Ying Xian Pan

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi Identification and characterization of a novel promoter of the mouse mu opioid receptor gene (Oprm) that generates eight splice variants
    Ying Xian Pan
    Laboratory of Molecular Neuro Pharmacology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Gene 295:97-108. 2002
  2. ncbi Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X
    Ying Xian Pan
    Department of Neurology, Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Biochem Biophys Res Commun 301:1057-61. 2003
  3. ncbi Diversity and complexity of the mu opioid receptor gene: alternative pre-mRNA splicing and promoters
    Ying Xian Pan
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    DNA Cell Biol 24:736-50. 2005
  4. ncbi Identification of four novel exon 5 splice variants of the mouse mu-opioid receptor gene: functional consequences of C-terminal splicing
    Ying Xian Pan
    Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Mol Pharmacol 68:866-75. 2005
  5. pmc Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions
    Ying Xian Pan
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 106:4917-22. 2009
  6. ncbi Dimerization of morphine and orphanin FQ/nociceptin receptors: generation of a novel opioid receptor subtype
    Ying Xian Pan
    Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, Weill College of Medicine of Cornell University, 1275 York Avenue, New York, NY 10021, USA
    Biochem Biophys Res Commun 297:659-63. 2002
  7. pmc Stabilization of the μ-opioid receptor by truncated single transmembrane splice variants through a chaperone-like action
    Jin Xu
    Department of Neurology and The Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Biol Chem 288:21211-27. 2013
  8. pmc Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene
    Jin Xu
    Department of Neurology and The Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Neurochem 108:962-72. 2009
  9. ncbi Expression of opioid receptors in mammalian cell lines
    Ying Xian Pan
    Laboratory of Molecular Neuro Pharmacology, Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Methods Mol Med 84:17-28. 2003
  10. pmc Mediation of buprenorphine analgesia by a combination of traditional and truncated mu opioid receptor splice variants
    Steven G Grinnell
    Department of Neurology and Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York
    Synapse 70:395-407. 2016

Collaborators

  • Gavril Pasternak
  • Jin Xu
  • Grace C Rossi
  • Annie Kim Gilbert
  • AVI MA'AYAN
  • Rui Yu
  • Ming Xu
  • Joan Subrath
  • Yuri A Kolesnikov
  • Luca Cartegni
  • Massimo Squatrito
  • Susruta Majumdar
  • Gina F Marrone
  • Zhigang Lu
  • Steven G Grinnell
  • Valerie Le Rouzic
  • Ankita Narayan
  • John Pintar
  • Andras Varadi
  • Amanda Hunkele
  • Michael Ansonoff
  • Stephanie E Sillivan
  • Maxim Burgman
  • Lisa Polikar
  • Steven Grinnell
  • Clare V LeFave
  • Elizabeth A Bolan
  • David A Pasternak
  • Sanjay Kalra
  • Evelyn Warner
  • Travis C Palmer
  • Attila Borics
  • Márton R Szabó
  • Sarah Marx
  • Daniel L Bassoni
  • Shainnel O Eans
  • Jessica M Medina
  • Jay P McLaughlin
  • Jeremy Pagirsky
  • Yasmin L Hurd
  • Lillian W Chiang
  • Francesca F Caputi
  • John D Whittard
  • Yanhua Ren
  • Eva Keller
  • Monika Horvath
  • Michelle M Jacobs
  • Amin R Mazloom
  • Kuni Nagakura
  • Anna R Pasternak
  • Nathan Haselton
  • Julie Ocampo
  • Eric C Holland
  • Cameron W Brennan
  • Gina L Rocco
  • Sandra Vorlova
  • Ling Pan

