Mark J Tomishima

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Production of green fluorescent protein transgenic embryonic stem cells using the GENSAT bacterial artificial chromosome library
    Mark J Tomishima
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Stem Cells 25:39-45. 2007
  2. pmc Modeling neural crest induction, melanocyte specification, and disease-related pigmentation defects in hESCs and patient-specific iPSCs
    Yvonne Mica
    The Center for Stem Cell Biology, Sloan Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA
    Cell Rep 3:1140-52. 2013
  3. pmc Efficient derivation of functional floor plate tissue from human embryonic stem cells
    Christopher A Fasano
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Ave, New York, NY 10065, USA
    Cell Stem Cell 6:336-47. 2010
  4. pmc Human iPSC-based modeling of late-onset disease via progerin-induced aging
    Justine D Miller
    The Center for Stem Cell Biology, Sloan Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA Developmental Biology Program, Sloan Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA Gerstner Sloan Kettering Graduate School, Sloan Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA
    Cell Stem Cell 13:691-705. 2013
  5. pmc Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs
    Gabsang Lee
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Ave, USA
    Nature 461:402-6. 2009
  6. doi request reprint Derivation of neural crest cells from human pluripotent stem cells
    Gabsang Lee
    Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA
    Nat Protoc 5:688-701. 2010
  7. pmc Identification of embryonic stem cell-derived midbrain dopaminergic neurons for engraftment
    Yosif M Ganat
    Center for Stem Cell Biology, Sloan Kettering Institute for Cancer Research, New York, NY, USA
    J Clin Invest 122:2928-39. 2012
  8. pmc ZFX controls the self-renewal of human embryonic stem cells
    Sivan Harel
    Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 7:e42302. 2012
  9. doi request reprint BAC transgenesis in human embryonic stem cells as a novel tool to define the human neural lineage
    Dimitris G Placantonakis
    Department of Neurosurgery, Sloan Kettering Institute for Cancer Research, New York, New York, USA
    Stem Cells 27:521-32. 2009
  10. doi request reprint Converting human pluripotent stem cells to neural tissue and neurons to model neurodegeneration
    Stuart M Chambers
    Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA
    Methods Mol Biol 793:87-97. 2011

