Gerald S Supinski

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. pmc Polyethylene glycol-superoxide dismutase prevents endotoxin-induced cardiac dysfunction
    Gerald S Supinski
    Pulmonary and Critical Care Division, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Am J Respir Crit Care Med 173:1240-7. 2006
  2. ncbi request reprint Diaphragmatic free radical generation increases in an animal model of heart failure
    Gerald S Supinski
    Pulmonary and Critical Care Division, Department of Medicine, Medical College of Georgia, Augusta, GA 30912 3135, USA
    J Appl Physiol (1985) 99:1078-84. 2005
  3. ncbi request reprint Hemin prevents cardiac and diaphragm mitochondrial dysfunction in sepsis
    Gerald S Supinski
    Pulmonary and Critical Care Division, Department of Medicine, 1120 15th St BBR 5513, Medical College of Georgia, Augusta, GA 30912, USA
    Free Radic Biol Med 40:127-37. 2006
  4. ncbi request reprint Caspase activation contributes to endotoxin-induced diaphragm weakness
    Gerald S Supinski
    Department of Medicine, 1120 15th St, Rm BBR 5513, Medical College of Georgia, Augusta, GA 30912 3135, USA
    J Appl Physiol (1985) 100:1770-7. 2006
  5. ncbi request reprint Diaphragm and cardiac mitochondrial creatine kinases are impaired in sepsis
    Leigh A Callahan
    Pulmonary and Critical Care Division, Department of Medicine, Medical College of Georgia, Augusta, Georgia, USA
    J Appl Physiol (1985) 102:44-53. 2007
  6. pmc Calpain activation contributes to endotoxin-induced diaphragmatic dysfunction
    Gerald S Supinski
    Department of Medicine, 740 South Limestone, University of Kentucky, Lexington, KY 40536 0284, USA
    Am J Respir Cell Mol Biol 42:80-7. 2010
  7. ncbi request reprint The extrinsic caspase pathway modulates endotoxin-induced diaphragm contractile dysfunction
    Gerald S Supinski
    Department of Medicine, Medical College of Georgia, Augusta, Georgia, USA
    J Appl Physiol (1985) 102:1649-57. 2007
  8. ncbi request reprint Downregulation of diaphragm electron transport chain and glycolytic enzyme gene expression in sepsis
    Leigh Ann Callahan
    Div of Pulmonary and Critical Care Medicine, 1120 15th St, Rm BBR 5513, Medical College of Georgia, Augusta, GA 30912 3135, USA
    J Appl Physiol (1985) 99:1120-6. 2005
  9. ncbi request reprint Sepsis induces diaphragm electron transport chain dysfunction and protein depletion
    Leigh A Callahan
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Medical College of Georgia, Augusta GA 30912 3135, USA
    Am J Respir Crit Care Med 172:861-8. 2005
  10. ncbi request reprint Free radical-mediated skeletal muscle dysfunction in inflammatory conditions
    Gerald S Supinski
    Chandler Medical Center, University of Kentucky, Lexington, KY 40536, USA
    J Appl Physiol (1985) 102:2056-63. 2007