Detail Information

Publications31

  1. ncbi Identification and characterization of a novel promoter of the mouse mu opioid receptor gene (Oprm) that generates eight splice variants
    Ying Xian Pan
    Laboratory of Molecular Neuro Pharmacology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Gene 295:97-108. 2002
    ..Mutation analysis suggested that the TATA box in the basal core region played a fundamental role in the exon 11 promoter, whereas the NF-1 site acted as a positive element...
  2. ncbi Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X
    Ying Xian Pan
    Department of Neurology, Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Biochem Biophys Res Commun 301:1057-61. 2003
    ..These two new human mu opioid receptors are the first human MOR-1 variants containing new exons and suggest that the complex splicing present in mice may extend to humans...
  3. ncbi Diversity and complexity of the mu opioid receptor gene: alternative pre-mRNA splicing and promoters
    Ying Xian Pan
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    DNA Cell Biol 24:736-50. 2005
    ..This review summarizes these recent results and provides a new perspective on understanding and exploring complex opioid actions in animals and humans...
  4. ncbi Identification of four novel exon 5 splice variants of the mouse mu-opioid receptor gene: functional consequences of C-terminal splicing
    Ying Xian Pan
    Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Mol Pharmacol 68:866-75. 2005
    ..In conclusion, alterations in the amino acid sequence of the C terminus do not alter the mu-specificity of the receptor but they can influence the binding characteristics, efficacy, and potency of mu-opioids...
  5. pmc Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions
    Ying Xian Pan
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 106:4917-22. 2009
    ....
  6. ncbi Dimerization of morphine and orphanin FQ/nociceptin receptors: generation of a novel opioid receptor subtype
    Ying Xian Pan
    Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, Weill College of Medicine of Cornell University, 1275 York Avenue, New York, NY 10021, USA
    Biochem Biophys Res Commun 297:659-63. 2002
    ..Selective kappa(1) and delta opioids did not lower binding. Despite the dramatic increase in affinity for the opioid agonists in co-expressing cells, the opioid antagonists naloxone and diprenorphine failed to compete [3H]OFQ/N binding...
  7. pmc Stabilization of the μ-opioid receptor by truncated single transmembrane splice variants through a chaperone-like action
    Jin Xu
    Department of Neurology and The Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Biol Chem 288:21211-27. 2013
    ..Our studies suggest the functional roles of truncated receptors in other G protein-coupled receptor families. ..
  8. pmc Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene
    Jin Xu
    Department of Neurology and The Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Neurochem 108:962-72. 2009
    ..The presence of exon 11-associated variants in humans raises questions regarding their potential role in heroin and morphine-6beta-glucuronide actions in people as they do in mice...
  9. ncbi Expression of opioid receptors in mammalian cell lines
    Ying Xian Pan
    Laboratory of Molecular Neuro Pharmacology, Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Methods Mol Med 84:17-28. 2003
  10. pmc Mediation of buprenorphine analgesia by a combination of traditional and truncated mu opioid receptor splice variants
    Steven G Grinnell
    Department of Neurology and Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York
    Synapse 70:395-407. 2016
    ..Buprenorphine analgesia is complex and requires multiple mu receptor splice variant classes but other actions may involve alternative receptors. ..
  11. pmc Identification and characterization of seven new exon 11-associated splice variants of the rat μ opioid receptor gene, OPRM1
    Jin Xu
    Department of Neurology and Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Pain 7:9. 2011
    ..We now have examined 5' splicing in the rat...
  12. ncbi Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy
    David A Pasternak
    Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Neurochem 91:881-90. 2004
    ..Thus, selectivity of opioid action might be achieved by designing compounds with varying efficacies at different MOR-1 variants...
  13. pmc Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS
    Gina F Marrone
    Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065 Neuroscience and Pharmacology Graduate Programs, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065
    Proc Natl Acad Sci U S A 113:3663-8. 2016
    ..These observations support the existence of parallel opioid and nonopioid pain modulatory systems and highlight the ability to dissociate unwanted delta, kappa1, and α2 actions from analgesia...
  14. ncbi Identification of alternatively spliced variants from opioid receptor genes
    Ying Xian Pan
    Laboratory of Molecular Neuro Pharmacology, Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Methods Mol Med 84:65-75. 2003
  15. pmc Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects
    Susruta Majumdar
    Molecular Pharmacology and Chemistry Program and Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 108:19778-83. 2011
    ....
