Stig Palm

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi request reprint Single-cell irradiation from [211At] astatine-labeled C215 monoclonal antibody: improved estimates of radiosensitivity from measurements on cellular uptake and retention
    Stig Palm
    Department of Radiation Physics, Goteborg University, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Anticancer Res 23:1219-21. 2003
  2. ncbi request reprint Pharmacokinetics and Biodistribution of (86)Y-Trastuzumab for (90)Y dosimetry in an ovarian carcinoma model: correlative MicroPET and MRI
    Stig Palm
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Nucl Med 44:1148-55. 2003
  3. ncbi request reprint Microdosimetry of astatine-211 single-cell irradiation: role of daughter polonium-211 diffusion
    Stig Palm
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Med Phys 31:218-25. 2004
  4. ncbi request reprint Therapeutic efficacy of astatine-211-labeled trastuzumab on radioresistant SKOV-3 tumors in nude mice
    Stig Palm
    Department of Radiation Physics, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Int J Radiat Oncol Biol Phys 69:572-9. 2007
  5. ncbi request reprint 211At radioimmunotherapy of subcutaneous human ovarian cancer xenografts: evaluation of relative biologic effectiveness of an alpha-emitter in vivo
    Tom Bäck
    Department of Radiation Physics, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Nucl Med 46:2061-7. 2005
  6. ncbi request reprint Administered activity and metastatic cure probability during radioimmunotherapy of ovarian cancer in nude mice with 211At-MX35 F(ab')2
    Jörgen Elgqvist
    Department of Radiation Physics, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Int J Radiat Oncol Biol Phys 66:1228-37. 2006
  7. ncbi request reprint Alpha-radioimmunotherapy of intraperitoneally growing OVCAR-3 tumors of variable dimensions: Outcome related to measured tumor size and mean absorbed dose
    Jörgen Elgqvist
    Department of Radiation Physics, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Nucl Med 47:1342-50. 2006
  8. ncbi request reprint Therapeutic efficacy and tumor dose estimations in radioimmunotherapy of intraperitoneally growing OVCAR-3 cells in nude mice with (211)At-labeled monoclonal antibody MX35
    Jörgen Elgqvist
    Department of Radiation Physics, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Nucl Med 46:1907-15. 2005
  9. ncbi request reprint Fractionated radioimmunotherapy of intraperitoneally growing ovarian cancer in nude mice with 211At-MX35 F(ab')2: therapeutic efficacy and myelotoxicity
    Jörgen Elgqvist
    Department of Radiation Physics, The Sahlgrenska Academy at Goteborg University, SE 413 45 Goteborg, Sweden
    Nucl Med Biol 33:1065-72. 2006
  10. ncbi request reprint Astatine-211-labeled antibodies for treatment of disseminated ovarian cancer: an overview of results in an ovarian tumor model
    Hakan Andersson
    Department of Oncology, Sahlgrenska University Hospital, Goteborg University, SE 413 45 Goteborg, Sweden
    Clin Cancer Res 9:3914S-21S. 2003

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Single-cell irradiation from [211At] astatine-labeled C215 monoclonal antibody: improved estimates of radiosensitivity from measurements on cellular uptake and retention
    Stig Palm
    Department of Radiation Physics, Goteborg University, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Anticancer Res 23:1219-21. 2003
    ..The results from each experiment were then fit to a mono-exponential function. From the exponential fit, an average of 35 +/- 2 (SD) astatine-211 decays per cell are required for 37% apparent cell survival (D0)...
  2. ncbi request reprint Pharmacokinetics and Biodistribution of (86)Y-Trastuzumab for (90)Y dosimetry in an ovarian carcinoma model: correlative MicroPET and MRI
    Stig Palm
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Nucl Med 44:1148-55. 2003
    ..MicroPET and MRI-based preclinical biodistribution and localization data were obtained and used to assess the therapeutic potential of (90)Y-trastuzumab monoclonal antibody (mAb) (anti-HER2/neu) against ovarian carcinoma...
  3. ncbi request reprint Microdosimetry of astatine-211 single-cell irradiation: role of daughter polonium-211 diffusion
    Stig Palm
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Med Phys 31:218-25. 2004
    ..This will result in fewer alpha-particle events in the cell nucleus. For dispersed cells, the diffusion of 211Po atoms will reduce the total dose from cell-bound 211At by a factor of 2...
  4. ncbi request reprint Therapeutic efficacy of astatine-211-labeled trastuzumab on radioresistant SKOV-3 tumors in nude mice
    Stig Palm
    Department of Radiation Physics, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Int J Radiat Oncol Biol Phys 69:572-9. 2007
    ..To investigate the potential use of astatine-211 (211At)-labeled trastuzumab for the treatment of HER-2-positive, radioresistant ovarian carcinoma...
  5. ncbi request reprint 211At radioimmunotherapy of subcutaneous human ovarian cancer xenografts: evaluation of relative biologic effectiveness of an alpha-emitter in vivo
    Tom Bäck
    Department of Radiation Physics, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Nucl Med 46:2061-7. 2005
    ..This study was performed to evaluate the relative biological effectiveness (RBE) of 211At compared with that of 60Co gamma-irradiation in an RIT model. Our endpoint was growth inhibition (GI) of subcutaneous xenografts...
