Richard C Venema

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. ncbi request reprint Subunit interactions of endothelial nitric-oxide synthase. Comparisons to the neuronal and inducible nitric-oxide synthase isoforms
    R C Venema
    Department of Pediatrics, Medical College of Georgia, Augusta 30912, USA
    J Biol Chem 272:1276-82. 1997
  2. ncbi request reprint Bradykinin stimulates the tyrosine phosphorylation and bradykinin B2 receptor association of phospholipase C gamma 1 in vascular endothelial cells
    V J Venema
    Department of Pediatrics, Medical College of Georgia, Augusta 30912, USA
    Biochem Biophys Res Commun 246:70-5. 1998
  3. ncbi request reprint Post-translational mechanisms of endothelial nitric oxide synthase regulation by bradykinin
    Richard C Venema
    Department of Pediatrics, Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Boulevard, CB 3207, Augusta, GA 30912 2500, USA
    Int Immunopharmacol 2:1755-62. 2002
  4. ncbi request reprint Agonist-stimulated endothelial nitric oxide synthase activation and vascular relaxation. Role of eNOS phosphorylation at Tyr83
    David Fulton
    Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd, Augusta, GA 30912 2500, USA
    Circ Res 102:497-504. 2008
  5. pmc Interaction of the endothelial nitric oxide synthase with the CAT-1 arginine transporter enhances NO release by a mechanism not involving arginine transport
    Chunying Li
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    Biochem J 386:567-74. 2005
  6. pmc Inhibition of endothelial nitric oxide synthase by the lipid phosphatase PTEN
    Jarrod E Church
    Medical College of Georgia, Augusta, Georgia 30912, USA
    Vascul Pharmacol 52:191-8. 2010
  7. ncbi request reprint Src kinase activates endothelial nitric-oxide synthase by phosphorylating Tyr-83
    David Fulton
    Vascular Biology Center and Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912 2500, USA
    J Biol Chem 280:35943-52. 2005
  8. pmc Calcineurin-mediated dephosphorylation of eNOS at serine 116 affects eNOS enzymatic activity indirectly by facilitating c-Src binding and tyrosine 83 phosphorylation
    Ling Ruan
    Vascular Biology Center, Medical College of Georgia, Georgia Regents University, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
    Vascul Pharmacol 59:27-35. 2013
  9. ncbi request reprint Nitric oxide preconditioning regulates endothelial monolayer integrity via the heat shock protein 90-soluble guanylate cyclase pathway
    Galina N Antonova
    Vascular Biology Center, Medical College of Georgia, Augusta, GA, 30912 2500, USA
    Am J Physiol Heart Circ Physiol 292:H893-903. 2007
  10. pmc Role of eNOS phosphorylation at Ser-116 in regulation of eNOS activity in endothelial cells
    Chunying Li
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    Vascul Pharmacol 47:257-64. 2007

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Subunit interactions of endothelial nitric-oxide synthase. Comparisons to the neuronal and inducible nitric-oxide synthase isoforms
    R C Venema
    Department of Pediatrics, Medical College of Georgia, Augusta 30912, USA
    J Biol Chem 272:1276-82. 1997
    ..In contrast, iNOS subunit association involves only oxygenase domain interactions...
  2. ncbi request reprint Bradykinin stimulates the tyrosine phosphorylation and bradykinin B2 receptor association of phospholipase C gamma 1 in vascular endothelial cells
    V J Venema
    Department of Pediatrics, Medical College of Georgia, Augusta 30912, USA
    Biochem Biophys Res Commun 246:70-5. 1998
    ..Activation of PLC gamma isoforms, rather than PLC beta isoforms, may, therefore, be primarily responsible for BK-stimulated IP3 generation in endothelial cells...
