Jeff D Shadley
Affiliation: Medical College of Wisconsin
- Identification and functional analysis of a novel human CYP2E1 far upstream enhancerJeff D Shadley
Clinical Pharmacology, Pharmacogenetics and Teratology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 4801, USA
Mol Pharmacol 71:1630-9. 2007..The enhancer sequence is conserved within the human population but seems species-specific. The identification of this novel enhancer and its putative mechanism adds to the complexities of human CYP2E1 regulation...
- Differential regulation of human hepatic flavin containing monooxygenase 3 (FMO3) by CCAAT/enhancer-binding protein beta (C/EBPbeta) liver inhibitory and liver activating proteinsDavid E Klick
Department of Pediatrics and Pharmacology, Medical College of Wisconsin and Children s Hospital and Health System, Milwaukee, WI 53226, USA
Biochem Pharmacol 76:268-78. 2008..Chromatin immunoprecipitation demonstrated C/EBPbeta binding to the FMO3 domain I element in intact cells and adult liver tissue. These results are consistent with C/EBPbeta being important for regulating hepatic FMO3 expression...