S Sharma

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi request reprint Oral chemotherapeutic agents for colorectal cancer
    S Sharma
    Gastrointestinal Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Oncologist 5:99-107. 2000
  2. ncbi request reprint Phase I study of topoisomerase I inhibitor exatecan mesylate (DX-8951f) given as weekly 24-hour infusions three of every four weeks
    S Sharma
    Division of Gastrointestinal Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Cancer Res 7:3963-70. 2001
  3. ncbi request reprint A phase II trial of farnesyl protein transferase inhibitor SCH 66336, given by twice-daily oral administration, in patients with metastatic colorectal cancer refractory to 5-fluorouracil and irinotecan
    S Sharma
    Gastrointestinal Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 11201, USA
    Ann Oncol 13:1067-71. 2002
  4. pmc Ectopic expression of the thyroperoxidase gene augments radioiodide uptake and retention mediated by the sodium iodide symporter in non-small cell lung cancer
    M Huang
    Pulmonary Immunology and Gene Medicine Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, UCLA and VA Greater Heathcare System, Los Angeles, California 90073, USA
    Cancer Gene Ther 8:612-8. 2001
  5. ncbi request reprint Surgical debulking and intraperitoneal chemotherapy for established peritoneal metastases from colon and appendix cancer
    A T Culliford
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg Oncol 8:787-95. 2001
  6. ncbi request reprint Phase I study of weekly oxaliplatin plus irinotecan in previously treated patients with metastatic colorectal cancer
    N Kemeny
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Oncol 13:1490-6. 2002
  7. pmc The interaction of glutathione S-transferase M1-null variants with tobacco smoke exposure and the development of childhood asthma
    A J Rogers
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Exp Allergy 39:1721-9. 2009
  8. ncbi request reprint Patient selection for oral chemotherapy
    S Sharma
    Memorial Sloan-Kettering Cancer Center, Medical College of Cornell University, New York, New York, USA
    Oncology (Williston Park) 15:33-5. 2001
  9. pmc Association of VEGF polymorphisms with childhood asthma, lung function and airway responsiveness
    S Sharma
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Channing Laboratory, Harvard Medical School, Boston, MA 02115, USA
    Eur Respir J 33:1287-94. 2009
  10. pmc Non-small cell lung cancer cyclooxygenase-2-dependent invasion is mediated by CD44
    M Dohadwala
    Lung Cancer Research Program of the UCLA Jonsson Comprehensive Cancer Center, Division of Pulmonary Medicine, Department of Medicine, UCLA, School of Medicine, Los Angeles California 90095-1690, USA
    J Biol Chem 276:20809-12. 2001

Detail Information

Publications44

  1. ncbi request reprint Oral chemotherapeutic agents for colorectal cancer
    S Sharma
    Gastrointestinal Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Oncologist 5:99-107. 2000
    ..Economic issues, patient preference, and patient selection issues surrounding oral chemotherapy for colorectal cancer will also be discussed...
  2. ncbi request reprint Phase I study of topoisomerase I inhibitor exatecan mesylate (DX-8951f) given as weekly 24-hour infusions three of every four weeks
    S Sharma
    Division of Gastrointestinal Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Cancer Res 7:3963-70. 2001
    ..In conclusion, the recommended Phase II dose for DX-8951f administered as a weekly 24-h infusion on a 3-of-4 week schedule is 0.8 mg/m(2) in minimally pretreated patients and 0.53 mg/m(2) in patients who are heavily pretreated...
  3. ncbi request reprint A phase II trial of farnesyl protein transferase inhibitor SCH 66336, given by twice-daily oral administration, in patients with metastatic colorectal cancer refractory to 5-fluorouracil and irinotecan
    S Sharma
    Gastrointestinal Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 11201, USA
    Ann Oncol 13:1067-71. 2002
    ..ras genes encode Ras proteins that are important for signal transduction in cancer cells. Farnesyl protein transferase (FPTase) is an enzyme that is responsible for a critical post-translational modification of Ras...