  3. ncbi request reprint Post-translational mechanisms of endothelial nitric oxide synthase regulation by bradykinin
    Richard C Venema
    Department of Pediatrics, Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Boulevard, CB 3207, Augusta, GA 30912 2500, USA
    Int Immunopharmacol 2:1755-62. 2002
    ..In addition, BK stimulates an increase in eNOS activity through phosphorylation of the enzyme at three specific amino acid residues as well as through dephosphorylation at a fourth residue...
  4. ncbi request reprint Agonist-stimulated endothelial nitric oxide synthase activation and vascular relaxation. Role of eNOS phosphorylation at Tyr83
    David Fulton
    Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd, Augusta, GA 30912 2500, USA
    Circ Res 102:497-504. 2008
    ..Moreover, our results demonstrate an important role for Src-mediated phosphorylation of eNOS at Tyr83 in agonist stimulation of eNOS activation and vascular relaxation...
  5. pmc Interaction of the endothelial nitric oxide synthase with the CAT-1 arginine transporter enhances NO release by a mechanism not involving arginine transport
    Chunying Li
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    Biochem J 386:567-74. 2005
    ..Taken together, these data suggest that direct interaction of eNOS with CAT-1 enhances NO release by a mechanism not involving arginine transport...
  6. pmc Inhibition of endothelial nitric oxide synthase by the lipid phosphatase PTEN
    Jarrod E Church
    Medical College of Georgia, Augusta, Georgia 30912, USA
    Vascul Pharmacol 52:191-8. 2010
    ..We conclude that PTEN is a regulator of eNOS function both when expressed in COS-7 cells and in human endothelial cells, and does so via its effects on the PI3K/Akt pathway...
  7. ncbi request reprint Src kinase activates endothelial nitric-oxide synthase by phosphorylating Tyr-83
    David Fulton
    Vascular Biology Center and Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912 2500, USA
    J Biol Chem 280:35943-52. 2005
    ..Furthermore, the Y83F eNOS mutation attenuated thapsigargin-stimulated NO production. Taken together, these data indicate that Src-mediated tyrosine phosphorylation of eNOS at Tyr-83 modulates eNOS activity in endothelial cells...
  8. pmc Calcineurin-mediated dephosphorylation of eNOS at serine 116 affects eNOS enzymatic activity indirectly by facilitating c-Src binding and tyrosine 83 phosphorylation
    Ling Ruan
    Vascular Biology Center, Medical College of Georgia, Georgia Regents University, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
    Vascul Pharmacol 59:27-35. 2013
    ....
  9. ncbi request reprint Nitric oxide preconditioning regulates endothelial monolayer integrity via the heat shock protein 90-soluble guanylate cyclase pathway
    Galina N Antonova
    Vascular Biology Center, Medical College of Georgia, Augusta, GA, 30912 2500, USA
    Am J Physiol Heart Circ Physiol 292:H893-903. 2007
    ..HSP90/sGC may thus play a role in the protective effects of NO-generating drugs from injurious stimuli...
  10. pmc Role of eNOS phosphorylation at Ser-116 in regulation of eNOS activity in endothelial cells
    Chunying Li
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    Vascul Pharmacol 47:257-64. 2007
    ..eNOS phosphorylation at Ser-116, therefore, appears to contribute to negative modulation of eNOS activity and hence to regulation of vascular tone...
  11. pmc Nitric oxide reduces NADPH oxidase 5 (Nox5) activity by reversible S-nitrosylation
    Jin Qian
    Vascular Biology Center, Georgia Health Sciences University, Augusta, GA 30912, USA
    Free Radic Biol Med 52:1806-19. 2012
    ..Collectively, these results suggest that endogenously produced NO can directly S-nitrosylate and inhibit the activity of Nox5...
  12. ncbi request reprint Chaperone-dependent E3 ligase CHIP ubiquitinates and mediates proteasomal degradation of soluble guanylyl cyclase
    Tian Xia
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Am J Physiol Heart Circ Physiol 293:H3080-7. 2007
    ..This study reveals a new mechanism for the regulation of sGC, an important mediator of cellular and vascular function...