  6. ncbi request reprint Administered activity and metastatic cure probability during radioimmunotherapy of ovarian cancer in nude mice with 211At-MX35 F(ab')2
    Jörgen Elgqvist
    Department of Radiation Physics, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Int J Radiat Oncol Biol Phys 66:1228-37. 2006
    ..The study was performed using the alpha-particle emitter Astatine-211 (211At) labeled to the mAb MX35 F(ab')2...
  7. ncbi request reprint Alpha-radioimmunotherapy of intraperitoneally growing OVCAR-3 tumors of variable dimensions: Outcome related to measured tumor size and mean absorbed dose
    Jörgen Elgqvist
    Department of Radiation Physics, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Nucl Med 47:1342-50. 2006
    ....
  8. ncbi request reprint Therapeutic efficacy and tumor dose estimations in radioimmunotherapy of intraperitoneally growing OVCAR-3 cells in nude mice with (211)At-labeled monoclonal antibody MX35
    Jörgen Elgqvist
    Department of Radiation Physics, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Nucl Med 46:1907-15. 2005
    ..Previous studies on mAb MOv18 did not allow for dosimetry because of antigen shedding in vitro...
  9. ncbi request reprint Fractionated radioimmunotherapy of intraperitoneally growing ovarian cancer in nude mice with 211At-MX35 F(ab')2: therapeutic efficacy and myelotoxicity
    Jörgen Elgqvist
    Department of Radiation Physics, The Sahlgrenska Academy at Goteborg University, SE 413 45 Goteborg, Sweden
    Nucl Med Biol 33:1065-72. 2006
    ..The study was performed using the monoclonal antibody MX35 F(ab')(2) labeled with the alpha-particle emitter (211)At...
  10. ncbi request reprint Astatine-211-labeled antibodies for treatment of disseminated ovarian cancer: an overview of results in an ovarian tumor model
    Hakan Andersson
    Department of Oncology, Sahlgrenska University Hospital, Goteborg University, SE 413 45 Goteborg, Sweden
    Clin Cancer Res 9:3914S-21S. 2003
    ..The aim of the study was to establish and refine a preclinical model to alpha-immunoradiotherapy of ovarian cancer...
  11. doi request reprint Absorbed Doses and Risk Estimates of (211)At-MX35 F(ab')2 in Intraperitoneal Therapy of Ovarian Cancer Patients
    Elin Cederkrantz
    Department of Radiation Physics, Institute for Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Int J Radiat Oncol Biol Phys 93:569-76. 2015
    ..In the present study, we calculated absorbed and relative biological effect (RBE)-weighted (equivalent) doses in relevant normal tissues and estimated the effective dose associated with i.p. administration of (211)At-MX35 F(ab')2...
  12. ncbi request reprint Alpha-particle emitting atomic generator (Actinium-225)-labeled trastuzumab (herceptin) targeting of breast cancer spheroids: efficacy versus HER2/neu expression
    Ase M Ballangrud
    Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Clin Cancer Res 10:4489-97. 2004
    ..225)Ac has a 10-day half-life and a decay scheme yielding four alpha-particles...
  13. doi request reprint Synthesis and Evaluation of Astatinated N-[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide Immunoconjugates
    Emma Aneheim
    Department of Radiation Physics, Gothenburg University, Gula Straket 2b, 41345 Gothenburg, Sweden
    Bioconjug Chem 27:688-97. 2016
    ....
  14. doi request reprint Biokinetic Modeling and Dosimetry for Optimizing Intraperitoneal Radioimmunotherapy of Ovarian Cancer Microtumors
    Stig Palm
    Department of Radiation Physics, Institute for Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    J Nucl Med 57:594-600. 2016
    ..The model was used to calculate the absorbed dose to both anticipated microtumors and critical healthy organs and demonstrated how intraperitoneal targeted radiotherapy can be optimized to maximize the ratio between them...
  15. pmc Automated astatination of biomolecules--a stepping stone towards multicenter clinical trials
    Emma Aneheim
    Targeted Alpha Therapy, Department of Radiation Physics, Sahlgrenska Academy at Gothenburg University, Gothenburg 41345, Sweden
    Sci Rep 5:12025. 2015
    ..In this work, we describe the process platform, and we demonstrate the production of both astaine-211, for preclinical use, and astatine-211 labelled antibodies. ..
  16. pmc Binding Affinity, Specificity and Comparative Biodistribution of the Parental Murine Monoclonal Antibody MX35 (Anti-NaPi2b) and Its Humanized Version Rebmab200
    Sture Lindegren
    Department of Radiation Physics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 10:e0126298. 2015
    ..Taken together, our data support the further development of Rebmab200 for radioimmunotherapy and diagnostics. ..
  17. ncbi request reprint Patient-specific alpha-particle dosimetry
    Stig Palm
    Dosimetry and Medical Radiation Physics Section, International Atomic Energy Agency IAEA, Vienna, Austria
    Curr Radiopharm 4:329-35. 2011
    ....
  18. doi request reprint Differences in radiosensitivity between three HER2 overexpressing cell lines
    Ann Charlott Steffen
    Department of Oncology, Radiology and Clinical Immunology, Rudbeck Laboratory, Uppsala University, Uppsala, 751 85, Sweden
    Eur J Nucl Med Mol Imaging 35:1179-91. 2008
    ..Therefore, it is of interest to analyse whether HER2 overexpressing tumour cells have different inherent radiosensitivity...