Kebin Liu

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. pmc TNFα cooperates with IFN-γ to repress Bcl-xL expression to sensitize metastatic colon carcinoma cells to TRAIL-mediated apoptosis
    Feiyan Liu
    College of Life Sciences, Zhejiang University, Hangzhou, People s Republic of China
    PLoS ONE 6:e16241. 2011
  2. pmc IFN-γ upregulates survivin and Ifi202 expression to induce survival and proliferation of tumor-specific T cells
    Mary Zimmerman
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Health Sciences University, Augusta, Georgia, USA
    PLoS ONE 5:e14076. 2010
  3. pmc Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons
    Yonju Ha
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912 2000, USA
    Invest Ophthalmol Vis Sci 52:527-40. 2011
  4. doi request reprint Type 2 cGMP-dependent protein kinase regulates proliferation and differentiation in the colonic mucosa
    Rui Wang
    Department of Biochemistry and Molecular Biology, Georgia Health Sciences University, Augusta, Georgia, GA 30912 2100, USA
    Am J Physiol Gastrointest Liver Physiol 303:G209-19. 2012
  5. ncbi request reprint Downregulation of IFN-gammaR in association with loss of Fas function is linked to tumor progression
    Dafeng Yang
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA
    Int J Cancer 122:350-62. 2008
  6. doi request reprint Colonic gene expression in conventional and germ-free mice with a focus on the butyrate receptor GPR109A and the butyrate transporter SLC5A8
    Gail A Cresci
    Department of Surgery, Medical College of Georgia, Augusta, GA 30912, USA
    J Gastrointest Surg 14:449-61. 2010
  7. pmc Verticillin A overcomes apoptosis resistance in human colon carcinoma through DNA methylation-dependent upregulation of BNIP3
    Feiyan Liu
    College of Life Sciences, Zhejiang University, Hangzhou, PR China
    Cancer Res 71:6807-16. 2011
  8. pmc Unphosphorylated STAT1 promotes sarcoma development through repressing expression of Fas and bad and conferring apoptotic resistance
    Mary A Zimmerman
    Department of Biochemistry and Molecular Biology, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Cancer Res 72:4724-32. 2012
  9. pmc NF-κB directly regulates Fas transcription to modulate Fas-mediated apoptosis and tumor suppression
    Feiyan Liu
    Department of Biochemistry and Molecular Biology, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    J Biol Chem 287:25530-40. 2012
  10. pmc Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells
    Mary A Zimmerman
    Department of Biochemistry, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Am J Physiol Gastrointest Liver Physiol 302:G1405-15. 2012

