WILLIAM J O'BRIEN

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Expression of NADPH oxidase in rabbit corneal epithelial and stromal cells in culture
    WILLIAM J O'BRIEN
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, USA
    Invest Ophthalmol Vis Sci 47:853-63. 2006
  2. pmc NADPH oxidase expression and production of superoxide by human corneal stromal cells
    WILLIAM J O'BRIEN
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI, USA
    Mol Vis 15:2535-43. 2009
  3. pmc Properties of membranes derived from the total lipids extracted from the human lens cortex and nucleus
    Laxman Mainali
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Biochim Biophys Acta 1828:1432-40. 2013
  4. pmc Lipid-protein interactions in plasma membranes of fiber cells isolated from the human eye lens
    Marija Raguz
    Department of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA Department of Medical Physics and Biophysics, School of Medicine, University of Split, Split, Croatia
    Exp Eye Res 120:138-51. 2014
  5. pmc Expression of NADPH oxidase (NOX) 5 in rabbit corneal stromal cells
    Farhan Rizvi
    Departments of Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 7:e34440. 2012
  6. ncbi request reprint Changes in the Properties and Organization of Human Lens Lipid Membranes Occurring with Age
    Laxman Mainali
    a Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA
    Curr Eye Res . 2016
  7. pmc Organization of lipids in fiber-cell plasma membranes of the eye lens
    Witold K Subczynski
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA Electronic address
    Exp Eye Res . 2016
  8. pmc Amounts of phospholipids and cholesterol in lipid domains formed in intact lens membranes: Methodology development and its application to studies of porcine lens membranes
    Marija Raguz
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA Department of Medical Physics and Biophysics, School of Medicine, University of Split, Split, Croatia
    Exp Eye Res 140:179-86. 2015
  9. pmc Properties of membranes derived from the total lipids extracted from clear and cataractous lenses of 61-70-year-old human donors
    Laxman Mainali
    Department of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA
    Eur Biophys J 44:91-102. 2015
  10. pmc Lipid domains in intact fiber-cell plasma membranes isolated from cortical and nuclear regions of human eye lenses of donors from different age groups
    Marija Raguz
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA Department of Medical Physics and Biophysics, School of Medicine, University of Split, Split, Croatia
    Exp Eye Res 132:78-90. 2015

Research Grants

  1. PATHOGENESIS OF HERPETIC KERATITIS
    WILLIAM O BRIEN; Fiscal Year: 2002

Collaborators

  • Farhan Rizvi
  • Laxman Mainali
  • Marija Raguz
  • Witold K Subczynski
  • WILLIAM O BRIEN

Detail Information

Publications12

  1. ncbi request reprint Expression of NADPH oxidase in rabbit corneal epithelial and stromal cells in culture
    WILLIAM J O'BRIEN
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, USA
    Invest Ophthalmol Vis Sci 47:853-63. 2006
    ..The purpose of these studies was to determine whether corneal epithelial and stromal cells are capable of producing O2-* via an NADPH oxidase complex...
  2. pmc NADPH oxidase expression and production of superoxide by human corneal stromal cells
    WILLIAM J O'BRIEN
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI, USA
    Mol Vis 15:2535-43. 2009
    ..via nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, a family of protein complexes believed to be responsible for the localized and limited production of O(2) (.-) with regulatory activity...
  3. pmc Properties of membranes derived from the total lipids extracted from the human lens cortex and nucleus
    Laxman Mainali
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Biochim Biophys Acta 1828:1432-40. 2013
    ..Properties of human membranes are compared with those obtained for membranes made of lipids extracted from cortex and nucleus of porcine and bovine eye lenses...
  4. pmc Lipid-protein interactions in plasma membranes of fiber cells isolated from the human eye lens
    Marija Raguz
    Department of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA Department of Medical Physics and Biophysics, School of Medicine, University of Split, Split, Croatia
    Exp Eye Res 120:138-51. 2014
    ..Relationships between the organization of lipids into lipid domains in fiber cells plasma membranes and the organization of membrane proteins are discussed. ..
  5. pmc Expression of NADPH oxidase (NOX) 5 in rabbit corneal stromal cells
    Farhan Rizvi
    Departments of Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 7:e34440. 2012
    ..Several isoforms of NOXes function as multi-protein complexes while NOX5 and DUOXs do not require the accessory proteins for their activity and possess calcium binding EF hands...
  6. ncbi request reprint Changes in the Properties and Organization of Human Lens Lipid Membranes Occurring with Age
    Laxman Mainali
    a Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA
    Curr Eye Res . 2016
    ..This research was undertaken to document the changes in the organization and properties of human lens lipid membranes that occur with age...
  7. pmc Organization of lipids in fiber-cell plasma membranes of the eye lens
    Witold K Subczynski
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA Electronic address
    Exp Eye Res . 2016
    ..The purpose of this review is to inform researchers about the importance of the lipid bilayer portion of the lens fiber cell plasma membranes in the maintaining lens homeostasis, and thus protecting against cataract development...
  8. pmc Amounts of phospholipids and cholesterol in lipid domains formed in intact lens membranes: Methodology development and its application to studies of porcine lens membranes
    Marija Raguz
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA Department of Medical Physics and Biophysics, School of Medicine, University of Split, Split, Croatia
    Exp Eye Res 140:179-86. 2015
    ..Most likely the significant differences in the lipid composition were responsible for the observed differences. ..
  9. pmc Properties of membranes derived from the total lipids extracted from clear and cataractous lenses of 61-70-year-old human donors
    Laxman Mainali
    Department of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA
    Eur Biophys J 44:91-102. 2015
    ..These results suggest that high Chol content, formation of CBDs, and formation of Chol crystals should not be regarded as major predispositions for the development of age-related cataracts. ..
  10. pmc Lipid domains in intact fiber-cell plasma membranes isolated from cortical and nuclear regions of human eye lenses of donors from different age groups
    Marija Raguz
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA Department of Medical Physics and Biophysics, School of Medicine, University of Split, Split, Croatia
    Exp Eye Res 132:78-90. 2015
    ..In clear lenses, age-related changes in the lens lipid and protein composition and organization appear to occur in ways that increase fiber cell plasma membrane resistance to oxygen permeation. ..
  11. pmc Properties of fiber cell plasma membranes isolated from the cortex and nucleus of the porcine eye lens
    Laxman Mainali
    Department of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Exp Eye Res 97:117-29. 2012
    ..It is concluded that formation of rigid and practically impermeable domains is enhanced in the lens nucleus, indicating changes in membrane composition that may help to maintain low oxygen concentration in this lens region...
  12. pmc Mitochondrial dysfunction links ceramide activated HRK expression and cell death
    Farhan Rizvi
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 6:e18137. 2011
    ..We have undertaken the present study to investigate the mechanism of death induced by C6 ceramide in cultures of human corneal stromal (HCSF) fibroblasts...

Research Grants1

  1. PATHOGENESIS OF HERPETIC KERATITIS
    WILLIAM O BRIEN; Fiscal Year: 2002
    ..The long-term goal is to understand the pathogenesis of edema in order to develop effective and specific alternatives to corticosteroids for the therapy of HSV-induced edema and stromal disease. ..