  16. pmc Differential expressions of the alternatively spliced variant mRNAs of the µ opioid receptor gene, OPRM1, in brain regions of four inbred mouse strains
    Jin Xu
    Department of Neurology and Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 9:e111267. 2014
    ..The expression levels of a number of the variant mRNAs in certain brain regions appear to correlate with strain sensitivities to morphine analgesia, tolerance and physical dependence in four mouse strains. ..
  17. pmc Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associated μ opioid receptor (MOR-1) splice variants
    Susruta Majumdar
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    J Med Chem 55:6352-62. 2012
    ..Thus, the aryl-naloxamide scaffold can generate a potent analgesic acting through the 6TM/E11 sites with advantageous side-effect profile and greater selectivity...
  18. pmc Tetrapeptide Endomorphin Analogs Require Both Full Length and Truncated Splice Variants of the Mu Opioid Receptor Gene Oprm1 for Analgesia
    Gina F Marrone
    Department of Neurology and Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States
    ACS Chem Neurosci . 2016
    ..Together, these data indicate that endomorphin analogs represent a unique, genetically defined, and distinct class of mu opioid analgesic...
  19. pmc Stabilization of morphine tolerance with long-term dosing: association with selective upregulation of mu-opioid receptor splice variant mRNAs
    Jin Xu
    Department of Neurology and The Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065 and
    Proc Natl Acad Sci U S A 112:279-84. 2015
    ..These findings reconcile preclinical and clinical observations regarding the development of morphine tolerance. ..
  20. pmc Morphine regulates expression of μ-opioid receptor MOR-1A, an intron-retention carboxyl terminal splice variant of the μ-opioid receptor (OPRM1) gene via miR-103/miR-107
    Zhigang Lu
    Department of Neurology and The Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York
    Mol Pharmacol 85:368-80. 2014
    ....
  21. pmc Isolating and characterizing three alternatively spliced mu opioid receptor variants: mMOR-1A, mMOR-1O, and mMOR-1P
    Jin Xu
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York, 10065
    Synapse 68:144-52. 2014
    ....
  22. pmc Characterizing exons 11 and 1 promoters of the mu opioid receptor (Oprm) gene in transgenic mice
    Jin Xu
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021 USA
    BMC Mol Biol 7:41. 2006
    ..The aim of this study is to further characterize the E11 and E1 promoters in vivo using a transgenic mouse model...
  23. ncbi Functional analysis of MOR-1 splice variants of the mouse mu opioid receptor gene Oprm
    Elizabeth A Bolan
    Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Synapse 51:11-8. 2004
    ..Together, these findings reveal marked functional differences among the variants that only can be explained by their structural differences at the tip of their C-terminus...
  24. doi Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2
    Andras Varadi
    Molecular Pharmacology and Chemistry Program and Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States
    J Med Chem 59:8381-97. 2016
    ....
  25. pmc Mu opioids and their receptors: evolution of a concept
    Gavril W Pasternak
    Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065
    Pharmacol Rev 65:1257-317. 2013
    ..These chemical biologic approaches were then eclipsed by the molecular biology revolution, which now reveals a complexity of the morphine-like agents and their receptors that had not been previously appreciated. ..
  26. pmc Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas
    Clare V LeFave
    Department of Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    EMBO J 30:4084-97. 2011
    ....
  27. pmc Opposing actions of neuronal nitric oxide synthase isoforms in formalin-induced pain in mice
    Yuri A Kolesnikov
    Department of Anesthesiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Brain Res 1289:14-21. 2009
    ..Together, these observations illustrate the complexity of nNOS in pain perception and the existence of opposing nNOS systems likely due to splice variants of nNOS...
  28. pmc Mu opioid receptors in pain management
    Gavril Pasternak
    Department of Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, NY 10065, USA
    Acta Anaesthesiol Taiwan 49:21-5. 2011
    ..It now appears that this gene undergoes extensive splicing, in which a single gene can generate multiple proteins. Evidence now suggests that these splice variants may help explain the clinical variability in responses among patients...
  29. ncbi Molecular cloning of opioid receptors by cDNA library screening
    Ying Xian Pan
    Laboratory of Molecular Neuro Pharmacology, Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Methods Mol Med 84:3-16. 2003
  30. pmc ELK1 transcription factor linked to dysregulated striatal mu opioid receptor signaling network and OPRM1 polymorphism in human heroin abusers
    Stephanie E Sillivan
    Departments of Psychiatry and Neuroscience SES, JDW, MMJ, YR, FFC, YLH Department of Pharmacology and Systems Therapeutics SES, MMJ, YR, arm, FFC, AM, YLH, Ichan School of Medicine at Mount Sinai, New York, New York
    Biol Psychiatry 74:511-9. 2013
    ..The striatum is a structure central to reward and habitual behavior and neurobiological changes in this region are thought to underlie the pathophysiology of addiction disorders...