Collaborators

Detail Information

Publications30

  1. pmc TNFα cooperates with IFN-γ to repress Bcl-xL expression to sensitize metastatic colon carcinoma cells to TRAIL-mediated apoptosis
    Feiyan Liu
    College of Life Sciences, Zhejiang University, Hangzhou, People s Republic of China
    PLoS ONE 6:e16241. 2011
    ..The aim of this study is to investigate the synergistic effect of TNFα and IFN-γ in sensitizing metastatic colon carcinoma cells to TRAIL-mediated apoptosis...
  2. pmc IFN-γ upregulates survivin and Ifi202 expression to induce survival and proliferation of tumor-specific T cells
    Mary Zimmerman
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Health Sciences University, Augusta, Georgia, USA
    PLoS ONE 5:e14076. 2010
    ..The aim of this study is to elucidate the molecular mechanisms underlying the effects of stimulation conditions on proliferation and survival of tumor-specific CTLs...
  3. pmc Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons
    Yonju Ha
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912 2000, USA
    Invest Ophthalmol Vis Sci 52:527-40. 2011
    ..To investigate the mechanism of σ receptor 1 (σR1) neuroprotection in retinal neurons...
  4. doi request reprint Type 2 cGMP-dependent protein kinase regulates proliferation and differentiation in the colonic mucosa
    Rui Wang
    Department of Biochemistry and Molecular Biology, Georgia Health Sciences University, Augusta, Georgia, GA 30912 2100, USA
    Am J Physiol Gastrointest Liver Physiol 303:G209-19. 2012
    ..The similarities in phenotype between PKG2 and GCC knockout mice positions PKG2 as a likely mediator of the homeostatic effects of cGMP signaling in the colon...
  5. ncbi request reprint Downregulation of IFN-gammaR in association with loss of Fas function is linked to tumor progression
    Dafeng Yang
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA
    Int J Cancer 122:350-62. 2008
    ..These findings suggest that coordinate downregulation of Fas and IFN-gammaR, 2 key components of cancer immunosurveillance system on tumor cells, leads to a more aggressive metastatic phenotype...
  6. doi request reprint Colonic gene expression in conventional and germ-free mice with a focus on the butyrate receptor GPR109A and the butyrate transporter SLC5A8
    Gail A Cresci
    Department of Surgery, Medical College of Georgia, Augusta, GA 30912, USA
    J Gastrointest Surg 14:449-61. 2010
    ....
  7. pmc Verticillin A overcomes apoptosis resistance in human colon carcinoma through DNA methylation-dependent upregulation of BNIP3
    Feiyan Liu
    College of Life Sciences, Zhejiang University, Hangzhou, PR China
    Cancer Res 71:6807-16. 2011
    ..Taken together, our findings identify Verticillin A as a potent apoptosis sensitizer with great promise for further development as an adjuvant agent to overcome drug resistance in human cancer therapy...
  8. pmc Unphosphorylated STAT1 promotes sarcoma development through repressing expression of Fas and bad and conferring apoptotic resistance
    Mary A Zimmerman
    Department of Biochemistry and Molecular Biology, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Cancer Res 72:4724-32. 2012
    ....
  9. pmc NF-κB directly regulates Fas transcription to modulate Fas-mediated apoptosis and tumor suppression
    Feiyan Liu
    Department of Biochemistry and Molecular Biology, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    J Biol Chem 287:25530-40. 2012
    ..Our observations suggest that canonical NF-κB is a Fas transcription activator and alternate NF-κB is a Fas transcription repressor, and Fas functions as a suppressor of spontaneous sarcoma and colon carcinoma...
  10. pmc Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells
    Mary A Zimmerman
    Department of Biochemistry, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Am J Physiol Gastrointest Liver Physiol 302:G1405-15. 2012
    ....
  11. pmc Deregulation of apoptotic factors Bcl-xL and Bax confers apoptotic resistance to myeloid-derived suppressor cells and contributes to their persistence in cancer
    Xiaolin Hu
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Biol Chem 288:19103-15. 2013
    ..Therefore, targeting Bcl-xL is potentially effective in suppression of MDSC persistence in cancer therapy. ..
  12. ncbi request reprint IFN regulatory factor 8 mediates apoptosis in nonhemopoietic tumor cells via regulation of Fas expression
    Dafeng Yang
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 179:4775-82. 2007
    ..Taken together, our data suggest that IRF8 is an essential mediator of Fas-mediated apoptosis and that IRF8 mediates apoptosis through regulation of Fas expression in nonhemopoietic tumor cells...
  13. pmc Extracellular signal-regulated kinase signaling pathway regulates breast cancer cell migration by maintaining slug expression
    Haoming Chen
    Department of Biochemistry, Medical College of Georgia, Augusta, Georgia, USA
    Cancer Res 69:9228-35. 2009
    ..Our study suggests that the ERK pathway regulates breast cancer cell migration by maintaining slug expression...
  14. pmc IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia
    Xiaolin Hu
    Department of Biochemistry and Molecular Biology, and Cancer Center, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Cancer Res 71:2882-91. 2011
    ..In summary, our findings determine the mechanism of IRF8 downregulation in CML cells and they determine a primary pathway of resistance to Fas-mediated apoptosis and disease progression...
  15. doi request reprint Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis
    In Kiu Kwon
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Cancer 112:1462-70. 2008
    ..Type 1 cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) reportedly has exhibited antitumor properties, and its expression is down-regulated in many tumors...
  16. doi request reprint Cyclic 3',5'-guanosine monophosphate-dependent protein kinase inhibits colon cancer cell adaptation to hypoxia
    In Kiu Kwon
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia, USA
    Cancer 117:5282-93. 2011
    ..The present study examined the mechanism underlying the inhibition of angiogenesis by PKG...
  17. pmc Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger
