Yi Zhang

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. pmc QTL-based association analyses reveal novel genes influencing pleiotropy of metabolic syndrome (MetS)
    Y Zhang
    TOPS Obesity and Metabolic Research Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Obesity (Silver Spring) 21:2099-111. 2013
  2. pmc A comprehensive analysis of adiponectin QTLs using SNP association, SNP cis-effects on peripheral blood gene expression and gene expression correlation identified novel metabolic syndrome (MetS) genes with potential role in carcinogenesis and systemic inf
    Yi Zhang
    TOPS Obesity and Metabolic Research Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    BMC Med Genomics 6:14. 2013
  3. pmc Fatty acid binding protein 3 (fabp3) is associated with insulin, lipids and cardiovascular phenotypes of the metabolic syndrome through epigenetic modifications in a Northern European family population
    Yi Zhang
    TOPS Obesity and Metabolic Research Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    BMC Med Genomics 6:9. 2013
  4. pmc Obesity-related dyslipidemia associated with FAAH, independent of insulin response, in multigenerational families of Northern European descent
    Yi Zhang
    Medical College of Wisconsin, Milwaukee, Wisconsin, WI 53226, USA
    Pharmacogenomics 10:1929-39. 2009
  5. pmc STAT5 requires the N-domain to maintain hematopoietic stem cell repopulating function and appropriate lymphoid-myeloid lineage output
    Geqiang Li
    Department of Medicine, Division of Hematology Oncology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA
    Exp Hematol 35:1684-94. 2007
  6. ncbi request reprint Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells
    Jiang Zhu
    Department of Medicine, Division of Hematology Oncology, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104, USA
    Blood 109:3706-12. 2007
  7. pmc Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index
    Wanqing Wen
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    Hum Mol Genet 23:5492-504. 2014
  8. doi request reprint Putting the Invader assay to work: laboratory application and data management
    Yi Zhang
    Biotechnology and Bioengineering Center, Medical College of Wisconsin, Milwaukee, WI, USA
    Methods Mol Biol 578:363-77. 2009
  9. pmc Meta-analysis identifies common variants associated with body mass index in east Asians
    Wanqing Wen
    Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Nat Genet 44:307-11. 2012
  10. pmc Abnormal hematopoiesis in Gab2 mutant mice
    Yi Zhang
    Department of Medicine, Division of Hematology, Case Western Reserve University School of Medicine, Cleveland, OH 44106 7284, USA
    Blood 110:116-24. 2007

