Genomes and Genes
Affiliation: Memorial Sloan-Kettering Cancer Center
- Threading with chemostructural restrictions method for predicting fold and functionally significant residues: application to dipeptidylpeptidase IV (DPP-IV)Boris Reva
Novartis Institute for Biomedical Research, Summit, New Jersey, USA
Proteins 47:180-93. 2002..Cell 1998;94:161-170) and use this structure for modeling the interaction of DPP-IV with inhibitor...
- Matrix Metalloproteinase-9 (MMP-9) polymorphisms in patients with cutaneous malignant melanomaJavier Cotignola
Memorial Sloan Kettering Cancer Center, New York, NY, USA
BMC Med Genet 8:10. 2007..Some polymorphisms are known to influence gene expression, protein activity, stability, and interactions, and they were shown to be associated with certain tumor phenotypes and cancer risk...
- Determinants of protein function revealed by combinatorial entropy optimizationBoris Reva
Computational Biology Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
Genome Biol 8:R232. 2007..Such predicted functional determinants are useful for interpreting the functional consequences of mutations in natural evolution and disease...
- The molecular diversity of Luminal A breast tumorsGiovanni Ciriello
Computational Biology Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Breast Cancer Res Treat 141:409-20. 2013..Our work provides for a further molecular stratification of Luminal A breast tumors, with potential direct clinical implications. ..
- Strand-specific in vivo screen of cancer-associated miRNAs unveils a role for miR-21(∗) in SCC progressionYejing Ge
Howard Hughes Medical Institute and Laboratory of Mammalian Cell Biology and Development, Rockefeller University, New York, New York 10065, USA
Nat Cell Biol 18:111-21. 2016..Through in vivo physiological miR screens, our findings add an interesting twist to an increasingly important oncomiR locus. ..
- MAP2K1 (MEK1) Mutations Define a Distinct Subset of Lung Adenocarcinoma Associated with SmokingMaria E Arcila
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York
Clin Cancer Res 21:1935-43. 2015..Somatic mutations in MEK1, located downstream of BRAF, are rare and remain poorly defined as a distinct molecular subset...
- Genetic variation in DNA repair pathways and risk of non-Hodgkin's lymphomaJustin Rendleman
NYU School of Medicine, New York University, New York, New York, United States of America
PLoS ONE 9:e101685. 2014..While the findings generated here warrant independent validation, the results of our large study suggest that ATM may be a novel locus associated with the risk of multiple subtypes of NHL...
- Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomasDaniel Schramek
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
Science 343:309-13. 2014..Myosin IIa is diminished in human SCCs with poor survival, which suggests that in vivo RNAi technology might be useful for identifying potent but low-penetrance tumor suppressors. ..
- Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research networkA Ari Hakimi
Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Clin Cancer Res 19:3259-67. 2013..To investigate the impact of newly identified chromosome 3p21 epigenetic tumor suppressors PBRM1, SETD2, and BAP1 on cancer-specific survival (CSS) of 609 patients with clear cell renal cell carcinoma (ccRCC) from 2 distinct cohorts...
- Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cellsTakashi Asai
Molecular Pharmacology and Chemistry Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Blood 120:1601-12. 2012..We conclude that necdin functions as a molecular switch in adult hematopoiesis, acting in a p53-like manner to promote HSC quiescence in the steady state, but suppressing p53-dependent apoptosis in response to genotoxic stress...
- The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics dataEthan Cerami
Computational Biology Center, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer Discov 2:401-4. 2012....
- Predicting the functional impact of protein mutations: application to cancer genomicsBoris Reva
Computational Biology Center, Memorial Sloan Kettering Cancer Center, NY 10065, USA
Nucleic Acids Res 39:e118. 2011..In addition, we estimate that at least 5% of cancer-relevant mutations involve switch of function, rather than simply loss or gain of function...