Eric D Hostetler

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. doi request reprint Synthesis, characterization, and monkey PET studies of [¹⁸F]MK-1312, a PET tracer for quantification of mGluR1 receptor occupancy by MK-5435
    Eric D Hostetler
    Imaging, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Synapse 65:125-35. 2011
  2. doi request reprint Evaluation of [¹⁸F]MK-0911, a positron emission tomography (PET) tracer for opioid receptor-like 1 (ORL1), in rhesus monkey and human
    Eric D Hostetler
    Imaging, Merck Research Laboratories, West Point, PA 19486, USA
    Neuroimage 68:1-10. 2013
  3. ncbi request reprint A remote-controlled high pressure reactor for radiotracer synthesis with [11C]carbon monoxide
    Eric D Hostetler
    Merck Research Laboratories, PO Box 4 WP44C 2, West Point, Pennsylvania 19486, USA
    Nucl Med Biol 29:845-8. 2002
  4. doi request reprint Synthesis, characterization, and monkey positron emission tomography (PET) studies of [18F]Y1-973, a PET tracer for the neuropeptide Y Y1 receptor
    Eric D Hostetler
    Imaging, Merck Research Laboratories, West Point, PA 19486, USA
    Neuroimage 54:2635-42. 2011
  5. doi request reprint [18F]Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey
    Eric D Hostetler
    Merck Research Laboratories, PA 19486, USA
    Nucl Med Biol 38:1193-203. 2011
  6. doi request reprint In vivo quantification of calcitonin gene-related peptide receptor occupancy by telcagepant in rhesus monkey and human brain using the positron emission tomography tracer [11C]MK-4232
    Eric D Hostetler
    Merck Research Laboratories, West Point, Pennsylvania E D H, A D J, S S B, H F, Z Z, M P, L G, K R, M W, S O, P M H G S, S N G, I M B, C A S, S A K, C C L, R J H, C S, J J C, J L E Division of Nuclear Medicine, University Hospital and KU Leuven, Leuven, Belgium T d G, K V L Lab Radiopharmacy KU Leuven, Leuven, Belgium G B Merck Sharp and Dohme, Brussels, Belgium T R, R D, I D L Merck Clinical Pharmacology, Upper Gwynedd, Pennsylvania W P K
    J Pharmacol Exp Ther 347:478-86. 2013
  7. doi request reprint Discovery of [¹¹C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors
    Christopher D Cox
    Discovery Chemistry, Merck Research Laboratories, West Point, PA 19486, USA Electronic address
    Bioorg Med Chem Lett 25:4893-8. 2015
  8. doi request reprint Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia
    Izzat T Raheem
    Discovery Chemistry, Merck Research Laboratories, West Point, PA 19486, United States
    Bioorg Med Chem Lett 26:126-32. 2016
  9. ncbi request reprint The role of MRI and PET/SPECT in Alzheimer's disease
    Alexandre Coimbra
    Department of Imaging Research, Merck Research Laboratories, West Point, PA 19486, USA
    Curr Top Med Chem 6:629-47. 2006

Detail Information

Publications9

  1. doi request reprint Synthesis, characterization, and monkey PET studies of [¹⁸F]MK-1312, a PET tracer for quantification of mGluR1 receptor occupancy by MK-5435
    Eric D Hostetler
    Imaging, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Synapse 65:125-35. 2011
    ..Taken together, these results are promising for clinical PET studies with [¹⁸F]MK-1312 to determine mGluR1 occupancy of MK-5435...
  2. doi request reprint Evaluation of [¹⁸F]MK-0911, a positron emission tomography (PET) tracer for opioid receptor-like 1 (ORL1), in rhesus monkey and human
    Eric D Hostetler
    Imaging, Merck Research Laboratories, West Point, PA 19486, USA
    Neuroimage 68:1-10. 2013
    ..Additionally, [(18)F]MK-0911 may be a useful tool for studying the pharmacology of ORL1 in various human populations and disease states...
  3. ncbi request reprint A remote-controlled high pressure reactor for radiotracer synthesis with [11C]carbon monoxide
    Eric D Hostetler
    Merck Research Laboratories, PO Box 4 WP44C 2, West Point, Pennsylvania 19486, USA
    Nucl Med Biol 29:845-8. 2002
    ..For example, AMPA receptor modulator [11C]CX546 was synthesized from its respective precursors in 37% isolated yield, uncorrected from trapped [11C]CO...
  4. doi request reprint Synthesis, characterization, and monkey positron emission tomography (PET) studies of [18F]Y1-973, a PET tracer for the neuropeptide Y Y1 receptor
    Eric D Hostetler
    Imaging, Merck Research Laboratories, West Point, PA 19486, USA
    Neuroimage 54:2635-42. 2011
    ..18)F]Y1-973 is a suitable PET tracer for imaging NPY Y1 in rhesus monkey with potential for translation to human PET studies...
  5. doi request reprint [18F]Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey
    Eric D Hostetler
    Merck Research Laboratories, PA 19486, USA
    Nucl Med Biol 38:1193-203. 2011
    ..This work describes our approach to evaluate and select a candidate PET tracer for in vivo quantification of human amyloid plaque...
  6. doi request reprint In vivo quantification of calcitonin gene-related peptide receptor occupancy by telcagepant in rhesus monkey and human brain using the positron emission tomography tracer [11C]MK-4232
    Eric D Hostetler
    Merck Research Laboratories, West Point, Pennsylvania E D H, A D J, S S B, H F, Z Z, M P, L G, K R, M W, S O, P M H G S, S N G, I M B, C A S, S A K, C C L, R J H, C S, J J C, J L E Division of Nuclear Medicine, University Hospital and KU Leuven, Leuven, Belgium T d G, K V L Lab Radiopharmacy KU Leuven, Leuven, Belgium G B Merck Sharp and Dohme, Brussels, Belgium T R, R D, I D L Merck Clinical Pharmacology, Upper Gwynedd, Pennsylvania W P K
    J Pharmacol Exp Ther 347:478-86. 2013
    ..Therefore, it is unlikely that antagonism of central CGRP-R is required for migraine efficacy. However, it is not known whether high central CGRP-R antagonism may provide additional therapeutic benefit. ..
  7. doi request reprint Discovery of [¹¹C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors
    Christopher D Cox
    Discovery Chemistry, Merck Research Laboratories, West Point, PA 19486, USA Electronic address
    Bioorg Med Chem Lett 25:4893-8. 2015
    ....
  8. doi request reprint Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia
    Izzat T Raheem
    Discovery Chemistry, Merck Research Laboratories, West Point, PA 19486, United States
    Bioorg Med Chem Lett 26:126-32. 2016
    ..Further, PyP-1 displays in vivo preclinical target engagement as measured by PET enzyme occupancy in concert with [(11)C]MK-8193, a novel PDE10A PET tracer. ..
  9. ncbi request reprint The role of MRI and PET/SPECT in Alzheimer's disease
    Alexandre Coimbra
    Department of Imaging Research, Merck Research Laboratories, West Point, PA 19486, USA
    Curr Top Med Chem 6:629-47. 2006
    ..However, many questions remain concerning the validity and sensitivity of these imaging biomarkers to aid in the assessment of potential new treatments, especially those related to increased levels of amyloid peptides in the brain...