  4. pmc Ectopic expression of the thyroperoxidase gene augments radioiodide uptake and retention mediated by the sodium iodide symporter in non-small cell lung cancer
    M Huang
    Pulmonary Immunology and Gene Medicine Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, UCLA and VA Greater Heathcare System, Los Angeles, California 90073, USA
    Cancer Gene Ther 8:612-8. 2001
    ..Thus, TPO could be used as a therapeutic strategy to enhance the NIS-based radioiodide concentrator gene therapy for locally advanced lung cancer...
  5. ncbi request reprint Surgical debulking and intraperitoneal chemotherapy for established peritoneal metastases from colon and appendix cancer
    A T Culliford
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg Oncol 8:787-95. 2001
    ..We reviewed our institutional experience to assess patient selection, complications, and outcome...
  6. ncbi request reprint Phase I study of weekly oxaliplatin plus irinotecan in previously treated patients with metastatic colorectal cancer
    N Kemeny
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Oncol 13:1490-6. 2002
    ..Oxaliplatin exerts its antineoplastic activity through the formation of platinum-DNA adducts. Resistance to oxaliplatin is through repair of these adducts, which is inhibited by irinotecan...
  7. pmc The interaction of glutathione S-transferase M1-null variants with tobacco smoke exposure and the development of childhood asthma
    A J Rogers
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Exp Allergy 39:1721-9. 2009
    ....
  8. ncbi request reprint Patient selection for oral chemotherapy
    S Sharma
    Memorial Sloan-Kettering Cancer Center, Medical College of Cornell University, New York, New York, USA
    Oncology (Williston Park) 15:33-5. 2001
    ..This article discusses these issues, which include patient preference, selection, and compliance...
  9. pmc Association of VEGF polymorphisms with childhood asthma, lung function and airway responsiveness
    S Sharma
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Channing Laboratory, Harvard Medical School, Boston, MA 02115, USA
    Eur Respir J 33:1287-94. 2009
    ..VEGF polymorphisms are associated with childhood asthma, lung function and airway responsiveness in two populations, suggesting that VEGF polymorphisms influence asthma susceptibility, airflow obstruction and airways responsiveness...
  10. pmc Non-small cell lung cancer cyclooxygenase-2-dependent invasion is mediated by CD44
    M Dohadwala
    Lung Cancer Research Program of the UCLA Jonsson Comprehensive Cancer Center, Division of Pulmonary Medicine, Department of Medicine, UCLA, School of Medicine, Los Angeles California 90095-1690, USA
    J Biol Chem 276:20809-12. 2001
    ..Because tumor COX-2 expression appears to have a multifaceted role in conferring the malignant phenotype, COX-2 may be an important target for gene or pharmacologic therapy in NSCLC...
  11. ncbi request reprint Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial
    Talmadge E King
    Department of Medicine, University of California San Francisco, San Francisco, CA 94143 0120, USA
    Lancet 374:222-8. 2009
    ..We assessed whether treatment with interferon gamma-1b improved survival compared with placebo in patients with idiopathic pulmonary fibrosis and mild-to-moderate impairment of pulmonary function...
  12. pmc Altered immune responses in interleukin 10 transgenic mice
    A Hagenbaugh
    Molecular Biology Institute, Department of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Exp Med 185:2101-10. 1997
    ..These mice will be useful in defining differences in inflammatory conditions and cellular immunity mediated by IL-10...
  13. ncbi request reprint Iodide sensitizes genetically modified non-small cell lung cancer cells to ionizing radiation
    L Zhang
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA and Veterans Affairs Greater Los Angeles Healthcare System, CA 90095, USA
    Cancer Gene Ther 13:74-81. 2006
    ..Thus, iodide may serve as an enhancer to markedly improve the efficacy of radiation therapy in combined therapeutic modalities...
