Shailendra B Patel

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. pmc A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol
    Eric L Klett
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, SC 29403, USA
    BMC Med 2:5. 2004
  2. pmc Localization of ABCG5 and ABCG8 proteins in human liver, gall bladder and intestine
    Eric L Klett
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, STR 541, 114 Doughty Street, Charleston, South Carolina 29403, USA
    BMC Gastroenterol 4:21. 2004
  3. pmc Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome
    Hongwei Yu
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, STR 541, 114 Doughty Street, Charleston, SC 29403, USA
    BMC Dev Biol 4:1. 2004
  4. pmc The rat STSL locus: characterization, chromosomal assignment, and genetic variations in sitosterolemic hypertensive rats
    Hongwei Yu
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, STR 541, 114 Doughty Street, Charleston, SC 29403, USA
    BMC Cardiovasc Disord 3:4. 2003
  5. pmc Ezetimibe: a novel cholesterol-lowering agent that highlights novel physiologic pathways
    Shailendra B Patel
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, STR 541, 114 Doughty Street, Charleston, SC 29403, USA
    Curr Cardiol Rep 6:439-42. 2004
  6. pmc Selective reconstitution of liver cholesterol biosynthesis promotes lung maturation but does not prevent neonatal lethality in Dhcr7 null mice
    Hongwei Yu
    Division of Endocrinology, Metabolism and Nutrition, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    BMC Dev Biol 7:27. 2007
  7. pmc Loss of apolipoprotein E exacerbates the neonatal lethality of the Smith-Lemli-Opitz syndrome mouse
    Curzio Solcà
    Division of Endocrinology, Metabolism and Clinical Nutrition, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Mol Genet Metab 91:7-14. 2007
  8. pmc Sterolins ABCG5 and ABCG8: regulators of whole body dietary sterols
    Starr E Hazard
    Biomolecular Computing Resource, Medical University of South Carolina, Charleston, SC 29403, USA
    Pflugers Arch 453:745-52. 2007
  9. pmc The missense mutation in Abcg5 gene in spontaneously hypertensive rats (SHR) segregates with phytosterolemia but not hypertension
    Jianliang Chen
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, STR 541, 114 Doughty Street, Charleston, SC 29403, USA
    BMC Genet 6:40. 2005
  10. ncbi request reprint Partial rescue of neonatal lethality of Dhcr7 null mice by a nestin promoter-driven DHCR7 transgene expression
    Hongwei Yu
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, STR 541, 114 Doughty Street, Charleston, SC 29403, USA
    Brain Res Dev Brain Res 156:46-60. 2005

