Deborah L Clarke

Summary

Affiliation: MedImmune Vaccines
Country: USA

Publications

  1. doi Is personalised medicine the key to heterogeneity in idiopathic pulmonary fibrosis?
    Deborah L Clarke
    MedImmune Ltd, Granta Park, Cambridge CB21 6GH, UK Electronic address
    Pharmacol Ther 169:35-46. 2017
  2. pmc TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein
    Deborah L Clarke
    Nottingham Respiratory Biomedical Research Unit, City Hospital, University of Nottingham, Nottingham NG5 1PB, United Kingdom
    J Biol Chem 285:29101-10. 2010
  3. pmc Transcriptional regulation of monocyte chemotactic protein-1 release by endothelin-1 in human airway smooth muscle cells involves NF-kappaB and AP-1
    Amy M Sutcliffe
    Nottingham Respiratory Biomedical Research Unit, University of Nottingham, City Hospital, Nottingham NG5 1PB, UK
    Br J Pharmacol 157:436-50. 2009
  4. ncbi PKCbetaII augments NF-kappaB-dependent transcription at the CCL11 promoter via p300/CBP-associated factor recruitment and histone H4 acetylation
    Deborah L Clarke
    Division of Respiratory Medicine, University of Nottingham, City Hospital, Nottingham, United Kingdom
    J Immunol 181:3503-14. 2008
  5. doi Development of a mouse model mimicking key aspects of a viral asthma exacerbation
    Deborah L Clarke
    Department of Respiratory, Inflammation and Autoimmunity, MedImmune, Granta Park, Cambridge CB21 6GH, U K
    Clin Sci (Lond) 126:567-80. 2014
  6. pmc Matrix regulation of idiopathic pulmonary fibrosis: the role of enzymes
    Deborah L Clarke
    MedImmune Ltd, Granta Park, Cambridge CB21 6GH, UK
    Fibrogenesis Tissue Repair 6:20. 2013

Collaborators

Detail Information

Publications7

  1. doi Is personalised medicine the key to heterogeneity in idiopathic pulmonary fibrosis?
    Deborah L Clarke
    MedImmune Ltd, Granta Park, Cambridge CB21 6GH, UK Electronic address
    Pharmacol Ther 169:35-46. 2017
    ..Below we review the ongoing quest for novel therapeutic approaches and highlight, where appropriate attempts have been made to identify patients for which a specific pathway or mediator may be driving disease progression...
  2. pmc TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein
    Deborah L Clarke
    Nottingham Respiratory Biomedical Research Unit, City Hospital, University of Nottingham, Nottingham NG5 1PB, United Kingdom
    J Biol Chem 285:29101-10. 2010
    ....
  3. pmc Transcriptional regulation of monocyte chemotactic protein-1 release by endothelin-1 in human airway smooth muscle cells involves NF-kappaB and AP-1
    Amy M Sutcliffe
    Nottingham Respiratory Biomedical Research Unit, University of Nottingham, City Hospital, Nottingham NG5 1PB, UK
    Br J Pharmacol 157:436-50. 2009
    ..We studied the effect of ET-1 on expression of the chemokine, monocyte chemotactic protein-1 (MCP-1), in primary cultures of human airway smooth muscle cells...
  4. ncbi PKCbetaII augments NF-kappaB-dependent transcription at the CCL11 promoter via p300/CBP-associated factor recruitment and histone H4 acetylation
    Deborah L Clarke
    Division of Respiratory Medicine, University of Nottingham, City Hospital, Nottingham, United Kingdom
    J Immunol 181:3503-14. 2008
    ..These data suggest a novel important biological role for PKCbetaIotaIota in NF-kappaB-mediated CCL11 transcription by p/CAF activation and histone H4 acetylation...
  5. doi Development of a mouse model mimicking key aspects of a viral asthma exacerbation
    Deborah L Clarke
    Department of Respiratory, Inflammation and Autoimmunity, MedImmune, Granta Park, Cambridge CB21 6GH, U K
    Clin Sci (Lond) 126:567-80. 2014
    ..This model may provide better understanding of disease mechanisms underlying viral exacerbations and could be used to build early confidence in novel therapeutic axes targeting viral asthma exacerbations in Th2 asthmatics...
  6. pmc Matrix regulation of idiopathic pulmonary fibrosis: the role of enzymes
    Deborah L Clarke
    MedImmune Ltd, Granta Park, Cambridge CB21 6GH, UK
    Fibrogenesis Tissue Repair 6:20. 2013
    ..Elevated expression of a number of enzymes that can directly modulate the ECM has been reported, and recent data indicates that modulating the activity of these enzymes can have a downstream effect on fibrotic tissue remodeling. ..