Iestyn Whitehouse

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. doi request reprint Opening windows to the genome
    Iestyn Whitehouse
    Sloan Kettering Institute, New York, NY 12750, USA
    Cell 137:400-2. 2009
  2. pmc Chromatin dynamics at the replication fork: there's more to life than histones
    Iestyn Whitehouse
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Curr Opin Genet Dev 23:140-6. 2013
  3. pmc Intrinsic coupling of lagging-strand synthesis to chromatin assembly
    Duncan J Smith
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Nature 483:434-8. 2012
  4. pmc Quantitative, genome-wide analysis of eukaryotic replication initiation and termination
    Sean R McGuffee
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Cell 50:123-35. 2013
  5. pmc Chromatin Constrains the Initiation and Elongation of DNA Replication
    Sujan Devbhandari
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA
    Mol Cell . 2016
  6. pmc Replication-Coupled Nucleosome Assembly and Positioning by ATP-Dependent Chromatin-Remodeling Enzymes
    Tejas Yadav
    Weill Cornell Graduate School of Medical Sciences, 1300 York Avenue, New York, NY 10065, USA Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Cell Rep . 2016
  7. pmc Post-licensing Specification of Eukaryotic Replication Origins by Facilitated Mcm2-7 Sliding along DNA
    Julien Gros
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center MSKCC, 1275 York Avenue, New York, NY 10065, USA
    Mol Cell 60:797-807. 2015
  8. pmc Detection and Sequencing of Okazaki Fragments in S. cerevisiae
    Duncan J Smith
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA
    Methods Mol Biol 1300:141-53. 2015

Collaborators

  • T Tsukiyama
  • Duncan J Smith
  • Tejas Yadav
  • Sujan Devbhandari
  • Charanya Kumar
  • Dirk Remus
  • Julien Gros
  • Sean R McGuffee
  • Jieqing Jiang
  • Gerard Lynch

Detail Information

Publications8

  1. doi request reprint Opening windows to the genome
    Iestyn Whitehouse
    Sloan Kettering Institute, New York, NY 12750, USA
    Cell 137:400-2. 2009
    ..Hartley and Madhani (2009) now demonstrate the power of this approach and show that a chromatin regulator alters nucleosome positioning in the promoters of a large number of genes in the budding yeast Saccharomyces cerevisiae...
  2. pmc Chromatin dynamics at the replication fork: there's more to life than histones
    Iestyn Whitehouse
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Curr Opin Genet Dev 23:140-6. 2013
    ..Here, we will discuss the disruption and re-establishment of chromatin structure during replication, and the consequences of these processes for epigenetic inheritance...
  3. pmc Intrinsic coupling of lagging-strand synthesis to chromatin assembly
    Duncan J Smith
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Nature 483:434-8. 2012
    ..Our studies represent the first high-resolution analysis--to our knowledge--of eukaryotic Okazaki fragments in vivo, and reveal the interconnection between lagging-strand synthesis and chromatin assembly...
  4. pmc Quantitative, genome-wide analysis of eukaryotic replication initiation and termination
    Sean R McGuffee
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Cell 50:123-35. 2013
    ..The replication profile is predominantly determined by the kinetics of origin firing, allowing us to reconstruct chromosome-wide timing profiles from an asynchronous culture...
  5. pmc Chromatin Constrains the Initiation and Elongation of DNA Replication
    Sujan Devbhandari
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA
    Mol Cell . 2016
    ..This system thus provides a functional platform for the detailed mechanistic analysis of eukaryotic chromosome replication...
  6. pmc Replication-Coupled Nucleosome Assembly and Positioning by ATP-Dependent Chromatin-Remodeling Enzymes
    Tejas Yadav
    Weill Cornell Graduate School of Medical Sciences, 1300 York Avenue, New York, NY 10065, USA Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Cell Rep . 2016
    ..Altogether, our data provide in vivo evidence for coordinated "loading and remodeling" of nucleosomes behind the replication fork, allowing for rapid organization of chromatin during S phase...
  7. pmc Post-licensing Specification of Eukaryotic Replication Origins by Facilitated Mcm2-7 Sliding along DNA
    Julien Gros
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center MSKCC, 1275 York Avenue, New York, NY 10065, USA
    Mol Cell 60:797-807. 2015
    ..These results reveal a eukaryotic origin specification mechanism that departs from the classical replicon model, helping eukaryotic cells to negotiate transcription-replication conflict...
  8. pmc Detection and Sequencing of Okazaki Fragments in S. cerevisiae
    Duncan J Smith
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA
    Methods Mol Biol 1300:141-53. 2015
    ..Altogether this approach represents a tractable system to investigate key aspects of DNA replication and chromatin assembly. ..