    Jaya P Gnana-Prakasam
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA
    Biochem J 424:243-52. 2009
    ..Wild-type mouse RPE cells and human RPE cell lines, when loaded with iron by exposure to ferric ammonium citrate, showed increased expression and activity of xCT, reproducing the biochemical phenotype observed with Hfe-/- RPE cells...
  18. pmc The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity
    Navjotsingh Pabla
    Department of Cellular Biology and Anatomy, Medical College of Georgia and Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia 30912, USA
    Am J Physiol Renal Physiol 296:F505-11. 2009
    ..Notably, cimetidine can further reduce cisplatin uptake and cisplatin toxicity in Ctr1-downregulated cells. The results have demonstrated the first evidence for a role of Ctr1 in cisplatin uptake and nephrotoxicity...
  19. pmc DNA methylation represses IFN-gamma-induced and signal transducer and activator of transcription 1-mediated IFN regulatory factor 8 activation in colon carcinoma cells
    Jon M McGough
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, 1459 Laney Walker Boulevard, Augusta, GA 30912, USA
    Mol Cancer Res 6:1841-51. 2008
    ..Our data thus suggest that human colon carcinoma cells silence IFN-gamma-activated IRF8 expression through MBD1-dependent and PIAS1-mediated inhibition of pSTAT1 function at the methylated IRF8 promoter...
  20. pmc IFN regulatory factor 8 sensitizes soft tissue sarcoma cells to death receptor-initiated apoptosis via repression of FLICE-like protein expression
    Dafeng Yang
    Department of Biochemistry, Medical College of Georgia, Augusta, GA 30912, USA
    Cancer Res 69:1080-8. 2009
    ....
  21. pmc Decitabine and vorinostat cooperate to sensitize colon carcinoma cells to Fas ligand-induced apoptosis in vitro and tumor suppression in vivo
    Dafeng Yang
    Department of Biochemistry and Molecular Biology, Georgia Health Sciences University, Augusta, GA 30912, USA
    J Immunol 188:4441-9. 2012
    ..Thus, our data suggest that combined modalities of chemotherapy to sensitize the tumor cell to Fas-mediated apoptosis and CTL immunotherapy is an effective approach for the suppression of colon cancer metastasis...
  22. pmc GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon
    Muthusamy Thangaraju
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Cancer Res 69:2826-32. 2009
    ..These studies show that GPR109A mediates the tumor-suppressive effects of the bacterial fermentation product butyrate in colon...
  23. ncbi request reprint Targeting lymphotoxin beta receptor with tumor-specific T lymphocytes for tumor regression
    Dafeng Yang
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Clin Cancer Res 13:5202-10. 2007
    ..Therefore, we sought to identify perforin- and Fas-independent cytotoxic pathways and explored the potential of targeting LTbetaR with tumor-specific CTLs to induce tumor rejection in vivo...
  24. pmc GCN2-dependent metabolic stress is essential for endotoxemic cytokine induction and pathology
    Haiyun Liu
    Cancer Immunology, Inflammation, and Tolerance Program, GRU Cancer Center, Medical College of Georgia, Georgia Regents University, Augusta, Georgia, USA
    Mol Cell Biol 34:428-38. 2014
    ..Thus, the data show that amino acid depletion stress signals (via GCN2) synergize with proinflammatory signals to potently increase innate immune responsiveness. ..
  25. pmc Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression
    Amy V Paschall
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA
    BMC Cancer 14:24. 2014
    ..We aimed at identifying molecular targets of ceramide in metastatic human colon and breast cancer cells, and determining the efficacy of ceramide analog in suppression of colon and breast cancer metastasis...
  26. pmc Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury
    Man Jiang
    Department of Cellular Biology and Anatomy, Medical College of Georgia, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
    Am J Pathol 176:1181-92. 2010
    ..Together, the results demonstrated autophagy induction during hypoxic and ischemic renal injury. Under these pathological conditions, autophagy may provide a protective mechanism for cell survival...
  27. ncbi request reprint Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells
    Dafeng Yang
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia, USA
    Cancer Res 67:3301-9. 2007
    ....
  28. pmc Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery
    Kyungsoo Ha
    Cancer Center, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA
    Hum Mol Genet 20:126-40. 2011
    ..Taken together, our studies provide compelling additional evidence for DNMT1 acting as a regulator of genome integrity and as an early responder to DNA DSBs...
  29. pmc Endogenous elevation of homocysteine induces retinal neuron death in the cystathionine-beta-synthase mutant mouse
    Preethi S Ganapathy
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912 2000, USA
    Invest Ophthalmol Vis Sci 50:4460-70. 2009
    ..To determine the effects of endogenous elevation of homocysteine on the retina using the cystathionine beta-synthase (cbs) mutant mouse...
  30. ncbi request reprint Effects of targeted Bcl-2 expression in mitochondria or endoplasmic reticulum on renal tubular cell apoptosis
    Kirti Bhatt
    Department of Cellular Biology and Anatomy, Medical College of Georgia and Veterans Affairs Medical Center, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
    Am J Physiol Renal Physiol 294:F499-507. 2008
    ..Collectively, the results suggest that the cytoprotective effects of Bcl-2 in different renal injury models are largely determined by its subcellular localizations...

Research Grants3

  1. Role of Epigenetic Repression of IRF8 in Tumor Progression/Metastasis
    Kebin Liu; Fiscal Year: 2009
    ..Successful completion of the proposed research will provide a novel strategy for targeting the deadly metastatic human colorectal cancer. ..
  2. Role of Epigenetic Repression of IRF8 in Tumor Progression/Metastasis
    Kebin Liu; Fiscal Year: 2010
    ..Successful completion of the proposed research will provide a novel strategy for targeting the deadly metastatic human colorectal cancer. ..