  13. pmc Expression and functional significance of NADPH oxidase 5 (Nox5) and its splice variants in human blood vessels
    Deepesh Pandey
    Vascular Biology Center, Georgia Health Sciences University, Augusta, GA 30912, USA
    Am J Physiol Heart Circ Physiol 302:H1919-28. 2012
    ..The Nox5-α and -β splice variants are the major isoforms that are expressed and the only variants capable of ROS production. Nox5-ε can inhibit Nox5 activity and activate ERK and HVSMC proliferation...
  14. pmc Pin1 prolyl isomerase regulates endothelial nitric oxide synthase
    Ling Ruan
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Arterioscler Thromb Vasc Biol 31:392-8. 2011
    ....
  15. ncbi request reprint Acute activation and phosphorylation of endothelial nitric oxide synthase by HMG-CoA reductase inhibitors
    M Brennan Harris
    Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912 2500, USA
    Am J Physiol Heart Circ Physiol 287:H560-6. 2004
    ....
  16. ncbi request reprint Effects of hsp90 binding inhibitors on sGC-mediated vascular relaxation
    Gunay Yetik-Anacak
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Am J Physiol Heart Circ Physiol 291:H260-8. 2006
    ..These studies suggest that hsp90 regulates both eNOS- and sGC-dependent relaxations...
  17. ncbi request reprint Insulin resistance does not diminish eNOS expression, phosphorylation, or binding to HSP-90
    David Fulton
    Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
    Am J Physiol Heart Circ Physiol 287:H2384-93. 2004
    ....
  18. pmc Alterations in lung arginine metabolism in lambs with pulmonary hypertension associated with increased pulmonary blood flow
    Shruti Sharma
    Vascular Biology Center, 1459 Laney Walker Boulevard, CB3201B, Medical College of Georgia, Augusta, GA 30912, USA
    Vascul Pharmacol 51:359-64. 2009
    ....
  19. ncbi request reprint Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase
    Richard C Venema
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Am J Physiol Heart Circ Physiol 285:H669-78. 2003
    ....
  20. pmc Heat shock protein 90 inhibitors prolong survival, attenuate inflammation, and reduce lung injury in murine sepsis
    Anuran Chatterjee
    Program in Pulmonary Vascular Disease, Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Am J Respir Crit Care Med 176:667-75. 2007
    ..We hypothesized that Hsp90 inhibitors may ameliorate the inflammation and ALI associated with severe sepsis...
  21. ncbi request reprint Endostatin induces acute endothelial nitric oxide and prostacyclin release
    Chunying Li
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    Biochem Biophys Res Commun 329:873-8. 2005
    ..Short-term exposure of EC to ES, therefore, unlike long-term exposure which is anti-angiogenic, may be pro-angiogenic...
  22. pmc Increased nitric oxide synthase activity and Hsp90 association in skeletal muscle following chronic exercise
    M Brennan Harris
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Eur J Appl Physiol 104:795-802. 2008
    ..This interaction may play a role in altering muscle blood flow and skeletal muscle redox status...
  23. ncbi request reprint Nitric oxide and superoxide generation from endothelial NOS: modulation by HSP90
    Neetu Sud
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1444-53. 2007
    ....
  24. ncbi request reprint Sulforaphane suppresses angiogenesis and disrupts endothelial mitotic progression and microtubule polymerization
    Steven J T Jackson
    Medical College of Georgia, Vascular Biology Center, CB 3330, 1459 Laney Walker Boulevard Augusta, GA 30912, USA
    Vascul Pharmacol 46:77-84. 2007
    ..This mechanism of SUL-induced endothelial microtubule disruption and early mitotic arrest may further discern a potential role of SUL as a chemopreventive agent...
  25. ncbi request reprint pH and nitric oxide synthase activity and expression in bovine aortic endothelial cells
    Sandor Nagy
    Section of Neonatology, Medical College of Georgia, Augusta, Georgia 30912 3740, USA
    Acta Paediatr 95:814-7. 2006
    ....