Collaborators

Detail Information

Publications16

  1. pmc QTL-based association analyses reveal novel genes influencing pleiotropy of metabolic syndrome (MetS)
    Y Zhang
    TOPS Obesity and Metabolic Research Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Obesity (Silver Spring) 21:2099-111. 2013
    ..We conducted a study to elucidate the genetic basis underlying linkage signals for multiple representative traits of MetS that we had previously identified at two significant QTLs on chromosomes 3q27 and 17p12...
  2. pmc A comprehensive analysis of adiponectin QTLs using SNP association, SNP cis-effects on peripheral blood gene expression and gene expression correlation identified novel metabolic syndrome (MetS) genes with potential role in carcinogenesis and systemic inf
    Yi Zhang
    TOPS Obesity and Metabolic Research Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    BMC Med Genomics 6:14. 2013
    ..We previously performed microsatellite linkage analyses using adiponectin as a surrogate marker and revealed two QTLs on chr5 (5p14) and chr14 (14q13)...
  3. pmc Fatty acid binding protein 3 (fabp3) is associated with insulin, lipids and cardiovascular phenotypes of the metabolic syndrome through epigenetic modifications in a Northern European family population
    Yi Zhang
    TOPS Obesity and Metabolic Research Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    BMC Med Genomics 6:9. 2013
    ..The objective of this study was to test the hypothesis that CpG methylation status of a key regulator of lipid homeostasis, FABP3, is a quantitative trait associated with status of MetS phenotypes in humans...
  4. pmc Obesity-related dyslipidemia associated with FAAH, independent of insulin response, in multigenerational families of Northern European descent
    Yi Zhang
    Medical College of Wisconsin, Milwaukee, Wisconsin, WI 53226, USA
    Pharmacogenomics 10:1929-39. 2009
    ..In recent years, there has been tremendous interest in understanding the endocannabinoid system as a novel therapeutic target for the treatment of obesity-related dyslipidemia...
  5. pmc STAT5 requires the N-domain to maintain hematopoietic stem cell repopulating function and appropriate lymphoid-myeloid lineage output
    Geqiang Li
    Department of Medicine, Division of Hematology Oncology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA
    Exp Hematol 35:1684-94. 2007
    ..The goal of these studies was to use transplantation-based assays to analyze the degree of STAT5 deltaN activity in hematopoietic stem cells (HSC) and throughout lymphomyeloid development...
  6. ncbi request reprint Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells
    Jiang Zhu
    Department of Medicine, Division of Hematology Oncology, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104, USA
    Blood 109:3706-12. 2007
    ..Taken together, these results demonstrate that osteoblasts are both necessary and sufficient for murine B-cell commitment and maturation, and thereby constitute the cellular homolog of the avian bursa of Fabricius...
  7. pmc Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index
    Wanqing Wen
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    Hum Mol Genet 23:5492-504. 2014
    ..0 × 10(-8)) and an additional 14 at P < 1.0 × 10(-3) with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity. ..
  8. doi request reprint Putting the Invader assay to work: laboratory application and data management
    Yi Zhang
    Biotechnology and Bioengineering Center, Medical College of Wisconsin, Milwaukee, WI, USA
    Methods Mol Biol 578:363-77. 2009
    ..Here, from an end-user point of view, we discuss how a commercially available genotyping platform, the Invader assay, can be utilized to meet the needs and demands of human genomic research in a laboratory...
  9. pmc Meta-analysis identifies common variants associated with body mass index in east Asians
    Wanqing Wen
    Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Nat Genet 44:307-11. 2012
    ..0 × 10(-7). Findings from this study may shed light on new pathways involved in obesity and demonstrate the value of conducting genetic studies in non-European populations...
  10. pmc Abnormal hematopoiesis in Gab2 mutant mice
    Yi Zhang
    Department of Medicine, Division of Hematology, Case Western Reserve University School of Medicine, Cleveland, OH 44106 7284, USA
    Blood 110:116-24. 2007
    ..Therefore, we demonstrate that Gab2 adapter function is intrinsically required for hematopoietic cell response to early-acting cytokines, resulting in defective hematopoiesis in Gab2-deficient mice...
  11. pmc Long-term functional engraftment of mesenchymal progenitor cells in a mouse model of accelerated aging
    Lakshman Singh
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Stem Cells 31:607-11. 2013
    ....
  12. pmc Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index
    Tes M Baye
    Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Pharmacogenomics 9:1647-56. 2008
    ..We therefore tested the hypothesis that genetic variation in CNR1 is associated with common obesity-related metabolic disorders...
  13. doi request reprint Retroviral transduction of murine hematopoietic stem cells
    Peter Haviernik
    Department of Medicine, Division of Hematology Oncology, Center for Stem Cell and Regenerative Medicine, Case Western Reserve University, Cleveland, OH, USA
    Methods Mol Biol 430:229-41. 2008
    ..We also describe methods for transplantation and subsequent analysis of transplanted mice as a bona fide assay for the stem cell transduction efficiency...
  14. pmc c-Myb contributes to G2/M cell cycle transition in human hematopoietic cells by direct regulation of cyclin B1 expression
    Yuji Nakata
    Division of Hematology Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Cell Biol 27:2048-58. 2007
    ....
  15. ncbi request reprint Host-reactive CD8+ memory stem cells in graft-versus-host disease
    Yi Zhang
    Department of Medicine, University of Pennsylvania School of Medicine, Room 510, Maloney, 3600 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Nat Med 11:1299-305. 2005
    ..Memory stem cells will be important targets for understanding and influencing diverse chronic immune reactions, including GVHD...
  16. pmc NF-Ya activates multiple hematopoietic stem cell (HSC) regulatory genes and promotes HSC self-renewal
    Jiang Zhu
    Department of Medicine, and Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 102:11728-33. 2005
    ..Thus, NF-Ya is a potent cellular regulator of HSC self-renewal...