  14. ncbi request reprint Genetic polymorphism of the CYP1A1, CYP2E1, GSTM1 and GSTT1 genes and lung cancer susceptibility in a north indian population
    R C Sobti
    Department of Biotechnology, Punjab University, Chandigarh, India
    Mol Cell Biochem 266:1-9. 2004
    ..008). Taken together, these findings, the first to be analyzed in north Indian population, suggest that combined GSTT1 , GSTM1 and CYP1A1 polymorphisms could be susceptible to lung cancer induced by bidi (an Indian cigarette) smoking...
  15. ncbi request reprint Pelvic exenterations for gynecological malignancies: twenty-year experience at Roswell Park Cancer Institute
    S Sharma
    Division of Gynecologic Oncology, Department of Surgery, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Int J Gynecol Cancer 15:475-82. 2005
    ..Intraoperative radiation in select few patients needs to be further studied...
  16. pmc CCL19 reduces tumour burden in a model of advanced lung cancer
    S Hillinger
    Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland
    Br J Cancer 94:1029-34. 2006
    ..Our findings show that CCL19 may serve as a potential immune stimulator and provide a strong rationale for the evaluation of CCL19 in cancer immunotherapy...
  17. ncbi request reprint Hepatic tuberculosis mimicking carcinoma gall bladder
    Jai Bikhchandani
    Department of Surgery, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, India
    Indian J Gastroenterol 24:25. 2005
    ..We report a 50-year-old man with tuberculosis of the liver with calculous cholecystitis. The diagnosis was made when the patient underwent cholecystectomy. He responded to antitubercular therapy...
  18. ncbi request reprint Chronic oral administration of beta-adrenoceptor agonist clenbuterol affects myosin heavy chain (MHC) expression in adult mouse heart
    S N Patiyal
    Department of Biosciences, Himachal Pradesh University sumer Hill, Shimla, India
    Physiol Res 56:275-83. 2007
    ....
  19. ncbi request reprint Linear temporal characteristics of heart interbeat interval as an index of the pilot's perceived risk
    S Sharma
    BAE SYSTEMS Australia, Adelaide, SA, 5111, Australia
    Ergonomics 49:874-84. 2006
    ....
  20. ncbi request reprint A DNA vaccine that encodes rabies virus glycoprotein lacking transmembrane domain enhances antibody response but not protection
    P K Gupta
    Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, UP, India
    Acta Virol 50:87-92. 2006
    ..This indicates that the transmembrane domain of RV gp is important for generating protection against rabies and should be present in RV DNA vaccines...
  21. ncbi request reprint Keith DJ, Ong TK, Martin IC. The role of thoracic computed tomography in staging newly-diagnosed oral squamous cell carcinoma. Br J Oral Maxillofac Surg 2006;44:198-202
    P A Brennan
    Br J Oral Maxillofac Surg 45:255-6. 2007
  22. ncbi request reprint The long-term effect of raloxifene on the genitourinary tract
    S Sharma
    Centre for Metabolic Bone Disease, Hull, UK
    Climacteric 10:244-8. 2007
    ..To investigate the effect of long-term treatment with raloxifene on pelvic organ prolapse and urinary incontinence...
  23. ncbi request reprint Beta-agonists enhance the lactic dehydrogenase (LDH) expression in serum and ventricular myocytes of mice
    M Kaundal
    Department of Biosciences, Himachal Pradesh University, Summer Hill, Shimla 171005, India
    Acta Physiol Hung 94:249-59. 2007
    ..Increase in total LDH in serum is not due to release from heart but from some other tissues having anaerobic metabolism...
  24. ncbi request reprint A pilot pharmacokinetic study of oral azacitidine
    G Garcia-Manero
    Department of Leukemia, University of Texas M D Anderson Cancer, Houston, TX 77030, USA
    Leukemia 22:1680-4. 2008
    ..4% of historic s.c. exposure. No severe drug-related toxicities were observed. These data suggest that oral azacitidine is bioavailable in humans and should be studied in formal phase 1 trials...