  26. ncbi request reprint Quercetin inhibits eNOS, microtubule polymerization, and mitotic progression in bovine aortic endothelial cells
    Steven J T Jackson
    Medical College of Georgia, Vascular Biology Center, CB 3207, Augusta, GA 30912, USA
    J Nutr 136:1178-84. 2006
    ..This novel mechanism of QRN in endothelial cells may in part explain its inhibitory action on angiogenesis and further discern a potential role of QRN as a chemopreventive agent...
  27. doi request reprint TNFα reduces eNOS activity in endothelial cells through serine 116 phosphorylation and Pin1 binding: Confirmation of a direct, inhibitory interaction of Pin1 with eNOS
    Simone Kennard
    Vascular Biology Center, Medical College of Georgia, Georgia Regents University, 1459 Laney Walker Blvd, Augusta, Georgia 30912, USA
    Vascul Pharmacol 81:61-8. 2016
    ..Moreover, we find that phosphorylation of this site is not detectable in mouse eNOS. ..
  28. ncbi request reprint Heat-induced increases in endothelial NO synthase expression and activity and endothelial NO release
    M Brennan Harris
    Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Am J Physiol Heart Circ Physiol 285:H333-40. 2003
    ..We conclude that prior heat shock is a physical stimulus of increased eNOS expression and is associated with an increase in eNOS activity, agonist-stimulated NO release, and a decreased vasoconstrictor response...
  29. pmc An essential role for SRC-activated STAT-3 in 14,15-EET-induced VEGF expression and angiogenesis
    Sergey Y Cheranov
    Department of Physiology, University of Tennessee Health Science Center, Memphis 38163, USA
    Blood 111:5581-91. 2008
    ..These results reveal that Src-dependent STAT-3-mediated VEGF expression is a major mechanism of 14,15-EET-induced angiogenesis...
  30. ncbi request reprint Interaction between the 90-kDa heat shock protein and soluble guanylyl cyclase: physiological significance and mapping of the domains mediating binding
    Andreas Papapetropoulos
    G P Livanos and M Simou Laboratories, Evangelismos Hospital, Department of Critical Care and Pulmonary Services, University of Athens, Greece
    Mol Pharmacol 68:1133-41. 2005
    ..Hsp90 binding to sGC regulates the pool of active enzymes by affecting the protein levels of the two subunits...
  31. ncbi request reprint Identification of regulatory sites of phosphorylation of the bovine endothelial nitric-oxide synthase at serine 617 and serine 635
    Belinda J Michell
    St Vincent s Institute of Medical Research, Fitzroy, Victoria 3065, Australia
    J Biol Chem 277:42344-51. 2002
    ..These data show that phosphorylation of both Ser(617) and Ser(635) regulates eNOS activity and contributes to the agonist-stimulated eNOS activation process...
  32. ncbi request reprint Direct interaction of the cell division cycle 37 homolog inhibits endothelial nitric oxide synthase activity
    M Brennan Harris
    Department of Kinesiology, College of William and Mary, Williamsburg, VA 23187 8795, USA
    Circ Res 98:335-41. 2006
    ..Taken together, these data suggest that Cdc37 has a direct regulatory interaction with eNOS and may play an important role in mediating the eNOS protein complex formation as well as subsequent eNOS phosphorylation and activation...
  33. ncbi request reprint Pharmacological interference with dimerization of human neuronal nitric-oxide synthase expressed in adenovirus-infected DLD-1 cells
    Hans Jörg Habisch
    Institut fur Pharmakologie und Toxikologie, Karl Franzens Universitat Graz, Graz, Austria
    Mol Pharmacol 63:682-9. 2003
    ..As time-dependent inhibitors of NOS dimerization, BBS-1 and related compounds provide a promising strategy to develop a new class of selective and clinically useful NOS inhibitors...