Collaborators

Detail Information

Publications15

  1. pmc Production of green fluorescent protein transgenic embryonic stem cells using the GENSAT bacterial artificial chromosome library
    Mark J Tomishima
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Stem Cells 25:39-45. 2007
    ..Our protocols provide a simple and efficient strategy to utilize the whole GENSAT BAC library to create hundreds of novel fluorescent cell lines for use in ES cell biology...
  2. pmc Modeling neural crest induction, melanocyte specification, and disease-related pigmentation defects in hESCs and patient-specific iPSCs
    Yvonne Mica
    The Center for Stem Cell Biology, Sloan Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA
    Cell Rep 3:1140-52. 2013
    ..Our data define a highly specific requirement for WNT signaling during NC induction and enable the generation of pure populations of human iPSC-derived melanocytes for faithful modeling of pigmentation disorders...
  3. pmc Efficient derivation of functional floor plate tissue from human embryonic stem cells
    Christopher A Fasano
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Ave, New York, NY 10065, USA
    Cell Stem Cell 6:336-47. 2010
    ..These data define the early signals that drive human FP versus AN specification and determine regional identity in hESC-derived FP...
  4. pmc Human iPSC-based modeling of late-onset disease via progerin-induced aging
    Justine D Miller
    The Center for Stem Cell Biology, Sloan Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA Developmental Biology Program, Sloan Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA Gerstner Sloan Kettering Graduate School, Sloan Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA
    Cell Stem Cell 13:691-705. 2013
    ..Thus, our study suggests that progerin-induced aging can be used to reveal late-onset age-related disease features in hiPSC-based disease models...
  5. pmc Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs
    Gabsang Lee
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Ave, USA
    Nature 461:402-6. 2009
    ..Our study illustrates the promise of iPSC technology for gaining new insights into human disease pathogenesis and treatment...
  6. doi request reprint Derivation of neural crest cells from human pluripotent stem cells
    Gabsang Lee
    Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA
    Nat Protoc 5:688-701. 2010
    ..Our protocol has been validated in multiple independent hESC and hiPSC lines. The average time required for generating purified hPSC-NC precursors using this protocol is 2-5 weeks...
  7. pmc Identification of embryonic stem cell-derived midbrain dopaminergic neurons for engraftment
    Yosif M Ganat
    Center for Stem Cell Biology, Sloan Kettering Institute for Cancer Research, New York, NY, USA
    J Clin Invest 122:2928-39. 2012
    ..These data demonstrate remarkable fate specificity of ESC-derived DA neurons and outline a sequential stage-specific ESC reporter line paradigm for in vivo gene discovery...
  8. pmc ZFX controls the self-renewal of human embryonic stem cells
    Sivan Harel
    Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 7:e42302. 2012
    ..Thus, ZFX acts as a molecular rheostat regulating the balance between self-renewal and differentiation in hESCs, revealing the close evolutionary conservation of the self-renewal mechanisms in murine and human ESCs...
  9. doi request reprint BAC transgenesis in human embryonic stem cells as a novel tool to define the human neural lineage
    Dimitris G Placantonakis
    Department of Neurosurgery, Sloan Kettering Institute for Cancer Research, New York, New York, USA
    Stem Cells 27:521-32. 2009
    ....
  10. doi request reprint Converting human pluripotent stem cells to neural tissue and neurons to model neurodegeneration
    Stuart M Chambers
    Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA
    Methods Mol Biol 793:87-97. 2011
    ..In this chapter, we detail methods to direct hESCs or hiPSCs into early neural cells and subsequently postmitotic neurons...
  11. doi request reprint Dual-SMAD Inhibition/WNT Activation-Based Methods to Induce Neural Crest and Derivatives from Human Pluripotent Stem Cells
    Stuart M Chambers
    Developmental Biology Program, Center for Stem Cell Biology, Sloan Kettering Institute, 1275 York Ave, New York, NY, 10065, USA
    Methods Mol Biol 1307:329-43. 2016
    ..Here, we discuss recent publications and methods for efficiently differentiating hPSCs into NC. We also provide methods to direct NC into two different terminal fates: melanocytes and sensory neurons. ..
  12. pmc Derivation of Diverse Hormone-Releasing Pituitary Cells from Human Pluripotent Stem Cells
    Bastian Zimmer
    The Center for Stem Cell Biology, Sloan Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA Developmental Biology Program, Sloan Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA
    Stem Cell Reports 6:858-72. 2016
    ..This work lays the foundation for future cell therapy applications in patients with hypopituitarism. ..
  13. doi request reprint The endothelial cell line bEnd.3 maintains human pluripotent stem cells
    Katherine Joubin
    Developmental Biology Program, SKI Stem Cell Research Facility, Center for Stem Cell Biology, Sloan Kettering Institute, New York, New York, USA
    Stem Cells Dev 21:2312-21. 2012
    ..We demonstrate this capability by producing fluorescent and drug-resistant feeder cells. Further, we show that bEnd.3 secretes an activity that maintains human embryonic stem cells without direct contact...
  14. doi request reprint Neural Crest Cells from Dual SMAD Inhibition
    Faranak Fattahi
    Developmental Biology Program, Sloan Kettering Institute, New York, New York
    Curr Protoc Stem Cell Biol 33:1H.9.1-9. 2015
    ..Here, we provide a minor variation to this NC protocol that has been successful for many in our laboratories...
  15. pmc Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation
    Eirini P Papapetrou
    Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:12759-64. 2009
    ..The vector system described here presents a powerful tool for mechanistic studies of reprogramming and the optimization of hiPSC generation...