  25. ncbi request reprint Laparoscopic sleeve gastrectomy as an initial weight-loss procedure for high-risk patients with morbid obesity
    D Cottam
    Department of Surgery, University of Pittsburgh Medical Centre, Veterans Hospital, Pittsburgh, PA, USA
    Surg Endosc 20:859-63. 2006
    ..In an effort to achieve more favorable outcomes, we have employed a two-stage approach to such high-risk patients. This study evaluates our initial outcomes with this technique...
  26. ncbi request reprint In vitro anti-resorptive activity and prevention of ovariectomy-induced osteoporosis in female Sprague-Dawley rats by ormeloxifene, a selective estrogen receptor modulator
    M Arshad
    Division of Endocrinology, Central Drug Research Institute, Lucknow, India
    J Steroid Biochem Mol Biol 91:67-78. 2004
    ..Findings suggest potential of ormeloxifene in management of post-menopausal osteoporosis and beneficial effect on BMD in women taking this SERM for contraception or any hormone-related clinical disorder...
  27. ncbi request reprint Pharmacokinetic study of 11-Keto beta-Boswellic acid
    S Sharma
    Pharmacology, Indira Gandhi Medical College, Nagpur, India
    Phytomedicine 11:255-60. 2004
    ..However human kinetic studies are lacking for this. Hence to better elucidate its effects in humans and determine its optimal dosing, this study was planned...
  28. ncbi request reprint Circulating intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin in urological malignancies
    F Perabo
    Department of Urology, Rheinische Friedrich-Wilhelms-University of Bonn, Germany
    Indian J Cancer 38:1-7. 2001
    ..Despite of significant ICAM-1 or VCAM-1 serum levels in some locally advanced tumors or metastatic disease, this observation does not provide enough relevant clinical information for use as tumor markers...
  29. ncbi request reprint Screening and monitoring for bladder cancer: refining the use of NMP22
    L E Ponsky
    Cleveland Clinic Urological Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Urol 166:75-8. 2001
    ..8% and 94.1%). CONCLUSIONS: Awareness and exclusion of the categories of false-positive results can increase the specificity and positive predictive value of NMP22, enhancing the clinical use of this urinary tumor marker...
  30. ncbi request reprint Purification of diacylglycerol kinase from Microsporum gypseum and its phosphorylation by the catalytic subunit of protein kinase A
    E Haq
    Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh-160 012, India
    Arch Biochem Biophys 392:219-25. 2001
    ..Whether this in vitro phosphorylation and activation of DG-kinase occurs under physiological conditions remains to be elucidated...
  31. ncbi request reprint Implant complications and failures: the complete overdenture
    C J Watson
    Leeds Dental Institute, Leeds
    Dent Update 28:234-8, 240. 2001
    ..A number of implant systems have been reviewed and the results of the authors' clinical experiences with referred and their own cases are reported...
  32. ncbi request reprint Secondary lymphoid organ chemokine reduces pulmonary tumor burden in spontaneous murine bronchoalveolar cell carcinoma
    S Sharma
    University of California Los Angeles School of Medicine, Wadsworth Pulmonary Immunology Laboratory, Veterans Administration Greater Los Angeles Healthcare System, 90073, USA
    Cancer Res 61:6406-12. 2001
    ..Significant reduction in tumor burden in a model in which tumors develop in an organ-specific manner provides a strong rationale for additional evaluation of SLC in regulation of tumor immunity and its use in lung cancer immunotherapy...
  33. pmc Anti-inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor
    D Raeburn
    , Dagenham Research Centre, Essex
    Br J Pharmacol 113:1423-31. 1994
    ..RP 73401 may have a role as a bronchodilator and, more importantly, as a prophylactic anti-inflammatory agent in the treatment of asthma...
  34. ncbi request reprint Morbidity and mortality in rheumatoid arthritis patients with prolonged and profound therapy-induced lymphopenia
    J D Isaacs
    University of Leeds, UK
    Arthritis Rheum 44:1998-2008. 2001
    ..These data are also relevant to patients receiving lymphocytotoxic mAb therapy for other indications, and to patients receiving other lymphodepleting therapies such as autologous stem cell transplantation...
