all phases of human clinical trials...
  9. ncbi request reprint Production and formulation of adenovirus vectors
    Nedim E Altaras
    Fermentation and Cell Culture, Merck Research Laboratories, West Point, Pennsylvannia 19486 0004, USA
    Adv Biochem Eng Biotechnol 99:193-260. 2005
    ..These and other advances in the production of adenovirus vectors are discussed in detail in this review. In addition, the needs for the next decade are highlighted...
  10. doi request reprint A multi-species assay for siRNA-mediated mRNA knockdown analysis without the need for RNA purification
    Zhibin Wang
    Department of Safety Assessment, Merck Research Laboratories, Merck and Co, Inc, WP45 338, 770 Sumneytown Pike, West Point, PA 19486, USA
    J Pharmacol Toxicol Methods 63:174-9. 2011
    ....