Collaborators

  • Leigh A Callahan
  • Leigh Ann Callahan

Detail Information

Publications10

  1. pmc Polyethylene glycol-superoxide dismutase prevents endotoxin-induced cardiac dysfunction
    Gerald S Supinski
    Pulmonary and Critical Care Division, Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Am J Respir Crit Care Med 173:1240-7. 2006
    ..Sepsis produces significant mitochondrial and contractile dysfunction in the heart, but the role of superoxide-derived free radicals in the genesis of these abnormalities is not completely understood...
  2. ncbi request reprint Diaphragmatic free radical generation increases in an animal model of heart failure
    Gerald S Supinski
    Pulmonary and Critical Care Division, Department of Medicine, Medical College of Georgia, Augusta, GA 30912 3135, USA
    J Appl Physiol (1985) 99:1078-84. 2005
    ..03). These findings indicate that cardiac dysfunction due to coronary ligation increases diaphragm free radical generation and that free radicals evoke reductions in diaphragm force generation...
  3. ncbi request reprint Hemin prevents cardiac and diaphragm mitochondrial dysfunction in sepsis
    Gerald S Supinski
    Pulmonary and Critical Care Division, Department of Medicine, 1120 15th St BBR 5513, Medical College of Georgia, Augusta, GA 30912, USA
    Free Radic Biol Med 40:127-37. 2006
    ..Measures that increase heme oxygenase levels may provide a means of reducing sepsis-induced mitochondrial dysfunction and tissue injury...
  4. ncbi request reprint Caspase activation contributes to endotoxin-induced diaphragm weakness
    Gerald S Supinski
    Department of Medicine, 1120 15th St, Rm BBR 5513, Medical College of Georgia, Augusta, GA 30912 3135, USA
    J Appl Physiol (1985) 100:1770-7. 2006
    ..001). Caspase inhibitors also prevented spectrin degradation. In conclusion, endotoxin administration elicits significant diaphragm caspase 3 activation and caspase-mediated diaphragmatic weakness...
  5. ncbi request reprint Diaphragm and cardiac mitochondrial creatine kinases are impaired in sepsis
    Leigh A Callahan
    Pulmonary and Critical Care Division, Department of Medicine, Medical College of Georgia, Augusta, Georgia, USA
    J Appl Physiol (1985) 102:44-53. 2007
    ..001 and P = 0.009, respectively, comparing sepsis to control conditions). Our data indicate that endotoxin markedly impairs the MtCK-ATP transporter system; this phenomenon may have significant effects on diaphragm and cardiac function...
  6. pmc Calpain activation contributes to endotoxin-induced diaphragmatic dysfunction
    Gerald S Supinski
    Department of Medicine, 740 South Limestone, University of Kentucky, Lexington, KY 40536 0284, USA
    Am J Respir Cell Mol Biol 42:80-7. 2010
    ..Moreover, calpain inhibition attenuates endotoxin-induced diaphragm weakness, suggesting that such inhibitors may be a potential treatment to improve respiratory muscle function in infected patients...
  7. ncbi request reprint The extrinsic caspase pathway modulates endotoxin-induced diaphragm contractile dysfunction
    Gerald S Supinski
    Department of Medicine, Medical College of Georgia, Augusta, Georgia, USA
    J Appl Physiol (1985) 102:1649-57. 2007
    ..The caspase-8 pathway is strongly activated in the diaphragm following endotoxin and is responsible for caspase-3 activation and diaphragm weakness...
  8. ncbi request reprint Downregulation of diaphragm electron transport chain and glycolytic enzyme gene expression in sepsis
    Leigh Ann Callahan
    Div of Pulmonary and Critical Care Medicine, 1120 15th St, Rm BBR 5513, Medical College of Georgia, Augusta, GA 30912 3135, USA
    J Appl Physiol (1985) 99:1120-6. 2005
    ....
  9. ncbi request reprint Sepsis induces diaphragm electron transport chain dysfunction and protein depletion
    Leigh A Callahan
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Medical College of Georgia, Augusta GA 30912 3135, USA
    Am J Respir Crit Care Med 172:861-8. 2005
    ..Sepsis significantly alters skeletal muscle mitochondrial function, but the mechanisms responsible for this abnormality are unknown...
  10. ncbi request reprint Free radical-mediated skeletal muscle dysfunction in inflammatory conditions
    Gerald S Supinski
    Chandler Medical Center, University of Kentucky, Lexington, KY 40536, USA
    J Appl Physiol (1985) 102:2056-63. 2007
    ..As a result, free radicals appear to play an important role in regulating a number of downstream processes that collectively act to impair muscle function and lead to reductions in muscle strength and mass in inflammatory conditions...