  35. pmc Oral toxicity of Photorhabdus luminescens W14 toxin complexes in Escherichia coli
    N Waterfield
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
    Appl Environ Microbiol 67:5017-24. 2001
    ..The implications for the potential mode of action of the toxin complex genes are discussed...
  36. ncbi request reprint Increased hepatic oxidative DNA damage in patients with hepatocellular carcinoma
    K B Schwarz
    Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Dig Dis Sci 46:2173-8. 2001
    ..31 +/- 108-OH-dG/10(6)dG). Oxidative DNA damage can be both mutagenic and carcinogenic; our data suggested it will be important in future studies to determine the chronology of this type of liver injury relative to hepatocarcinogenesis...
  37. ncbi request reprint Inflammatory pseudotumor of the esophagus
    A P Saklani
    Department of Thoracic Surgical Services, Tata Memorial Hospital, Mumbai, India
    Dis Esophagus 14:274-7. 2001
    ..Our patient could not be diagnosed on preoperative investigations and required an esophagotomy with frozen section. We debulked the mass and the patient is asymptomatic 6 months after surgery...
  38. ncbi request reprint The quality of life of patients with hypertension
    J D Stein
    Center for Evidence Based Health Care Economics, Flourtown, PA 19031, USA
    J Clin Hypertens (Greenwich) 4:181-8. 2002
    ..The relatively low impact that hypertensive individuals indicate high blood pressure has on their quality of life may contribute to their lack of compliance with treatment regimens...
  39. ncbi request reprint Role of poly [DL-lactide-co-glycolide] in development of a sustained oral delivery system for antitubercular drug(s)
    Q Ain
    Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India
    Int J Pharm 239:37-46. 2002
    ..Further, work is being carried out to evaluate the chemotherapeutic efficacy of the antitubercular drugs encapsulated in PLG microspheres...
  40. ncbi request reprint Early onset of the maximum protein anabolic effect induced by isoproterenol in chick skeletal and cardiac muscle
    S Kumar
    Department of Biosciences, Himachal Pradesh University, Shimla, India
    Acta Physiol Hung 90:57-67. 2003
    ..The results suggest that prolonged treatment of chicks produced changes that were not much different from those recorded immediately within a fortnight...
  41. ncbi request reprint Pro-Leu-glycinamide and its peptidomimetic, PAOPA, attenuate haloperidol induced vacuous chewing movements in rat: A model of human tardive dyskinesia
    S Sharma
    Department of Psychiatry, Faculty of Health Sciences, McMaster University, 1200 Main Street West, Ont, L8N 3Z5, Hamilton, Canada
    Peptides 24:313-9. 2003
    ..These results suggest that PLG may play a role in D2 receptor expression and function, as well as providing a therapy for neuroleptic induced TD...
  42. ncbi request reprint CYP1A1 and CYP2D6 polymorphism and risk of lung cancer in a North Indian population
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    Biomarkers 8:415-28. 2003
    ..This study is the first to be carried out on a North Indian population, and, although small, suggests that CYP1A1 and CYP2D6 polymorphisms might have a role in determining the risk for lung cancer and should be investigated further...
  43. ncbi request reprint Effectiveness of nutrition education, iron supplementation or both on iron status in children
    D Kapur
    Department of Pediatrics, University College of Medical Sciences and GTB Hospital, Delhi, India
    Indian Pediatr 40:1131-44. 2003
    ..A community-based, randomized trial was designed to compare the effect of nutrition education and/or iron supplementation (weekly) on iron status of children in an urban slum in Delhi...
  44. ncbi request reprint 99mTc labeled VIP analog: evaluation for imaging colorectal cancer
    P S Rao
    Thomas Jefferson University, Department of Radiology, Philadelphia, PA, USA
    Nucl Med Biol 28:445-50. 2001
    ..In these non-fasting volunteers hepatobiliary clearance was slow and in cancer patients tumor uptake was rapid. Data suggest that (99m)Tc-TP3654 is a promising agent for imaging colorectal cancer...