Kara S Cox

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. pmc DNA gag/adenovirus type 5 (Ad5) gag and Ad5 gag/Ad5 gag vaccines induce distinct T-cell response profiles
    Kara S Cox
    Department of Vaccine Basic Research, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    J Virol 82:8161-71. 2008
  2. ncbi request reprint Evaluation of cellular immune responses in subjects chronically infected with HIV type 1
    Tong Ming Fu
    Merck Research Laboratories, West Point, PA 19486, USA
    AIDS Res Hum Retroviruses 23:67-76. 2007
  3. pmc Co-Administration of Lipid Nanoparticles and Sub-Unit Vaccine Antigens Is Required for Increase in Antigen-Specific Immune Responses in Mice
    Elizabeth A Thoryk
    Infectious Diseases and Vaccines, Merck Research Laboratories, Merck and Co, Inc, Kenilworth, NJ 07033, USA
    Vaccines (Basel) 4:. 2016
  4. ncbi request reprint A comparison of standard immunogenicity assays for monitoring HIV type 1 gag-specific T cell responses in Ad5 HIV Type 1 gag vaccinated human subjects
    Timothy W Tobery
    Department of Vaccines and Biologics Research, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    AIDS Res Hum Retroviruses 22:1081-90. 2006
  5. pmc A Tetravalent Sub-unit Dengue Vaccine Formulated with Ionizable Cationic Lipid Nanoparticle induces Significant Immune Responses in Rodents and Non-Human Primates
    Gokul Swaminathan
    Infectious Diseases and Vaccines, Merck Research Laboratories, Merck and Co, Inc, Kenilworth, NJ, USA
    Sci Rep 6:34215. 2016
  6. ncbi request reprint A replication-defective human cytomegalovirus vaccine for prevention of congenital infection
    Dai Wang
    Merck Research Laboratories, Merck and Co Inc, Kenilworth, NJ 07033, USA
    Sci Transl Med 8:362ra145. 2016
  7. ncbi request reprint PD-1 blockade in rhesus macaques: impact on chronic infection and prophylactic vaccination
    Adam C Finnefrock
    Vaccine Basic Research, Merck Research Laboratories, West Point, PA 19486, USA
    J Immunol 182:980-7. 2009
  8. doi request reprint A novel lipid nanoparticle adjuvant significantly enhances B cell and T cell responses to sub-unit vaccine antigens
    Gokul Swaminathan
    Infectious Diseases and Vaccine Research, Merck Research Laboratories, Merck and Co Inc, Merck Sharp and Dohme Corp, West Point, PA, United States
    Vaccine 34:110-9. 2016

Detail Information

Publications8

  1. pmc DNA gag/adenovirus type 5 (Ad5) gag and Ad5 gag/Ad5 gag vaccines induce distinct T-cell response profiles
    Kara S Cox
    Department of Vaccine Basic Research, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    J Virol 82:8161-71. 2008
    ..Implications of these results for future vaccine development will be discussed...
  2. ncbi request reprint Evaluation of cellular immune responses in subjects chronically infected with HIV type 1
    Tong Ming Fu
    Merck Research Laboratories, West Point, PA 19486, USA
    AIDS Res Hum Retroviruses 23:67-76. 2007
    ..Our findings suggest that the high levels of ELISpot responses in chronically infected subjects were reflective of their persistent viral infection...
  3. pmc Co-Administration of Lipid Nanoparticles and Sub-Unit Vaccine Antigens Is Required for Increase in Antigen-Specific Immune Responses in Mice
    Elizabeth A Thoryk
    Infectious Diseases and Vaccines, Merck Research Laboratories, Merck and Co, Inc, Kenilworth, NJ 07033, USA
    Vaccines (Basel) 4:. 2016
    ..Overall, our data demonstrate that the administration of LNPs and vaccine antigen together enables their immune-stimulatory properties...
  4. ncbi request reprint A comparison of standard immunogenicity assays for monitoring HIV type 1 gag-specific T cell responses in Ad5 HIV Type 1 gag vaccinated human subjects
    Timothy W Tobery
    Department of Vaccines and Biologics Research, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    AIDS Res Hum Retroviruses 22:1081-90. 2006
    ....
  5. pmc A Tetravalent Sub-unit Dengue Vaccine Formulated with Ionizable Cationic Lipid Nanoparticle induces Significant Immune Responses in Rodents and Non-Human Primates
    Gokul Swaminathan
    Infectious Diseases and Vaccines, Merck Research Laboratories, Merck and Co, Inc, Kenilworth, NJ, USA
    Sci Rep 6:34215. 2016
    ..Overall, our novel studies, across multiple species, reveal a promising tetravalent Dengue virus sub-unit vaccine candidate...
  6. ncbi request reprint A replication-defective human cytomegalovirus vaccine for prevention of congenital infection
    Dai Wang
    Merck Research Laboratories, Merck and Co Inc, Kenilworth, NJ 07033, USA
    Sci Transl Med 8:362ra145. 2016
    ..The vaccine was immunogenic in multiple animal species and induced durable neutralizing antibodies, as well as CD4+ and CD8+ T cells, to multiple viral antigens in nonhuman primates...
  7. ncbi request reprint PD-1 blockade in rhesus macaques: impact on chronic infection and prophylactic vaccination
    Adam C Finnefrock
    Vaccine Basic Research, Merck Research Laboratories, West Point, PA 19486, USA
    J Immunol 182:980-7. 2009
    ..05) increase in the peak percentage of T cells specific for the CM9 Gag epitope. These new results on PD-1 blockade in nonhuman primates point to a broader role for PD-1 immunomodulation and to potential applications in humans...
  8. doi request reprint A novel lipid nanoparticle adjuvant significantly enhances B cell and T cell responses to sub-unit vaccine antigens
    Gokul Swaminathan
    Infectious Diseases and Vaccine Research, Merck Research Laboratories, Merck and Co Inc, Merck Sharp and Dohme Corp, West Point, PA, United States
    Vaccine 34:110-9. 2016
    ....