Detail Information

Publications19

  1. pmc A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol
    Eric L Klett
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, SC 29403, USA
    BMC Med 2:5. 2004
    ..No phenotypic difference has yet been described in humans with complete defects in either ABCG5 or ABCG8. These proteins, based upon the defects in humans, are responsible for regulating dietary sterol entry and biliary sterol secretion...
  2. pmc Localization of ABCG5 and ABCG8 proteins in human liver, gall bladder and intestine
    Eric L Klett
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, STR 541, 114 Doughty Street, Charleston, South Carolina 29403, USA
    BMC Gastroenterol 4:21. 2004
    ..Based upon the defects in sitosterolemia, ABCG5 and ABCG8 serve specifically to exclude non-cholesterol sterol entry at the intestinal level and are involved in sterol excretion at the hepatobiliary level...
  3. pmc Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome
    Hongwei Yu
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, STR 541, 114 Doughty Street, Charleston, SC 29403, USA
    BMC Dev Biol 4:1. 2004
    ..Although they have a number of biochemical and structural abnormalities, one cause of death is from apparent respiratory failure due to developmental pulmonary abnormalities...
  4. pmc The rat STSL locus: characterization, chromosomal assignment, and genetic variations in sitosterolemic hypertensive rats
    Hongwei Yu
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, STR 541, 114 Doughty Street, Charleston, SC 29403, USA
    BMC Cardiovasc Disord 3:4. 2003
    ..These genes are organized in a head-to-head configuration at the STSL locus on human chromosome 2p21...
  5. pmc Ezetimibe: a novel cholesterol-lowering agent that highlights novel physiologic pathways
    Shailendra B Patel
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, STR 541, 114 Doughty Street, Charleston, SC 29403, USA
    Curr Cardiol Rep 6:439-42. 2004
    ..Both the disease, as well as this therapeutic agent, have led to the concept that ezetimibe may be also useful in dissecting the role of these noncholesterol sterols in the pathogenesis of atherosclerosis...
  6. pmc Selective reconstitution of liver cholesterol biosynthesis promotes lung maturation but does not prevent neonatal lethality in Dhcr7 null mice
    Hongwei Yu
    Division of Endocrinology, Metabolism and Nutrition, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    BMC Dev Biol 7:27. 2007
    ....
  7. pmc Loss of apolipoprotein E exacerbates the neonatal lethality of the Smith-Lemli-Opitz syndrome mouse
    Curzio Solcà
    Division of Endocrinology, Metabolism and Clinical Nutrition, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Mol Genet Metab 91:7-14. 2007
    ..Thus the murine data suggest that maternal loss of ApoE or Ldl-r function further exacerbates the neonatal lethality, suggesting they may play a role in maternal transfer of cholesterol to the embryo...
  8. pmc Sterolins ABCG5 and ABCG8: regulators of whole body dietary sterols
    Starr E Hazard
    Biomolecular Computing Resource, Medical University of South Carolina, Charleston, SC 29403, USA
    Pflugers Arch 453:745-52. 2007
    ..This review will also highlight the current limitations in our knowledge gap...
  9. pmc The missense mutation in Abcg5 gene in spontaneously hypertensive rats (SHR) segregates with phytosterolemia but not hypertension
    Jianliang Chen
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, STR 541, 114 Doughty Street, Charleston, SC 29403, USA
    BMC Genet 6:40. 2005
    ....
  10. ncbi request reprint Partial rescue of neonatal lethality of Dhcr7 null mice by a nestin promoter-driven DHCR7 transgene expression
    Hongwei Yu
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, STR 541, 114 Doughty Street, Charleston, SC 29403, USA
    Brain Res Dev Brain Res 156:46-60. 2005
    ..Another conclusion is that even small and subtle changes in the brain sterol metabolism were sufficient to enable rescue. These data also provide important clues as to the cause of the variable expressivity seen in SLOS...
  11. pmc Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5 and Abcg8
    Kangmo Lu
    Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, Charleston, SC 29403, USA
    J Lipid Res 43:565-78. 2002
    ..Although a large number of polymorphic variants were identified, strains reported to show significant differences in cholesterol absorption rates did not show significant genomic variations in Abcg5 or Abcg8...
  12. pmc A detailed Hapmap of the Sitosterolemia locus spanning 69 kb; differences between Caucasians and African-Americans
    Bhaswati Pandit
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, STR 541, 114 Doughty Street, Charleston, SC 29403, USA
    BMC Med Genet 7:13. 2006
    ..ABCG5 and ABCG8 are thought to have evolved by gene duplication event and are arranged in a head-to-head configuration. We report here a detailed characterization of the STSL in Caucasian and African-American cohorts...
  13. pmc Liver transplantation in a patient with sitosterolemia and cirrhosis
    Tatu A Miettinen
    Department of Medicine, University of Helsinki, Finland
    Gastroenterology 130:542-7. 2006
    ..Because the diagnosis of sitosterolemia is based on specialized plasma analyses, we would propose that some consideration to this diagnosis should be given in appropriate cases...
  14. pmc The use of the Dhcr7 knockout mouse to accurately determine the origin of fetal sterols
    G S Tint
    Research Service, Department of Veterans Affairs Medical Center, East Orange, NJ 07018, USA
    J Lipid Res 47:1535-41. 2006
    ..The early fetal brain also appears to conserve cholesterol by keeping cholesterol 24-hydroxylase expression low until approximately E18...
  15. ncbi request reprint Diosgenin-induced biliary cholesterol secretion in mice requires Abcg8
    Astrid Kosters
    AMC Liver Center Academic Medical Center, Amsterdam, The Netherlands
    Hepatology 41:141-50. 2005
    ..Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html)...
  16. pmc The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice
    Astrid Kosters
    AMC Liver Center, Academic Medical Center, Amsterdam, The Netherlands
    J Lipid Res 47:1959-66. 2006
    ..Our data support the model that ABCG5/ABCG8 primarily play a role in flopping cholesterol (and sterols) from the inner leaflet to the outer leaflet of the canalicular membrane...
  17. pmc Quantifying anomalous intestinal sterol uptake, lymphatic transport, and biliary secretion in Abcg8(-/-) mice
    Helen H Wang
    Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Harvard Digestive Diseases Center, Boston, MA, USA
    Hepatology 45:998-1006. 2007
    ....
  18. ncbi request reprint Intestinal cholesterol absorption inhibitor ezetimibe added to cholestyramine for sitosterolemia and xanthomatosis
    Gerald Salen
    Department of Medicine, UMD New Jersey Medical School, Newark, New Jersey Veterans Affairs Medical Center, East Orange, New Jersey, USA
    Gastroenterology 130:1853-7. 2006
    ....
  19. pmc A transmission disequilibrium test for general pedigrees that is robust to the presence of random genotyping errors and any number of untyped parents
    Derek Gordon
    Laboratory of Statistical Genetics, Rockefeller University, Box 192, 1230 York Avenue, New York, NY 10021, USA
    Eur J Hum Genet 12:752-61. 2004
    ..5 x 10(-9) for the marker locus nearest to the sitosterolemia disease genes. We have developed software to perform TDT(ae) calculations, which may be accessed from our ftp site...